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| 1 | Betulinic acid inhibits autophagic flux and induces apoptosis in human multiple myeloma cells in vitro显示文摘目的: 处理在在二之间的多重骨髓瘤房间和关系在 apoptosis 和 autophagic 流动上调查 betulinic 酸(BA ) 的效果。 | Li-jing YANG Yan CHEN Jing HE Sha YI Lu WEN Jie ZHAO Ben-ping ZHANG Guo-hui CUI | 2012 | Acta Pharmacologica Sinica2012，33，12： | 16 |
| 2 | Oridonin induces NPM mutant protein translocation and apoptosis in NPM1c+ acute myeloid leukemia cells in vitro显示文摘 | Fei-fei LI Sha YI Lu WEN Jing HE Li-jing YANG Jie ZHAO Ben-ping ZHANG Guo-hui CUI Yan CHEN | 2014 | Acta Pharmacologica Sinica2014，35，6： | 11 |
| 3 | Manganese salts function as potent adjuvants显示文摘Aluminum-containing adjuvants have been used for nearly 100 years to enhance immune responses in billions of doses of vaccines.To date,only a few adjuvants have been approved for use in humans,among which aluminum-containing adjuvants are the only ones widely used.However,the medical need for potent and safe adjuvants is currently continuously increasing,especially those triggering cellular immune responses for cytotoxic T lymphocyte activation,which are urgently needed for the development of efficient virus and cancer vaccines.Manganese is an essential micronutrient required for diverse biological activities,but its functions in immunity remain undefined.We previously reported that Mn^(2+) is important in the host defense against cytosolic dsDNA by facilitating cGAS-STING activation and that Mn^(2+)alone directly activates cGAS independent of dsDNA,leading to an unconventional catalytic synthesis of 2′3′-cGAMP.Herein,we found that Mn^(2+) strongly promoted immune responses by facilitating antigen uptake,presentation,and germinal center formation via both cGAS-STING and NLRP3 activation.Accordingly,a colloidal manganese salt(Mn jelly,MnJ)was formulated to act not only as an immune potentiator but also as a delivery system to stimulate humoral and cellular immune responses,inducing antibody production and CD4^(+)/CD8^(+)T-cell proliferation and activation by either intramuscular or intranasal immunization.When administered intranasally,MnJ also worked as a mucosal adjuvant,inducing high levels of secretory IgA.MnJ showed good adjuvant effects for all tested antigens,including T cell-dependent and T cell-independent antigens,such as bacterial capsular polysaccharides,thus indicating that it is a promising adjuvant candidate. | Rui Zhang Chenguang Wang Yukun Guan Xiaoming Wei Mengyin Sha Mengran Yi Miao Jing Mengze Lv Wen Guo Jing Xu Yi Wan Xin-Ming Jia Zhengfan Jiang | 2021 | Cellular & Molecular Immunology2021，18，5： | 7 |
| 4 | Urodynamic assessment of bladder storage function after radical hysterectomy for cervical cancer显示文摘Background:After radical hysterectomy for cervical cancer,the most common complication is lower urinary tract symptoms.Post-operatively,bladder capacity can alter bladder function for a prolonged period.This study aimed to identify factors affecting bladder storage function.Methods:A multicenter,retrospective cohort study was conducted.Information of patients with stages IA2 to IIB cervical cancer with urodynamic study results were retrospectively collected from nine hospitals between June 2013 and June 2018 according to the inclusion criteria.Demographic,surgical,and oncological data were collected.The univariate and multivariate logistic regression was used to identify clinical factors associated with bladder storage function.Results:Two hundred and three patients with cervical cancer had urodynamic testing post-operatively.Ninety-five(46.8%)patients were diagnosed with stress urinary incontinence(SUI).The incidence of low bladder compliance(LBC)was 23.2%.Twenty-seven(13.3%)patients showed detrusor overactivity(DO).Fifty-seven patients(28.1%)presented with a decreased maximum cystometric capacity(DMCC).The probability of composite bladder storage dysfunction was 68.0%.Multivariate analysis confirmed that laparoscopy represents a protective factor for SUI with an odds ratio of 0.498(P=0.034).Patients who underwent a nerve-sparing procedure were less odds to experience SUI(P=0.014).A significant positive correlation between LBC and DO was observed(P<0.001).A greater length of the resected vagina and chemoradiotherapy were common risk factors for LBC and DO,while radiotherapy exerted a stronger effect than chemotherapy.Additionally,patients who received chemoradiotherapy frequently developed a DMCC.The follow-up time was not correlated with bladder storage function.Conclusion:A nerve-sparing procedure without longer resected vagina is recommended for protecting the bladder storage function. | Ting-Ting Cao Hong-Wu Wen Yu-Nong Gao Qiu-Bo Lyu Hui-Xin Liu Sha Wang Shi-Yan Wang Hua-Xin Sun Na Yu Hai-Bo Wang Yi Li Zhi-Qi Wang Olivia H.Chang Xiu-Li Sun Jian-Liu Wang | 2020 | Chinese Medical Journal2020，，19： | 7 |
