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| 1 | Colonization of endophyte Acremonium sp. D212 in Panax notoginseng and rice mediated by auxin and jasmonic acid显示文摘Endophytic fungi can be beneficial to plant growth. However, the molecular mechanisms under-lying colonization of Acremonium spp. remain unclear. In this study, a novel endophytic Acremonium strain was isolated from the buds of Panax notoginseng and named Acremonium sp. D212. The Acremonium sp. D212 could colonize the roots of P. notoginseng, enhance the resistance of P. notoginseng to root rot disease, and promote root growth and saponin bio-synthesis in P. notoginseng. Acremonium sp. D212 could secrete indole-3-acetic acid (IAA) and jasmonic acid (JA), and inoculation with the fungus increased the endogenous levels of IAA and JA in P. noto-ginseng. Colonization of the Acremonium sp. D212 in the roots of the rice line Nipponbare was dependent on the concentration of methyl jasmonate (MeJA) (2–15μmol/L) and 1-naphthalenacetic acid (NAA) (10–20μmol/L). Moreover, the roots of the JA signaling-defective coi1-18 mutant were colonized by Acremonium sp. D212 to a lesser degree than those of the wild-type Nipponbare and miR393b-overexpressing lines, and the colonization was res-cued by MeJA but not by NAA. It suggests that the cross-talk between JA signaling and the auxin biosynthetic pathway plays a crucial role in the colonization of Acremonium sp. D212 in host plants. | Li Han Xuan Zhou Yiting Zhao Shusheng Zhu Lixia Wu Yunlu He Xiangrui Ping Xinqi Lu Wuying Huang Jie Qian Lina Zhang Xi Jiang Dan Zhu Chongyu Luo Saijie Li Qian Dong Qijing Fu Kaiyuan Deng Xin Wang Lei Wang Sheng Peng Jinsong Wu Weimin Li JiǐíFriml Youyong Zhu Xiahong He Yunlong Du | 2020 | Journal of Integrative Plant Biology2020，62，9： | 2 |
| 2 | The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease显示文摘Mammary and extramammary Paget’s Diseases(PD)are a malignant skin cancer characterized by the appearance of Paget cells.Although easily diagnosed,its pathogenesis remains unknown.Here,single-cell RNA-sequencing identified distinct cellular states,novel biomarkers,and signaling pathways—including mTOR,associated with extramammary PD.Interestingly,we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin,and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological,single-cell and molecular levels.Using this mouse model,we identified novel biomarkers of Paget-like cells that translated to human Paget cells.Furthermore,single-cell trajectory,RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion,supporting the in situ transformation theory of disease pathogenesis.Mechanistically,the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion,and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans,suggesting mTOR inhibition as a novel therapeutic treatment in PD. | Yongli Song Christian F.Guerrero-Juarez Zhongjian Chen Yichen Tang Xianghui Ma Cong Lv Xueyun Bi Min Deng Lina Bu Yuhua Tian Ruiqi Liu Ran Zhao Jiuzhi Xu Xiaole Sheng Sujuan Du Yeqiang Liu Yunlu Zhu Shi-jun Shan Hong-duo Chen Yiqiang Zhao Guangbiao Zhou Jianwei Shuai Fazheng Ren Lixiang Xue Zhaoxia Ying Xing Dai Christopher J.Lengner Bogi Andersen Maksim V.Plikus Qing Nie Zhengquan Yu-Show | 2020 | Cell Research2020，30，10： | 2 |
| 3 | Warm dense matter research at HIAF显示文摘The research activities on warm dense matter driven by intense heavy ion beams at the new project High Intensity heavy-ion AcceleratorFacility (HIAF) are presented. The ion beam parameters and the simulated accessible state of matter at HIAF are introduced, respectively. Theprogresses of the developed diagnostics for warm dense matter research including high energy electron radiography, multiple-channel pyrometer,in-situ energy loss and charge state of ion detector are briefly introduced. | Rui Cheng Yu Lei Xianming Zhou Yuyu Wang Yanhong Chen Yongtao Zhao Jieru Ren Lina Sheng Jiancheng Yang Zimin Zhang Yingchao Du Wei Gai Xinwen Ma Guoqing Xiao | 2018 | Matter and Radiation at Extremes2018，3，2： | 2 |
| 4 | Improved catalytic activi-ty and stability of mesostructured sulfated zirconia by Al promoter显示文摘 | YIN Y S LINA Y SHENG Q M | 2004 | Applied Catalysis A: General2004，268，15： | 1 |
