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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | 星形胶质细胞转录组分析指导的脑卒中靶标鉴定显示文摘星形胶质细胞支持正常的脑功能,但在卒中等病理条件下,星形胶质细胞反应性激活,其也可能参与神经退行性改变。反应性星形胶质细胞增生对机体有益或有害,与环境背景有关,但其分子基础仍未得到充分解释。借助RiboTag技术,我们在特异性地短暂性大脑中动脉闭塞(tMCAO)72h后的小鼠星形胶质细胞中,纯化翻译mRNA,构建卒中特异性星形胶质细胞翻译组数据库。我们发现,与对照组脑组织相比,tMCAO后的反应性星形胶质细胞显示与A2表型相关的转录物的富集,这与神经保护相关。星形胶质细胞也会上调大量潜在的神经毒性基因。我们共鉴定了1003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1变化最明显。为了进一步探索Stat3介导的通路对卒中发病机制的影响,我们选择星形胶质细胞特异性条件性缺失Stat3的小鼠制造tMCAO模型,发现这些小鼠的局灶性缺血卒中体积减少,且梗死72h后小鼠的运动结果改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,并肯定了星形胶质细胞是脑功能的关键保障细胞。 | Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊 | 2019 | 神经损伤与功能重建2019，14，6： | 2 |
| 3 | Biolumines-Cence imaging of vacciniavirus:effects of interfereon on viral replication and spread显示文摘 | Luker K Hutchens M Schultz T | 2005 | Virol2005，341，： | 1 |
| 4 | Yolk sac ab- sorption and initiation of growth m broilers显示文摘 | Chamblee T N Brake J D Schultz C D | 1992 | Poul Sci1992，71，： | 1 |
| 5 | Isolation ofvolatile components from a model system显示文摘 | Schultz T H Flath R A Richard Mon T | 1977 | J Agric FoodChem1977，25，3： | 1 |
| 6 | Autism显示文摘 | Susan E Levy David S Mandell Robert T Schultz | 2009 | The Lancet2009，，9701： | 1 |
| 7 | The role of policy in improving diets: experiences from the Pacific obesity prevention in communities food policy project显示文摘 | Thow A M Snowdon W Schultz J T | 2011 | Obesity Reviews2011，12，2： | 1 |
| 8 | Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line显示文摘 | Kogai T Schultz JJ Johnson LS | 2000 | Proc Natl Acad Sci USA2000，97，15： | 1 |
| 9 | Synthesis of social surveys on noise annoyance 显示文摘 | SCHULTZ T J | 1978 | Journal of the Acoustical Society of America1978，64，2： | 1 |
| 10 | The optimal carrier for BMP-2 a comparison of collagen versus fibrin ma-trix显示文摘 | Schützenberger S Schultz A Hausner T | 2012 | Arch Orthop Trauma Surg2012，132，9： | 1 |
| 11 | Investment in humancapital显示文摘 | SCHULTZ T W | 1961 | Am Econ Rev1961，51，： | 1 |
| 12 | Identification of a new class of small molecules that efficiently reactivate latent Epstein - Barr virus显示文摘 | Tikhmyanova N Schultz D C Lee T | 2014 | ACS chemical biology2014，9，3： | 1 |
| 13 | Consensusdegenerate hybrid oligonucleotide primers for amplification of distantly related sequences显示文摘 | Rose T M Schultz E R Henikoff J G | 1998 | Nucleic Acids Res1998，26，7： | 1 |
| 14 | Investment in Human Capital显示文摘 | T | 1961 | American Economic Review1961，，3： | 1 |
| 15 | Hyperspectral imaging: A novel approach for microscopic analysis 显示文摘 | Schultz RA Nielsen T Zavaleta IR | 2001 | Cytometry2001，43，4： | 1 |
| 16 | Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans显示文摘 | Parikh S M Mammoto T Schultz A | 2006 | PLoS Med2006，3，3： | 1 |
| 17 | Investigations on thermally forced hydrolysis and phase formation in aqueous iron ( Ⅲ ) nitrate solutions显示文摘 | Schultz M Burckhardt W Barth S T | 1999 | J Mater Sci1999，34，： | 1 |
| 18 | QSAR study of the toxicity of nitrobenzenes to tetrehymena pyrifirmis显示文摘 | Dearden J C Cronin M T D Schultz T M | 1995 | Quant Truct -Act Relat1995，14，： | 1 |
| 19 | The prensent status of QSAR in toxicology显示文摘 | T Wayne Schultz Mark T D Cronin | 2003 | Journal of Molecular Structure:THEOCHEM2003，622，12： | 1 |
| 20 | Endogeneity and the corporate governance - performance relation 显示文摘 | Schultz E L Tan D T Walsh K D | 2010 | Aus- tralian journal of Management2010，35，2： | 1 |
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