|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 2 | Systematic review and meta-analysis on the association of tuberculosis in Crohn's disease patients treated with tumor necrosis factor-α inhibitors(Anti-TNFα)显示文摘AIM To perform a meta-analysis on the risk of developing Mycobacterium tuberculosis(TB) infection in Crohn's disease(CD) patients treated with tumor necrosis factoralpha(TNFα) inhibitors.METHODS A meta-analysis of randomized, double-blind, placebocontrolled trials of TNFα inhibitors for treatment of CD in adults was conducted. Arcsine transformation of TB incidence was performed to estimate risk difference. A novel epidemiologically-based correction(EBC) enabling inclusions of studies reporting no TB infection cases in placebo and treatment groups was developed to estimate relative odds.RESULTS Twenty-three clinical trial studies were identified, including 5669 patients. Six TB infection cases were reported across 5 studies, all from patients receiving TNFα inhibitors. Eighteen studies reported no TB infection cases in placebo and TNFα inhibitor treatment arms. TB infection risk was significantly increased among patients receiving TNFα inhibitors, with a risk difference of 0.028(95%CI: 0.0011-0.055). The odds ratio was 4.85(95%CI: 1.02-22.99) with EBC and 5.85(95%CI: 1.13-30.38) without EBC.CONCLUSION The risk of TB infection is higher among CD patients receiving TNFα inhibitors. Understanding the immunopathogenesis of CD is crucial, since using TNFα inhibitors in these patients could favor mycobacterial infections, particularly Mycobacterium avium subspecies paratuberculosis, which ultimately could worsen their clinical condition. | Brent L Cao Ahmad Qasem Robert C Sharp Latifa S Abdelli Saleh A Naser | 2018 | World Journal of Gastroenterology2018，24，25： | 4 |
| 3 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 4 | Role of PTPN2/22 polymorphisms in pathophysiology of Crohn's disease显示文摘AIM To establish the relationship of protein tyrosine phosphatase non-receptor type 2 and 22(PTPN2/22) polymorphisms and mycobacterial infections in Crohn's disease(CD). METHODS All 133 subjects' blood samples were genotyped for nine single nucleotide polymorphisms(SNPs) in PTPN2/22 using TaqMan^(?) genotyping, while the effect of the SNPs on PTPN2/22 and IFN-γ gene expression was determined using RT-PCR. Detection of Mycobacterium avium subspecies paratuberculosis(MAP) IS900 gene was done by nPCR after DNA extraction from the isolated leukocytes of each subjects' blood samples. T-cells isolated from the patient samples were tested for response to phytohematoagglutonin(PHA) mitogen or mycobacterial antigens by Brd U proliferation assays for T-cell activity. RESULTS Out of the nine SNPs examined, subjects with either heterozygous(TC)/minor(CC) alleles in PTPN2:rs478582 occurred in 83% of CD subjects compared to 61% healthy controls(P-values < 0.05; OR = 3.03). Subjects with either heterozygous(GA)/minor(AA) alleles in PTPN22:rs2476601 occurred in 16% of CD compared to 6% healthy controls(OR = 2.7). Gene expression in PTPN2/22 in CD subjects was significantly decreased by 2 folds compared to healthy controls(P-values < 0.05). IFN-γ expression levels were found to be significantly increased by approxiately 2 folds in subjects when either heterozygous or minor alleles in PTPN2:rs478582 and/or PTPN22:rs2476601 were found(P-values < 0.05). MAP DNA was detected in 61% of CD compared to only 8% of healthy controls(P-values < 0.05, OR = 17.52), where subjects with either heterozygous or minor alleles in PTPN2:rs478582 and/or PTPN22:rs2476601 had more MAPbacteremia presence than subjects without SNPs did. T h e average T-cell proliferation in CD treated with PHA or mycobacteria antigens was, respectively, 1.3 folds and 1.5 folds higher than healthy controls without any significant SNP. CONCLUSION The data suggests that SNPs in PTPN2/22 affect the negative regulation of the immune response in CD patients, thus leading to an increase in inflammation/apoptosis and susceptibility of mycobacteria. | Robert C Sharp Shazia A Beg Saleh A Naser | 2018 | World Journal of Gastroenterology2018，24，6： | 2 |
| 5 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 6 | Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel 显示文摘 | Cranage M Sharpe S Herrera C | 2008 | PLoS Med2008，5，8： | 1 |
| 7 | Control of mitochondrial permeability by Bcl-2 family members显示文摘 | SHARPE J C AMOULTT D YOULE R J | 2004 | Biochim Biophys Acta2004，1644，23： | 1 |
| 8 | Activities of several noveloxazolidinones against Mycobacterium tuberculosis in a murine model显示文摘 | Cynamon M H Klemens S P Sharpe C A | 1999 | Atimicrob AgentsChemother1999，43，： | 1 |
| 9 | The influence of the MAPK pathway on T cell lineage commitment显示文摘 | SHARP L L SCHWARZ D A BOTT C M | 1997 | Immunity1997，7，5： | 1 |
| 10 | Investigation into tile role of P2X (3)/ P2X(2/3 ) receptors in neuropathic pain following chronic con- striction injury in the rat:an electrophysiological study显示文摘 | Sharp C Reeve AJ Collions SD | 2006 | Br J Phamla- col2006，148，6： | 1 |
| 11 | Plasma fibrinogen andcoronar y heart disease in elderly Japanese-American men 显示文摘 | Sharp D S Abbott R D Burchfied C M | 1996 | Arterioscler Thromb Vase Biol1996，16，2： | 1 |
| 12 | Chicken leptin 显示文摘 | Sharp P J Dunn I C Waddington D | 2008 | Gen Comp Endocrinol2008，1，1： | 1 |
| 13 | Calcium sulfoalumi- nate cements-low-energy cements, special cements or what 显示文摘 | J H Sharp C D Lawrence R Yang | 1999 | Adcance in Cement Research1999，11，1： | 1 |
| 14 | Simultaneous equations in anti-dumping investigation显示文摘 | Prusa T J Sharp D C | 2001 | Journal of Forensic Economics2001，14，1： | 1 |
| 15 | Measurement and parameterization of albedo variations at Haut Glacier d'Arolla, Switzerland显示文摘 | Brock B W Willis I C Sharp M J | 2000 | 46(155) : 675-6882000，46，155： | 1 |
| 16 | A single genetic loc us assoc iated with starchgranule proterties and noodle quality in wheat显示文摘 | Zhao X C Batey I L Sharp P J | 1998 | Journal of Cereal Science1998，27，： | 1 |
| 17 | Relationships between prolactin LH and broody behaviour in bantam hens显示文摘 | Sharp P J Maenamee M C | 1998 | J Endocrinol1998，118，： | 1 |
| 18 | ICP registration using invariant features显示文摘 | Sharp G C Lee S W Wehe D K | 2002 | IEEE transactions on pattern analysis and machine intelligence2002，24，1： | 1 |
| 19 | siRNAs can function as miRNAs显示文摘 | Doench J G Petersen C P Sharp P A | | 0，，04： | 1 |
| 20 | In-plane vibration of annular rings显示文摘 | Ambati G Bell J F W Sharp J C K | 1976 | Journal of Sound and Vibration1976，47，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员