| 5 | Wnt3a:functions and implications in cancer显示文摘Wnt3a,one of Wnt family members,plays key roles in regulating pleiotropic cellular functions,including self-renewal,proliferation,differentiation,and motility.Accumulating evidence has suggested that Wnt3 a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type.In addition,the roles of Wnt3 a signaling can be inhibited by multiple proteins or chemicals.Herein,we summarize the latest findings on Wnt3 a as an important therapeutic target in cancer. | Sha He Yi Lu Xia Liu Xin Huang Evan T.Keller Chao-Nan Qian Jian Zhang | 2015 | Chinese Journal of Cancer2015，34，12： | 5 |
| 6 | Interface structures and mechanical properties of corrugated + flat rolled and traditional rolled Mg/Al clad plates显示文摘The corrugated + flat rolling(CFR) and traditional rolling(TR) methods were used to prepare Mg/Al clad plates using AZ31 B Mg and 5052 Al plates, and the interface morphologies and mechanical properties of the resulting clad plates were compared. Examination of the microstructures of the plates showed that the TRed Mg/Al clad plate presented a straight interface, while a corrugated interface containing fractured intermetallic particulates was observed for the CFRed plate due to the inhomogeneous strain induced by the corrugated roller. During the CFR process, the corrugated roller can accelerate the rupture of the substrate work-hardening layers and facilitate the mutual extrusion of fresh metals to enhance the interface bonding. Compared with the traditional basal texture of the Mg alloy, the CFR process can change the texture morphology, thereby enhancing the plastic deformation ability of the Mg plate. Tensile tests showed that the CFRed Mg/Al clad plate exhibited a higher ultimate tensile strength(UTS, 316 MPa), which was~ 8% higher than that of the TRed plate(293 MPa). In addition, the bending curve of the CFRed clad plate was smooth and there was no stress sudden drop phenomenon in the bending process. The higher UTS and excellent bending properties of the CFRed clad plate could be attributed to the enhanced coordinated deformation ability of the substrates induced by the corrugated interface, grain refinement, and the change in the Mg alloy texture morphology. | Sha Li Chao Luo Muhammad-Umar Bashir Yi Jia Jian-Chao Han Tao Wang | 2021 | Rare Metals2021，40，10： | 5 |
| 7 | Pterygium epithelium abnormal differentiation related to activation of extracellular signal-regulated kinase signaling pathway in vitro显示文摘AIM: To investigate whether the abnormal differentiation of the pterygium epithelium is related to the extracellular signal-regulated kinase(ERK) signaling pathway in vitro.·METHODS: The expression levels of phosphorylated ERK(P-ERK), keratin family members including K19 and K10 and the ocular master control gene Pax-6 were measured in 16 surgically excised pterygium tissues and 12 eye bank conjunctiva. In colony-forming cell assays,the differences in clone morphology and in K10, K19, PERK and Pax-6 expression between the head and body were investigated. When cocultured with the ERK signaling pathway inhibitor PD98059, the changes in clone morphology, colony-forming efficiency,differentiated marker K10, K19 and Pax-6 expression and P-ERK protein expression level were examined by immunoreactivity and Western blot analysis.