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| 1 | 膈肌超声:一种预测机械通气患者撤机结局的新方法显示文摘目的:评价超声检查膈肌增厚和活动度对机械通气患者撤机结局的预测价值。方法:纳入54例成功通过自主呼吸试验(SBT)的患者进行研究。SBT过程中,采用超声检查评估患者的膈肌活动度、吸气末和呼气末的膈肌厚度(Tdi)以及膈肌增厚分数(DTF%);同时记录常规的撤机参数。撤机后,追踪观察患者48小时。结果:54例患者中,14例(25.9%)患者撤机失败。撤机成功患者的膈肌活动度、吸气末和呼气末Tdi以及DTF%均高于撤机失败的患者,差异有统计学意义(P<0.05)。与撤机成功相关的膈肌指标的临界值为:膈肌活动度≥10.5mm;吸气末Tdi≥21mm;呼气末Tdi≥10.5mm;DTF%≥34.2%。各指标预测撤机成功的敏感性分别为87.5%、77.5%、80.0%和90.0%;特异性分别为71.5%、86.6%、50.0%和64.3%。将膈肌活动度≥10.5mm和吸气末Tdi≥21mm两者结合,预测撤机成功的敏感性降低至64.9%,但特异性升高至100%;浅快呼吸指数(RSBI)<105用于预测撤机成功的敏感性达90.0%,但特异性仅有18.7%。结论:对通过SBT的患者,膈肌活动度和吸气末膈肌厚度的超声评估,是优质的机械通气患者撤机结局的预测指标。因此,推荐考虑使用上述指标和RSBI,以改善撤机结局。 | Shereen Farghaly Ali A.Hasan | 2017 | 中国护理管理2017，17，1： | 61 |
| 2 | The effect of environmental contaminants on testicular function显示文摘男繁殖健康在最后几十年更加败坏了。营养,社会经济,生活方式和环境因素(在其它之中) 被归因于损害男繁殖健康。在最近的年里,一条大量证据积累了那建议减少的男富饶的趋势(以精子,计数,质量和其它处于男繁殖健康变化) 可能由于到环境有毒物的暴露。这些环境沾染物能模仿自然雌激素并且指向 Sertoli 和 Leydig 房间的阴囊的精子发生, steroidogenesis,和功能。最环境的有毒物被显示了导致反应的氧种类,从而在睾丸的各种各样的分隔空间引起氧化应力的一个状态。然而,睾丸上的环境有毒物的行动的分子的机制还得被阐明。这评论通过氧化应力和 apoptosis 的正式就职在阴囊的功能上讨论一些更通常使用的环境沾染物的效果。 | Premendu Prakash Mathur Shereen Cynthia D'Cruz | 2011 | Asian Journal of Andrology2011，13，4： | 13 |
| 3 | Reversibility of minimal hepatic encephalopathy following liver transplantation in Egyptian cirrhotic patients显示文摘AIM To evaluate the reversibility of minimal hepatic encephalopathy(MHE) following liver transplantation(LT) in Egyptian cirrhotic patients. METHODS This prospective study included twenty patients with biopsy-proven liver cirrhosis listed for LT and twenty ageand sex-matched healthy control subjects. All underwent neuro-psychiatric examination, laboratory investigations, radiological studies and psychometric tests including trail making test A(TMT A), TMT B, digit symbol test and serial dotting test. The psychometric hepatic encephalopathy score(PHES) was calculated for patients to diagnose MHE. Psychometric tests were repeated six months following LT in the cirrhotic patient group. RESULTS Before LT, psychometric tests showed highly significant deficits in cirrhotic patients in comparison to controls(P < 0.001). There was a statistically significant improvement in test values in the patient group after LT; however, their values were still significantly worse than those of the controls(P < 0.001). The PHES detected MHE in 16 patients(80%) before LT with a median value of -7 ± 3.5. The median PHES value was significantly improved following LT, reaching-4.5 ± 5(P < 0.001), and the number of patients with MHE decreased to 11(55%). The pre-transplant model for end-stage liver disease(MELD) score ≥ 15 was significantly related to the presence of post-transplant MHE(P = 0.005). More patients in whom reversal of MHE was observed had a pre-transplant MELD score < 15.CONCLUSION Reversal of MHE in cirrhotic patients could be achieved by LT, especially in those with a MELD score < 15. | Mahmoud A Osman Moataz M Sayed Khaled A Mansour Shereen A Saleh Wesam A Ibrahim Sara M Abdelhakam Mohamed Bahaa Wael A Yousry Hosam S Elbaz Reginia N Mikhail Azza M Hassan Ehab H Elsayed Dalia A Mahmoud | 2016 | World Journal of Hepatology2016，8，30： | 11 |
| 4 | Effects of plants and plant products on the testis显示文摘几个世纪,植物和基于植物的产品作为药的珍贵、安全的生来的来源被使用了治疗各种各样的疾病。大多数这些植物的治疗学的潜力能被归功于到他们的 anticancer, antidiabetic, hepatoprotective, cardioprotective,镇痉药,止痛剂和许多其他的药理学性质。然而,几通常使用的植物被报导了不利地在野生动物和人影响男繁殖功能。与大多数植物和基于植物的产品观察的效果被归因于 antispermatogenic 或至少一活跃成分的 antisteroidogenic 性质。这评论在睾丸在各种各样的目标房间上讨论一些通常使用的植物的有害效果。进这些自然混合物的行动的分子的机制的更深的卓见能为对他们的毒性开发治疗学的策略铺平道路。 | Shereen Cynthia D'Cruz Selvaraju Vaithinathan Rajamanickam Jubendradass Premendu Prakash Mathur | 2010 | Asian Journal of Andrology2010，12，4： | 6 |
