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| 1 | Original article Efficacy and safety of Changfu peritoneal dialysis solution: a multi-center prospective randomized controlled trial显示文摘 | ZHOU Jian-hui NI Zhao-hui MEI Chang-lin YU Xue-qing LIU Fu-you MIAO Li-ning LIU Zhi-hong YUAN Wei-jie ZHANG Ai-ping LIN Hong-li CHEN Meng-hua CHEN Jiang-hua ZHANG Jin-yuan HE Ya-ni CHEN Jian ZHAO Jiu-yang DING Xiao-qiang LI Ying LI Rong-shan XIE Ru-juan LIU Wen-hu XING Chang-ying WANG Rong DENG Yue-yi CAO Xue-ying CAI Guang-yan MOU Shan MAO Zhi-guo YANG Xiao LIU Hong SUN Jing YU Yu-sheng LIU Jun SHI Shu-mei LI Long-kai TIAN Na ZHANG Xiao-hui ZHOU Wei YANG Jie ZHANG Yong SUN Jing-di JI Jun ZHANG Tao YAN Yan LIU Xiao-gang WANG Gang ZHANG Li ZHANG Hong LUO Jian-hua CHEN Xiang-mei | 2013 | Chinese Medical Journal2013，，22： | 4 |
| 2 | Cystic meconium peritonitis with jejunoileal atresia:Is it associated with unfavorable outcome?显示文摘AIM To compare the outcome between patients with jejunoileal atresia(JIA) associated with cystic meconium peritonitis(CMP) and patients with isolated JIA(JIA without CMP).METHODS A retrospective study was conducted for all neonates with JIA operated in our institute from January 2005 to January 2016.Demographics including the gestation age,sex,birth weight,age at operation,the presence of associated syndrome was recorded.Clinical outcome including the type of operation performed,operative time,the need for reoperation and mortality were studied.The demographics and the outcome between the 2 groups were compared.RESULTS During the study period,53 neonates had JIA underwent operation in our institute.Seventeen neonates(32%) were associated with CMP.There was no statistical difference on the demographics in the two groups.Patients with CMP had earlier operation than patients with isolated JIA(mean 1.4 d vs 3 d,P = 0.038).Primaryanastomosis was performed in 16 patients(94%) with CMP and 30 patients(83%) with isolated JIA(P = 0.269).Patients with CMP had longer operation(mean 190 min vs 154 min,P = 0.004).There were no statistical difference the need for reoperation(3 vs 6,P = 0.606) and mortality(2 vs 1,P = 0.269) between the two groups.CONCLUSION Primary intestinal anastomosis can be performed in94% of patients with JIA associated with CMP.Although patients with CMP had longer operative time,the mortality and reoperation rates were low and were comparable to patients with isolated JIA. | Kin Wai Edwin Chan Kim Hung Lee Hei Yi Vicky Wong Siu Yan Bess Tsui Yuen Shan Wong Kit Yi Kristine Pang Jennifer Wai Cheung Mou Yuk Him Tam | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 3 |
| 3 | Microaerobic Fe (Ⅱ) oxidation coupled to carbon assimilation processes driven by microbes from paddy soil显示文摘Microaerobic Fe(Ⅱ) oxidation process at neutral pH, driven by microbes can couple to carbon assimilation process in iron-rich freshwater and marine environments;however, few studies report such coupled processes in paddy soil of the critical zone in South China. In this study, rhizosphere soil from flooded paddy field was used as the inoculum to enrich the microaerophilic Fe(Ⅱ)-oxidizing bacteria(FeOB) in gradient tubes with different Fe(Ⅱ) substrates(FeS and FeCO_3) and ^(13)C-biocarbonate as inorganic carbon source to track the carbon assimilation. Kinetics of Fe(Ⅱ) oxidation and biomineralization were analyzed, and the composition and abundance of the microbial community were profiled using 16 S rRNA gene-based highthroughput sequencing. Results showed that microbial cell bands were formed 0.5–1.0 cm below the medium surface in the inoculated tubes with Fe(Ⅱ) substances, while no cell band was found in the non-inocula controls. The protein concentrations in the cell bands reached the highest values at 18.7–22.9 mg m^L(-1) on 6 d in the inocula tubes with Fe(Ⅱ) substrates. A plateau of the yields of ^(13)C-biocarbonate incorporation was observed during 6–15 d at 0.44–0.54% and 1.61–1.98% in the inocula tubes with FeS and FeCO_3, respectively. The inocula tube with FeS showed a higher Fe(Ⅱ) oxidation rate of 0.156 mmol L^(-1) d^(-1) than that with FeCO_3(0.106 mmol L^(-1) d^(-1)). Analyses of X-ray diffraction and scanning electron microscopy with energy-dispersive X-ray spectroscopy revealed that amorphous iron oxide was formed on the surface of rod-shaped bacteria after Fe(Ⅱ) oxidation.Relative to the agar only control, the abundances of Clostridium and Pseudogulbenkiania increased in the inocula tube with FeS,while those of Vogesella, Magnetospirillum, Solitalea, and Oxalicibacterium increased in the inocula tube with FeCO_3, all of which might be the potential microaerophilic FeOB in paddy soil. The findings in this study suggest that microbes that couple microaerobic Fe(Ⅱ) oxidation to carbon assimilation existed in the paddy soil, which provides an insight into the iron-carbon coupling transformation under microaerobic conditions in the critical zone of the iron-rich red soil. | Xiaomin LI Shan MOU Yating CHEN Tongxu LIU Jun DONG Fangbai LI | 2019 | Science China Earth Sciences2019，62，11： | 3 |