· RESULTS: The expression of K19 and Pax-6 decreased in the pterygium, especially in the head. No staining of K10 was found in the normal conjunctiva epithelium, but it was found to be expressed in the superficial cells in the head of the pterygium.Characteristic upregulation of P-ERK was observed by immunohistochemistry. The clone from the head with more differentiated cells in the center expressed more K10, and the clone from the body expressed more K19.The P-ERK protein level increased in the pterygium epithelium compared with conjunctiva and decreased when cocultured with PD98059. The same medium with the ERK inhibitor PD98059 was more effective in promoting clonal growth than conventional medium with3T3 murine feeder layers. It was observed that the epithelium clone co-cultured with the inhibitor had decreased K10 expression and increased K19 and Pax-6 expression.· CONCLUSION: We suggest ERK signaling pathway activation might play a role in the pterygium epithelium abnormal differentiation. | Juan Peng Xiang-Yin Sha Yi Liu Rui-Ming Yang Ye Wen | 2015 | International Journal of Ophthalmology(English edition)2015，8，6： | 5 |
| 8 | Design, Synthesis, and Biological Activity of Novel Aromatic Amide Derivatives Containing Sulfide and Sulfone Substructures显示文摘In recent years,the damage caused by soil nematodes has become increasingly serious;however,the varieties and structures of the nematicides available on the market are deficient.Fluopyram,a succinate dehydrogenase inhibitor(SDHI)fungicide developed by Bayer AG in Germany,has been widely used in the prevention and control of soil nematodes due to its high efficiency and novel mechanism of action.In this paper,two series of novel target compounds were designed and synthesized with nematicidal and fungicidal fluopyram as the molecular skeleton in order to introduce sulfide and sulfone substructures.The structures were identified and characterized by 1H nuclear magnetic resonance(NMR),13C NMR,and high-resolution mass spectrometer(HRMS).The bioassays revealed that most of the compounds showed excellent nematicidal activities at 200 lgmL-1 in comparison with fluopyram,while the nematode mortality rate dropped sharply at 100μg·mL-1,except for compounds I-11 and II-6.In terms of fungicidal activity,compound I-9 was discovered to have an excellent inhibitory rate,and a molecular docking simulation was performed that can provide important guidance for the design and exploration of efficient fungicidal lead compounds. | Xuewen Hua Nannan Liu Sha Zhou Leilei Zhana Hao Yin Guiqing Wang Zhijin Fan Yi Mac | 2020 | Engineering2020，6，5： | 4 |
| 9 | Salidroside Reduces PDE2A Expression by Down-regulating p53 in Human Embryonic Lung Fibroblasts显示文摘Salidroside(SAL) is a glucoside of tyrosol and a key constituent of Rhodiola rosea L. The diverse pharmacological activities of SAL include anti-inflammatory, cardioprotective, and neuroprotective effects(1)Our previous investigation showed that the anti-aging effects of SAL involve reductions of the levels of advanced glycation end products in a D-galactose induced mouse model(2)Additionally. | XING Wen Min CHEN Sha Sha WANG San Ying GAO Wen Yan WAN Xiao Qing SU Hui Li YANG Yi ZHANG Jing YAN Jing MAO Gen Xiang | 2019 | Biomedical and Environmental Sciences2019，32，2： | 3 |
| 10 | Combined detection and subclass characteristics analysis of CTCs and CTECs by SE-iFISH in ovarian cancer显示文摘Objective:Hematogenous metastasis is essential for the progression of ovarian cancer(OC),and circulating tumor cells(CTCs)are part of the metastatic cascade.However,the detection rate of CTC is low due to the use of less sensitive detection methods.Therefore,this study aimed to detect CTCs and circulating tumorigenic endothelial cells(CTECs)in patients with OC using subtraction enrichment and immunostaining and fluorescence in situ hybridization(SE-iFISH).Methods:We enrolled a total of 56 subjects,including 20 OC patients and 36 ovarian benign tumor patients.CTCs and CTECs were captured by subtraction enrichment(SE)and counted and classified according to immunofluorescence staining of tumor markers(TMs)carbohydrate antigen 125(CA125)and human epididymis protein 4(HE4)combined with fluorescence in situ hybridization(iFISH)of chromosome 8(Chr8)aneuploidy.The diagnostic value and subtype characteristics of CTCs and CTECs were investigated.Results:The detection rate of CTCs by SE-iFISH was high.Compared with CA125 and HE4,Chr8 aneuploidy was the major identification feature of CTC.CTC counts in OC were statistically higher than those in benign groups.CTC and CTEC with≥pentaploidy were detected in both groups,illustrating the poor