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| 1 | Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease显示文摘AIM: To compare the clinical efficacy of the secondgeneration H2 RA lafutidine with that of lansoprazole in Japanese patients with mild gastroesophageal reflux disease(GERD). METHODS: Patients with symptoms of GERD and a diagnosis of grade A reflux esophagitis(according to the Los Angeles classification) were randomized to receive lafutidine(10 mg, twice daily) or lansoprazole(30 mg, once daily) for an initial 8 wk, followed by maintenance treatment comprising half-doses of the assigned drug for 24 wk. The primary endpoint was the frequency and severity of heartburn during initial and maintenance treatment. The secondary endpoints were the sum score of questions 2 and 3 in the Gastrointestinal Symptom Rating Scale(GSRS), and the satisfaction score.RESULTS: Between April 2012 and March 2013, a total of 53 patients were enrolled, of whom 24 and 29 received lafutidine and lansoprazole, respectively. After 8 wk, the frequency and severity of heartburn was significantly reduced in both groups. However, lafutidine was significantly inferior to lansoprazole with regard to the severity of heartburn during initial and maintenance treatment(P = 0.016). The sum score of questions 2 and 3 in the GSRS, and satisfaction scores were also significantly worse in the lafutidine group than the lansoprazole group(P = 0.0068 and P = 0.0048, respectively).CONCLUSION: The clinical efficacy of lafutidine was inferior to that of lansoprazole, even in Japanese patients with mild GERD. | Ryuta Takenaka Hiroyuki Okada Seiji Kawano Yoshinori Komazawa Fumiya Yoshinaga Shinji Nagata Masafumi Inoue Hirohisa Komatsu Seiji Onogawa Yoshinori Kushiyama Shinichi Mukai Hiroko Todo Hideharu Okanobu Noriaki Manabe Shinji Tanaka Ken Haruma Yoshikazu Kinoshita | 2016 | World Journal of Gastroenterology2016，22，23： | 2 |
| 2 | Stiffening requirements for unbonded braces encased in concrete panels显示文摘 | Kazuo Inoue Shinichi Sawaizumi Yasuo Higashibata | 2001 | Journal of Structural Engineering ASCE2001，127，6： | 1 |
| 3 | Preparation of novel titania support by applying the multi-gelation method for ultra-deep HDS of diesel oil Applied显示文摘 | Shinichi Inoue Akihiro Muto | 2004 | Catalysis A:General2004，269，12： | 1 |
| 4 | Preparation of novel titania support by applying the multi-gelation method for ultra-deep HDS of diesel oil显示文摘 | Shinichi Inoue Alcihiro Muto Hidehiko Kudou | 2004 | Appl Catal A: General2004，269，12： | 1 |
| 5 | Bioethanol production fromball milled bagasse using an on-site produced fungal enzyme cocktail and xylose-fermenting Pichia stipitis显示文摘 | BENCHAPORN BUABAN HIROYUKI INOUE SHINICHI YANO | 2010 | Bioscience and Bioengineering2010，110，1： | 1 |
| 6 | Three-dimensional ultrasound imaging of breast cancer by a real-time intraoperative navigation system显示文摘 | Tomoo Inoue Yasuhiro Tamaki Yoshinobu Sato Masahiko Nakamoto Shinichi Tamura Yoshio Tanji Tetsuya Taguchi Shinzaburo Noguchi | 2005 | Breast Cancer2005，，2： | 1 |
| 7 | Combininghot-compressed water and ball milling pretreatments to improve the efficiency of the enzymatic hydrolysis of eucalyptus显示文摘 | Hiroyuki Inoue Shinichi Yano Takashi Endo | 2008 | Biotechnology for Biofuels2008，1，1： | 1 |
| 8 | Clinical usefulness of ECG-gated18F-FDG PET combined with99mTc-MIBI gated SPECT for evaluating myocardial viability and function显示文摘 | Yohei Yamakawa Nobukazu Takahashi Toshiyuki Iswkawa Kazuaki Uchino Yasuyuki Mochida Toshiaki Ebina Tsukasa Kobayashi Kohei Matsushita Katsumi Matsumoto Noriko Kawasaki Mie Shimura Yasuo Ohkusu Shinichi Sumita Kazuo Kimura Tomio Inoue Satoshi Umemura | 2004 | Annals of Nuclear Medicine2004，，5： | 1 |
