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您的检索式：作者名="David M.Kim"
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| 1 | High sensitivity and high selectivity terahertz biomedical imaging显示文摘We demonstrate two distinct emerging terahertz (THz) biomedical imaging techniques.One is based on the use of a new single frequency THz quantum cascade laser and the other is based on broadband THz time domain spectrocopy.The first method is employed to derive a metastasis lung tissue imaging at 3.7 THz with clear contrast between cancerous and healthy areas.The second approach is used to study an osseous tissue under several imaging modalities and achieve full THz spectroscopic imaging based on the frequency domain or on a fixed THz propagation time-delay.Sufficient contrast is achieved which facilitated the identification of regions with different cellular types and density compositions. | Seongsin M.Kim William Baughman David S.Wilbert Lee Butler Michael Bolus Soner Balci Patrick Kung | 2011 | Chinese Optics Letters2011，9，11： | 4 |
| 2 | Biological efficacy of perpendicular type-I collagen protruded from TiO_(2)-nanotubes显示文摘The aim of this study was to evaluate the biological efficacy of a unique perpendicular protrusion of type-I collagen(Col-I)from TiO2 nanotubes(NT-EPF surface).We hypothesized that the NT-EPF surface would play bifunctional roles in stimulating plateletmediated fibroblast recruitment and anchoring fibroblast-derived Col-I to form a perpendicular collagen assembly,mimicking the connective tissue attachment around natural teeth for the long-term maintenance of dental implants.Ti surface modification was accomplished in two steps.First,TiO2 nanotubes(NT)array was fabricated via anodization.Diameters and depths of NTs were controlled by applied voltage and duration.Subsequently,an electrophoretic fusion(EPF)method was applied to fuse Col-I into nanotube arrays in a perpendicular fashion.Surface wettability was assessed by contact angle measurement.The bioactivity of modified TiO2 surfaces was evaluated in terms of NIH3T3 fibroblast attachment,platelet activation,and collagen extension.Early attachment,aggregation,and activation of platelets as well as release of platelet-related growth factors were demonstrated on NTEPF surfaces.Platelet-mediated NIH3T3 cells migration toward NT-EPF was significantly increased and the attached cells showed a typical fibrous morphology with elongated spindle shape.A direct linkage between pseudopod-like processes of fibroblasts to NTEPF surfaces was observed.Furthermore,the engineered EPF collagen protrusion linked with cell-derived collagen in a perpendicular fashion.Within the limitation of this in vitro study,the TiO2 nanotube with perpendicular Col-I surface(NT-EPF)promoted better cell attachment,induced a strong platelet activation which suggested the ability to create a more robust soft tissue seal. | Chia-Yu Chen David M.Kim Cliff Lee John Da Silva Shigemi Nagai Toshiki Nojiri Masazumi Nagai | 2020 | International Journal of Oral Science2020，12，4： | 3 |
| 3 | Epithelial cell adhesion efficacy of a novel peptide identified by panning on a smooth titanium surface显示文摘Epithelial attachment via the basal lamina on the tooth surface provides an important structural defence mechanism against bacterial invasion in combating periodontal disease. However, when considering dental implants, strong epithelial attachment does not exist throughout the titanium-soft tissue interface, making soft tissues more susceptible to peri-implant disease. This study introduced a novel synthetic peptide(A10) to enhance epithelial attachment. A10 was identified from a bacterial peptide display library and synthesized. A10 and protease-activated receptor 4-activating peptide(PAR4-AP, positive control) were immobilized on commercially pure titanium. The peptide-treated titanium showed high epithelial cell migration ability during incubation in platelet-rich plasma. We confirmed the development of dense and expanded BL(stained by Ln5) with pericellular junctions(stained by ZO1) on the peptide-treated titanium surface. In an adhesion assay of epithelial cells on A10-treated titanium, PAR4-AP-treated titanium, bovine root and non-treated titanium, A10-treated titanium and PAR4-AP-treated titanium showed significantly stronger adhesion than non-treated titanium. PAR4-AP-treated titanium showed significantly higher inflammatory cytokine release than non-treated titanium. There was no significant difference in inflammatory cytokine release between A10-treated and non-treated titanium. These results indicated that A10 could induce the adhesion and migration of epithelial cells with low inflammatory cytokine release. This novel peptide has a potentially useful application that could improve clinical outcomes with titanium implants and abutments by reducing or preventing peri-implant disease. | Hidemichi Kihara David M.Kim Masazumi Nagai Toshiki Nojiri Shigemi Nagai Chia-Yu Chen Cliff Lee Wataru Hatakeyama Hisatomo Kondo John Da Silva | 2018 | International Journal of Oral Science2018，10，3： | 2 |
| 4 | 通过结合了平台转移和激光蚀刻种植体-基台系统来检验其对于保持犬种植体间骨高度的循证学研究显示文摘上颌美学区种植体间牙龈乳头的存在是实现种植修复美学的关键,然而稳定的植体间牙龈乳头形态离不开其下方稳定的种植体周围牙槽骨的支持。大量研究证明.种植体间距应严格控制在3mm左右.如果间距少于3mm.牙槽嵴顶骨就会发生吸收。这份临床前的循证医学研究检验了一种新型种植体-基台系统.其设计包含结合了平台转移和精密激光蚀刻的基台及表面微螺纹的种植体.在种植体距离是2mm和4mm时观察种植体间牙槽骨的维持情况。这项临床前研究结果认为通过精密的种植体或者基台设计的改变.即使种植体间距在2~4mm时也不会引起牙龈乳头下牙槽嵴顶骨吸收。 | Myron Nevins Marc Nevins Luca Gobbato Hyo-Jung Lee Chin-Wei Wang David M.kim 田忠奎 汤春波 | 2015 | 中国口腔医学继续教育杂志2015，0，1： | 0 |
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