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| 1 | Relationship between post-ERCP pancreatitis and the change of serum amylase level after the procedure显示文摘AIM: To clarify the relationship between the change of serum amylase level and post-ERCP pancreatitis. METHODS: Between January 1999 and December 2002, 1291 ERCP-related procedures were performed. Serum amylase concentrations were measured before the procedure and 3, 6, and 24 h afterward. The frequency and severity of post-ERCP pancreatitis and the relationship between these phenomena and the change in amylase level were estimated. RESULTS: Post-ERCP pancreatitis occurred in 47 patients (3.6%). Pancreatitis occurred in 1% of patients with normal amylase levels 3 h after ERCP, and in 1%, 5%, 20%, 31% and 39% of patients with amylase levels elevated 1-2 times, 2-3 times, 3-5 times, 5-10 times and over 10 times the upper normal limit at 3 h after ERCP, respectively (level < 2 times vs ≥ 2 times, P < 0.001). Of the 143 patients with levels higher than the normal limit at 3 h after ERCP followed by elevation at 6 h, pancreatitis occurred in 26%. In contrast, pancreatitis occurred in 9% of 45 patients with a level higher than two times the normal limit at 3 h after ERCP followed by a decrease at 6 h (26% vs 9%, P < 0.05). CONCLUSION: Post-ERCP pancreatitis is frequently associated with an increase in serum amylase level greater than twice the normal limit at 3 h after ERCP with an elevation at 6 h. A decrease in amylase level at 6 h after ERCP suggests the unlikelihood of development of post-ERCP pancreatitis. | Kei Ito Naotaka Fujita Yutaka Noda Go Kobayashi Jun Horaguchi Osamu Takasawa Takashi Obana | 2007 | World Journal of Gastroenterology2007，13，28： | 19 |
| 2 | Pancreatic guidewire placement for achieving selective biliary cannulation during endoscopic retrograde cholangio-pancreatography显示文摘AIM: To investigate the frequency and risk factors for acute pancreatitis after pancreatic guidewire placement (P-GW) in achieving cannulation of the bile duct during endoscopic retrograde cholangio-pancreatography (ERCP). METHODS: P-GW was performed in 113 patients in whom cannulation of the bile duct was difficult. The success rate of biliary cannulation, the frequency and risk factors of post-ERCP pancreatitis, and the frequency of spontaneous migration of the pancreatic duct stent were investigated. RESULTS: Selective biliary cannulation with P-GW was achieved in 73% of the patients. Post-ERCP pancreatitis occurred in 12% (14 patients: mild, 13; moderate, 1). Prophylactic pancreatic stenting was attempted in 59% of the patients. Of the 64 patients who successfully underwent stent placement, three developed mild pancreatitis (4.7%). Of the 49 patients without stent placement, 11 developed pancreatitis (22%: mild, 10; moderate, 1). Of the five patients in whom stent placement was unsuccessful, two developed mild pancreatitis. Univariate and multivariate analyses revealed no pancreatic stenting to be the only significant risk factor for pancreatitis. Spontaneous migration of the stent was observed within two weeks in 92% of the patients who had undergone pancreatic duct stenting.CONCLUSION: P-GW is useful for achieving selective biliary cannulation. Pancreatic duct stenting after P-GW can reduce the incidence of post-ERCP pancreatitis, which requires evaluation by means of prospective randomized controlled trials. | Kei Ito Naotaka Fujita Yutaka Noda Go Kobayashi Takashi Obana Jun Horaguchi Osamu Takasawa Shinsuke Koshita Yoshihide Kanno | 2008 | World Journal of Gastroenterology2008，14，36： | 14 |
| 3 | Histological changes at an endosonography-guided biliary drainage site:A case report显示文摘Endosonography-guided biliary drainage (ESBD) is a new method enabling internal drainage of an obstructed bile duct. However,the histological conditions associated with fistula development via the duodenum to the bile duct have not been reported. We performed ESBD 14 d preoperatively in a patient with an ampullary carcinoma and histologically confirmed changes in and around the fistula. The female patient developed no complications relevant to ESBD. Levels of serum bilirubin and hepatobiliary enzymes declined quickly,and pancreatoduodenectomy was carried out uneventfully. The resected specimen was sliced and stained with hematoxylin-eosin. Histological evaluation of the puncture site in the duodenum and bile-duct wall,and the sinus tract revealed no hematoma,bile leakage,or abscess in or around the sinus tract. Little sign of granulation,fibrosis,and inflammatory cell infiltration was observed. Although further large-scale confirmatory studies are needed,the findings here may encourage more active use of ESBD as a substitute for percutaneous transhepatic drainage in cases with failed/difficult endoscopic biliary stenting. | Naotaka Fujita Yutaka Noda Go Kobayashi Kei Ito Takashi Obana Jun Horaguchi Osamu Takasawa Kazunari Nakahara | 2007 | World Journal of Gastroenterology2007，13，41： | 4 |
| 4 | Can pancreatic duct stenting prevent post-ERCP pancreatitis in patients who undergo pancreatic duct guidewire placement for achieving selective biliary cannulation? A prospective randomized controlled trial显示文摘 | Kei Ito Naotaka Fujita Yutaka Noda Go Kobayashi Takashi Obana Jun Horaguchi Osamu Takasawa Shinsuke Koshita Yoshihide Kanno Takahisa Ogawa | 2010 | Journal of Gastroenterology2010，，11： | 2 |
