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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Improved catalytic activi-ty and stability of mesostructured sulfated zirconia by Al promoter显示文摘 | YIN Y S LINA Y SHENG Q M | 2004 | Applied Catalysis A: General2004，268，15： | 1 |
| 3 | Identification of wheat alien chromosome addition lines for breeding wheat with high phosphor- us efficiency显示文摘 | Shiwen W Lina Y Hiroyuki T | 2010 | Breeding Sei2010，60，： | 1 |
| 4 | Involvement of Panton-valentine Leukocidin-producing Staphylococcus Aureus in primary Skin Infections and Pneumonia显示文摘 | Lina G Piemont Y Godail Gamot F | 1999 | Clin Infect Dis1999，29，5： | 1 |
| 5 | Development of new features of ant colony optimization for flowshop scheduling显示文摘 | LUB C Y SHYUC S J | 2008 | International Journal of Production Economics2008，112，2： | 1 |
| 6 | Attenuation relations of Arias intensity based on the Chi-Chi Taiwan earthquake data 显示文摘 | HWANGA H LINA C K YEHB Y T CHENGB S N CHENC K C | 2004 | Soil Dynamics and Earthquake Engineering2004，24，7： | 1 |
| 7 | Cycling and composition of organic matter in terrestrial and marine ecosystems显示文摘 | Baldock J A Masiello C A Gélinas Y | | 0，，1： | 1 |
| 8 | Form Design of Product Image Using Grey Relational Analysis and Neural Network Models显示文摘 | Laia H H Lina Y C Yeh C H | 2005 | International Journal of Industrial Ergonomics2005，32，10： | 1 |
| 9 | Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia显示文摘 | Lina G Piémont Y Godail-Gamot F | 1999 | Clin Infect Dis1999，29，5： | 1 |
| 10 | Leaching characteristics of heavy metals and brominated flame retardants from waste printed circuit boards显示文摘 | ZHOU X Y GUO J LINA K F | 2013 | Journal of Hazardous Materials2013，，246247： | 1 |
| 11 | Improved catalytic activity and stability of meso structured sulfated zirconia by Al promoter显示文摘 | Yin y S Lina Y Sheng Q M | 2004 | Applied Catalysis A:General2004，268，： | 1 |
| 12 | User-orien ted design for the optimal combination on product de sign显示文摘 | LAIA H H LINA Y C YEH C H | 2006 | International Journal of Production Econom ics2006，，100： | 1 |
| 13 | Fibrotic disease显示文摘 | Blank M Shoenfeld Y | 2002 | Harefnah2002，141，97： | 1 |
| 14 | Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages 显示文摘 | Lina N Satoa T Takayamaa Y | 2003 | Biochem Pharm2003，65，12： | 1 |
| 15 | Polymerase chain reaction identification in aqueous humor of patients with postoperative endophthalmitis显示文摘 | Chiquet C Lina G Benito Y | 2007 | J Cataract Refract Surg2007，33，4： | 1 |
| 16 | Polymerase chain reaction identification in aqueous humor of patients with postoperative endophthalmitis显示文摘 | Chiquet C Lina G Benito Y | 2007 | J Cataract Refract Surg2007，33，4： | 1 |
| 17 | Comparison of EKF, Pseudomeasurement and Particle Filters for a Bearing-only Target Tracking Problem 显示文摘 | X Lina T Kirubarajan Y BarSha-kloma | 2002 | Signal and Data Processing of Small Tar- gets2002，4728，： | 1 |
| 18 | Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia显示文摘 | Lina G Piemont Y Godail-Gamot F | 1999 | Clin Infect Dis1999，29，： | 1 |
| 19 | Gas diffusion layer for proton exchange membrane fuel cells--a review 显示文摘 | Cindrella L Kannana A M Lina J F Saminathana K Hoc Y Lind C W Wertze J | 2009 | Journal of Power Sources2009，194，： | 1 |
| 20 | Involvement ofPanton-Valentine leukocidin-producing staphylococcus au-reus in primary skin infections and pneumonia显示文摘 | Lina G Piemont Y Godail-Gamot F | 1999 | Clin In-fect Dis1999，29，5： | 1 |
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