| 5 | Advances in lentinan: Isolation, structure, chain conformation and bioactivities显示文摘 | Yangyang Zhang Sheng Li Xiaohua Wang Lina Zhang Peter C.K. Cheung | 2010 | Food Hydrocolloids2010，，2： | 1 |
| 6 | Inhibitory effect on protein kinase Cθ by Crocetin attenuates palmitate-induced insulin insensitivity in 3T3-L1 adipocytes显示文摘 | Lina Yang Zhiyu Qian Hui Ji Ruhui Yang Yuhuan Wang Liang Xi Liang Sheng Bohua Zhao Xiaoming Zhang | 2010 | European Journal of Pharmacology2010，，1： | 1 |
| 7 | EFFECT OF CROCETIN ON BLOOD PRESSURE RESTORATION AND SYNTHESIS OF INFLAMMATORY MEDIATORS IN HEART AFTER HEMORRHAGIC SHOCK IN ANESTHETIZED RATS显示文摘 | Junling Yan Zhiyu Qian Liang Sheng Bohua Zhao Lina Yang Hui Ji Xiaoyuan Han Rong Zhang | 2010 | Shock2010，，1： | 1 |
| 8 | Improved catalytic activity and stability of meso structured sulfated zirconia by Al promoter显示文摘 | Yin y S Lina Y Sheng Q M | 2004 | Applied Catalysis A:General2004，268，： | 1 |
| 9 | Improved catalytic activity and stability of mesostructured sulfated zirconia by Al promoter显示文摘 | Yiny S Lina Y Sheng Q M | 2004 | Applied Catalysis A: General2004，268，12： | 1 |
| 10 | Propofol in the endoscopy application 显示文摘 | HE SALTY SOLDIERS WANG HUM SHENG WANG LINA | 2003 | Journal of Clinical Anesthesiology2003，19，11： | 1 |
| 11 | Inhibition and destruction of Pseudomonas aeruginosa hiofilms by antibiotics and antimicrobial peptides显示文摘 | Sheng Lina Zhu Meijun | 2014 | Food Control2014，46，： | 1 |
| 12 | High energy density physics research at IMP,Lanzhou, China显示文摘Recent research activities relevant to high energy density physics(HEDP) driven by the heavy ion beam at the Institute of Modern Physics, Chinese Academy of Sciences are presented. Radiography of static objects with the fast extracted high energy carbon ion beam from the Cooling Storage Ring is discussed. Investigation of the low energy heavy ion beam and plasma interaction is reported. With HEDP research as one of the main goals, the project HIAF(High Intensity heavy-ion Accelerator Facility), proposed by the Institute of Modern Physics as the 12 th five-year-plan of China, is introduced. | Yongtao Zhao Rui Cheng Yuyu Wang Xianming Zhou Yu Lei Yuanbo Sun Ge Xu Jieru Ren Lina Sheng Zimin Zhang Guoqing Xiao | 2014 | High Power Laser Science and Engineering2014，2，4： | 1 |
| 13 | Improved catalytic activity and stability of meso structured sulfated zirconia by A1 promoter显示文摘 | Yin Y S Lina Y Sheng Q M | 2004 | Applied Catalysis A: General2004，，268： | 1 |
| 14 | A new multi-turn beam dump scheme design and simulation for HIAF-BRing machine protection显示文摘Purpose To protect accelerator devices from being damaged by high-power beam,a new beam dump system is under design for HIAF-BRing.Method Based on the optical characteristics,unwanted particles are safely deflected to a specific internal absorber through a local bump orbit generated by active-discharging magnets,which is achieved by paralleling a bleeder resistor of 600 m�to two of dipole magnet power supplies.Results Taking alignment and multipolefield errors into account,discarded beam can be dumped within 5 ms with an efficiency of more than 99.8%at any operation stage.Conclusion The proposed beam dump solution satisfies the machine protection requirements for BRing and can provide a new idea for similar facilities. | Ren Hang Yang Jiancheng Shen Guodong Wang Geng Yao Liping Ruan Shuang Sheng Lina Wu Junxia Zhao He Liu Jie Cai Fucheng Gao Yunzhe Chang Mingxuan Li Minxiang | 2022 | Radiation Detection Technology and Methods2022，6，4： | 1 |
