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| 1 | Current hepatitis B virus infection situation in Indonesia and its genetic diversity显示文摘Indonesia has a moderate to high endemicity of hepatitis B virus(HBV) infection. The risk for chronic HBV infection is highest among those infected during infancy. Since 1997, hepatitis B(Hep B) vaccination of newborns has been fully integrated into the National Immunization Program. Al though HBV infection has been reduced by the universal newborn Hep B immunization program, it continues to occur in Indonesia. The low birth dose coverage and the presence of vaccine escape mutants might contribute to this endemicity among children. Although limited information is available for an analysis of occult HBV infection(OBI), several variations and substitutions in the pre-S/S region have been detected in Indonesian HBV strains. Additionally, persistent infection and disease progression of chronic hepatitis B are related to not only viral factors but also the host genome. Indonesia is one of the most ethnically heterogeneous nations, with Javanese and Sundanese as the two highest ethnic groups. This multi-ethnicity makes genomic research in Indonesia difficult. In this article, we focused on and reviewed the following aspects: the current hepatitis B immunization program and its efficacy, OBI, HBV infection among high-risk patients, such as hemodialysis patients, and research regarding the host genome in Indonesia. | Maria Inge Lusida Juniastuti Yoshihiko Yano | 2016 | World Journal of Gastroenterology2016，22，32： | 6 |
| 2 | 乙型肝炎病毒前S2基因变异与肝病发病机制的研究进展显示文摘乙肝病毒感染已被认为是导致许多肝病发病的主要原因。但其致病机制复杂,目前为止尚未完全阐明。近年来,许多文献报道乙肝病毒Pre-S2的基因变异是导致乙肝相关性疾病发病的重要因素之一。本文就PreS2基因变异导致相关肝病发病的最新研究进展进行综述。 | 李志军 舒涛 司晶 徐哲 郑志 张亮 黄伟 叶少军 王彦峰 叶啟发 | 2017 | 武汉大学学报(医学版)2017，38，6： | 1 |
| 3 | 乙型肝炎病毒前S2基因变异与肝病进展关系的研究进展显示文摘乙型肝炎病毒(hepatitis B virus, HBV)前 S2区全长165 bp,编码前S2蛋白的55个氨基酸。前S2和S基因共同编码中蛋白,前S1、前S2和S基因共同编码大蛋白。有前S/S基因变异的HBV感染者,HBV DNA复制与乙肝表面抗原(hepatitis B surface antigen, HBsAg)分泌似乎是分离的[1],临床上检测前S2抗原可弥补因病毒变异和其他原因造成的乙肝病毒e抗原(hepatitis B e antigen, HBeAg)阴性的“误寻”,尤其在隐匿性HBV感染者中。 | 姚佩君 张志波 高建鹏 | 2014 | 实用医学杂志2014，30，14： | 0 |
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