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| 1 | Livelihood diversification of farmers and nomads of eastern transect in Tibetan Plateau显示文摘在西藏的高原的农民和流浪者的生计被草地和草药的资源退化严重地影响。怎么帮助他们完成生计多样化是一个关键持续发展问题。这份报纸在西藏的高原在东方横断的 3 个区域检验生计财产,生计多样化水平和农民和流浪者的生计策略。结果证明生计多样化是流行策略。从高山塞满区域到山高原区域和高原区域,生计多样化水平被减少,并且扩大生计的生计活动和比例也减少。有举起的增加的生计财产和生计多样化水平减少,主要出现在人的财产和自然财产。生计多样化水平是高度有生计财产的关联词,主要出现在自然财产,人的财产和社会财产。仍然基于存在生计财产,农民和流浪者的生计改进策略主要正在提起家畜和挖的植物,并且更少的农民和流浪者认为离开农场是雇用或做的生意。在高原区域的流浪者应该在高山峡区域和山高原区域从人的扩大生计的经验学习大部分。因此,政府的帮助应该集中于减轻生计多样化的限制因素并且帮助他们改进他们的能力建立扩大类型生计。 | YAN Jianzhong WU Yingying ZHANG Yili ZHOU Shaobin | 2010 | Journal of Geographical Sciences2010，20，5： | 22 |
| 2 | Characterization of miRNomes in Acute and Chronic Myeloid Leukemia Cell Lines显示文摘Myeloid leukemias are highly diverse diseases and have been shown to be associated with microRNA(miRNA) expression aberrations. The present study involved an in-depth miRNome analysis of two human acute myeloid leukemia(AML) cell lines, HL-60 and THP-1, and one human chronic myeloid leukemia(CML) cell line, K562, via massively parallel signature sequencing. mRNA expression profiles of these cell lines that were established previously in our lab facilitated an integrative analysis of miRNA and mRNA expression patterns. miRNA expression profiling followed by differential expression analysis and target prediction suggested numerous miRNA signatures in AML and CML cell lines. Some miRNAs may act as either tumor suppressors or oncomiRs in AML and CML by targeting key genes in AML and CML pathways. Expression patterns of cell type-specific miRNAs could partially reflect the characteristics of K562, HL-60 and THP-1 cell lines, such as actin filament-based processes, responsiveness to stimulus and phagocytic activity. miRNAs may also regulate myeloid differentiation, since they usually suppress differentiation regulators. Our study provides a resource to further investigate the employment of miRNAs in human leukemia subtyping, leukemogenesis and myeloid development. In addition, the distinctive miRNA signatures may be potential candidates for the clinical diagnosis, prognosis and treatment of myeloid leukemias. | Qian Xiong Yadong Yang Hai Wang Jie Li Shaobin Wang Yanming Li Yaran Yang Kan Cai Xiuyan Ruan Jiangwei Yan Songnian Hu Xiangdong Fang | 2014 | Genomics, Proteomics & Bioinformatics2014，12，2： | 6 |
| 3 | Progress in the development of techniques based on light scattering for single nanoparticle detection显示文摘Nanoparticles have recently attracted extensive attention in view of their great potential in biomedicine and bioanalytical ap- plications. Single particle detection via light scattering offers a simple and efficient approach for the size, size distribution, and concentration analysis of nanoparticles. In particular, intrinsic heterogeneity or rare events masked by ensemble averaging can be revealed. However, the sixth power dependence of Rayleigh scattering on particle size makes it very challenging to detect individual nanoparticles of small sizes. This article is intended to provide an overview of recent progress in the development of techniques based on light scattering for the detection of single nanoparticles. | ZHU ShaoBin, WANG Shuo, YANG LingLing, HUANG TianXun & YAN XiaoMei Department of Chemical Biology, College of Chemistry and Chemical Engineering Key Laboratory for Chemical Biology of Fujian Province Key Laboratory of Analytical Science, Xiamen University, Xiamen 361005, China | 2011 | Science China Chemistry2011，54，8： | 5 |