diagnostic value of CTC or CTEC.Distributions of triploid and tetraploid CTC subtypes were significantly different,and combined detection of triploid and tetraploid CTCs showed the best diagnostic value.In contrast,the distribution of CTECs in the OC and benign groups had no statistically significant difference.Small CTCs accounted for over 1/3 of the total CTC count.We also found that small CTCs and CTECs primarily comprised triploid cells,while large CTCs and CTECs mainly comprised pentaploidy and beyond.Conclusions:The application of SE-iFISH offered a more comprehensive understanding of heterogeneous CTCs and CTECs in OC.Analysis of subclass characteristics of the CTCs and CTECs according to Chr8 aneuploidy and cell size may broaden their potential clinical utility and deepen mechanistic studies in OC. | Hongyan Cheng Shang Wang Wenqing Luan Xue Ye Sha Dou Zhijian Tang Honglan Zhu Peter Ping Lin Yi Li Heng Cui Xiaohong Chang | 2021 | Chinese Journal of Cancer Research2021，33，2： | 3 |
| 11 | Heat flow pattern,base of methane hydrates stability zones and BSRs in Shenhu Area,northern South China Sea显示文摘Using the collected 433 heat flow values,we estimated the bases of methane hydrate stability zone (BHSZ),in northern South China Sea (NSCS).Through comparing BHSZs with the depths of bottom simulating reflectors (BSRs),in Shenhu Area (SA),we found that there are big differences between them.In the north of SA,where the water depth is shallow,many slumps developed and the sedimentation rate is high,it appears great negative difference (as large as-192%).However,to the southeast of SA,where the water depth is deeper,sedimentation rate is relatively low and uplift basement topography exists,it changes to positive difference (as large as +45%).The differences change so great,which haven't been observed in other places of the world.After considering the errors from the process of heat flow measurement,the BSR depth,the relationship of thermal conductivity with the sediments depth,and the fluid flow activities,we conclude that the difference should be not caused by these errors.Such big disagreement may be due to the misunderstanding of BSR.The deviant 'BSRs' could represent the paleo-BSRs or just gas-bearing sediment layers,such as unconformities or the specific strata where have different permeability,which are not hydraterelated BSRs. | ZHANG Yi HE Lijuan WANG Jiyang XU Xing SHA Zhibing GONG Yuehua WANG Hongbing LIANG Jinqiang | 2011 | Acta Oceanologica Sinica2011，30，1： | 2 |
| 12 | Utility of in vitro interferon‐γ release assay in differential diagnosis between intestinal tuberculosis and C rohn’s disease显示文摘 | Yuan Lei Feng Ming Yi Jie Zhao Rishi Vishal Luckheeram Sha Huang Min Chen Mei Fang Huang Jin Li Rui Zhou Gui Fang Yang Bing Xia | 2013 | Journal of Digestive Diseases2013，，2： | 2 |
| 13 | A spatiotemporal data collection of viral cases for COVID-19 rapid response显示文摘Under the global health crisis of COVID-19,timely,and accurate epi-demic data are important for observation,monitoring,analyzing,modeling,predicting,and mitigating impacts.Viral case data can be jointly analyzed with relevant factors for various applications in the context of the pandemic.Current COVID-19 case data are scattered across a variety of data sources which may consist of low data quality accompanied by inconsistent data structures.To address this short-coming,a multi-scale spatiotemporal data product is proposed as a public repository platform,based on a spatiotemporal cube,and allows the integration of different data sources by adopting various data standards.Within the spatiotemporal cube,a comprehensive data processing workflow gathers disparate COVID-19 epidemic data-sets at the global,national,provincial/state,county,and city levels.This proposed framework is supported by an automatic update with a 2-h frequency and the crowdsourcing validation team to produce and update data on a daily time step.This rapid-response dataset allows the integration of other relevant socio-economic and environ-mental factors for spatiotemporal analysis.The data is available in Harvard Dataverse platform(http://gffzz9c54d31c51204187s99659kobvb0k6590.ffgz.tsg.suse.edu.cn/dataset.xhtml?persistentId=doi:10.7910/DVN/8HGECN)and GitHub open source repository(http://gffzz188fe103f8f1460as99659kobvb0k6590.ffgz.tsg.suse.edu.cn/stccenter/COVID-19-Data). | Dexuan Sha Yi Liu Qian Liu Yun Li Yifei Tian Fayez Beaini Cheng Zhong Tao Hu Zifu Wang Hai Lan You Zhou Zhiran Zhang Chaowei Yang | 2021 | Big Earth Data2021，5，1： | 2 |
