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| 1 | Endoscopic characteristics of small intestinal malignant tumors observed by balloon-assisted enteroscopy显示文摘BACKGROUND Capsule endoscopy and balloon-assisted enteroscopy(BAE) enable visualization of rare small bowel conditions such as small intestinal malignant tumors.However,details of the endoscopic characteristics of small intestinal malignant tumors are still unknown.AIM To elucidate the endoscopic characteristics of small intestinal malignant tumors.METHODS From March 2005 to February 2017,1329 BAE procedures were performed at Keio University Hospital. Of these procedures,malignant tumors were classified into three groups,Group 1: epithelial tumors including primary small intestinal cancer,metastatic small intestinal cancer,and direct small intestinal invasion by an adjacent organ cancer; Group 2: small intestinal malignant lymphoma; and Group 3,small intestinal gastrointestinal stromal tumors. We systematically collected clinical and endoscopic data from patients' medical records to determine the endoscopic characteristics for each group.RESULTS The number of patients in each group was 16(Group 1),23(Group 2),and 6(Group 3),and the percentage of solitary tumors was 100%,43.5%,and 100%,respectively(P < 0.001). Patients' clinical background parameters including age,symptoms,and laboratory data were not significantly different between the groups. Seventy-five percent of epithelial tumors(Group 1) were located in the upper small intestine(duodenum and ileum),and approximately 70% of gastrointestinal stromal tumors(Group 3) were located in the jejunum. Solitary protruding or mass-type tumors were not seen in malignant lymphoma(Group2)(P < 0.001). Stenosis was seen more often in Group 1,(68.8%,27.3%,and 0%;Group 1,2,and 3,respectively; P = 0.004). Enlarged white villi inside and/or surrounding the tumor were seen in 12.5%,54.5%,and 0% in Group 1,2,and 3,respectively(P = 0.001).CONCLUSION The differential diagnosis of small intestinal malignant tumors could be tentatively made based on BAE findings. | Tomofumi Horie Naoki Hosoe Kaoru Takabayashi Yukie Hayashi Kenji JL Limpias Kamiya Ryoichi Miyanaga Shinta Mizuno Kayoko Fukuhara Seiichiro Fukuhara Makoto Naganuma Masayuki Shimoda Haruhiko Ogata Takanori Kanai | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，5： | 4 |
| 2 | Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients显示文摘AIM:To identify the prevalence of hepatitis B e antigen (HBeAg) and to assess the association of hepatitis B virus (HBV) core promoter mutations and viral load in Indonesian patients.METHODS:Sixty-four patients with chronic hepatitis,65 with liver cirrhosis and 50 with hepatocellular carcinoma were included in this study.HBeAg and hepatitis B e antibody (HBeAb) tests were performed using enzyme-linked immunosorbent assay and the mutations were analyzed by sequencing.Viral load was measured by real-time polymerase chain reaction.RESULTS:Of 179 patients,108 (60.3%) were HBeAg(-) and 86 (79.6%) of these HBeAg(-) patients had been seroconverted.The A1896 mutation was not found in HBeAg(+) patients,however,this mutation was detected in 70.7% of HBeAg(-) patients.This mutation was frequently found when HBeAg was not expressed (87.7%),compared to that found in HBeAg seroconverted patients (65.1%).The A1899 mutation was also more prevalent in HBeAg(-) than in HBeAg(+) patients (P=0.004).The T1762/A1764 mutation was frequently found in both HBeAg(+) and