|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Foreign object ingestion and esophageal food impaction:An update and review on endoscopic management显示文摘Foreign body ingestion encompasses both foreign object ingestion(FOI) and esophageal food impaction(EFI) and represents a common and clinically significant scenario among patients of all ages. The immediate risk to the patient ranges from negligible to life-threatening, depending on the ingested substance,its location, patient fitness, and time to appropriate therapy. This article reviews the FOI and EFI literature and highlights important considerations and implications for pediatric and adult patients as well as their providers. Where published literature is insufficient to provide evidence-based guidance, expert opinion is included to supplement the content of this comprehensive review. | Brian M Fung Seth Sweetser Louis M Wong Kee Song James H Tabibian | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，3： | 15 |
| 2 | Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner显示文摘AIM:To investigate the role of osteopontin(OPN) and its splice variants in the proliferation of hepatocellular carcinoma(HCC).METHODS:The expression of OPN variants in HCC cell lines as well as HCC tissue samples and nontumour tissue was studied using polymerase chain reaction.OPN variant cDNAs were cloned into a mammalian expression vector allowing both transient expression and the production of stable OPN expressing cell lines.OPN expression was studied in these cells using Western blotting,immunofluoresnce and enzyme linked immunosorbent assay.A CD44 blocking antibody and siRNA targeting of CD44 were used to examine the role of this receptor in the OPN stimulated cell growth observed in culture.Huh-7 cells stably expressing either OPN-A,-B or-C were injected subcutaneously into the flanks of nude mice to observe in vivo tumour growth.Expression of OPN mRNA and protein in these tumours was examined using reverse transcriptionpolymerase chain reaction and immunohistochemistry.RESULTS:OPN is expressed in HCC in 3 forms,the full length OPN-A and 2 splice variants OPN-B and-C.OPN variant expression was noted in HCC tissue as well as cognate surrounding cirrhotic liver tissue.Expression of these OPN variants in the HCC derived cell line Huh-7 resulted in secretion of OPN into the culture medium.Transfer of OPN conditioned media to na ve Huh-7 and HepG2 cells resulted in significant cell growth suggesting that all OPN variants can modulate cell proliferation in a paracrine manner.Furthermore the OPN mediated increase in cellular proliferation was dependent on CD44 as only CD44 positive cell lines responded to OPN conditioned media while siRNA knockdown of CD44 blocked the proliferative effect.OPN expression also increased the proliferation of Huh-7 cells in a subcutaneous nude mouse tumour model,with Huh-7 cells expressing OPN-A showing the greatest proliferative effect.CONCLUSION:This study demonstrates that OPN plays a significant role in the proliferation of HCC through interaction with the cell surface receptor CD44.Modulation of this interaction could represent a novel strategy for the control of HCC. | Renee J Phillips Karla J Helbig Kylie H Van der Hoek Devanshi Seth Michael R Beard | 2012 | World Journal of Gastroenterology2012，18，26： | 12 |
| 3 | Aggressive juvenile polyposis in children with chromosome 10q23 deletion显示文摘Juvenile polyps are relatively common findings in children,while juvenile polyposis syndrome(JPS) is a rare hereditary syndrome entailing an increased risk of colorectal cancer.Mutations in BMPR1A or SMAD4 are found in roughly half of patients diagnosed with JPS.Mutations in PTEN gene are also found in patients with juvenile polyps and in Bannayan-Riley-Ruvalcaba syndrome and Cowden syndrome.Several previous reports have described microdeletions in chromosome 10q23 encompassing both PTEN and BMPR1A causing aggressive polyposis and malignancy in childhood.These reports have also described