| 14 | Genome constitution of Elymus tangutorum (Poaceae: Triticeae)inferred from meiotic pairing behavior and genomic in situ hybridization显示文摘Elymus tangutorum (Nevski ) Hand.-Mazz (2n = 6x = 42 ) 是在部落 Triticeae 的长期的种,它在尼泊尔和北方和西北中国散布。然而, E 的染色体体质。tangutorum 是争论的,它的分类地位不是清楚的。E 的杂交。tangutorum 与 E 被执行。wawawaiensis J. R。Carlson 与 Barkworth, Roegneria grandis Keng (猪圈) ,和 E (StH ) 。dahuricus Turcz。前 Griseb。(StYH ) 。在混血儿 E 配对的 Meiotic。tangutorum × E。wawawaiensis (StH ) , E。tangutorum × R。grandis (猪圈) ,和 E。tangutorum × E。dahuricus (StYH ) 平均 10.48, 11.12,和 20.92 bivalents 每房间分别地。结果建议了那 E。tangutorum 是 allohexaploid 并且包含 StYH 染色体。在 situ 杂交分析的 genomic 的结果强烈支持了配对数据的染色体。因此, E。tangutorum 应该被当作 Campeiostachys dahurica var。tangutorum (Nevski )B. R。Baum, J.L. 杨与 C。日元。E 的 Intergenomic 重新整理。tangutorum 可以被环境因素影响。 | Cai-Rong Yang Hai-qin Zhang Fu-qiang Zhao Xiao-Yan Liu Xing Fan Li-Na Sha Hou-Yang Kang Yi Wang Yong-Hong Zhou | 2015 | Journal of Systematics and Evolution2015，53，6： | 2 |
| 15 | Transcription regulation by DNA methylation under stressful conditions in human cancer显示文摘 | Sha Cao Yi Zhou Yue Wu Tianci Song Burair Alsaihati Ying Xu | 2017 | Frontiers of Electrical and Electronic Engineering in China2017，5，4： | 2 |
| 16 | Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride显示文摘 | Taoguang Huo Shuang Cai Xiumei Lu Yi Sha Mingyang Yu Famei Li | 2009 | Journal of Pharmaceutical and Biomedical Analysis2009，，4： | 1 |
| 17 | Traffic-based load balancing routing protocol in Ad Hoc network prediction 显示文摘 | Sha Yi Zhang Ting Chen Jin | 2010 | Jouma1 of Northeastern University2010，31，3： | 1 |
| 18 | Conjugated Polyelectrolyte-Ag+ Fluorescent Switch for Biothiol Sensing显示文摘 | XIAO Yi LI Sha HUANG Hong-mei ZHANG Ye XUE Zun-zun TANG Xue-yan HE Xiao-xiao WANG Ke-min | 2013 | Chemical Research in Chinese Universities2013，29，5： | 1 |
| 19 | Utility of in vitro interferon‐γ release assay in differential diagnosis between intestinal tuberculosis and C rohn’s disease显示文摘 | Yuan Lei Feng Ming Yi Jie Zhao Rishi Vishal Luckheeram Sha Huang Min Chen Mei Fang Huang Jin Li Rui Zhou Gui Fang Yang Bing Xia | 2013 | Journal of Digestive Diseases2013，，2： | 1 |
| 20 | Autoimmune pancreatitis characterized by predominant CD8+ Tlymphocyte infiltration显示文摘Autoimmune pancreatitis(AIP)is a rare form of pan-creatitis characterized by prominent lymphocyte inf iltration and pancreatic f ibrosis resulting in organ dysfunc-tion.The pathogenesis and pathology of AIP remain unknown.A 64-year-old Chinese man presented with symptoms and signs of bile duct obstruction diffuse enlargement of the head of pancreas,elevated IgG levels,and negative autoimmune antibody responses.A pylorus-preserving pancreatoduodenectomy was per-formed and a pancreatic tumor was suspected.Howev-er,periductal lymphoplasmacytic inf iltration and f ibrosis were found in the head of pancreas and nearby organs instead of tumor cells.Four months after surgery,the patient was readmitted because of reoccurrence ofsevere jaundice and sustained abdominal distension.Prednisone 30 mg/d was administered orally as an AIP was suspected.One and a half months later,the symp-toms of the patient disappeared,and globulin,amino-transferase and bilirubin levels decreased signif icantly.Over a 9-mo follow-up period,the dose of prednisone was gradually decreased to 10 mg/d and the patient remained in good condition.We further demonstrated dominant CD3+/CD8+ populations,CD20+ cells and a few CD4+ cells in the pancreatic parenchyma,duo-denum and gallbladder wall by immunohistochemical assay.This AIP case presented with signif icant CD8+ T lymphocyte inf iltration in the pancreas and extra-pan-creatic lesions,indicating that this cell population may be more important in mediating AIP pathogenesis than previously known and that AIP might be a poorly defined autoimmune disease with heterogeneous pathogenesis. | She-Yu Li Xiang-Yang Huang Yong-Tao Chen Yi Liu Sha Zhao | 2011 | World Journal of Gastroenterology2011，17，41： | 1 |
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