|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Inter-annual and seasonal variations in hydrological parameters and its implications on chlorophyll a distribution along the southwest coast of Bay of Bengal显示文摘Seasonal and inter-annual variability of hydrological parameters and its impact on chlorophyll distribution was studied from January 2009 to December 2011 at four coastal stations along the southwest Bay of Bengal. Statistical analysis(principal component analysis(PCA), two-way analysis of variance(ANOVA) and correlation analysis)showed the significant impact of hydrological parameters on chlorophyll distribution in the study area. The ranges of different parameters recorded were 23.8–33.8°C(SST), 4.00–36.00(salinity), 7.0–9.2(p H), 4.41–8.32 mg/L(dissolved oxygen), 0.04–2.45 μmol/L(nitrite), 0.33–16.10 μmol/L(nitrate), 0.02–2.51 μmol/L(ammonia),0.04–3.32 μmol/L(inorganic phosphate), 10.09–85.28 μmol/L(reactive silicate) and 0.04–13.8 μg/L(chlorophyll).PCA analysis carried out for different seasons found variations in the relationship between physico-chemical parameters and chlorophyll in which nitrate and chlorophyll were positively loaded at PC1(principal component1) during spring inter-monsoon and at PC2(principal component 2) during other seasons. Likewise correlation analysis also showed significant positive relationship between chlorophyll and nutrients especially with nitrate(r=0.734). Distribution of hydrobiological parameters between stations and distances was significantly varying as evidenced from the ANOVA results. The study found that the spatial and temporal distribution of chlorophyll was highly dependent on the availability of nutrients especially, nitrate in the southwest Bay of Bengal coastal waters. | Shanthi R. Poornima D. Raja K. Sarangi R.K. Saravanakumar A. Thangaradjou T. | 2015 | Acta Oceanologica Sinica2015，34，6： | 1 |
| 2 | Targeted Deletion of Metalloproteinase 9 Attenuates Experimental Colitis in Mice: Central Role of Epithelial-Derived MMP显示文摘 | Florencia E. Castaneda Baljit Walia Matam Vijay–Kumar Neal R. Patel Susanne Roser Vasantha L. Kolachala Mauricio Rojas Lixin Wang Gabriela Oprea Pallavi Garg Andrew T. Gewirtz Jesse Roman Didier Merlin Shanthi V. Sitaraman | 2005 | Gastroenterology2005，，6： | 1 |
| 3 | Computational analysis of deleterious missense mutations in aspartoacylase that cause Canavan's disease显示文摘In this work, the most detrimental missense mutations of aspartoacylase that cause Canavan's disease were identified computationally and the substrate binding efficiencies of those missense mutations were analyzed. Out of 30 missense mutations, I-Mutant 2.0, SIFT and PolyPhen programs identified 22 variants that were less stable, deleterious and damaging respectively. Subsequently, modeling of these 22 variants was performed to understand the change in their conformations with respect to the native aspartoacylase by computing their root mean squared deviation (RMSD). Furthermore, the native protein and the 22 mutants were docked with the substrate NAA (N-Acetyl-Aspartic acid) to explain the substrate binding efficiencies of those detrimental missense mutations. Among the 22 mutants, the docking studies identified that 15 mutants caused lower binding affinity for NAA than the native protein. Finally, normal mode analysis determined that the loss of binding affinity of these 15 mutants was caused by altered flexibility in the amino acids that bind to NAA compared with the native protein. Thus, the pre- sent study showed that the majority of the substrate-binding amino acids in those 15 mutants displayed loss of flexibility, which could be the theoretical explanation of decreased binding affinity between the mutant aspartoacylases and NAA. | SREEVISHNUPRIYA K. CHANDRASEKARAN P. SENTHILKUMAR A. SETHUMADHAVAN R. SHANTHI V. DAISY P. NISHA J. RAMANATHAN K. RAJASEKARAN R. | 2012 | Science China(Life Sciences)2012，55，12： | 0 |
| 4 | A computational approach to explore the functional missense mutations in the spindle check point protein Mad1显示文摘在这个工作, Mad1 蛋白质的最有害的错误感觉变化那个原因癌症的各种各样的类型计算地被识别,那些错误感觉变化的底层绑定效率被分析。从 13 个错误感觉变化, IMutant 2.0, SIFTand PolyPhen 程序识别了分别地是不太稳定的、有害、损坏的 3 变体。随后,这 3 变体当模特儿被执行由计算他们的根平均数关于本国的 Mad1 在他们的符合构造理解变化摆平的偏差(RMSD ) 。而且,本国的蛋白质和 3 异种与有约束力的搭挡 Mad2 被停靠向底层解释那些有害错误感觉变化的有约束力的效率。停靠研究鉴别所有 3 异种比本国的蛋白质为 Mad2 引起了更低的有约束力的亲密关系。最后,正常模式分析决定这 3 异种的有约束力的亲密关系的损失被改变的灵活性在与本国的蛋白质相比绑在 Mad2 的氨基酸引起。因此,现在的学习证明在那些 3 异种的底层绑定氨基酸的那个多数显示了灵活性的损失,它能是与变异的 Mad1 和 Mad2 的减少的有约束力的亲密关系的理论解释。 | Merlin LOPUS Rao SETHUMADHAVAN P. CHANDRASEKARAN K. SREEVISHNUPRIYA A.W. VARSHA V. SHANTHI K. RAMANATHAN R. RAJASEKARAN | 2013 | Frontiers in Biology2013，8，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员