| 15 | Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure显示文摘Peritoneal fibrosis together with increased capillaries is the primary cause of peritoneal dialysis failure.Mesothelial cell loss is an initiating event for peritoneal fibrosis.We find that the elevated glucose concentrations in peritoneal dialysate drive mesothelial cell pyroptosis in a manner dependent on caspase-3 and Gasdermin E,driving downstream inflammatory responses,including the activation of macrophages.Moreover,pyroptosis is associated with elevated vascular endothelial growth factor A and C,two key factors in vascular angiogenesis and lymphatic vessel formation.GSDME deficiency mice are protected from high glucose induced peritoneal fibrosis and ultrafiltration failure.Application of melatonin abrogates mesothelial cell pyroptosis through a MT1R-mediated action,and successfully reduces peritoneal fibrosis and angiogenesis in an animal model while preserving dialysis efficacy.Mechanistically,melatonin treatment maintains mitochondrial integrity in mesothelial cells,meanwhile activating m TOR signaling through an increase in the glycolysis product dihydroxyacetone phosphate.These effects together with quenching free radicals by melatonin help mesothelial cells maintain a relatively stable internal environment in the face of high-glucose stress.Thus,Melatonin treatment holds some promise in preserving mesothelium integrity and in decreasing angiogenesis to protect peritoneum function in patients undergoing peritoneal dialysis. | Hongxia Ruan Xuejuan Li Lina Zhou Zihan Zheng Rulin Hua Xu Wang Yuan Wang Yujie Fan Shuwen Guo Lihua Wang Shafiq ur Rahman Ziwei Wang Yuyuan Wei Shuangyan Yu Rongzhi Zhang Qian Cheng Jie Sheng Xue Li Xiaoyan Liu Ruqiang Yuan Xiaoyan Zhang Lihong Chen Guowang Xu Youfei Guan Jing Nie Hongqiang Qin Feng Zheng | 2024 | Science China(Life Sciences)2024，67，2： | 0 |
| 16 | Recent advances in metal-free CDs/g-C_(3)N_(4) photocatalysts:Synthetic strategies,mechanism insight,and applications显示文摘Carbon dots/graphite carbon nitride(CDs/g-C_(3)N_(4)),a novel composite photocatalyst,has shown great po-tential for applications in energy regeneration and environmental remediation owing to its following advantages:metal-free,low cost,easily tunable,and excellent photocatalytic performance.Hence,we reviewed the development of synthetic strategies,photocatalytic enhancement mechanisms,and pho-tocatalytic applications of CDs/g-C_(3)N_(4) in this study.First,the three composite strategies of CDs and g-C_(3)N_(4)-self-assembly,solvothermal,and calcination polymerization are outlined,and their advantages and disadvantages are described in detail.Moreover,the photocatalytic enhancement mechanism of the com-posite strategies was elucidated according to the variation trends of CDs/g-C_(3)N_(4) band structure,electronic properties,light absorption range,and interfacial charge transfer.Then,the applications of CDs/g-C_(3)N_(4) in hydrogen evolution,pollutant degradation,CO_(2) reduction,and bacterial disinfection in recent years are reviewed systematically.Finally,the current obstacles and future research directions of CDs/g-C_(3)N_(4) are discussed from the perspective of preparation technology and practical applications,respectively. | Xingxing Yang Lina Sheng Yongli Ye Jiadi Sun Zaijun Li Xiao Ning Jin Cao Xiulan Sun | 2023 | Journal of Materials Science & Technology2023，，19： | 0 |
| 17 | Uniformity Control of Scanned Beam in 300 MeV Proton and Heavy Ion Accelerator Complex at SESRI显示文摘In recent years,heavy ion accelerator technology has been rapidly developing worldwide and widely applied in the fields of space radiation simulation and particle therapy.Usually,a very high uniformity in the irradiation area is required for the extracted ion beams,which is crucial because it directly affects the experimental precision and therapeutic effect.Specifically,ultra-large-area and high-uniformity scanning are crucial requirements for spacecraft radiation effects assessment and serve as core specification for beamline terminal design.In the 300 MeV proton and heavy ion accelerator complex at the Space Environment Simulation and Research Infrastructure(SESRI),proton and heavy ion beams will be accelerated and ultimately delivered to three irradiation terminals.In order to achieve the required large irradiation area of 320 mm×320 mm,horizontal and vertical scanning magnets are used in the extraction beam line.However,considering the various requirements for beam species and energies,the tracking accuracy of power supplies(PSs),the eddy current effect of scanning magnets,and the fluctuation of ion bunch structure will reduce the irradiation uniformity.To mitigate these effects,a beam uniformity optimization method based on the measured beam distribution was proposed and applied in the accelerator complex at SESRI.In the experiment,the uniformity is successfully optimized from 75%to over 90%after five iterations of adjustment to the PS waveforms.In this paper,the method and experimental results were introduced. | HOU Lingxiao YUAN Youjin SHEN Guodong RUAN Shuang LIU Jie ZHU Yunpeng WANG Geng GUO Hongliang LYU Mingbang GAO Daqing XU Zhiguo SHENG Lina YANG Jiancheng | 2024 | 原子能科学技术2024，58，4： | 0 |