| 4 | Rockburst characteristics of several hard brittle rocks:A true triaxial experimental study显示文摘Rockburst is a typical rock failure which frequently threatens both human life and construction equipment during highly stressed underground excavation.Rock lithology is a control factor of rockburst.In this paper,rockburst tests were conducted on rectangular prismatic specimens of six types of intact hard brittle rocks,i.e.granodiorite,granite,marble,basalt,sandstone and limestone,under one-free-face true triaxial loading conditions.With the use of high-speed cameras,an acoustic emission(AE)system and a scanning electron microscope(SEM),rockburst of different rocks was investigated.The results show that the strainbursts of granodiorite,granite and marble were accompanied by tensile splitting near the free face,and consequently were relatively strong with a large amount of fragment ejection and kinetic energy release.For basalt,sandstone and limestone,failure was primarily dominated by shear rupture.The strainbursts of basalt and sandstone were relatively small with minor fragment ejection and kinetic energy release;while no burst failure occurred on limestone due to its relatively low peak strength.Rock strength,fracturing and fragmentation characteristics,and failure modes of different rocks can significantly affect rockburst proneness and magnitude.The AE evolution coupled with SEM analysis reveals that the differences in the inhe rent microstructures and fracture evolution under loading are the primary factors accounting for different rockbursts in various rock types. | Shaobin Zhai Guoshao Su Shunde Yin Bin Zhao Liubin Yan | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，2： | 4 |
| 5 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 6 | Equilibrium morphology of gas–liquid Janus droplets: A numerical analysis of buoyancy effect显示文摘In this article, a theoretical model for predicting the equilibrium morphology of gas–liquid Janus droplets was built. Based on this model, the effects of bubble radius and volume ratio on morphology change was systematically studied. The increase of bubble radius causes the two parts(bubble and oil drop) in Janus droplets tend to merge while the impact of volume ratio is complicated. When volume ratio increases, these two parts firstly tend to merge, then gradually separate. The accuracy of this model was verified by experimental results. | Shaobin Zhang Helen Yan Yuhao Geng Ke Wang Jianhong Xu | 2018 | Chinese Journal of Chemical Engineering2018，26，10： | 1 |
| 7 | Tests on Application of Soil Magnetic and Integrated Gamma Ray TLD and TC Methods to the Exploration of Sandstone-Type Uranium Deposits显示文摘This paper introduces the test results of the soil magnetic survey and the integrated gamma-ray TLD and TC methods for sandstone-type uranium exploration and describes the prospecting mechanism. The tests have proved that these approaches have yielded good results on classifying the sedimentary fades, defining the redox transitional zones and reflecting deep mineralization information. They may probably become new methods on searching for sandstone-type uranium deposits. | ZOU Ligui ZHANG Jiyun YAN Jun GUAN Shaobin | 2000 | Acta Geologica Sinica(English Edition)2000，74，2： | 1 |
| 8 | Photocatalytic fuel cell for simultaneous antibiotic wastewater treatment and electricity production by anatase TiO_(2) nanoparticles anchored on Ni foam显示文摘Photocatalytic fuel cell (PFC) holds great potential for the sustainable production of electricity and degradation of organic pollutants for solving global energy and environmental problems.However,the efficient photodegradation of organic dyes and antibiotic drugs,such as ciprofloxacin (CIP) and methylene blue(MB),remains challenging.Aiming at improving the separation efficiency of hole and electron for electricity generation in the PFC system,TiO_(2)-NPs@NF-x photoanode was fabricated by a cost-effective and laborsaving hydrothermal approach.The as-fabricated photoanode demonstrated abundant active sites,enhanced light harvesting capacity and photogenerated charge carrier separation.At a CIP-HCl concentration of 10 mg/L and p H value of about 7,85%of CIP-HCl can be efficiently removed after 3 h irradiation by 300 W Xe lamp.TiO_(2)-NPs@NF-20 photoelectrode based PFC system exhibited an impressed ability to simultaneously degrade ciprofloxacin and generate electricity under light irradiation with an open circuit voltage of 1.021 V,short circuit current density and maximum power density of 2.4 mA/cm^(2),0.357 mW/cm^(2),respectively.This work