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| 1 | Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation显示文摘The intra-islet microvasculature is a critical interface between the blood and islet endocrine cells governing a number of cellular and pathophysiological processes associated with the pancreatic tissue. A growing body of evidence indicates a strong functional and physical interdependency of β-cells with endothelial cells(ECs), the building blocks of islet microvasculature. Intra-islet ECs, actively regulate vascular permeability and appear to play a role in fine-tuning blood glucose sensing and regulation. These cells also tend to behave as 'guardians', controlling the expression and movement of a number of important immune mediators, thereby strongly contributing to the physiology of islets. This review will focus on the molecular signalling and crosstalk between the intra-islet ECs and β-cells and how their relationship can be a potential target for intervention strategies in islet pathology and islet transplantation. | Siddharth Narayanan Gopalakrishnan Loganathan Maheswaran Dhanasekaran William Tucker Ankit Patel Venugopal Subhashree SriPrakash Mokshagundam Michael G Hughes Stuart K Williams Appakalai N Balamurugan | 2017 | World Journal of Transplantation2017，7，2： | 1 |
| 2 | Stratifying Risk of Biliary Complications in Adult Living Donor Liver Transplantation by Magnetic Resonance Cholangiography显示文摘 | Randeep Kashyap Adel Bozorgzadeh Peter Abt Georgios Tsoulfas Manoj Maloo Rajeev Sharma Siddharth Patel David Dombroski Parvez Mantry Saman Safadjou Ashok Jain Mark Orloff | 2008 | Transplantation2008，，11： | 1 |
| 3 | The Cumulative Effects of Cold Ischemic Time and Older Donor Age on Liver Graft Survival显示文摘 | James R. Cassuto Siddharth A. Patel Georgios Tsoulfas Mark S. Orloff Peter L. Abt | 2008 | Journal of Surgical Research2008，，1： | 1 |
| 4 | Stratifying Risk of Biliary Complications in Adult Living Donor Liver Transplantation by Magnetic Resonance Cholangiography显示文摘 | Randeep Kashyap Adel Bozorgzadeh Peter Abt Georgios Tsoulfas Manoj Maloo Rajeev Sharma Siddharth Patel David Dombroski Parvez Mantry Saman Safadjou Ashok Jain Mark Orloff | 2008 | Transplantation2008，，11： | 1 |
| 5 | Gut microbiota interactions with anti-diabetic medications and pathogenesis of type 2 diabetes mellitus显示文摘Microorganisms including bacteria,viruses,protozoa,and fungi living in the gastrointestinal tract are collectively known as the gut microbiota.Dysbiosis is the imbalance in microbial composition on or inside the body relative to healthy state.Altered Firmicutes to Bacteroidetes ratio and decreased abundance of Akkermansia muciniphila are the predominant gut dysbiosis associated with the pathogenesis of type 2 diabetes mellitus(T2DM)and metabolic syndrome.Pathophysiological mechanisms linking gut dysbiosis,and metabolic diseases and their complications include altered metabolism of short-chain fatty acids and bile acids,interaction with gut hormones,increased gut microbial metabolite trimethylamine-N-oxide,bacterial translocation/Leaky gut syndrome,and endotoxin production such as lipopolysaccharides.The association between the gut microbiota and glycemic agents,however,is much less understood and is the growing focus of research and conversation.Recent studies suggest that the gut microbiota and anti-diabetic medications are interdependent on each other,meaning that while anti-diabetic medications alter the gut microbiota,the gut microbiota also alters the efficacy of anti-diabetic medications.With increasing evidence regarding the significance of gut microbiota,it is imperative to review the role of gut microbiota in the pathogenesis of T2DM.This review also discusses the interaction between gut microbiota and the various medications used in the treatment of T2DM. | Ravi Kant Lakshya Chandra Vipin Verma Priyanshu Nain Diego Bello Siddharth Patel Subash Ala Rashmi Chandra Mc Anto Antony | 2022 | World Journal of Methodology2022，12，4： | 1 |
| 6 | Stroke in COVID-19: a single-centre initial experience in a hotspot of the pandemic显示文摘Background COVID-19,caused by SARS-CoV-2,is a global pandemic that has been an immense burden on healthcare systems all over the world.These patients may be at higher risk for acute ischaemic stroke(AIS).We present our experience with AIS in patients with COVID-19.Methods We reviewed all patients admitted to our hospital during a 6-week period with a positive nasopharyngeal swab test for SARS-CoV-2.Among these patients,we identified AIS.We reviewed the demographics,clinical,laboratory,imaging characteristics,treatments received and outcomes of AIS in patients with COVID-19.Results We identified 683 patients admitted with COVID-19 during the study period,of which 20 patients had AIS.Large-vessel occlusion(LVO)was noted in 11 patients(55%).Intravenous alteplase was administered in four patients(20%)and mechanical thrombectomy was performed in five patients(25%).Respiratory symptoms preceded the onset of AIS in most of the patients(70%)by 1 to 21 days.Mortality in patients with AIS was 50%compared with 26%of all COVID-19 admissions.Most of these patients died due to non-neurological causes(70%).Three patients with AIS had clinical and imaging findings consistent with COVID-19,but were negative for multiple nasopharyngeal swab tests.Interpretation LVO was more common in patients with AIS and COVID-19.They had more severe disease and higher mortality rates.Most of the patients had respiratory symptoms preceding AIS by days to weeks.This could explain certain patients with clinical picture of COVID-19 but negative nasopharyngeal swab tests. | Ivo Bach Pratibha Surathi Nora Montealegre Osama Abu-Hadid Sara Rubenstein Sviatoslav Redko Siddharth Gupta Machteld Hillen Pratit Patel Priyank Khandelwal Adham Kamel | 2020 | Stroke & Vascular Neurology2020，5，4： | 0 |
| 7 | 心血管造影和介入学会/血管内科学会(SCAI/SVM)颈动脉支架置入术培训及资格认证专家共识声明显示文摘颈动脉支架置入术(carotid artery stcnting,CAS)已成为心血管内科项目针对卒中预防提供的治疗方案中不可或缺的一部分。该专家共识声明的目的在于为这些项目提供医师培训和资格认证方面的指导,从而促进CAS安全有效地融入临床实践。自从2005年《颈动脉支架置入术临床能力声明》发表以来,介入器械出现了大量创新,众多临床试验和观察性研究发表,积累了丰富的真实世界临床经验,而且有健全的国家质量改进计划的广泛参与。总的来说,这些进展已导致在患者合理选择以及安全有效实施CAS所需的认知、技术和临床技能方面发生了实质性变化。因此,我们总结出版了这份指南,旨在介绍培训路径,概述能力要素,提供转归随访策略,明确设施、设备和人员要求,并提出维持CAS能力的标准。 | Herbert D. Aronow Tyrone J. Collins William A. Gray Michael R. Jaff Bryan W. Kluck Rajah A. G. Patel Kenneth A. Rosenfield Robert D. Safian Piotr S. Sobieszczyk Siddharth A. Wayangankar Christopher J. White 胡挺 段振晖 马敏敏 | 2017 | 国际脑血管病杂志2017，25，5： | 0 |
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