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| 1 | Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7,Species Differences, and Regulation by Paclitaxel显示文摘Voltage-gated sodium channels(Navs) play an important role in human pain sensation. However, the expression and role of Nav subtypes in native human sensory neurons are unclear. To address this issue, we obtained human dorsal root ganglion(hDRG) tissues from healthy donors. PCR analysis of seven DRG-expressed Nav subtypes revealed that the hDRG has higher expression of Nav1.7(~50% of total Nav expression) and lower expression of Nav1.8(~12%), whereas the mouse DRG has higher expression of Nav1.8(~45%) and lower expression of Nav1.7(~18%). To mimic Nav regulation in chronic pain, we treated hDRG neurons in primary cultures with paclitaxel(0.1-1 μmol/L) for 24 h. Paclitaxel increased the Nav 1.7 but not Nav1.8 expression and also increased the transient Na^+ currents and action potential firing frequency in small-diameter(<50 μm) hDRG neurons. Thus, the hDRG provides a translational model in which to study'human pain in a dish' and test new pain therapeutics. | Wonseok Chang Temugin Berta Yong Ho Kim Sanghoon Lee Seok-Yong Lee Ru-Rong Ji | 2018 | Neuroscience Bulletin2018，34，1： | 12 |
| 2 | Formation Mechanism of Chunky Graphite and Its Preventive Measures显示文摘矮胖的石墨的形成机制被考察了并且学习。学习由一个单向性的团结方法,一个小微滴方法和炉子冷却法组成了。也就是,四种铁样品被准备纯 Fe-C, Fe-C-S, Fe-C-Ce 和 Fe-C-Si-Ce 合金,和三种镍取样,也就是 Ni-C, Ni-C-S 和 Ni-C-Mg 合金。Ni-C 合金的单向性的团结的结果证明那块球状的石墨没在连续团结的区域,仅仅像薄片的石墨在被观察被观察,当球状的石墨通常在熄灭的液体区域被观察时。在团结的阶段的球状的石墨的存在仅仅在 Ni-C-Mg 合金的不连续的生长模式被认出在球状的石墨直接从 melt 被使结晶并且由被连续生长模式形成的像薄片的矮胖的石墨骗诱的 150 个 mm/h.This 工具团结了。在小微滴方法, Fe-C 或 Fe-C-Ce 样品的一小片在然后在 He-3%H2 气氛以不同冷却率凉下来的一个纯石墨盘子上被融化。在 Fe-C-Ce 合金的石墨通常是球形的。不过,最后的团结的区域的石墨形态学变化了从对球形对有冷却的率的增加的 ledeburite 矮胖、矮胖。这意味着矮胖的石墨被团结在剩余液体区域变成 Fe 石墨系统。样品在一个炉子被凉下来,并且石墨形态学变化从对球形对有在 Si 内容的减少的 ledeburite 矮胖、矮胖。这些现象能被这些样品的冷却曲线证实。 | Hideo Nakae Sanghoon Jung Ho-Chul Shin | 2008 | Journal of Materials Science & Technology2008，24，3： | 7 |
| 3 | Helicobacter pylori infection following partial gastrectomy for gastric cancer显示文摘Gastric remnants are an inevitable consequence of partial gastrectomy following resection for gastric cancer.The presence of gastric stumps is itself a risk factor for redevelopment of gastric cancer.Helicobacter pylori(H.pylori)infection is also a well-known characteristic of gastric carcinogenesis.H.pylori colonization in the remnant stomach therefore draws special interest from clinicians in terms of stomach cancer development and pathogenesis;however,the H.pylori-infected gastric remnant is quite different from the intact organ in several aspects and researchers have expressed conflicting opinions with respect to its role in pathogenesis.For instance,H.pylori infection of the gastric stump produced controversial results in several recent studies.The prevalence of H.pylori infection in the gastric stump has varied among recent reports.Gastritis developing in the remnant stomach presents with a unique pattern of inflammation that is different from the pattern seen in ordinary gastritis of the intact organ.Bilerefluxate also has a significant influence on the colonization of the stomach stump,with several studies reporting mixed results as well.In contrast,the elimination of H.pylori from the gastric stump has shown a dramatic impact on eradication rate.H.pylori elimination is recognized to be important for cancer prevention and considerable agreement of opinion is seen among researchers.To overcome the current discrepancies in the literature regarding the role of H.pylori in the gastric stump,further research is required. | Sanghoon Park Hoon Jai Chun | 2014 | World Journal of Gastroenterology2014，20，11： | 6 |
| 4 | Radiotherapy for 65 patients with advanced unresectable hepatocellular carcinoma显示文摘AIM: To evaluate the efficacy of radiotherapy (RT) in patients with advanced unresectable hepatocellular carcinoma (HCC). METHODS: A total of 65 patients were treated with RT in the Korea University Medical Center. The median age of the patients was 60 years, and 86.2% were men. 18.5% and 81.5% of the patients were diagnosed as TNM stage Ⅲ and Ⅳ-A, respectively. Treatment response was assessed 4 mo after initiation of RT. Tumor regression rate 1 mo after initiation of RT (TRR1m) was also assessed. Duration of survival was calculated from the initiation of RT. RESULTS: The objective treatment response was 56.9%. The 12 mo survival rate was 34.7%. Predictive factors for survival were Child-Pugh grade, α-fetoprotein level and treatment response. An objective response was achieved more frequently in patients with TRR1m ≥ 20% than in those with TRR1m < 20% (P < 0.001). CONCLUSION: RT is effective in treating advanced HCC with a tumor response rate of 56.9%. | Yeon Seok Seo Jin Nam Kim Bora Keum Sanghoon Park Yong Dae Kwon Yong Sik Kim Yoon Tae Jeen Hoon Jai Chun Chul Yong Kim Chang Duck Kim Ho Sang Ryu Soon Ho Um | 2008 | World Journal of Gastroenterology2008，14，15： | 4 |