extra-intestinal findings in most cases including cardiac anomalies,developmental delay and macrocephaly.In this report we describe a boy with a 5.75 Mb deletion of chromosome 10q23 and a 1.03 Mb deletion within chromosome band 1p31.3who displayed aggressive juvenile polyposis and multiple extra-intestinal anomalies including macrocephaly,developmental delay,short stature,hypothyroidism,atrial septal defect,ventricular septal defect and hypospadias.He required colectomy at six years of age,and early colectomy was a common outcome in other children with similar deletions.Due to the aggressive polyposis and reports of dysplasia and even malignancy at a young age,we propose aggressive gastrointestinal surveillance in children with 10q23 microdeletions encompassing the BMPR1A and PTEN genes to include both the upper and lower gastrointestinal tracts,and also include a flowchart for an effective genetic testing strategy in children with juvenile polyposis. | Seth Septer Lei Zhang Caitlin E Lawson Jose Cocjin Thomas Attard Holly H Ardinger | 2013 | World Journal of Gastroenterology2013，19，14： | 4 |
| 4 | A Tutorial on Visual Servo Control显示文摘 | Seth H Gregory D H Peter I C | 1996 | IEEE Trans on Robotics and Automation1996，12，65： | 1 |
| 5 | (Pro)renin Receptor mediates both angiotensinⅡdependent and-independent oxidative stress in neuronal cells显示文摘 | Peng H Li W Seth DM | 2013 | PLo S One2013，8，58： | 1 |
| 6 | Virtual reality for assembly methods prototyping: A review 显示文摘 | Seth A Vance J M Oliver J H | 2011 | Virtual Reality2011，15，1： | 1 |
| 7 | Experimental and modeling study of hydrogen/syngas production and particulate emissions from a natural gas-fueled partial oxidation engine显示文摘 | Michael H McMillian Seth A Lawson | 2006 | J Hydrogen Energy2006，31，7： | 1 |
| 8 | Nutrient-induced gastrointestinal hyperemia and specific dynamic action in rainbow trout (Oncorhynchus mykiss)--importance of proteins and lipids 显示文摘 | H SETH E SANDBLOM M AXELSSON | 2009 | Am J Physiol Regul Integr Comp Physiol2009，296，2： | 1 |
| 9 | S2 nitro so human serum albumin reduces ischemia/reperfusion injury in pig heart after unprotected warm ischemia显示文摘 | Seth H Maximilian F Haralcl G | 2007 | Cardiovascular Research Advanse Access Published2007，10，22： | 1 |
| 10 | Picroliv preconditioning protects the rat liver against ischemia-reperfusion injury显示文摘 | Singh AK Mani H seth P | 2000 | Eur J Pharmacol2000，395，3： | 1 |
| 11 | The interpretation of interference tests in naturally fractured reservoirs with uniform fracture distribution显示文摘 | Kazemi H Seth M S Thomas G W | | 0，，04： | 1 |
| 12 | Distribution of benzoapyrene in discrete regions of rat brain显示文摘 | Das M Seth P K Mukhtar H | 1985 | Environmental Contamination and Toxicology1985，35，4： | 1 |
| 13 | In-proccess density control of extruded foam PVC using wavelet packet analysis 显示文摘 | Nidal H Abu-Zahra Ashish Seth | 2002 | Mechatronics2002，12，： | 1 |
| 14 | Inheritance of fresh seed dormancy in groundnut 显示文摘 | Asibuo J Y Akromah R Safo-Kantanka O Adu-Dupaah H Seth KO Agyemen A | 2008 | African Journal of Biotechnology2008，7，4： | 1 |
| 15 | EEG background activity described by a large computerized database显示文摘 | AURLIEN H GJERDE I O AAR SETH J H | 2004 | Clinical Neurophysiology2004，115，3： | 1 |
| 16 | Anergy induction by dimeric TCR ligands显示文摘 | Appel H Seth NP Gauthier L | 2001 | J lmmunol2001，166，： | 1 |
| 17 | Virtual reality for assembly methods prototyping:a review显示文摘 | Seth A Vance J M Oliver J H | | 0，，01： | 1 |
| 18 | Clinical pratiee guideline: Hoarseness(Dysphonia) 显示文摘 | Seth R Seth H Ellen S | 2009 | Otolaryngol Head Neck Surg2009，141，： | 1 |
| 19 | SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates 显示文摘 | SETH D GORRELL M D MCGUINNESS P H | 2003 | J Biochem Biophys Methods2003，55，1： | 1 |
| 20 | A real-time national GPS network for atmospheric research and education显示文摘 | Randolph H Ware David W Fulker Seth A Stein | 2004 | Bull Amer Meteor Soc2004，81，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员