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| 1 | 手术中知晓事件的新分级标准显示文摘背景有外显记忆的手术中知晓事件的发生率仅为1/1000—2/1000。因其较罕见,为了更好的了解手术中知晓事件及其后遗效直,需要对大批量的研究数据进行统计。因此,对其进行标准描述和表达将很有价值。方法本研究创建了一种新的手术中知晓事件评估标准:0级:未发生手术中知晓;1级:仅存在听觉感知;2级:感知触觉(比如手术操作、气管插管);3级:感知痛觉;4级:感知麻痹(比如感到不能活动、说话或呼吸);5级:感知麻痹及痛觉。患者主述有恐惧、焦虑、窒息、末日感、濒死感及其他相关显性描述,另行附加“D”(distress[痛苦、悲伤])。本研究回顾了15项详细提供手术中知晓报告信息的研究。来自3个研究并创建了该项分级标准的5位麻醉医生,各自独立的评估了这些病例。另外20名相关人员(麻醉主治医生、麻醉住院医生、麻醉护士、医学生及其辅助工作人员),虽未参与该分级标准的创建,但也独立对手术中知晓事件进行了评估。用Flwiss’s κ系数评估观察者之间的一致性。结果对151例确认发生手术中知晓事件的成年病例进行数据分析。基础评估1~5级中,总体κ系数为0.851(95%可信区间CI0.847~0.856)。包括附加情感障碍“D”的评估中,总体κ系数为0.779(95%可信区间CI 0.776~0.783)。结论本研究创建了新的手术中知晓事件评估标准,在评估者间具有近乎完美的一致性,这将有助于手术中知晓事件的研究。 | George A. Mashour Roy K. Esaki Kevin K. Tremper David B. Glick Michael O'Connor Michael S. Avidan 潘鹏(译) 李文志(校) | 2009 | 麻醉与镇痛2009，，6： | 3 |
| 2 | Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy显示文摘AIM: To evaluate the impact of hepatitis C virus (HCV) infection with genotype 1 or 3 and the presence or absence of liver cirrhosis (LC) in the early viral kinetics response to treatment. METHODS: Naive patients (n = 46) treated with interferon-α (IFN-α) and ribavirin and followed up with frequent early HCV-RNA determinations were analysed. Patients were infected with genotype 1 (n = 28, 7 with LC) or 3 (n = 18, 5 with LC). RESULTS: The fi rst phase decline was larger in geno- type 3 patients than in genotype 1 patients (1.72 vs 0.95 log IU/mL, P < 0.001). The second phase slope decline was also larger in genotype 3 patients than in genotype 1 patients (0.87 vs 0.15 log/wk, P < 0.001). Differences were found in both cirrhotic and non-cirrhotic patients. Genotype 1 cirrhotic patients had a slower 2nd phase slope than non-cirrhotic patients (0.06 vs 0.18 log/wk, P < 0.02). None of genotype 1 cirrhotic patients had a 1st phase decline larger than 1 log (non-cirrhotic patients: 55%, P < 0.02). A similar trend toward a slower 2nd phase slope was observed in genotype 3 cirrhotic pa- tients but the 1st phase slope decline was not different. Sustained viral response was higher in genotype 3 pa- tients than in genotype 1 patients (72% vs 14%, P < 0.001) and in genotype 1 non-cirrhotic patients than in genotype 1 cirrhotic patients (19% vs 0%). A secondphase decline slower than 0.3 log/wk was predictive of non-response in all groups. CONCLUSION: Genotype 3 has faster early viral decline than genotype 1. Cirrhosis correlates with a slower 2nd phase decline and possibly with a lower 1st phase slope decline in genotype 1 patients. | José Eymard Medeiros-Filho Isabel Maria Vicente Guedes de Carvalho Mello Joo Renato Rebello Pinho Avidan U Neumann Fernanda de Mello Malta Luiz Caetano da Silva Flair José Carrilho | 2006 | World Journal of Gastroenterology2006，12，45： | 3 |
| 3 | Support vector tracking 显示文摘 | Avidan S | 2004 | IEEE Transactions on Pattern Analysis and Machine Intelligence2004，26，8： | 1 |
| 4 | Anesthesia aware-ness and the bispectral index显示文摘 | Avidan MS | 2008 | N Eng J Med2008，13，10： | 1 |
| 5 | The trace amine receptor 4gene is not associated with schizophrenia in a sample linked to chromosome 6q23显示文摘 | Amann D Avidan N Kanyas K | 2006 | Mol Psychiatry2006，11，2： | 1 |
| 6 | Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain 显示文摘 | Brambrink AM Evers AS Avidan MS Farber NB Smith DJ Zhang X | 2010 | Anesthesiology2010，112，4： | 1 |
| 7 | Prevention of awareness dur- ing general anesthesia显示文摘 | Avidan MS Mashou GA Gliek DB | 2009 | Med Rep2009，1，： | 1 |
| 8 | Acid Reflux Is a Poor Predictor for Severity of Erosive Reflux Esophagitis显示文摘 | Benjamin Avidan Amnon Sonnenberg Thomas G. Schnell Stephen J. Sontag | 2002 | Digestive Diseases and Sciences2002，，11： | 1 |
| 9 | Metacognition in schizophrenia and schizotypy:Relation to symptoms of schizophrenia,traits of schizotypy and social quality of life显示文摘 | Rabin S J Hasson-Ohayon I Avidan M | 2014 | The Israel Journal of Psychiatry and Related Sciences2014，51，1： | 1 |
| 10 | Supporl vector tracking显示文摘 | Avidan S | 2004 | IEEE Transactions on Pattern Analysis and Machine Intelligence2004，26，5： | 1 |
| 11 | Anesthesia awareness and the bispeetral index 显示文摘 | Avidan MS Zhang L Burnside BA | 2008 | N Engl J Med2008，358，11： | 1 |
| 12 | Natural video matting using camera arrays 显示文摘 | Joshi N Matusik W Avidan S | 2006 | ACM Transactions on Graphics2006，25，3： | 1 |
| 13 | Novel view synthesis by cascading trilintensors 显示文摘 | Avidan Shuahua A | 1998 | IEEE Transaction on Visualization and Computer Graphics1998，4，3： | 1 |
| 14 | The UDP-N- acetylglueosamine 2-epimerase/N-aeetylmannosamine kinase gene is mutated in recessive hereditary inclusion body myopathy 显示文摘 | Eisenberg I Avidan N Potikha T | 2001 | Nat Genet2001，29，： | 1 |
| 15 | Anesthesia awareness and the bispectral index显示文摘 | Avidan MS Zhang LN Burnside BA | 2008 | N Engl J Med2008，358，： | 1 |
| 16 | Postoperative delirium 显示文摘 | Whitlock EL Vannucci A Avidan MS | 2011 | Minerva Anestesiol2011，77，： | 1 |
| 17 | Multi-operator media retar- geting 显示文摘 | Rubinstein M Shamir A Avidan S | 2009 | ACM Transactions on Graphics2009，28，3： | 1 |
| 18 | Ensemble tracking显示文摘 | Avidan S | 2007 | IEEE Transactions on Pattern Analysis and Machine Intelligence2007，29，2： | 1 |
| 19 | Ensemble tracking显示文摘 | Avidan S | 2007 | IEEE Transactions on Pattern Analysis and Machine Intelligence2007，29，2： | 1 |
| 20 | Anesthesia awareness and the bispectral index显示文摘 | Avidan MS Zhang L Burnside BA | 2008 | N Engl J Med2008，358，： | 1 |
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