| 5 | M2BPGi for assessing liver fibrosis in patients with hepatitis C treated with direct-acting antivirals显示文摘BACKGROUND Assessing liver fibrosis is important for predicting the efficacy of direct-acting antivirals(DAAs)and patient prognosis.Non-invasive techniques to assess liver fibrosis are becoming important.Recently,serum Mac-2 binding protein glycosylation isomer(M2BPGi)was identified as a non-invasive marker of liver fibrosis.AIM To investigate the diagnostic accuracy of M2BPGi in assessing liver fibrosis in patients with chronic hepatitis C(CHC)treated with DAAs.METHODS From December 2017 to August 2018,80 treatment-naive adult patients with CHC who were eligible for DAAs therapy were consecutively enrolled in this observational cohort study.For 12 weeks,65 patients were treated with sofosbuvir/daclatasvir,and 15 patients were treated with sofosbuvir/daclatasvir and a weight-based dose of ribavirin at knowledge and technology association for hepatitis C management clinic,Cairo,Egypt.We measured serum M2BPGi levels,PAPAS index,fibrosis-4(FIB-4)score and liver stiffness measurements(LSM)at baseline and 12 weeks after the end of treatment.Serum M2BPGi levels were measured using enzyme-linked immunosorbent assay.RESULTS All patients achieved sustained virologic response(SVR12)(100%).Serum M2BPGi levels,LSM,FIB-4 score and PAPAS index decreased significantly at SVR12(P<0.05).Serum M2BPGi levels correlated positively with LSM at baseline and SVR12(P<0.001).At baseline,compared with the FIB-4 score and PAPAS index,M2BPGi was the best marker to distinguish patients with grade F4 fibrosis(AUC=0.801,P<0.001),patients with grade F2 from grade F0-1 fibrosis(AUC=0.713,P=0.012),patients with grade F3-4 from grade F0-2 fibrosis(AUC=0.730,P<0.001),and patients with grade F2-4 from grade F0-1 fibrosis(AUC=0.763,P<0.001).At SVR12,M2BPGi had the greatest AUCs for differentiating patients with grade F4 fibrosis(AUC=0.844,P<0.001),patients with grade F3 from grade F0-2 fibrosis(AUC=0.893,P=0.002),patients with grade F3-4 from grade F0-2 fibrosis(AUC=0.891,P<0.001),and patients with grade F2-4 from grade F0-1 fibrosis(AUC=0.750,P<0.001).CONCLUSION M2BPGi is a reliable marker for the non-invasive assessment and prediction of liver fibrosis regression in patients with CHC who achieved an SVR with DAAs therapy. | Shereen A Saleh Mohamed M Salama Marwan M Alhusseini Ghada A Mohamed | 2020 | World Journal of Gastroenterology2020，26，21： | 3 |
| 6 | Anfioxidant activity of the roots ofDecalepis hamiltonii 显示文摘 | Anup Srivastava Shereen R Harish | 2006 | LWT2006，39，： | 1 |
| 7 | Invasion and meteatasis in chronic cancer 显示文摘 | Shereen K Peter B Roman I | 2003 | Mol Cancer2003，2，1： | 1 |
| 8 | Ex vivo diffusion tensor imaging and neuropathological correlation in a murine model of hypoxia- isch- emia-induced thrombotic stroke 显示文摘 | Shereen A Nemkul N Yang D | 2011 | Cereb Blood Flow Metab2011，31，4： | 1 |
| 9 | Exvivo diffusion tensor im- aging and neuropathological correlation in a murine model of hy- poxia - ischemia - induced thrombotic stroke显示文摘 | Shereen A Nemkul N Yang D | 2011 | J Cereb Blood Flow Metab2011，31，4： | 1 |
| 10 | The miR-17-92 Cluster is Over Expressed in and Has an Oncogenic Effect on Renal Cell Carcinoma显示文摘 | Tsz-fung F. Chow Marina Mankaruos Andreas Scorilas Youssef Youssef Andrew Girgis Sarah Mossad Shereen Metias Yostina Rofael R. John Honey Robert Stewart Kenneth T. Pace George M. Yousef | 2010 | The Journal of Urology2010，，2： | 1 |
| 11 | Choriodecidua and amnion exhibit selective leukocyte chemotaxis during term human labor显示文摘 | Nardhy Gomez-Lopez Lourdes Vadillo-Perez Shereen Nessim David M. Olson Felipe Vadillo-Ortega | 2011 | American Journal of Obstetrics and Gynecology2011，，4： | 1 |
| 12 | The pathogenesis of pituitary tumours显示文摘 | SYLVIA L A SHEREEN E | 2002 | Nature2002，2，3： | 1 |
