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| 1 | Non-alcoholic fatty liver disease and diabetes: From physiopathological interplay to diagnosis and treatment显示文摘Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients with diabetes mellitus and increasing evidence suggests that patients with type 2diabetes are at a particularly high risk for developing the progressive forms of NAFLD,non-alcoholic steatohepatitis and associated advanced liver fibrosis.Moreover,diabetes is an independent risk factor for NAFLD progression,and for hepatocellular carcinoma development and liver-related mortality in prospective studies.Notwithstanding,patients with NAFLD have an elevated prevalence of prediabetes.Recent studies have shown that NAFLD presence predicts the development of type2 diabetes.Diabetes and NAFLD have mutual pathogenetic mechanisms and it is possible that genetic and environmental factors interact with metabolic derangements to accelerate NAFLD progression in diabetic patients.The diagnosis of the more advanced stages of NAFLD in diabetic patients shares the same challenges as in non-diabetic patients and it includes imaging and serological methods,although histopathological evaluation is still considered the gold standard diagnostic method.An effective established treatment is not yet available for patients with steatohepatitis and fibrosis and randomized clinical trials including only diabetic patients are lacking.We sought to outline the published data including epidemiology,pathogenesis,diagnosis and treatment of NAFLD in diabetic patients,in order to better understand the interplay between these two prevalent diseases and identify the gaps that still need to be fulfilled in the management of NAFLD in patients with diabetes mellitus. | Nathalie C Leite Cristiane A Villela-Nogueira Claudia R L Cardoso Gil F Salles | 2014 | World Journal of Gastroenterology2014，20，26： | 21 |
| 2 | Extragastric Diseases and H elicobacter pylori显示文摘 | Claire Roubaud Baudron Francesco Franceschi Nathalie Salles Antonio Gasbarrini | 2013 | Helicobacter2013，，： | 5 |
| 3 | 中医药在巴西的发展现状与分析显示文摘巴西医疗保险以统一医疗体系(Unified Health System,SUS)的免费医疗为主、私人保险为补充,已实现全民享有基本医疗服务。导致该国居民死亡的主要疾病是缺血性心脏病、脑卒中、下呼吸道感染,近年来AD、慢性肾脏病及糖尿病的发病率显著增高。以针灸为代表的中医疗法在19世纪初传入巴西,目前针灸治疗已得到较广泛的认可和应用,被纳入SUS,并在多所高校开设相关课程,但中医药整体特色有待加强,从业人员对中药的理解、运用不足,以及中医药教育缺乏规范等问题限制了中医药在巴西的发展。建议通过发挥中医药治未病的特色,加大中药研发力度并扩大市场,规范中医教育等措施,促进两国在中医药领域的广泛合作,推动中医药在巴西的发展与传播。 | 李皓月 党迎迎 Thaís Salles Araujo Fatima Terezinha Pelachini Farias Jaime Amador Soares Graciela Mendonça da Silva de Medeiros 于涛 魏竞竞 赵静 许家杰 曹洪欣 | 2021 | 国际中医中药杂志2021，43，5： | 5 |
| 4 | Mangiferin,a natural xanthone,accelerates gastrointestinal transit in mice involving cholinergic mechanism显示文摘AIM:To investigate the effects of mangiferin on gastrointestinal transit(GIT) in normal and constipated mice,together with the possible mechanism.METHODS:Intragastrically-administered charcoal mealwas used to measure GIT in overnight starved Swiss mice.In the first experiments,mangiferin(3 mg/kg,10 mg/kg,30 mg/kg,and 100 mg/kg,po) or tegaserod(1 mg/kg,ip) were administered 30 min before the charcoal meal to study their effects on normal transit.In the second series,mangiferin(30 mg/kg) was tested on delayed GIT induced by several different pharmacological agonists(morphine,clonidine,capsaicin) or antagonists(ondansetron,verapamil,and atropine) whereas in the third series,mangiferin(30 mg/kg,100 mg/kg and 300 mg/kg) or tegaserod(1 mg/kg) were tested on 6 h fecal pellets outputted by freely fed mice.The ratio of wet to dry weight was calculated and used as a marker of fecal water content.RESULTS:Mangiferin administered orally significantly(P < 0.05) accelerated GIT at 30 mg/kg and 100 mg/kg(89% and 93%,respectively),similarly to 5-hydroxytryptamine4(5-HT4) agonist tegaserod(81%) when compared to vehicle-treated control(63%).Co-administered mangiferin(30 mg/kg) totally reversed the inhibitory effect of opioid agonist morphine,5-HT3-receptor antagonist ondansetron and transient receptor potential vanilloid-1 receptor agonist capsaicin on GIT,but only to a partial extent with the GIT-delay induced by 2-adrenoceptor agonist clonidine,and calcium antagonist verapamil.However,co-administered