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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Influence of Fe and Ni on creep of near a-Ti alloy IMI834显示文摘 | MISHRA H GHOSAL P NANDY T K SAGAR P K | 2005 | Materials Science and Engineering A2005，399，： | 1 |
| 3 | Surgical management of locally recurrent rectal cancer显示文摘 | Sagar P M Pemberton J H | 1996 | Br J Surg1996，83，3： | 1 |
| 4 | Surgical management of locally recurrent rectal cancer 显示文摘 | Sagar P M Pemberton J H | 1996 | Br J Surg1996，83，3： | 1 |
| 5 | Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-beta is an early biomarker for mild cognitive impairment preceding Alzheimer's disease显示文摘 | Sagare AP Deane R Zetterberg H | | Journal of Alzheimer's Disease0，，： | 1 |
| 6 | Entacapone is beneficial in both fluctuating and nonfluctuating patients with Parkinson's disease: a randomized, placebo controlled, double blind, six month study 显示文摘 | Brooks D J Sagar H | 2003 | Neurol Neurosurg Psychiatry2003，74，： | 1 |
| 7 | NPACT : Naturally occurringplant-based anti-cancer compound-activity-target database 显示文摘 | Mangal M Sagar P Singh H | 2013 | Nucleic Acids Res2013，41，： | 1 |
| 8 | Effect of trace impurities on the creep behavior of a near α titanium alloy显示文摘 | MISHRA H SATYANARAYANA D V V NANDY T K SAGAR P K | 2008 | Scripta Materialia2008，59，： | 1 |
| 9 | Detection of porcine reproductive and respiratory syndrome virus by reverse transcription polymerase chain reaction using different regions of the viral genome 显示文摘 | Guarino H Sagar M G MichaelP M etal | 1999 | J Vet Diagn In vest1999，11，： | 1 |
| 10 | Detection of porcine reproductive and respiratory syndrome virus by reverse transcription polymerase chain reaction using different regions of the viral genome 显示文摘 | Guarino H Sagar M G Michael P M | 1999 | Vet Diagn Invest1999，11，： | 1 |
| 11 | Synthesis of symmetrical diaryl ethers from arylhoronic acids mediated by copper(Ⅱ ) acetate显示文摘 | Sagar A D Tale R H Adude R N | 2003 | Tetrahedron Lett2003，44，： | 1 |
| 12 | An audit of the treatment of cancer of the oesophagus显示文摘 | SAGAR PM SUE-LING H MCMAHON MJ | 1994 | Gut1994，35，7： | 1 |
| 13 | HSP70 heat shock protein induction following global ischemia in the rat 显示文摘 | Gaspary H Graham SH Sagar SM | 1995 | Brain Res Mol Brain Res1995，34，3： | 1 |
| 14 | Rare cause of thoracic myelopathy:ossifiedligamentumflavum显示文摘 | Sagar H Fernandez-Madrid F Kupsky W | 2010 | J ClinRheumatol2010，16，7： | 1 |
| 15 | Prevalence of hypovitaminosis D in cardiovascular diseases(from the National Health and Nutrition Examination Survey 2001 to 2004)显示文摘 | KIM D H SABOUR S SAGAR U N | 2008 | Am J Cardiol2008，102，11： | 1 |
| 16 | Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD)collaborative update of CANMAT guidelines for the management of patients with bipolar disorder:update 2013显示文摘 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh | 2013 | Bipolar Disorders2013，15，： | 1 |
| 17 | An audit of the treatment of cancer of the oesophagus显示文摘 | Sagar PM Sue-Ling H McMahon M J | 1994 | Gut1994，35，： | 1 |
| 18 | Prevalence of hypovitaminosis D in cardiovascular diseases( from the Nation- al Health and Nutrition Examination Survey 2001 to 2004) 显示文摘 | KIM D H SABOU R S SAGAR U N | 2008 | A mJCardiol2008，102，11： | 1 |
| 19 | Furan in foods on the Swiss market Method and results 显示文摘 | Reinhard H Sagar F Zoller O | 2004 | Mitt Lebensm Hyg2004，95，： | 1 |
| 20 | The evolution of CANMAT Bipolar Disorder Guidelines: past, present, and future显示文摘 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Schaffer Serge Beaulieu Martin Alda Claire O’Donovan Glenda MacQueen Roger S McIntyre Verinder Sharma Arun Ravindran L Trevor Young Roumen Milev David J Bond Benicio N Frey Benjamin I Goldstein | 2013 | Bipolar Disorders2013，，： | 1 |
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