| 13 | Predictors of early re-bleeding and mortality after acute variceal haemorrhage<!-- Predictors of early re-bleeding and mortality -->显示文摘 | Shereen Shoukry Hunter Sherif Hamdy | 2013 | Arab Journal of Gastroenterology2013，，2： | 1 |
| 14 | The role of hormones,growth factor and there receptors in pituitary tumorigenesis显示文摘 | Shereen Ezzat | 2001 | Brain Pathology2001，11，： | 1 |
| 15 | Invasion and meteatasis in pancreatic cancer显示文摘 | Shereen K Peter B Roman L | 2003 | Molecular Cancer2003，2，1： | 1 |
| 16 | The pathogenesis of pituitary turmours显示文摘 | Shereen E | 2002 | Nature2002，2，3： | 1 |
| 17 | Social influences on creativity: Evaluation, coaction, and surveillance显示文摘 | Teresa M. Amabile Phyllis Goldfarb Shereen C. Brackfleld | 1990 | Creativity Research Journal1990，，1： | 1 |
| 18 | Effect of different levels of zinc and phospho- rus on growth and chlorophyll content of wheat显示文摘 | Alam S M Shereen A | 2002 | Asian J Plant Sci2002，，1： | 1 |
| 19 | Sentence comprehension in Alzheimer’s disease显示文摘 | Ellen Grober Shereen Bang | 1995 | Developmental Neuropsychology1995，，1： | 1 |
| 20 | Childhood glaucoma profile in Dakahelia, Egypt: a retrospective study显示文摘AIM: To analyze childhood glaucoma regarding its demographics, presentations, different causes and surgical modalities used among patients in Dakahelia and to apply the Childhood Glaucoma Research Network(CGRN) classification retrospectively to evaluate its convenience.METHODS: A retrospective study in which the medical files of all glaucoma patients <16 years old presented to Mansoura Ophthalmic Center, Mansoura University from 2014 to 2017, were retrieved and analyzed. Collected data included: age, gender, laterality, visual acuity(VA), refraction, intraocular pressure(IOP), corneal diameter, cup-disc ratio, types and number of surgeries and antiglaucomatous drugs(AGD) at the first and last visit. Prevalence of different subtypes was calculated and means of clinical features were compared.RESULTS: A total of 305 eyes of 207 patients were included classified into 6 groups: primary congenital glaucoma(PCG), juvenile open angle glaucoma(JOAG), glaucoma associated with systemic disease, glaucoma associated with ocular anomalies, acquired glaucoma and glaucoma following cataract surgery. PCG was the predominant type(55.1%) followed by acquired glaucoma(29.5%). Males represented 63.8% of the whole studied patients. Glaucoma associated with ocular anomaly group showed the youngest age at diagnosis(21.9±30.0 mo). The shortest corneal diameter was recorded in post cataract group(10.4±0.5 mm). Highest cup-disc ratio was found in the PCG group(P<0.0005). Glaucoma associated with systemic disease presented with the highest baseline IOP(34.5±5.0 mm Hg). All the cases with PCG were treated surgically with 21.8% required more than one surgery. The majority of the patients(74.2%) in the acquired group were treated medically. Combined trabeculotomy-trabeculectomy was the most frequent operation done, accounting for 34.5% of all primary surgeries. Ahmed valve implantation comprised 87% of the secondary surgeries. Acquired glaucoma group had the highest percent of eyes with good final Snellen's VA(69.4%), while glaucoma associated with ocular anomaly group had poorest final VA. CONCLUSION: PCG is the most prevalent type of childhood glaucoma, followed by acquired glaucoma especially traumatic hyphema. Combined trabeculotomytrabeculectomy and Ahmed valve implantation are the most common surgical interventions. CGRN classification is found to provide a consensus skeleton and is recommended to be integrated in our routine ongoing clinical practice. | Tharwat H.Mokbel Eman M.El Hefney Sherein M.Hagras Ahmed A.ALNagdy Amani E.Badawi Manal A.Kasem Shereen M.El Shaer | 2018 | International Journal of Ophthalmology(English edition)2018，11，4： | 1 |
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