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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Lariat ethers-synthesis and cation binding of macrocyclic polyethers possessing axially disposed secondary donor groups 显示文摘 | Gokel G W Schultz R A Dishong D M | 1980 | J Chem Soc Chem Commun1980，，： | 2 |
| 3 | 互动式整合营销传播:统合IMC、新媒介以及数据库营销的力量显示文摘自上世纪九十年代中期开始,整合营销传播理论传入中国,掀起了一股IMC热潮,为市场营销、广告公关的理论和实践带来了强大的推动力.然而,近年来,有关整合营销传播的研究渐趋消沉.究其原因,主要有二:一,学界和业界对IMC概念和理论本身并未透彻理解;二,对有关IMC新的研究动态和成果未予以足够重视.2002年,舒尔茨教授等人提出了'互动式整合营销传播'的新概念.2003年,舒尔茨和威斯康新大学的James W.Peltier、内华达大学的John A.Schibrowsky三位教授又在上发表了一篇名为的论文,通过模型和案例系统阐述了'互动式整合营销传播'的概念,代表了IMC理论研究的最新成果,对国内的有关研究具有重要的借鉴意义.限于篇幅,本刊在发表时删去了文中的案例研究部分. | James W Peltier John A Schibrowsky Don E Schultz 陈欢 | 2004 | 新闻大学2004，，8： | 2 |
| 4 | Starvation induced cross- protection against heat or H2O2 challenge in Escherichia coli 显示文摘 | Jenkins D E Schultz J E Matin A | 1988 | Bacteriology1988，170，： | 1 |
| 5 | Isolation ofvolatile components from a model system显示文摘 | Schultz T H Flath R A Richard Mon T | 1977 | J Agric FoodChem1977，25，3： | 1 |
| 6 | Ischemic preconditioning in the intact rat heart is mediated by deltal but not mu-or kappa-opioid receptors显示文摘 | Schultz J E Hsu A K Gross G J | 1998 | Circulation1998，97，13： | 1 |
| 7 | Changes in the relative abundance of various housekeeping gene transcripts in vitro-produced early bovine embryos 显示文摘 | BILODEAU-GOESEELS S SCHULTZ G A | 1997 | Mol Reprod Dev1997，47，4： | 1 |
| 8 | Influence of the sevoflurane concentration on the occurrence of epileptiform EEG patterns 显示文摘 | Kreuzer I Osthaus WA Schultz A | 2014 | PLoS 0ne2014，9，89： | 1 |
| 9 | The role of policy in improving diets: experiences from the Pacific obesity prevention in communities food policy project显示文摘 | Thow A M Snowdon W Schultz J T | 2011 | Obesity Reviews2011，12，2： | 1 |
| 10 | Experimental Verification of a Negative Index of Refraction显示文摘 | SHELBY R A SMITH D R SCHULTZ S | 2001 | Science2001，292，： | 1 |
| 11 | Experimental Verification of a Negative Index of Refraction显示文摘 | SHELBY R A SMITH D R SCHULTZ S | 2001 | Science2001，292，5514： | 1 |
| 12 | Experimental verification of a negative index of refraction显示文摘 | SHELBY R A SMITH D R SCHULTZ S | 2001 | Science2001，292，10： | 1 |
| 13 | Experimental verification of a negative index of refraction显示文摘 | SHELBY R A SMITH D R SCHULTZ S | 2001 | Science2001，292，4： | 1 |
| 14 | Experimental verification of a negative index of refraction 显示文摘 | aSHELBY R A SMITH D R SCHULTZ S | 2001 | Science2001，292，： | 1 |
| 15 | Range doppler laser for midcourse discrimination:the firefly experiments显示文摘 | Schultz K Davidson S Stein A | 1993 | AIAA-93-26531993，，： | 1 |
| 16 | Sorption, desorption and mineralisation of the herbicides glyphosate and MCPA in samples from two Danish soil and subsurface profiles显示文摘 | Sorensen S R Schultz A Jacobsen O S | 2006 | Environ Pollut2006，141，： | 1 |
| 17 | Influence of oxygen on the viscosity of Zr-Al-Cu-Ni metallic glasses in the undercooled liquid region 显示文摘 | KUBLER A ECKERT J GEBERT A SCHULTZ L | 1998 | J Appl Phys1998，83，6： | 1 |
| 18 | Learning sequential decision rules using simulation models and competition显示文摘 | GREFENSTETTE J J RAMSEY C L SCHULTZ A C | 1990 | Machine Learning1990，5，： | 1 |
| 19 | The optimal carrier for BMP-2 a comparison of collagen versus fibrin ma-trix显示文摘 | Schützenberger S Schultz A Hausner T | 2012 | Arch Orthop Trauma Surg2012，132，9： | 1 |
| 20 | Laboratory investigations of impact-generated plasma显示文摘 | Crawford A Schultz P H | 1991 | JournalGeophysics Research1991，96，18： | 1 |
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