HBeAg(-) patients,however,the prevalence of this mutation did not significantly differ among the two groups (P=0.054).In HBeAg(+) patients,the T1762/A1764 mutation was correlated with lower HBV DNA (P < 0.001).The A1899 mutation did not correlate with HBV DNA (P=0.609).In HBeAg(-) patients,the T1762/A1764 mutation alone was not correlated with HBV DNA (P=0.095),however,the presence of either the T1762/A1764 or A1896 mutations was associated with increased HBV DNA (P < 0.001).CONCLUSION:The percentage of HBeAg(-) patients is high in Indonesia,and most of the HBeAg(-) patients had been seroconverted.The A1896 mutation was most likely the major cause of HBeAg loss.The T1762/A1764 mutation alone was associated with lower viral loads in HBeAg(+) patients,but not in HBeAg(-) patients. | Andi Utama Marlinang Diarta Siburian Sigit Purwantomo Mariana Destila Bayu Intan Tri Shinta Kurniasih Susan Tai Rino Alvani Gani Laurentius Adrianus Lesmana All Sulaiman Wenny Astuti Achwan Soewignjo Soemohardjo Arnelis Nasrul Zubir Julius Syafruddin AR Lelosutan Benyamin Lukito Tantoro Harmono | 2011 | World Journal of Gastroenterology2011，17，6： | 3 |
| 3 | Hepatitis B virus pre-S2 start codon mutations in Indonesian liver disease patients显示文摘AIM: To identify the prevalence of pre-S2 start codon mutations and to assess their association with liver disease progression. METHODS: The mutations were identified by direct sequencing from 73 asymptomatic carriers, 66 chronic hepatitis (CH), 66 liver cirrhosis (LC) and 63 hepatocellular carcinoma (HCC) patients. Statistical significances were determined using Fisher's exact test, χ 2 test, and t -test analyses whenever appropriate. Pre-S mutation as a risk factor for advanced liver disease was estimated by unconditional logistic regression model adjusted with age, sex, and hepatitis B e antigen (HBeAg). P < 0.05 was considered significant. RESULTS: Mutation of the hepatitis B virus (HBV) pre-S2 start codon was found in 59 samples from 268 subjects (22.0%), with higher prevalence in patients with cirrhosis 27/66 (40.9%) followed by HCC 18/63 (28.6%), chronic hepatitis 12/66 (18.2%) and asymptomatic carriers 2/73 (2.7%) (P < 0.001). Logistic regression analysis showed that pre-S2 start codon mutation was an independent factor for progressive liver disease. Other mutations, at T130, Q132, and A138, were also associated with LC and HCC, although this was not statistically significant when adjusted for age, sex, and HBeAg. The prevalence of pre-S2 start codon mutation was higher in HBV/B than in HBV/C (23.0% vs 19.1%), whilst the prevalence of T130, Q132, and A138 mutation was higher in HBV/C than in HBV/B. The prevalence of pre-S2 start codon mutation was higher in LC (38.9%) and HCC (40.0%) than CH (5.6%) in HBeAg(+) group, but it was similar between CH, LC and HCC in HBeAg(-) group. CONCLUSION: Pre-S2 start codon mutation was higher in Indonesian patients compared to other Asian countries, and its prevalence was associated with advanced liver disease, particularly in HBeAg(+) patients. | Andi Utama Marlinang Diarta Siburian Ismail Fanany Mariana Destila Bayu Intan Rama Dhenni Tri Shinta Kurniasih Syafruddin AR Lelosutan Wenny Astuti Achwan Nasrul Zubir Arnelis Benyamin Lukito Irawan Yusuf Laurentius Adrianus Lesmana Ali Sulaiman | 2012 | World Journal of Gastroenterology2012，18，38： | 3 |
| 4 | Preliminary outcomes of primary phacoemulsification plus intraocular lens implantation for primary angle closure glaucoma显示文摘 | Hiroko Hata Shinta Yamane So Hata | | 0，，03： | 1 |