| 4 | Laparoscopic excision of Meckel's diverticulum in children:What is the current evidence?显示文摘Complications aroused from Meckel's diverticulum tend to developed in children.Children presented with abdominal pain,intestinal obstruction,intussusception or gastrointestinal bleeding may actually suffered from complicated Meckel's diverticulum.With the advancement of minimally invasive surgery(MIS) in children,the use of laparoscopy in the diagnosis and subsequent laparoscopic excision of Meckel's diverticulum has gained popularity.Recently,single incision laparoscopic surgery(SILS) has emerged as a new technique in minimally invasive surgery.This review offers the overview in the development of MIS in the management of children suffered from Meckel's diverticulum.The current evidence in different laparoscopic techniques,including conventional laparoscopy,SILS,the use of special laparoscopic instruments,intracorporeal diverticulectomy and extracorporeal diverticulectomy in the management of Meckel's diverticulum in children were revealed. | Kin Wai Edwin Chan Kim Hung Lee Hei Yi Vicky Wong Siu Yan Bess Tsui Yuen Shan Wong Kit Yi Kristine Pang Jennifer Wai Cheung Mou Yuk Him Tam | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 5 | Plant-Derived Bioactive Compounds Produced by Endophytic Fungi显示文摘 | J. Zhao T. Shan Y. Mou L. Zhou | 2011 | Mini-Reviews in Medicinal Chemistry2011，，2： | 2 |
| 6 | Structural basis for gating mechanism of Pannexin 1 channel显示文摘Dear Editor,Pannexin 1(PANX1)plays extensive physiological roles across diverse fields of biology,including cell death,1,2 inflammation,3 cancer progression,4 and neurological disorders.5 As suggested by biochemical analysis,PANX1 forms an oligomeric channel for the facilitated diffusion of ions and large molecules across the plasma membrane upon activation.6 However,the underlying molecular gating mechanism of PANX1 and the structure of human PANX1 are still elusive.In the current study,we report the cryo-EM structures of full-length and carboxyl-terminal(CT)tail-cleaved human PANX1.Combined with single-channel electrophysiological study,we identified the key residues involved in the gating of PANX1. | Luqiu Mou Meng Ke Mengxiao Song Yuanyue Shan Qingjie Xiao Qingting Liu Jialu Li Ke Sun Lei Pu Li Guo Jia Geng Jianping Wu Dong Deng | 2020 | Cell Research2020，30，5： | 2 |
| 7 | Use of laparoscopy as the initial surgical approach of impalpable testes:10-year experience显示文摘AIM: To review the experience in the management of impalpable testes using laparoscopy as the initial approach and the need for inguinal exploration.METHODS: From January 2004 to June 2014, 339 patients with undescended testes underwent operation in our institute. Fifty patients(15%) had impalpable testes. All children with impalpable testes underwent initial laparoscopy. A retrospective review was conducted on this group of patients and the outcome was analyzed.RESULTS: Forty children had unilateral impalpable testis. Ten children had bilateral impalpable testes. Thirty-one children(78%) in the unilateral group underwent subsequent inguinal exploration while 4 children(40%) in the bilateral group underwent inguinal exploration(P < 0.05). Orchidopexy was performed in 16 children(40%) in the unilateral group and 9 children(90%) in the bilateral group(P < 0.05). Regarding the 24 children with unilateral impalpable testis and underwent orchidectomy for testicular nubbin(n = 19) or atrophic testes(n = 2) or has vanishing testes(n = 3); contralateral testicular hypertrophy was noticed in 10(41%). No intra-operative complication was encountered. Two children after staged Fowler-Stephensprocedure and 1 child after inguinal orchidopexy had atrophic testes.CONCLUSION: The use of laparoscopy in children with impalpable testes is a safe procedure and can guide the need for subsequent inguinal exploration. Children with unilateral impalpable testis were associated with an increased need for inguinal exploration after laparoscopy. Orchidopexies could be performed successfully in 90% of children with bilateral impalpable testes. | Kin Wai Edwin Chan Kim Hung Lee Hei Yi Vicky Wong Siu Yan Bess Tsui Yuen Shan Wong Kit Yi Kristine Pang Jennifer Wai Cheung Mou Yuk Him Tam | 2015 | World Journal of Clinical Pediatrics2015，4，4： | 2 |
