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| 1 | Understanding Spatial Genome Organization:Methods and Insights显示文摘The manner by which eukaryotic genomes are packaged into nuclei while maintaining crucial nuclear functions remains one of the fundamental mysteries in biology. Over the last ten years, we have witnessed rapid advances in both microscopic and nucleic acid-based approaches to map genome architecture, and the application of these approaches to the dissection of higherorder chromosomal structures has yielded much new information. It is becoming increasingly clear,for example, that interphase chromosomes form stable, multilevel hierarchical structures. Among them, self-associating domains like so-called topologically associating domains(TADs) appear to be building blocks for large-scale genomic organization. This review describes features of these broadly-defined hierarchical structures, insights into the mechanisms underlying their formation,our current understanding of how interactions in the nuclear space are linked to gene regulation,and important future directions for the field. | Vijay Ramani Jay Shendure Zhijun Duan | 2016 | Genomics, Proteomics & Bioinformatics2016，14，1： | 2 |
| 2 | Advanced sequencing technologies:methods and goals显示文摘 | Shendure J Mitra RD Varma C | 2004 | Nat Rev Genet2004，5，5： | 1 |
| 3 | Next generation DNA sequencing显示文摘 | Shendure J Ji H | 2008 | Nature Bioteehnology2008，26，： | 1 |
| 4 | Single molecule proling of alternative pre-mRNA splicing显示文摘 | Zhu J Shendure J Mitra R D | 2003 | Science2003，301，5634： | 1 |
| 5 | Advanced sequencing technologies: methods and goals 显示文摘 | SHENDURE J MITRA RD VARMA C | 2004 | Nat Rev Genet2004，5，5： | 1 |
| 6 | Next-generation DNA sequencing 显示文摘 | Shendure J Ji H 2008 | 2008 | Na- ture Biotechnology2008，26，： | 1 |
| 7 | Next-generation DNA sequencing显示文摘 | Shendure J Ji H | 2008 | Nat Biotechnol2008，26，： | 1 |
| 8 | Accuratemultiplex polony sequencing of an evolved bacterialgenome显示文摘 | Shendure J Porreca GJ Reppas NB | 2005 | Science2005，309，5741： | 1 |
| 9 | Next-generation DNA sequencing显示文摘 | SHENDURE J JI H | | 0，，10： | 1 |
| 10 | Next-generation DNA sequencing 显示文摘 | Shendure JJi H | 2008 | Nature bioteeh- nology2008，26，10： | 1 |
| 11 | Next-generation DNA sequencing显示文摘 | SHENDURE J JI H | 2008 | Nat Biotechnol2008，26，： | 1 |
| 12 | Next-generation DNA sequencing显示文摘 | Jay Shendure Hanlee Ji | 2008 | Nature Biotechnology2008，26，10： | 1 |
| 13 | Next-generation DNA sequencing显示文摘 | Shendure J Ji H | 2008 | Nature Bioteehnology2008，26，10： | 1 |
| 14 | Target-enrichment strategies for next-generation sequenc-ing显示文摘 | Mamanova L Coffey A.J Scott C.E Kozarewa I. Turn-er E.H. Kumar A. Howard E. Shendure J. Turner D.J | | 0，，： | 1 |
| 15 | Exome Sequencing Identifies SMAD3 Mutations as a Cause of Familial Thoracic Aortic Aneurysm and Dissection With Intracranial and Other Arterial Aneurysms显示文摘 | Ellen S. Regalado Dong-chuan Guo Carlos Villamizar Nili Avidan Dawna Gilchrist Barbara McGillivray Lorne Clarke Francois Bernier Regie L. Santos-Cortez Suzanne M. Leal Aida M. Bertoli-Avella Jay Shendure Mark J. Rieder Deborah A. Nickerson Dianna M. Milew | 2011 | Circulation Research2011，，6： | 1 |
| 16 | Next-generation DNA sequencing显示文摘 | Shendure J Ji H | 2008 | Nat Biotechnol2008，26，10： | 1 |
| 17 | Detection of minimal residual disease in NPM1 -mutated acute myeloid leukemia by next- generation sequencing 显示文摘 | Salipante SJ Fromm JR Shendure J | 2014 | Mod Pathol2014，27，11： | 1 |
| 18 | Next-generation DNA sequencing显示文摘 | Shendure J Ji H | 2008 | Nat Biotechnol2008，26，10： | 1 |
| 19 | Next-generation DNA sequencing显示文摘 | Shendure J Ji H | 2008 | Nat Biotechnol2008，26，： | 1 |
| 20 | Fluorescent in situ sequencing on polymerase colonies显示文摘 | MITRA R D SHENDURE J OLEJNIK J | 2003 | Anal Biochem2003，320，： | 1 |
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