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| 1 | Non-invasive splenic parameters of portal hypertension:Assessment and utility显示文摘BACKGROUND Portal hypertension is a major complication of cirrhosis that is associated with significant morbidity and mortality.The present gold-standard method to risk stratify and observe cirrhosis patients with portal hypertension is hepatic venous pressure gradient measurement or esophagogastroduodenoscopy.However,these methods are invasive,carry a risk of complications and are associated with significant patient discomfort.Therefore,non-invasive splenic parameters are of clinical interest as potential useful markers in determining the presence of portal hypertension.However,diagnostic accuracy and reproducibility remains unvalidated.AIM To assess the diagnostic accuracy of spleen stiffness,area and diameter in predicting the presence of portal hypertension.METHODS Of 50 patients with varying liver disease pathologies were prospectively recruited from the St.Mary’s Hospital Liver Unit in London;25 with evidence of portal hypertension and 25 with no evidence of portal hypertension.Liver stiffness,spleen stiffness,spleen diameter and spleen area were measured using the Philips Affiniti 70 elastography point quantification point shear wave elastography system.The aspartate aminotransferase-to-platelet-ratio-index(APRI)score was also calculated.Performance measures,univariate and multivariate logistic regression were used to evaluate demographic,clinical and elastography variables.Interclass correlation coefficient was used to determine the reproducibility of splenic area and diameter.RESULTS On univariate and individual performance,platelet count[area under the receiver operating characteristic(AUROC)0.846,P value<0.001],spleen area(AUROC 0.828,P value=0.002)and APRI score(AUROC 0.827,P value<0.001)were the most accurate variables in identifying the presence of portal hypertension.On multivariate logistic regression models constructed,the combination of spleen area greater than 57.90 cm2 and platelet count less than 126×10^9 had 63.2%sensitivity and 100%specificity,100%positive predictive value and 100%negative predictive value.An alternative combination of spleen stiffness greater than 29.99 kPa and platelet count less than 126×10^9 had 88%sensitivity,75%specificity,78.6%positive predictive value and 85.7%negative predictive value.An interclass correlation coefficient value of 0.98(95%CI:0.94-0.99,P value<0.001)and 0.96(95%CI:0.91-0.99,P value<0.001)were determined for inter-operator variability for spleen area and diameter respectively.CONCLUSION Spleen area,spleen stiffness and platelet count may be useful markers to assess the presence of portal hypertension in patients of various etiologies. | Ayesha Karim Ahmad Sebastiana Atzori James Maurice Simon D Taylor-Robinson Adrian KP Lim | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 2 | Chemical and biochemical properties of a clay soil under dryland agriculture system as affected by organic fertilization显示文摘 | Sebastiana Melero Engracia Madejón Juan Carlos Ruiz Juan Francisco Herencia | 2006 | European Journal of Agronomy2006，，3： | 1 |
| 3 | Long- term effects of conservation tillage on organic fractions in two soils in southwest of Spain 显示文摘 | SEBASTIANA M ROSA L G ENGRACIA M | 2009 | Agriculture Ecosysterrs & Environment2009，133，1： | 1 |
| 4 | Identification of plant genes involved on the initial contact between ectomycorrhizal symbionts (Castanea sativa-European chestnut and Pisolithus tinctorius) 显示文摘 | Sebastiana M Figueiredo A Acioli B | 2009 | European Journal of Soil Biology2009，45，： | 1 |
| 5 | The effect of glass additives on the microwave dielectric properties of Ba(Mg1/3 Ta2/3)O3 ceramics显示文摘 | SURENDRANA K P MOHANANB P SEBASTIANA M T | 2004 | J Solid State Chem2004，177，11： | 1 |
| 6 | Effect of implementing organic fanning on chemical and biochemical properties of an irrigated loam soil显示文摘 | SEBASTIANA M ENGRACIA M JUAN FRANCISCO HERENCIA | 2008 | Agronomy Journal2008，100，1： | 1 |
| 7 | Chemical and biochemical properties in a silty loam soil under conventional and organic management显示文摘 | Sebastiana M Juan C R P Juan F H | 2006 | Soil Tillage Research2006，，90： | 1 |
| 8 | Chemical and biochemical properties of a clay soil under dryland agriculture system as affected by organic fertilization 显示文摘 | Sebastiana Melero Engracia Madejon Juan Carlos Ruiz | 2007 | Europ Agronomy2007，26，： | 1 |
| 9 | Chemical and biochemical properties of a clay soil under dryland agriculture system as affected by organic fertilization显示文摘 | Sebastiana M Engracia M Carlos R J | 2007 | Eur J Agron2007，，26： | 1 |
| 10 | Silver nanowires by a sonoself-reduction template process显示文摘 | Graziella Malandrino Sebastiana T Finocchiaro Ignazio L Fragala | 2004 | Journal of Materials Chemistry2004，14，18： | 1 |
| 11 | Chemical and biochemical properties in a silty loam soil under conventional and organic management显示文摘 | Sebastiana Melero Juan Carlos Ruiz Porras Juan Francisco Herencia Engracia Madejon | 2005 | Soil & Tillage Research2005，，1： | 1 |
| 12 | Chemical and biochemical properties of a clay soil under dryland agriculture system as affected by organic fertilization显示文摘 | Sebastiana Melero Engracia Madejón Juan Carlos Ruiz Juan Francisco Herencia | 2006 | European Journal of Agronomy2006，，3： | 1 |
| 13 | Chianina beef tenderness investigated through integrated Omics显示文摘 | Angelo D’Alessandro Cristina Marrocco Sara Rinalducci Cristiana Mirasole Sebastiana Failla Lello Zolla | 2012 | Journal of Proteomics2012，，14： | 1 |
| 14 | Effect of implementing organic farming on chemical and biochemical properties of an irrigated loam soil 显示文摘 | Sebastiana M Engracia M Juan Francisco Herencia | 2008 | Agronomy Journal2008，100，1： | 1 |
| 15 | Methylglyoxal causes strong weakening of detoxifying capacity and apoptotic cell death in rat hippocampal neurons 显示文摘 | LORETO S D ZIMMITTI V SEBASTIANA P | 2008 | Intern J Biochem & Cell Biol2008，40，2： | 1 |
| 16 | A5B4O15 (A=Ba, Sr, Mg, Ca, Zn; B=Nb, Ta) microwave dielectric ceramics显示文摘 | Jawahara I N Mohananb P Sebastiana M T | 2003 | Mater Lett2003，57，： | 1 |
| 17 | Expression of Annexin-A1 and Galectin-1 Anti-Inflammatory Proteins and mRNA in Chronic Gastritis and Gastric Cancer显示文摘 | Yvana Cristina Jorge Mayra Mioto Mataruco Leandro Pires Araújo Ana Flávia Teixeira Rossi Juliana Garcia de Oliveira Marina Curado Valsechi Alaor Caetano Kenji Miyazaki Célia Sebastiana de Jesus Fazzio Jorge Alberto Thomé Paula Rahal Sonia Maria Oliani Ana | 2013 | Mediators of Inflammation2013，，： | 1 |
| 18 | A5B4O15 (A=Ba,Sr,Mg,Ca,Zn; B=Nb,Ta) microwave dielectric ceramics显示文摘 | Jawaha I N Mohananb P Sebastiana M T | 2003 | Mater Lett2003，57，： | 1 |
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