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| 1 | Overview of screening methods for fatty liver disease in children显示文摘The prevalence of obesity and obesity related comorbidities including diabetes and nonalcoholic fatty liver disease (NAFLD) has been rising globally. Nonalcoholic fatty liver disease is emerging as a common liver disease among adults which can lead to the eventua development of complications including cirrhosis and hepatocellular carcinoma. With the rise of obesity in children, the development of detection methods for the presence of NAFLD is becoming imperative. Although the gold standard for diagnosis is liver biopsy, practica issues limit pediatric use and warrant development of noninvasive or minimally invasive screening tools for the detection and staging of NAFLD. A variety of diagnostic methods have been studied including use aminotransferases, imaging studies and serologic markers which have some population-based limitations. Additional factors such as gender and ethnicity may also play a role in the screening of NAFLD in pediatric population studies. | Caroline Anitha Devadason Ann O Scheimann | 2012 | World Journal of Hepatology2012，4，1： | 3 |
| 2 | Histological Abnormalities in Children with Nonalcoholic Fatty Liver Disease and Normal or Mildly Elevated Alanine Aminotransferase Levels显示文摘 | Jean P. Molleston Jeffrey B. Schwimmer Katherine P. Yates Karen F. Murray Oscar W. Cummings Joel E. Lavine Elizabeth M. Brunt Ann O. Scheimann Aynur Unalp-Arida | 2013 | The Journal of Pediatrics2013，，： | 2 |
| 3 | Mutations in Bile Salt Export Pump ( ABCB11 ) in Two Children with Progressive Familial Intrahepatic Cholestasis and Cholangiocarcinoma显示文摘 | A.O. Scheimann S.S. Strautnieks A.S. Knisely J.A. Byrne R.J. Thompson M.J. Finegold | 2007 | The Journal of Pediatrics2007，，5： | 1 |
| 4 | Childhood Obesity for Pediatric Gastroenterologists显示文摘 | Jeannie S. Huang Sarah E. Barlow Ruben E. Quiros-Tejeira Ann Scheimann Joseph Skelton David Suskind Patrika Tsai Victor Uko Joshua P. Warolin Stavra A. Xanthakos | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，1： | 1 |
| 5 | Bile salt export pump (BSEP) deficiency is a significant risk factor for both pediatric and adult hepatobiliary malignancy 显示文摘 | Knisely AS Strantnieks S Scheimann AO | 2005 | Hepatology2005，42，： | 1 |
| 6 | Mutations in bile salt export pump ( ABCB11 ) in two children with progressive familial intrahepatic cholestasis and cholangiocarcinoma 显示文摘 | Scheimann AO Strautnieks SS Knisely AS | 2007 | J Pediatr2007，150，5： | 1 |
| 7 | Percutaneous Liver Biopsy in Children: Impact of Ultrasonography and Spring-Loaded Biopsy Needles显示文摘 | Ann O. Scheimann Jose M. Barrios Youhanna S. Al-Tawil Krista M. Gray Mark A. Gilger | 2000 | Journal of Pediatric Gastroenterology and Nutrition2000，，5： | 1 |
| 8 | Overview of the epidemiology and manage- ment ofof childhood obesity 显示文摘 | Santo DL Scheimann AO | 2012 | Minerva Pediatr2012，64，6： | 1 |
| 9 | Mutations in Bile Salt Export Pump ( ABCB11 ) in Two Children with Progressive Familial Intrahepatic Cholestasis and Cholangiocarcinoma显示文摘 | A.O. Scheimann S.S. Strautnieks A.S. Knisely J.A. Byrne R.J. Thompson M.J. Finegold | 2007 | The Journal of Pediatrics2007，，5： | 1 |
| 10 | Screening strategy for gastrointestinal and hepatopancreatobiliary cancers in cystic fibrosis显示文摘Based on systematic review and meta-analysis,the risk for developing cancers in patients with cystic fibrosis(CF)is known to be significantly greater than in the general population,including site-specific cancers of the esophagus,small bowel,colon,liver,biliary tract,and pancreas.An even higher risk has been found in patients who have severe CF transmembrane conductance regulator(CFTR)genotypes or who have undergone organ transplantation and are immunosuppressed.The risk continues to rise as life expectancies steadily climb due to advancements in medical care and treatment for CF.The colorectal cancer risk is at such a high level that CF has now been declared a hereditary colon cancer syndrome by the Cystic Fibrosis Foundation.The CFTR gene has been stronglyassociated with the development of gastrointestinal(GI)cancers and mortality in the CF population.Even CF carriers have shown an increased rate of GI cancers compared to the general population.Several limitations exist with the reported guidelines for screening of GI and hepatopancreatobiliary cancers in the CF population,which are largely universal and are still emerging.There is a need for more precise screening based on specific risk factors,including CFTR mutation,medical co-morbidities(such as gastroesophageal reflux disease,distal intestinal obstruction syndrome,and diabetes mellitus),familial risks for each cancer,gender,age,and other factors.In this review,we propose changes to the guidelines for GI screening of patients with CF.With the development of CFTR modulators,additional studies are necessary to elucidate if there is an effect on cancer risk. | Brett Hoskins Paul Wasuwanich Ann O Scheimann Wikrom Karnsakul | 2021 | World Journal of Gastrointestinal Oncology2021，13，9： | 0 |
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