provided a cost-effective method for the treatment of organic waste and generation of electrical power. | Jinhan Li Xicheng Li Shaobin Yu Shuai Gao Yang Zhang Yan Li Changzheng Wang Qiang Wang | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 9 | Microbial synthesis of anti-tumor agent oxysophoridine through one step by filamentous fungus显示文摘Sophoridine and oxysophoridine are alkaloids extracted from Chinese traditional medicinewith significant antitumor activities. Computer-aided design and preliminary structure-activity relationship studiesshowed that the biological activity of sophoridine can be improved after oxidation (oxysophoridine) whileits toxicity significantly decreased. A new method to prepare oxysophoridine from natural product Sophoridineby biotransformation was established for the first time except for traditional extraction from plants and chemicalsynthesis. Positive biocatalytic reaction was detected by TLC. Structure of conversion product was elucidatedbased on NMR spectroscopy. Optimizations of reactions including substrate concentration, pH, conversion timeand inoculation quantity were complemented which analyzed by LC-MS. Results showed that filamentous fungusXylariales. sp F005 (CCTCC M2014660) has the capacity of synthetizing oxysophoridine from sophoridinein the selected 37 strains. The yield of oxysophoridine reached highest at conditions pH 6.0, the third day ofconversion time, 5.0 mg substrate and 5% inoculums respectively. The method for preparing oxysophoridinecatalyzed by enzymes with green and sustainable synthetic processes was developed. | Qingfeng Meng Xuan Zhou Xu Ran Song Yan Shaobin Fu | 2019 | Journal of Pharmaceutical and Biopharmaceutical Research2019，1，2： | 0 |
| 10 | Genome sequencing revealed the red-flower trait candidate gene of a peach landrace显示文摘Peach(Prunus persica)is an economically important fruit crop globally and an excellent material for genomic studies.While considerable progress has been made in unveiling trait-associated genes within cultivars and wild relatives,certain novel genes controlling valuable traits in peach landraces,such as the red-flowering gene,remained unclear.In this study,we sequenced and assembled the diploid genome of the red-flower landrace‘Yingzui’(abbreviated as‘RedY’).Multi-omics profiling of red petals of‘RedY’revealed the intensified red coloration associated with anthocyanins accumulation and concurrent decline in f lavonols.This phenomenon is likely attributed to a natural variant of Flavonol Synthase(FLS)harboring a 9-bp exonic insertion.Intriguingly,the homozygous allelic configurations of this FLS variant were only observed in red-flowered peaches.Furthermore,the 9-bp sequence variation tightly associated with pink/red petal color in genome-wide association studies(GWAS)of collected peach germplasm resources.Functional analyses of the FLS variant,purified from procaryotic expression system,demonstrated its diminished enzymatic activity in f lavonols biosynthesis,impeccably aligning with the cardinal trait of red flowers.Therefore,the natural FLS variant was proposed as the best candidate gene for red-f lowering trait in peach.The pioneering unveiling of the red-flowered peach genome,coupled with the identification of the candidate gene,expanded the knowledge boundaries of the genetic basis of peach traits and provided valuable insights for future peach breeding efforts. | Ping Zhou Siru Lei Xiaodan Zhang Yinghao Wang Rui Guo Shaobin Yan Guang Jin Xingtan Zhang | 2023 | Horticulture Research2023，10，11： | 0 |
| 11 | A new genus and species of Phenacoccinae(Hemiptera:Coccomorpha:Pseudococcidae)from northwestern China显示文摘A new genus and species,Sananicoccus nanophytoni gen.&sp.nov.,is described and illustrated based on its adult female,adult male,first-instar nymph and pupa,collected on the leaves of Nanophyton erinaceum(Pall.)Bunge(Chenopodiaceae)from Xinjiang.The new genus is similar to the genus Synacanthococcus Morrison,1920,but differs by the absence of ostioles and dorsal cerarii,and no cerarii situated on a prominent sclerotized area. | Shaobin Huang Meiyu Yan | 2023 | Zoological Systematics2023，48，3： | 0 |