atropine completely blocked the stimulant effect of mangiferin on GIT,suggesting the involvement of muscarinic acetylcholine receptor activation.Although mangiferin significantly enhanced the 6 h fecal output at higher doses(245.5 ± 10.43 mg vs 161.9 ± 10.82 mg and 227.1 ± 20.11 mg vs 161.9 ± 10.82 mg of vehicle-treated control,at 30 and 100 mg/kg,P < 0.05,respectively),the effect of tegaserod was more potent(297.4 ± 7.42 mg vs 161.9 ± 10.82 mg of vehicle-treated control,P < 0.05).Unlike tegaserod,which showed an enhanced water content in fecal pellets(59.20% ± 1.09% vs 51.44% ± 1.19% of control,P < 0.05),mangiferin evidenced no such effect,indi-cating that it has only a motor and not a secretomotor effect.CONCLUSION:Our data indicate the prokinetic action of mangiferin.It can stimulate the normal GIT and also overcome the drug-induced transit delay,via a cholinergic physiological mechanism. | Talita Cavalcante Morais Synara Cavalcante Lopes Karine Maria Martins Bezerra Carvalho Bruno Rodrigues Arruda Francisco Thiago Correia de Souza Maria Teresa Salles Trevisan Vietla Satyanarayana Rao Flávia Almeida Santos | 2012 | World Journal of Gastroenterology2012，18，25： | 3 |
| 5 | Bile duct hamartomas-the von Meyenburg complex显示文摘ABSTRACT: Hamartomas of the bile duct (von Meyenburg complex) are benign neoplasms of the liver, constituted histologically cystic dilatations of the bile duct, encompassed by fibrous stroma. We report a 42-year-old female patient with symptomatic cholecystitis, whose gross and ultrasonic appearance suggestive of multiple liver metastases. Magnetic resonance imaging and liver biopsy are the gold standards for diagnosis of this rare hepatobiliary condition. | Valdemir José Alegre Salles Alexandre Marotta Jorge Miguel Kather Netto Manlio Basílio Speranzini Marcos Roberto Martins | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，1： | 3 |
| 6 | 难治性高血压患者动态血压及其变化与不良预后的关系:动态血压是否存在J形曲线?显示文摘本研究旨在探讨进行连续动态血压监测的难治性高血压患者1 474例随访期间的低血压及较大的血压变化与主要不良心血管事件以及死亡的关系。采用三次样条多变量Cox回归评估连续血压监测指标(时间加权的平均血压变化及最新血压测量值)与主要(主要不良心血管事件及全因死亡)及次要(心血管病死亡、心肌梗死、脑卒中)结局的关系。同时进行分类分析(包括最大血压降幅亚组及最低血压亚组)。 | 赵狄(摘译) 郑武洪(审校) Cardoso CRL Salles GF | 2021 | 中华高血压杂志2021，29，9： | 2 |
| 7 | VPL/VPM联合PAG/PVG脑深部电刺激治疗神经性疼痛的疗效分析显示文摘目的探讨丘脑腹后外侧核/腹后内侧核(VPL/VPM)脑深部电刺激(DBS)联合导水管周围灰质/脑室旁下丘脑核团(PAG/PVG)DBS治疗神经性疼痛的疗效。方法对24例神经性疼痛患者进行回顾性分析,除早期2例只使用PVG作为靶点外,其他患者均采用VPL/VPM联合PAG/PVGDBS进行治疗,并在术前、术后3个月采用视觉模拟评分(VAS)评估疼痛级别,比较分析治疗效果。结果22例成功接受VPL和PVG联合靶点治疗(其中5例为双侧),2例只接受单侧PVG—DBS。其中17例恢复良好(有效率70.8%),7例术后将DBS去除(1例颅内感染,6例疗效较差)。所有患者术前VAS评分平均为(8.04±0.86)分,术后VAS评分平均为(3.13±1.44)分,P〈0.05。有效患者中VPL靶点的疗效均满意,PVG靶点的有效例数为12例。7例PVG靶点产生明显不良反应,VPL靶点无明显不良反应。结论利用PVG/VPL联合治疗慢性神经痛有一定的疗效,但由于PVG的疗效不甚满意及不良反应较多,VPL也许更适合作为神经性疼痛治疗的靶点。 | 梁思泉 Antonio De Salles | 2012 | 中华神经外科杂志2012，28，8： | 2 |
| 8 | Impact of chronic Helicobacter pylori infection on Alzheimer’s disease: preliminary results显示文摘 | Claire Roubaud-Baudron Pierre Krolak-Salmon Isabelle Quadrio Francis Mégraud Nathalie Salles | 2012 | Neurobiology of Aging2012，，5： | 2 |
| 9 | Review of wind turbine control显示文摘 | De La Salle S A | 1990 | Int JControl1990，52，6： | 2 |
| 10 | Molecular imaging of movement disorders显示文摘Positron emission tomography measures the activity of radioactively labeled compounds which distribute and accumulate in central nervous system regions in proportion to their metabolic rate or blood flow. Specific circuits such as the dopaminergic nigrostriatal projection can be studied with ligands that bind to the pre-synaptic dopamine transporter or post-synaptic dopamine receptors(D1 and D2). Single photon emission computerized tomography(SPECT) measures the activity of similar tracers labeled with heavy radioactive species such as technetium and iodine. In essential tremor, there is cerebellar hypermetabolism and abnormal GABAergic function in premotor cortices, dentate nuclei and ventral thalami, without significant abnormalities in dopaminergic transmission. In Huntington's disease, there is hypometabolism in the striatum, frontal and temporal cortices. Disease progression is accompanied by reduction in striatal D1 and D2 binding that correlates with trinucleotide repeat length, disease duration and severity. In dystonia, there