| 5 | Endoscopic biliary drainage for patients with unresectable pancreatic cancer with obstructive jaundice who are to undergo gemcitabine chemotherapy显示文摘AIM: To assess optimum endoscopic biliary drainage (EBD) in cases with unresectable pancreatic cancer in the era of gemcitabine (GEM). METHODS: Thirty patients with unresectable pancreatic cancer, who presented with jaundice and underwent chemotherapy using GEM after EBD were included in this study (GEM group). Fifteen cases with the same clinical manifestation and stage of pancreatic cancer treated with EBD alone were also included as controls. A covered metallic stent (CMS) or a plastic stent (PS) was used for EBD. The mean survival time (MST) in each group, risk factors of survival time, type of stent used and associated survival time, occlusion rate of stent, patency period of stent, and risk factors of stent occlusion were evaluated. RESULTS: MST in the GEM group was longer than that in the control (9.9 mo vs 6.2 mo). In the GEM group, the survival time was not different between those who underwent metallic stenting and those who underwent plastic stenting. Stent occlusion occurred in 60% of the PS group and 7% of the CMS group. The median stent patency in the PS-GEM group and the CMS-GEM group was 5 mo and 7.5 mo, respectively. Use of a PS was the only risk factor of stent occlusion. CONCLUSION: A CMS is recommended in cases presenting with jaundice due to unresectable pancreatic cancer, since the use of a CMS makes it possible to continue chemotherapy using GEM without repetition of stent replacement. | Osamu Takasawa Naotaka Fujita Go Kobayashi Yutaka Noda Kei Ito Jun Horaguchi | 2006 | World Journal of Gastroenterology2006，12，45： | 2 |
| 6 | Dioxin reduction by sulfur component addition显示文摘 | Hiroshi Ogawa Norihiko Orita Mitsuhiro Horaguchi | 1996 | Chemoshere1996，32，： | 1 |
| 7 | Dioxin Reduction by Sulfur Component Addition显示文摘 | Hiroshi Ogawa Norihiko Orita Mitsuhiro Horaguchi | 1996 | Chemosphere1996，32，： | 1 |
| 8 | Economics of Reciprocal Networks : Collabora- tion n Knowledge And Emergence of Industrial Clusters 显示文摘 | Horaguchi H H | 2008 | Computational Economics2008，31，4： | 1 |
| 9 | Posterative anemiafollowing posterior decompression surgery for lumbar spinal canalstenosis显示文摘 | Sasaji T1 Horaguchi K Shinozaki N | 2013 | J Tohoku J Exp Med2013，229，1： | 1 |
| 10 | Postoperative anemia following posterior decompression surgery for lumbar spinal canal stenosis显示文摘 | Sasaji T Horaguchi K Shinozaki N | | 0，，： | 1 |
| 11 | Patellar dislocation:ar-throscopic patellar stabilization with anchor sutures显示文摘 | Fukushima K Horaguchi T Okano T | 2004 | Arthrosco-py2004，20，7： | 1 |
| 12 | Therapeutic endoscopic retrograde cholangiopancreatography using an anterior oblique-viewing endoscope for bile duct stones in patients with prior Billroth II gastrectomy显示文摘 | Kazunari Nakahara Jun Horaguchi Naotaka Fujita Yutaka Noda Go Kobayashi Kei Ito Takashi Obana Osamu Takasawa | 2009 | Journal of Gastroenterology2009，，3： | 1 |
| 13 | Patellar dislocation: Arthroscopic patellar stabilization with anchor sutures显示文摘 | Kazumasa Fukushima Takashi Horaguchi Tatsumasa Okano Toshinori Yoshimatsu Akiyoshi Saito Junnosuke Ryu | 2004 | Arthroscopy: The Journal of Arthroscopic and Related Surgery2004，，7： | 1 |
| 14 | Dioxin reduction by sulfur component addition显示文摘 | Ogawa H Orita N Horaguchi M | 1996 | Chemosphere1996，32，： | 1 |
| 15 | Amylase levels in bile in patients with a morphologically normal pancreaticnbiliary ductal arrangement 显示文摘 | Horaguchi J Fujita N Noda Y el al | 2008 | J Gastroenterol2008，43，4： | 1 |
| 16 | Red far-red photon flux ratio used as an index number of morphological control Of plant growth under artificial lighting conditions 显示文摘 | Murakami K Aiga I Horaguchi I | 1994 | Acta Horticulturae1994，2，： | 1 |
| 17 | Preparation of viable islet cells from dogs by a new method显示文摘 | HORAGUCHI A MERRELL RC | 1981 | Diabetes1981，30，5： | 1 |
| 18 | Therapeutic endoscopic retrograde cholangiography using a single‐balloon enteroscope in patients with R oux‐en‐ Y anastomosis显示文摘 | Takashi Obana Naotaka Fujita Kei Ito Yutaka Noda Go Kobayashi Jun Horaguchi Shinsuke Koshita Yoshihide Kanno Takahisa Ogawa Shinichi Hashimoto Kaori Masu | 2013 | Digestive Endoscopy2013，，6： | 1 |
| 19 | Mode of progression of intraductal papillary-mucinous tumor of the pancreas: analysis of patients with follow-up by EUS显示文摘 | Go Kobayashi Naotaka Fujita Yutaka Noda Kei Ito Jun Horaguchi Osamu Takasawa Satoshi Akaishi Takashi Tsuchiya Masao Kobari | 2005 | Journal of Gastroenterology2005，，7： | 1 |
| 20 | Can pancreatic duct stenting prevent post-ERCP pancreatitis in patients who undergo pancreatic duct guidewire placement for achieving selective biliary cannulation? A prospective randomized controlled trial显示文摘 | Kei Ito Naotaka Fujita Yutaka Noda Go Kobayashi Takashi Obana Jun Horaguchi Osamu Takasawa Shinsuke Koshita Yoshihide Kanno Takahisa Ogawa | 2010 | Journal of Gastroenterology2010，，11： | 1 |
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