| 5 | Agent-based diffusion model for an automobile market with fuzzy TOPSIS Based product adoption process 显示文摘 | KIM Shintae LEE Keeheon CHO Jangkyun | 2011 | Expert Systems with Applications2011，38，6： | 1 |
| 6 | Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor显示文摘 | David Masiello Shinta Cheng Glenn J | 2002 | J Biol Chem2002，277，26： | 1 |
| 7 | Crystallization of Polypropylene Containing Nucleators 显示文摘 | Nagasawa Shinta Fujimori Atsuhiro Masuko Toru | 2005 | Polymer2005，46，14： | 1 |
| 8 | Crystallisation of Polypropylene Containing Nucleators显示文摘 | Shinta Nagasawa Atsuhiro Fujimori Toru Masuko | 2005 | Polymer2005，46，： | 1 |
| 9 | Remotely-sensed land usepatterns and the presence of Anopheles larvae(Diptera∶Culicidae)in Sukabumi,West Java,Indonesia显示文摘 | Stoops CA Gionar YR Shinta | 2008 | J Vector Ecol2008，33，1： | 1 |
| 10 | Chlamydocinhydroxamic acid analogues as histone deacetylase inhibitors 显示文摘 | Norikazu Nishino Binoy Jose Ryuzo Shinta | 2004 | Bioorganic & Medicinal Chemistry2004，12，22： | 1 |
| 11 | pH-conductivity hybrid gradient cation exchange chromatography for process-scale monoclonal antibody purification显示文摘 | Zhou JX Shinta D Felix S | 2007 | J Chromatogr A2007，1175，12： | 1 |
| 12 | Agent-based diffusion model for an automobile market with fuzzy TOPSIS-based product adoption process显示文摘 | Shintae Kim Keeheon Lee Jang Kyun Cho Chang Ouk Kim | 2010 | Expert Systems With Applications2010，，6： | 1 |
| 13 | Histological increase in inflammatory infiltrate in sun- exposed skin of female subjects: the possible involvement of matrix metalloproteinase- 1 produced by inflammatory infiltrate on collagen degration显示文摘 | Hase T Shinta K Murase T | 2000 | Br J Dermtol2000，142，2： | 1 |
| 14 | Crystallisation of polypropylene containing nucleators 显示文摘 | SHINTA NAGASAWA ATSUHIRO FUJIMORI TORU MASUKO | 2005 | Polymer2005，46，： | 1 |
| 15 | Crystallization of polypropylene containing nucleators显示文摘 | Shinta Nagasawa Atsuhiro Fujimori Toru Masuko etal | 2005 | Polymer2005，46，14： | 1 |
| 16 | Factors affecting cyclic durability of all solid state lithium polymer batteries using poly (ethylene oxide) based solid polymer electrolytes显示文摘 | Masanobu Nakayama Shinta Wada Shigeki Kuroki | 2010 | Energy Environ Sei2010，3，： | 1 |
| 17 | Dysregulated balance of retinoid-related orphan receptor γt-dependent innate lymphoid cells is involved in the pathogenesis of chronic DSS-induced colitis显示文摘 | Kayoko Kimura Takanori Kanai Atsushi Hayashi Yohei Mikami Tomohisa Sujino Shinta Mizuno Tango Handa Katsuyoshi Matsuoka Tadakazu Hisamatsu Toshiro Sato Toshifumi Hibi | 2012 | Biochemical and Biophysical Research Communications2012，，4： | 1 |
| 18 | Crystallisation of polypropylene containing nucleators 显示文摘 | Shinta Nagasawa Atsuhiro Fujimori Toru Masuko Masatoshi Iguchi | 2005 | polymer2005，46，： | 1 |
| 19 | Capacity fading mechanism in all solid-state lithium poly mer secondary batteries using PEG-Borate/aluminate ester as plasticizer for polymer electrolytes显示文摘 | Fuminari Kaneko Shinta Wada Masanobu Nakayama | 2009 | Adv Funct Mater2009，19，： | 1 |
| 20 | Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier显示文摘 | Shinta Mizuno Yoshiyuki Yamagishi Hirotoshi Ebinuma Nobuhiro Nakamoto Mai Katahira Aya Sasaki Michiie Sakamoto Hidekazu Suzuki Takanori Kanai Toshifumi Hibi | 2013 | Clinical Journal of Gastroenterology2013，，2： | 1 |
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