| 12 | Synthesis of Acridinium Photocatalysts via Site-Selective C–H Alkylation显示文摘Acridinium dyes have been broadly used as photocatalysts,but it remains synthetically challenging to fine-tune their catalytic performance by functionalization of their structural cores.Acridinium photocatalysts are usually prepared through de novo synthesis,which involves difficult steps and requires sensitive organometallic reagents. | Hong Yan Jinshuai Song Shaobin Zhu Hai-Chao Xu | 2021 | CCS Chemistry2021，3，12： | 0 |
| 13 | Variation of DRB1 Gene in Tibetan Sheep显示文摘 | Li Shaobin Luo Yuzhu Hu Jiang Wang Jiqing Liu Xiu Yan Wei | 2015 | Journal of Life Sciences2015，9，6： | 0 |
| 14 | Selecting small molecule DNA aptamers with significant conformational changes for constructing transcriptional switches and biosensors显示文摘Small molecule aptamers discovered by traditional selection methods usually lack conformational changes upon target binding.This limits the use of aptamers as molecular probes for small molecule detection and regulatory elements of genetic circuits.Here,we report a new method called capture and in vitro transcription-systematic evolution of ligands by exponential enrichment(CIVT-SELEX)to select DNA aptamers that can not only bind to small molecule ligands but also undergo significant conformational changes.Through this method,we select a structure-switching aptamer of uridine-5′-diphosphate(UDP).Taking advantage of its conformational changes,we first construct a UDP-responsive transcriptional switch by inserting the aptamer in a genetic circuit and demonstrate that it can respond to the addition of UDP and regulate the transcription of downstream genes.We also build a UDP aptamer-based biosensor that can be used for active glycosyltransferase screening.We believe this method can provide a universal platform for selecting small molecule aptamers with conformational changes and expand the use of aptamers in small molecule detection and genetic regulation. | Shaobin Guo Jingjing Lin Lujie Lin Wen Xu Yan Guo Zipeng Xu Chunhua Lu Xianai Shi Lanlan Chen Huanghao Yang | 2023 | Science China Chemistry2023，66，5： | 0 |
| 15 | A cell wall invertase modulates resistance to fusarium crown rot and sharp eyespot in common wheat显示文摘Fusarium crown rot(FCR) and sharp eyespot(SE)are serious soil-borne diseases in wheat and its relatives that have been reported to cause wheat yield losses in many areas. In this study, the expression of a cell wall invertase gene, TaCWI-B1,was identified to be associated with FCR resistance through a combination of bulk segregant RNA sequencing and genome resequencing in a recombinant inbred line population. Two biparental populations were developed to further verify TaCWI-B1 association with FCR resistance.Overexpression lines and ethyl methanesulfonate(EMS) mutants revealed TaCWI-B1 positively regulating FCR resistance. Determination of cell wall thickness and components showed that the TaCWI-B1-overexpression lines exhibited considerably increased thickness and pectin and cellulose contents. Furthermore, we found that TaCWI-B1 directly interacted with an alphagalactosidase(TaGAL). EMS mutants showed that TaGAL negatively modulated FCR resistance. The expression of TaGAL is negatively correlated with TaCWI-B1 levels, thus may reduce mannan degradation in the cell wall, consequently leading to thickening of the cell wall. Additionally, TaCWI-B1-overexpression lines and TaGAL mutants showed higher resistance to SE;however, TaCWI-B1 mutants were more susceptible to SE than controls.This study provides insights into a FCR and SE resistance gene to combat soil-borne diseases in common wheat. | Guoguo Lv Yixiao Zhang Lin Ma Xiangning Yan Mingjie Yuan Jianhui Chen Yongzhen Cheng Xi Yang Qi Qiao Leilei Zhang Mohsin Niaz Xiaonan Sun Qijun Zhang Shaobin Zhong Feng Chen | 2023 | Journal of Integrative Plant Biology2023，65，7： | 0 |
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