| 5 | Adjuncts to colonic cleansing before colonoscopy显示文摘Pre-procedural cleansing of the bowel can maximize the effectiveness and efficiency of colonoscopy.Yet,efficacy of the current gold standard colonic preparation method-high-volume oral administration of purgative agents 12-24 h prior to the procedure-is limited by several factors,such as patient compliance(due to poor palatability and inconvenience of the dosing regimen)and risks of complications(due to drug interactions or intolerance).Attempts to resolve these limitations have included providing adjunctive agents and methods to promote the colonic cleansing ability of the principal purgative agent,with the aim of lessening unpleasant side effects(such as bloating)and reducing the large ingested volume requirement.Several promising adjunctive agents are bisacodyl,magnesium citrate,senna,simethicone,metoclopramide,and prokinetics,and each are being investigated for their potential.This review provides an up to date summary of the reported investigations into the potencies and weaknesses of the key adjuncts currently being applied in clinic as supplements to the traditional bowel preparation agents.While the comparative analysis ofthese adjuncts showed that no single agent or method has yet achieved the goal of completely overcoming the limitations of the current gold standard preparation method,they at least provide endoscopists with an array of alternatives to help improve the suboptimal efficacy of the main cleansing solutions when used alone.To aid in this clinical endeavor,a subjective grade was assigned to each adjunct to indicate its practical value.In addition,the systematic review of the currently available agents and methods provides insight into the features of each that may be overcome or exploited to create novel drugs and strategies that may become adopted as effective bowel cleansing adjuncts or alternatives. | Sanghoon Park Yun Jeong Lim | 2014 | World Journal of Gastroenterology2014，20，11： | 3 |
| 6 | Eutectic solidification mode of spheroidal graphite cast iron and graphitization显示文摘The shrinkage and chilling tendency of spheroidal graphite (abbreviated SG) cast iron is much greater than that of the flake graphite cast iron in spite of its higher amount of C and Si contents. Why? The main reason should be the difference in their graphitization during the eutectic solidification. In this paper, we discuss the difference in the solidification mechanism of both cast irons for solving these problems using unidirectional solidification and the cooling curves of the spheroidal graphite cast iron. The eutectic solidification rate of the SG cast iron is controlled by the diffusion of carbon through the austenite shell, and the final thickness is 1.4 times the radius of the SG, therefore, the reduction of the SG size, namely, the increase in the number, is the main solution of these problems. | Hideo Nakae Sanghoon Jung Takayuki Kitazawa | 2007 | China Foundry2007，4，1： | 3 |
| 7 | Antiviral treatment for hepatitis B virus recurrence following liver transplantation显示文摘 | Sanghoon Lee Choon Hyuck D. Kwon Hyung Hwan Moon Tae‐Seok Kim Youngnam Roh Sanghyun Song Milljae Shin Jong Man Kim Jae Berm Park Sung Joo Kim Jae‐Won Joh Suk‐Koo Lee | 2013 | Clin Transplant2013，，5： | 3 |
| 8 | High Ba-Sr adakitic charnockite suite from the Nagercoil Block,southern India:Vestiges of Paleoproterozoic arc and implications for Columbia to Gondwana显示文摘The Nagercoil block is the southernmost crustal segment of the Southern Granulite Terrane(SGT)in India and is mainly composed of charnockitic rocks and felsic gneisses(charnockite suite).In this study,we present petrologic,geochemical,zircon U-Pb,REE,and Hf isotopic studies on the charnockites and leucogneiss from the Nagercoil block.Based on field investigations and petrologic studies,the charnockites can be divided into garnet-bearing and garnet-absent anhydrous granulite facies rocks with orthopyroxene.The charnockites and leucogneiss show transition from adakites to non-adakitic magmatic rocks,with enrichment in LREEs(light