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| 1 | Effects of inoculating fungi on agilawood formation in Aquilaria sinensis显示文摘Agilawood is a costly heartwood medicine obtained from Aquilaria sinensis with active ingredients mainly composed of volatile and semi-volatile substances. However, the formation time of agilawood is quite long and little is known about its formation mechanism. Two highly active fungi obtained from natural agilawood were inoculated on A. sinensis trees to understand their interaction processes and elucidate the transformation rules of induced chemical compositions within different test periods. The results demonstrated that the fungi could successfully colonize living tissues and cells and activate the host defense system, resulting in agilawood accumulation. With increasing time, the main components of A. sinensis converted into constituents or analogs of agilawood and the host exhibited 'self-injury' to prevent fungal intrusion and protect other tissues. The data presented here could provide scientific basis for producing agilawood with the two new fungi in a safe, feasible, and sustainable manner without destroying rare Aquilaria plants. | CUI JinLong GUO ShunXing FU ShaoBin XIAO PeiGen WANG MengLiang | 2013 | Chinese Science Bulletin2013，58，26： | 8 |
| 2 | In situ synthesis of graphene oxide/gold nanorods theranostic hybrids for efficient tumor computed tomography imaging and photothermal therapy显示文摘Graphene 氧化物 / 黄金 nanorod (GO/GNR ) nanohybrids 被混合聚苯乙烯 sulfonate (PSS ) 在房间温度在 situ 生长方法与 GO-seed-mediated 和 gold-seed-mediated 综合 functionalized 去,第二等的生长答案,和金种子。与 GO/GNRs 或 graphene (G)/GNRs 的前 situ 准备方法相比,在里面 GO/GNRs 的 situ 合成在他们的附件前处理了 GNR 的聚集的问题到 GO 上。方法直接、环境友好。GO/GNRs 在 vitro 显示出显著 photothermal 效果。GO/GNR nanohybrids 的温度在女人上从 25 ~ 49.9 增加了光谱为宽事件角度的范围(365 ~ 1,100 nm )(0io 是超过 6.00 ~ 10 个病人和 35 age-/gender-matched 控制(吝啬的 s 吗?? | Bingmei Sun Jinrui Wu Shaobin Cui Huanhuan Zhu Wei An Qingge Fu Chengwei Shao Aihua Yao Bingdi Chen Donglu Shi | 2017 | Nano Research2017，10，1： | 4 |
| 3 | Experimental Study of Bowed-twisted Stators in an Axial Transonic Fan Stage显示文摘Bowed-twisted stators with large camber angles have been developed to replace the conventional tandem stators in an axial transonic fan stage working at high subsonic speeds.Experimental study is carried out on both stages with tandem stators and with bowed-twisted stators.Compared to the tandem stators,the bowed-twisted stators change the distribution of the low-energy fluid and the potential high-energy fluid at the compressor outlets,reduce the endwall loss significantly,improve the aerody-namic matching of rotors and stators,and eventually increase the fan stage performances.The aerodynamic performances of the fan stage at different operating points are compared and contrasted.The results show that the transonic fan stage with bowed-twisted stators has better aerodynamic performances.It is thus suggested that the bowed-twisted stators with large camber angles be popularized into the high-loaded transonic fan designs. | Chen Fu,Li Shaobin,Su Jiexian,Wang Zhongqi School of Energy Science and Engineering,Harbin Institute of Technology,Harbin 150001,China | 2009 | Chinese Journal of Aeronautics2009，22，4： | 2 |
| 4 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 5 | A New Clustering Model Based on Word2vec Mining on Sina Weibo Users' Tags显示文摘 | Bai Xue Chen Fu Zhan Shaobin | 2014 | International Journal of Grid Distribution Computing2014，7，3： | 1 |
| 6 | Microbial synthesis of anti-tumor agent oxysophoridine through one step by filamentous fungus显示文摘Sophoridine and oxysophoridine are alkaloids extracted from Chinese traditional medicinewith significant antitumor activities. Computer-aided design and preliminary structure-activity relationship studiesshowed that the biological activity of sophoridine can be improved after oxidation (oxysophoridine) whileits toxicity significantly decreased. A new method to prepare oxysophoridine from natural product Sophoridineby biotransformation was established for the first time except for traditional extraction from plants and chemicalsynthesis. Positive biocatalytic reaction was detected by TLC. Structure of conversion product was elucidatedbased on NMR spectroscopy. Optimizations of reactions including substrate concentration, pH, conversion timeand inoculation quantity were complemented which analyzed by LC-MS. Results showed that filamentous fungusXylariales. sp F005 (CCTCC M2014660) has the capacity of synthetizing oxysophoridine from sophoridinein the selected 37 strains. The yield of oxysophoridine reached highest at conditions pH 6.0, the third day ofconversion time, 5.0 mg substrate and 5% inoculums respectively. The method for preparing oxysophoridinecatalyzed by enzymes with green and sustainable synthetic processes was developed. | Qingfeng Meng Xuan Zhou Xu Ran Song Yan Shaobin Fu | 2019 | Journal of Pharmaceutical and Biopharmaceutical Research2019，1，2： | 0 |
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