|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Primary squamous cell carcinoma of the rectum: An update and implications for treatment显示文摘AIM: To provide an update on the aetiology, pathogenesis, diagnosis, staging and management of rectal squamous cell carcinoma(SCC).METHODS: A systematic review was conducted according to the preferred reporting items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search of Ovid MEDLINE was performed with the reference list of selected articles reviewed to ensure all relevant publications were captured. The search strategy was limited to the English language, spanning from 1946 to 2015. A qualitative analysis was undertaken examining patient demographics, clinical presentation, diagnosis, staging, treatment and outcome. The quantitaive analysis was limited to data extracted on treatment and outcomes including radiological, clinical and pathological complete response where available. The narrative and quantitative review were synthesised in concert.RESULTS: The search identified 487 articles in total with 79 included in the qualitative review. The quantitative analysis involved 63 articles, consisting of 43 case reports and 20 case series with a total of 142 individual cases. The underlying pathogenesis of rectal SCC while unclear, continues to be defined, with increasing evidence of a metaplasia-dysplasia-carcinoma sequence and a possible role for human papilloma virus in this progression. The presentation is similar to rectal adenocarcinoma, with a diagnosis confirmed by endoscopic biopsy. Many presumed rectal SCC's are in fact an extension of an anal SCC, and cytokeratin markers are a useful adjunct in this distinction. Staging is most accurately reflected by the tumour-nodemetastasis classification for rectal adenocarcinoma. It involves examining locoregional disease by way of magnetic resonance imaging and/or endorectal ultrasound, with systemic spread excluded by way of computed tomography. Positron emission tomography is integral in the workup to exclude an external siteof primary SCC with metastasis to the rectum. While the optimal treatment remains as yet undefined, recent studies have demonstrated a global shift away from surgery towards definitive chemoradiotherapy as primary treatment. Pooled overall survival was calculated to be 86% in patients managed with chemoradiation compared with 48% for those treated traditionally with surgery. Furthermore, local recurrence and metastatic rates were 25% vs 10% and 30% vs 13% for the chemoradiation vs conventional treatment cohorts.CONCLUSION: The changing paradigm in the treatment of rectal SCC holds great promise for improved outcomes in this rare disease. | Glen R Guerra Cherng H Kong Satish K Warrier Andrew C Lynch Alexander G Heriot Samuel Y Ngan | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 5 |
| 2 | Langerhans cell histiocytosis masquerading as acute appendicitis: Case report and review显示文摘Langerhans cell histiocytosis(LCH) is a rare syndrome characterized by unifocal,multifocal unisystem,or disseminated/multi-system disease that commonly involves the bone,skin,lymph nodes,pituitary,or sometimes lung(almost exclusively in smokers) causing a variety of symptoms from rashes and bone lesions to diabetes insipidus or pulmonary infiltrates.We present a previously unreported case of gastrointestinal LCH as well as a novel characteristic lesion affecting the colon of a young woman who presented with signs and symptoms mimicking acute on chronic appendicitis.Immunohistochemical analysis of appendectomy specimen and nodular specimens on colonoscopy demonstrated S-100,CD1a,and langerin reactivity.The patient underwent systemic chemotherapy with cytarabine and demonstrated excellent response to therapy. | Mohammad M Karimzada Michele N Matthews Samuel W French Daniel De Ugarte Dennis Y Kim | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，3： | 3 |
| 3 | Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression显示文摘 | Yoo Byoung Kwon Emdad Luni Su Zao-zhong Villanueva Augusto Chiang Derek Y Mukhopadhyay Nitai D Mills Alan Scott Waxman Samuel Fisher Robert A Llovet Josep M Fisher Paul B Sarkar Devanand | 2009 | Journal of Clinical Investigation2009，，3： | 2 |
| 4 | Human amnion epithelial cell transplantation abrogates lung fibrosis and augments repair显示文摘 | Moodley Y Ilancheran S Samuel C | 2010 | Am J Respir Crit Care Med2010，182，5： | 1 |
| 5 | ASPP proteins specificially stimulate the apoptotic function of p53 显示文摘 | SAMUELS LEV Y O'CONNOR D J BERGAMASCHI D | 2001 | Mol Cell2001，8，4： | 1 |
| 6 | Analysis of the genome to personalize therapy for melanoma显示文摘 | Davies MA Samuels Y | 2010 | Oncogene2010，29，： | 1 |
| 7 | The PIK3CA gene is mutated with high frequency in human breast cancers显示文摘 | Bachman KE Argani P Samuels Y | | 0，，08： | 1 |
| 8 | High frequency of mutations of the PIK3CA gene in human cancers显示文摘 | Samuels Y Wang Z Bardelli A | | 0，，： | 1 |
| 9 | iASPP oncopro- tein is a key inhibitor of P53 conserved from worm to human显示文摘 | BERGAMASCHI D SAMUELS Y LU X | 2003 | Nature genetics2003，33，2： | 1 |
| 10 | Fate ofpolybrominated diphenyl ethers in the environment of the Pearl RiverEstuary, South China显示文摘 | GUAN Y F SAMUEL SOJINU O S LI S M | 2009 | Environmental Pollution2009，157，7： | 1 |
| 11 | High frequency of muta- tions of the PIK3CA gene in human cancers显示文摘 | Samuels Y Wang Z Bardelli A | 2004 | Science2004，304，5670： | 1 |
| 12 | ASPP proteins specifically stimulate the apoptotic function of p53 显示文摘 | SAMUELS - LEV Y O 'CONNOR D J BERGAMASCHI D | 2001 | Mol Cell2001，8，： | 1 |
| 13 | Mutant PIK3CA promotes cell growth and invasion of human cancer ceils 显示文摘 | Samuels Y Diaz LA Jr Schmidt Kittler O | 2005 | Cancer Cell2005，7，6： | 1 |
| 14 | iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human显示文摘 | Bergamaschi D Samuels Y O'Neil N J | 2003 | Nat Genet2003，33，2： | 1 |
| 15 | High frequency of mutations of the PIK3CA gene in human cancers 显示文摘 | Samuels Y Wang Z Bardelli A | 2004 | Science2004，304，5670： | 1 |
| 16 | Quality assurance in blood culture: A retrospective study of blood culture contamination rate in a ter- tiary hospital in Nigeria显示文摘 | Chukwuemeka IK Samuel Y | 2014 | Niger Med J2014，55，3： | 1 |
| 17 | Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomas 显示文摘 | Boult JK Walker - Samuel S Jamin Y | 2011 | J Pathol2011，225，3： | 1 |
| 18 | High frequency of mutations of the PIK3CA gene in human cancers 显示文摘 | Samuels Y Wang Z Bardelli A | 2004 | Science2004，304，5670： | 1 |
| 19 | ASPP1 and ASPP2:common activators of p53 family members显示文摘 | BERGAMASCHI D SAMUELS Y JIN B | 2004 | Mol Cell Biol2004，24，3： | 1 |
| 20 | Duration and determinants of birth interval among women of child hearing age in Southern Ethiopia 显示文摘 | SAMUEL Y MEKITIE W MULUMEBET A | 2011 | BMC Pregnancy and Childbirth2011，11，38： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员