| 18 | Focusing High Energy Heavy Ions to Micrometers显示文摘 | Du Guanghua Sheng Lina Guo Jinlong Wu Ruqun Mao Ruishi Yang Weiqing Zhang Xiaoqi Yuan Youjin Song Mingtao | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 19 | Half‑Power Prediction and Its Application on the Energy Management Strategy for Fuel Cell City Bus显示文摘The fuel cell hybrid powertrain is a potential power supply system for fuel cell vehicles.The underlying problem is that the fuel cell vehicles encounter exhaustive hydrogen consumption.To effectively manage hydrogen consumption,the aim is to propose fuel cell city bus power and control system.The underlying idea is to determine the target power of fuel cell through simulation study on fuel cell and battery energy management strategy and road test verifications.A half-power prediction energy management strategy is implemented to predict the target power of the fuel cell in the current time step based on the demand power of the vehicle and the state of charge(SOC)of the battery in the previous time steps.This offers better understanding of the correlation between fuel cell power and vehicle drive cycle for enabling effective power supply management.The research results show that the half-power prediction energy management strategy effectively reduces the hydrogen consumption of the vehicle by 7.1%and the number of battery cycle by 6.0%,compared to the stepped manage-ment strategy of battery SOC.When applied to a 12-m fuel cell city bus—F12,specially designed and manufactured for the Winter Olympic Games in 2022—the fuel economy of 3.7 kg/100 km is achieved in urban road conditions.This study lays a foundation for providing the powertrain configuration and energy management strategy of fuel cell city bus. | Longhai Zhang Lina Ning Xueqing Yang Sheng Zeng Tian Yuan Gaopeng Li Changchun Ke Junliang Zhang | 2023 | Automotive Innovation2023，6，1： | 0 |
| 20 | Cooperation between NSPc1 and DNA methylation represses HOXA11 expression and promotes apoptosis of trophoblast cells during preeclampsia显示文摘Accumulating evidence has shown that the apoptosis of trophoblast cells plays an important role in the pathogenesis of preeclampsia,and an intricate interplay between DNA methylation and polycomb group(PcG)proteinmediated gene silencing has been highlighted recently.Here,we provide evidence that the expression of nervous system polycomb 1(NSPc1),a BMI1 homologous polycomb protein,is significantly elevated in trophoblast cells during preeclampsia,which accelerates trophoblast cell apoptosis.Since NSPc1 acts predominantly as a transcriptional inactivator that specifically represses HOXA11 expression in trophoblast cells during preeclampsia,we further show that NSPc1 is required for DNMT3a recruitment and maintenance of the DNA methylation in the HOXA11 promoter in trophoblast cells during preeclampsia.In addition,we find that the interplay of DNMT3a and NSPc1 represses the expression of HOXA11 and promotes trophoblast cell apoptosis.Taken together,these results indicate that the cooperation between NSPc1 and DNMT3a reduces HOXA11 expression in preeclampsia pathophysiology,which provides novel therapeutic approaches for targeted inhibition of trophoblast cell apoptosis during preeclampsia pathogenesis. | Lin Xie Ning Ding Siqi Sheng Honghong Zhang He Yin Lina Gao Hui Zhang Shengchao Ma Anning Yang Guizhong Li Yun Jiao Qing Shi Yideng Jiang Huiping Zhang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，2： | 0 |
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