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| 1 | 门静脉高压并非肝细胞癌肝切除术的绝对禁忌证显示文摘在肝细胞癌(hepatocellular carcinoma,HCC)的各种临床分期系统中,Bruix J团队领衔的巴塞罗那肝癌临床分期标准(Barcelona Clinic Liver Cancer,BCLC)最受推崇,美国和欧洲肝病协会指南的制定亦基于该分期系统。BCLC认为门静脉高压显著增加HCC肝切除术后患者发生肝功能衰竭的风险, | Zhong JH Li H Xiao N Ye XP Ke Y Wang YY Ma L Chen J You XM Zhang ZY Lu SD Li LQ 钟鉴宏 齐鲁楠 | 2014 | 中国癌症防治杂志2014，6，4： | 18 |
| 2 | LIM矿化蛋白-1抑制破骨前体细胞合成一氧化氮的分子机制研究显示文摘目的 探讨LIM矿化蛋白-1(LIM mineralization protein-1,LMp-1)抑制破骨前体细胞合成一氧化氮(nitric oxide,NO)的分子机制.方法 用不同浓度的TAT-LMP-1(0.05nmol/L,0.1 rimol/L,0.25 nmol/L)处理肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)或脂多糖(lipopolysaccharide,LPS)诱导的破骨前体细胞(RAW 264.7细胞),利用Greiss反应间接检测各组NO的生成量.用上述不同浓度的TAT-LMp-1处理LPS诱导的RAW 264.7细胞,使用逆转录-实时定量PCR和Western blot检测细胞中一氧化氮合酶(inducible NO synthase,iNOS)基因及蛋白的表达,利用Western blot检测细胞中NF-κB亚单位P65和磷酸化IκB含量,利用荧光素酶报告基因检测LMp-1对NF-κB通路转录活性的影响.结果 LMP-1可浓度依赖性抑制TNF-α或LPS诱导的RAW 264.7细胞合成NO.LMP-1可浓度依赖性抑制LPS诱导的RAW 264.7细胞中iNOS基因及蛋白的表达、NF-κB亚单位p65和磷酸化IκB含量升高以及NF-κB通路的转录活性.结论 LMp-1抑制LPS诱导的RAW 264.7细胞合成NO的可能分子机制为通过抑制IκB磷酸化使得p65不能与IκB解离,进而阻止p65核转移,导致NF-κB信号通路介导的iNOS生成障碍,最后引起NO生成减少. | 刘辉 Bargouti M 郑召民 张奎渤 Zughaier S 刘云山 Sangadala S Boden SD Titus L | 2011 | 中华骨科杂志2011，31，5： | 3 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | Angiopoietinl protects the adult vasculature against plasma leakage 显示文摘 | Thurston G Rudge JS Ioffe E Zhou H Ross L Croll SD | 2000 | Nat Med2000，6，4： | 1 |
| 5 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 6 | Evaluation of scanning parameters for a surface colour laser scanner显示文摘 | Bianchi SD Spada MC Bianchi L | 2004 | International Congress Series2004，1268，： | 1 |
| 7 | Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells显示文摘 | Lyman SD James L Vanden Bos T | 1993 | Cell1993，75，6： | 1 |
| 8 | Disulfide-dependent multimeric assembly of resistin family hormones显示文摘 | Patel SD Rajala MW Rossetti L | 2004 | Science2004，304，5674： | 1 |
| 9 | Disulfide-dependent multimeric assembly of resistin family hormones显示文摘 | Patel SD Rajala MV Rossetti L | 2004 | Science2004，304，： | 1 |
| 10 | Nerve growth factor:from neurotrophin to neurokine显示文摘 | Levi-Montalcini R Skaper SD Dal Toso R Petrelli L Leon A | 1996 | Trends Neurosci1996，19，11： | 1 |
| 11 | MicroRNA-managing the TH-17 inflammatory response显示文摘 | Martin AJ Zhou L Miller SD | 2009 | Nat Immunol2009，10，12： | 1 |
| 12 | Genetic variants in the UDP-glucuronosyhransferase 1A1 gene predict the risk of severe neutropenia of irinoteean 显示文摘 | Innocenti F Undevia SD lyer L et aI | 2004 | J Clin Oneol2004，22，8： | 1 |
| 13 | Sex-and brain region- specific acceleration of beta-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease 显示文摘 | Devi L Alldred MJ Ginsberg SD | 2010 | Mol Brain2010，3，： | 1 |
| 14 | Eutectic solidification and its role in casting porosity formation 显示文摘 | Lu L Nogita K McDonald SD | 2004 | JOM2004，56，11： | 1 |
| 15 | Angiopoietin-1 reduces cerebral blood vessel leakage and ischemic lesion volume after focal cerebral embolic ischemia in mice 显示文摘 | Zhang ZG Zhang L Croll SD | 2002 | Neuroscience2002，113，3： | 1 |
| 16 | Severe B cell hyperplasia and antoimmune disease in TALL-1 transgenic mice显示文摘 | Khere SD Sarosi l Xia XZ | | 0，，： | 1 |
| 17 | Tinnitus and suicide 显示文摘 | Lewis JE Stephens SD McKenna L | 1994 | Clinical Otolaryngolngy & Allied Sciences1994，19，1： | 1 |
| 18 | Analysis of ARD1 function in hypoxia response using retroviral RNA interference显示文摘 | Fisher TS Etages SD Hayes L | 2005 | J Biol Chem2005，280，17： | 1 |
| 19 | A randomized phase Ⅱ clinical trial of autologous blood stem cell transplantation comparing cryopreservation rising dirnethylsulfoxides vs dimethylsulfoxide with hydroxyethylstarch 显示文摘 | Rowley SD Feng Z Cheng L | 2003 | Bone Marrow Transplant2003，，11： | 1 |
| 20 | Genotype/phenotype correlations for coagulation factor ⅩⅢ:specific normal polymorphisms are associated with high or low factor ⅩⅢ specific activity显示文摘 | ALLIVAN L EDMONDS SD | 1999 | Blood1999，93，： | 1 |
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