rare earth elements)and LILEs(large ion lithophile elements),and depletion in HREEs(heavy rare earth elements)and HFSEs(high field strength elements).Some of the charnockites and the leucogneiss show typical HSA(high silica adakite)characters,(high SiO_(2),Al_(2)O_(3),Ba-Sr,La/Yb,and Sr/Y).The HSA is considered to have formed from the interaction of slab derived melts and peridotitic mantle wedge.The high Ba-Sr features were possibly inherited from subducted oceanic crust melting under high thermal gradient during Precambrian.The magmas were underplated and subjected to fractional crystallization.Zircon grains from the charnockite and leucogneiss show zoned magmatic cores surrounded by structureless metamorphic rims.Magmatic zircon grains from the charnockites show ages ranging from 1983±8.8 Ma to 2046±14 Ma,and the metamorphic domains show an age range of 502±14 Ma to 547±8.7 Ma.Zircon from the leucogneiss yielded magmatic and metamorphic ages of 1860±20 Ma and 575.6±8.8 Ma.Both charnockites and leucogneiss show two prominent age peaks at 1987 Ma and 568 Ma.The REE data of the zircon grains show LREE depletion and HREE enrichment,with the metamorphic grains showing more depletion in HREE.Zircon Hf isotopic data of the magmatic cores of zircon grains from the charnockite yieldedε_(Hf)(t)values from-1.17 to 0.46 with T_(DM)and T_(DM)~C and age peaks at 2392 Ma and 2638 Ma,suggesting Neoarchean to Paleoproterozoic juvenile sources.We suggest that the high Ba-Sr adakitic charnockite suite from the Nagercoil block formed in a Paleoproterozoic magmatic arc setting during the assembly of the Columbia supercontinent,and underwent high-grade metamorphism associated with the amalgamation of the Gondwana supercontinent during the late Neoproterozoic-Cambrian.Our study provides new insights into the vestiges of Columbia fragments within the Gondwana assembly with two distinct cycles of crustal evolution. | Pin Gao M.Santosh Cheng-Xue Yang Sanghoon Kwon Mu.Ramkumar | 2021 | Geoscience Frontiers2021，12，3： | 2 |
| 9 | CONGESTION OF RIGHT LIVER GRAFT IN LIVING DONOR LIVER TRANSPLANTATION显示文摘 | SungGyu Lee KwangMin Park Shin Hwang YoungJoo Lee DongNak Choi KiHoon Kim KyungSuck Koh SangHoon Han KyuTaek Choi KyuSam Hwang Masatoshi Makuuchi Yasuhiko Sugawara PyungChul Min | 2001 | Transplantation2001，，6： | 2 |
| 10 | CONGESTION OF RIGHT LIVER GRAFT IN LIVING DONOR LIVER TRANSPLANTATION显示文摘 | SungGyu Lee KwangMin Park Shin Hwang YoungJoo Lee DongNak Choi KiHoon Kim KyungSuck Koh SangHoon Han KyuTaek Choi KyuSam Hwang Masatoshi Makuuchi Yasuhiko Sugawara PyungChul Min | 2001 | Transplantation2001，，6： | 1 |
| 11 | Preparation of size-controlled bovine serum albumin (BSA) nanoparticles by a modified desolvation method显示文摘 | Ji Yeon Jun Hoang Hai Nguyen Sae-Yeol-Rim Paik Hyang Sook Chun Byeong-Cheol Kang Sanghoon Ko | 2011 | Food Chemistry2011，，4： | 1 |
| 12 | Post-weld heat treatment cracking susceptibility of T23 weld metals for fossil fuel applications显示文摘 | Kiduck Park Sanghoon Kim Jungchel Chang Changhee Lee | 2011 | Materials and Design2011，，： | 1 |
| 13 | MIMO beamforming forQoS enhancement via analog,digital and hybrid relaying显示文摘 | PARK Jongrok LEE Sanghoon | 2010 | IEEE Transactions on Broadcasting2010，56，4： | 1 |
| 14 | Voltage control strategy for maximumtorque operation of an induction machine in the field-weakeningregion显示文摘 | Sanghoon K Seungki S | 1997 | IEEE Transactions on Industrial Electronics1997，44，4： | 1 |
| 15 | Foveated video quality assessment显示文摘 | Lee Sanghoon Pattichis M S Bovik A C | 2002 | IEEE Transactions on Multimedia2002，4，1： | 1 |
| 16 | Preparation of micron - sized monodispersed thermoresponsive core - shell microcapsules显示文摘 | CHU LIANGYIN SANGHOON PARK TAKEO YAMAGUCHI | 2002 | Langmuir2002，18，： | 1 |
| 17 | Efficient video indexing scheme for content-based retrieval 显示文摘 | Hyun S C Sanghoon S Sang U L | 1999 | IEEE Trans on Circuits and Systems for Video Technology1999，9，8： | 1 |
| 18 | Carbon dioxide sensors for intelligent food packaging applications显示文摘 | Pradeep Puligundla Junho Jung Sanghoon Ko | 2011 | Food Control2011，，1： | 1 |
| 19 | Maximum torque control of an induction machine in the field weakening region显示文摘 | Sanghoon K Seungki S | 1995 | IEEE Transactions on Industry Applications1995，31，4： | 1 |
| 20 | Application of a Fiber-reactive Chitosan Derivative to Cotton Fabric As an Antimicrobial Textile Finish显示文摘 | Sanghoon LIM Samuel M HUDSON | 2004 | Carbohydrate Polymers2004，56，2： | 1 |
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