| 9 | A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease显示文摘AIM: To study a more accurate quantification of hepatic fibrosis which would provide clinically useful information for monitoring the progression of chronic liver disease. METHODS: Using a cDNA microarray containing over 22 000 clones, we analyzed the gene-expression profiles of non-cancerous liver in 74 patients who underwent hepatic resection. We calculated the ratio of azan- stained: total area, and determined the morphologic fibrosis index (MFI), as a mean of 9 section-images. We used the MFI as a reference standard to evaluate our method for assessing liver fibrosis. RESULTS: We identified 39 genes that collectively showed a good correlation (r > 0.50) between gene-expression and the severity of liver fibrosis. Many of the identified genes were involved in immune responses and cell signaling. To quantify the extent of liver fibrosis, we developed a new genetic fibrosis index (GFI) based on gene-expression profiling of 4 clones using a linear support vector regression analysis. This technique, based on a supervised learning analysis, correctly quantified the various degrees of fibrosis in both 74 training samples (r = 0.76, 2.2% vs 2.8%, P < 0.0001) and 12 independent additional test samples (r = 0.75, 9.8% vs 8.6%, P < 0.005). It was far better in assessing liver fibrosis than blood markers such as prothrombin time (r = -0.53), type Ⅳ collagen 7s (r = 0.48), hyaluronic acid (r = 0.41), and aspartate aminotransferase to platelets ratio index (APRI) (r = 0.38). CONCLUSION: Our cDNA microarray-based strategy may help clinicians to precisely and objectively monitor the severity of liver fibrosis. | Tohru Utsunomiya Masahiro Okamoto Shigeki Wakiyama Masaji Hashimoto Kengo Fukuzawa Takahiro Ezaki Shinichi Aishima Yasuji Yoshikawa Taizo Hanai Hiroshi Inoue Graham F Barnard Masaki Mori | 2007 | World Journal of Gastroenterology2007，13，3： | 1 |
| 10 | Angiopoietin 2 expression in invasive ductal carcinoma of the breast: its relationship to the VEGF expression and microvessel densityBreast 显示文摘 | Shinichi Tsutsui Hiroshi Inoue Kazuhiro Yasuda | 2006 | Cancer Research and Treatment2006，98，： | 1 |
| 11 | Applied Surface Science显示文摘 | Shinichi Todorkis Konishi T Inoue S | 2006 | 252:26402006，252，： | 1 |
| 12 | Prognostic utility of T-wave alternans in a real-world population of patients with left ventricular dysfunction: the PREVENT-SCD study显示文摘 | Satoshi Shizuta Kenji Ando Masakiyo Nobuyoshi Takanori Ikeda Hideaki Yoshino Shinichi Hiramatsu Yukio Kazatani Kohei Yamashiro Katsunori Okajima Teishi Kajiya Yoshinori Kobayashi Takao Kato Satoki Fujii Kazuaki Mitsudo Koichi Inoue Hiroshi Ito Yoshisumi H | 2012 | Clinical Research in Cardiology2012，，2： | 1 |
| 13 | Pilot Feasibility Study of Neoadjuvant Chemoradiotherapy with S-1 in Patients with Locally Advanced Gastric Cancer Featuring Adjacent Tissue Invasion or JGCA Bulky N2 Lymph Node Metastases显示文摘 | Tatsushi Inoue Shinichi Yachida Hisashi Usuki Tomoki Kimura Masanobu Hagiike Keiichi Okano Yasuyuki Suzuki | 2012 | Annals of Surgical Oncology2012，，9： | 1 |
| 14 | Measurement of fractional anisotropy using diffusion tensor MRI in supratentorial astrocytic tumors显示文摘 | Takaaki Beppu Takashi Inoue Yuji Shibata Akira Kurose Hiroshi Arai Kuniaki Ogasawara Akira Ogawa Shinichi Nakamura Hiroyuki Kabasawa | 2003 | Journal of Neuro - Oncology2003，，2： | 1 |
| 15 | 成人脊柱畸形行包括骶骨的长节段融合术后发生近端交界区后凸畸形的预测因素分析显示文摘手术治疗退变性、特发性脊柱侧凸及失代偿性后凸综合征等成人脊柱畸形的临床疗效较为肯定,多数患者术后临床症状及影像学参数可得到显著改善。但文献报道,手术相关并发症也高达10%~45%,在老年人群中发生率更高。其中近端交界性后凸畸形(proximal junctional kyphosis,PJK)是一种常见并发症,文献报道发生率高达17%~39%。 PJK的病理机制非常复杂,其在成人脊柱畸形,尤其是退变性畸形矫形术后的发病机制及危险因素报道相对较少。近来,有不少学者报道长节段融合术后可因上固定椎或其上方椎体骨折导致PJK。对于融合至骶骨的长节段矫形手术后PJK的发病机制及危险因素还没有明确的认识。 | 刘新宇 王连雷 Keishi Maruo Yoon Ha Shinichi Inoue | 2016 | 实用骨科杂志2016，22，7： | 1 |
| 16 | Prepa- ration of novel titania support by applying the multi-gelation method for uhra-deep HDS of diesel oil 显示文摘 | Shinichi Inoue Akihiro Muto Hidehiko Kudou | 2004 | Applied Cataly- sis2004，269，： | 1 |
| 17 | Long-term survival and prognostic factors in the surgical treatment of mass-forming type cholangiocarcinoma显示文摘 | Kazuto Inoue Masatoshi Makuuchi Tadatoshi Takayama Guido Torzilli Junji Yamamoto Kazuaki Shimada Tomoo Kosuge Susumu Yamasaki Masaru Konishi Taira Kinoshita Shinichi Miyagawa Seiji Kawasaki | 2000 | Surgery2000，，5： | 1 |
| 18 | Preparation of Novel Titania Support by Applying the Multi-gelation Method for Ultra-deep HDS of Diesel Oil显示文摘 | Shinichi Inoue Akihiro Muto Hidehiko Kudou | 2004 | Applied Catalysis A:General2004，269，： | 1 |
| 19 | Te- rpenoids from the seed of Platycladus orientalis显示文摘 | Masanori Inoue Shinichi Hasegawa Yoshiyuki Hirose | 1985 | Ph- ytochemistry1985，24，7： | 1 |
| 20 | Preparation of novel titania support applying the mufti-gelation method for ultra-deep HDS of diesel oil Applied显示文摘 | Shinichi Inoue Akihiro Muto | 2004 | Catalysis A:General2004，269，12： | 1 |
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