| 8 | Plant-derived bioactive compounds produced by endophytic fungi 显示文摘 | ZHAO J SHAN T MOU Y ct al | 2011 | Mini-Reviews in Medicinal Chemistry2011，11，： | 1 |
| 9 | Effects of polysaccharide elicitors from endophytic fusarium oxysporium Dzfl7 on growth and diosgenin production in cell suspension culture of Dioscorea zingiberensis显示文摘 | LI Peiqin MOU Yan SHAN Tijiang | | 0，，11： | 1 |
| 10 | Effects of po- lysaccharide elicitors from endophytic Fusarium oxysporium Dzfl7 on growth and diosgenin production in cell suspension culture of Dioscorea zingiberensis显示文摘 | Li P Q Mou Y Shan T J | 2011 | Molecules2011，16，： | 1 |
| 11 | Enhancement of diepoxin ζ production in liquid culture of endophytic fungus Berkleasmium sp. Dzf12 by polysaccharides from its host plant Dioscorea zingiberensis显示文摘 | Yan Li Peiqin Li Yan Mou Jianglin Zhao Tijiang Shan Chunbang Ding Ligang Zhou | 2012 | World Journal of Microbiology and Biotechnology2012，，4： | 1 |
| 12 | Plant-derived bioactive compounds pro- duced by endophytic fungi 显示文摘 | ZHAO J SHAN T MOU Y | 2011 | Mini-Reviews in Medicinal Chemistry2011，11，2： | 1 |
| 13 | Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis显示文摘 | Humphreys Benjamin D Xu Fengfeng Sabbisetti Venkata Grgic Ivica Naini Said Movahedi Wang Ningning Chen Guochun Xiao Sheng Patel Dhruti Henderson Joel M Ichimura Takaharu Mou Shan Soeung Savuth McMahon Andrew P Kuchroo Vijay K Bonventre Jos | 2013 | Journal of Clinical Investigation2013，，： | 1 |
| 14 | Effects of polysaccharide elicitors from endophytic Fusarium oxysporium Dzfl 7 on growth and diosgenin production in cell suspension culture of Dioscorea zingiberensis 显示文摘 | Li P Q Mou Y Shan T J | 2011 | Molecules2011，16，11： | 1 |
| 15 | Antimi- crobial Metabolites from the Endophytic Fungus Pichia guilliermondii Isolated From paris var Yunnanensis 显示文摘 | Jianglin Zhao Yan Mou Tijiang Shan | 2010 | Molecules2010，15，： | 1 |
| 16 | Prevalence of non-diabetic renal disease in patients with type 2 diabetes显示文摘 | Shan Mou Qin Wang Jian Liu Xiajing Che Minfang Zhang Liou Cao Wenyan Zhou Zhaohui Ni | 2009 | Diabetes Research and Clinical Practice2009，，3： | 1 |
| 17 | Plant derived bioactive com- pounds produced by endophytic fungi显示文摘 | Zhao J Shan T Mou Y | 2011 | Mini Reviews in Me- dicinal Chemistry2011，11，2： | 1 |
| 18 | Eradication of H elicobacter pylori Infection by the Probiotic Strains L actobacillus johnsonii MH ‐68 and L . salivarius ssp. salicinius AP ‐32显示文摘 | Pei‐Shan Hsieh Yi‐Chun Tsai Yi‐Chun Chen Su‐Fen Teh Chung‐Mou Ou V. An‐Erl King | 2012 | Helicobacter2012，，6： | 1 |
| 19 | Eradication of H elicobacter pylori Infection by the Probiotic Strains L actobacillus johnsonii MH ‐68 and L . salivarius ssp. salicinius AP ‐32显示文摘 | Pei‐Shan Hsieh Yi‐Chun Tsai Yi‐Chun Chen Su‐Fen Teh Chung‐Mou Ou V. An‐Erl King | 2012 | Helicobacter2012，，6： | 1 |
| 20 | Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β显示文摘The identification of effective drug targets and the development of bioactive molecules are areas of high need in cancer therapy.The phosphatidylinositol transfer protein alpha/beta isoform(PITPα/β)has been reported to play an essential role in integrating phosphoinositide trafficking and lipid metabolism in diverse cellular processes but remains unexplored as a potential target for cancer treatment.Herein,data analysis of clinical cancer samples revealed that PITPα/βexpression is closely correlated with the poor prognosis.Target identification by chemical proteomic methods revealed that microcolin H,a naturally occurring marine lipopeptide,directly binds PITPα/βand displays antiproliferative activity on different types of tumour cell lines.Furthermore,we identified that microcolin H treatment increased the conversion of LC3I to LC3II,accompanied by a reduction of the level of p62 in cancer cells,leading to autophagic cell death.Moreover,microcolin H showed preeminent antitumour efficacy in nude mouse subcutaneous tumour models with low toxicity.Our discoveries revealed that by targeting PITPα/β,microcolin H induced autophagic cell death in tumours with efficient anti-proliferating activity,which sheds light on PITPα/βas a promising therapeutic target for cancer treatment. | Hange Yang Xiaowei Zhang Cong Wang Hailong Zhang Juan Yi Kun Wang Yanzhe Hou Peihong Ji Xiaojie Jin Chenghao Li Min Zhang Shan Huang Haoyuan Jia Kuan Hu Lingyun Mou Rui Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
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