is hypermetabolism in the basal ganglia, supplementary motor areas and cerebellum at rest. Thalamic and cerebellar hypermetabolism is seen during dystonic movements, which can be modulated by globus pallidus deep brain stimulation(DBS). Additionally, GABA-A receptor activity is reduced in motor, premotor and somatosensory cortices. In Tourette's syndrome, there is hypermetabolism in premotor and sensorimotor cortices, as well as hypometabolism in the striatum, thalamus and limbic regions at rest. During tics, multiple areas related to cognitive, sensory and motor functions become hypermetabolic. Also, there is abnormal serotoninergic transmission in prefrontal cortices and bilateral thalami, as well as hyperactivity in the striatal dopaminergic system which can be modulated with thalamic DBS. In Parkinson's disease(PD), there is asymmetric progressive decline in striatal dopaminergic tracer accumulation, which follows a caudal-to-rostral direction. Uptake declines prior to symptom presentation and progresses from contralateral to the most symptomatic side to bilateral, correlating with symptom severity. In progressive supranuclear palsy(PSP) and multiple system atrophy(MSA), striatal activity is symmetrically and diffusely decreased. The caudal-to-rostral pattern is lost in PSP, but could be present in MSA. In corticobasal degeneration(CBD), there is asymmetric, diffuse reduction of striatal activity, contralateral to the most symptomatic side. Additionally, there is hypometabolism in contralateral parietooccipital and frontal cortices in PD; bilateral putamen and cerebellum in MSA; caudate, thalamus, midbrain, mesial frontal and prefrontal cortices in PSP; and contralateral cortices in CBD. Finally, cardiac sympathetic SPECT signal is decreased in PD. The capacity of molecular imaging to provide in vivo time courses of gene expression, protein synthesis, receptor and transporter binding, could facilitate the development and evaluation of novel medical, surgical and genetic therapies in movement disorders. | Karlo J Lizarraga Alessandra Gorgulho Wei Chen Antonio A De Salles | 2016 | World Journal of Radiology2016，8，3： | 2 |
| 11 | Odour - taste interactions: A way to enhance saltiness in low-sah content solutions 显示文摘 | Lawrence G Salles C Septier C | 2009 | Food Quality and Preference2009，20，： | 1 |
| 12 | Basic mechanisms of the aging gastrointestinal tract显示文摘 | Salles N | 2007 | Dig Dis2007，25，2： | 1 |
| 13 | Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus显示文摘 | Leite NC Salles GF Araujo AL | 2009 | Liver Int2009，，1： | 1 |
| 14 | Carbon stocks in Senegal's Sahel Transition Zone显示文摘 | Woomer P L Toure A Sall M | 2004 | Journal of Arid Environments2004，59，： | 1 |
| 15 | Restoration of ovarian steroid secretion and histologic assessment after freezing, thawing, and autograft of a hemi-ovary in sheep 显示文摘 | Salle B Lornage J Demirci B | 1999 | Fertil Steril1999，72，2： | 1 |
| 16 | Strategies and Metric for Resili- ence in Computer Networks 显示文摘 | Salles R M Marino D A J R | 2011 | The Computer Journal Ad- vance Access published2011，2011，： | 1 |
| 17 | I (Ks) blockade in border zone arrhythmias from guinea - pig ventricular myocardium sub- mitted to simulated ischemia and reperfusion显示文摘 | Puddu PE Salle L Gcrard JL | 2012 | Fundam Clin Pharmacoh2012，26，4： | 1 |
| 18 | International Prognostic Index, Type of Transplant and Response to Rituximab Are Key Parameters to Tailor Treatment in Adults With CD20‐Positive B Cell PTLD: Clues From the PTLD‐1 Trial显示文摘 | R. U. Trappe S. Choquet D. Dierickx P. Mollee J. M. Zaucha M. H. Dreyling U. Dührsen C. Tarella O. Shpilberg M. Sender G. Salles F. Morschhauser A. Jaccard T. Lamy P. Reinke R. Neuhaus H. Lehmkuhl H. A. Horst M. Leith?user P. Schlattmann I. Anagnostopoulo | 2015 | American Journal of Transplantation2015，，4： | 1 |
| 19 | Hyperglycemia cerebrospinal fluid lactic acidosis, and cerebral blood flow in severely head injured patients 显示文摘 | De Salles AA Muizelaar JP Young HF | 1987 | Neurosurg1987，21，1： | 1 |
| 20 | An evaluation of pooled samples in studies of genetic variation显示文摘 | Kraft T Sall T | 1999 | Heredity1999，82，： | 1 |
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