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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Breastfeeding and postpartum weight retention in a cohort of Brazilian women显示文摘 | Kac G Benicio MH Velasquez-Melendez G | 2004 | Am J Clin Nutr2004，79，3： | 1 |
| 3 | Oxidative stress markers in bipolar disorder: a meta-analysis 显示文摘 | Ana C Andreazza Marica Kauer-Sant'anna Benicio N Frey | 2008 | J Affect Disord2008，111，23： | 1 |
| 4 | Gestational weight gain and prepregnancy weight influence postpartum weight retention in a cohort of brazilian women 显示文摘 | Kac G Benicio MH Velasquez-Melendez G | 2004 | J Nutr2004，134，： | 1 |
| 5 | Cavo-pulmonary anastomosis associated with left ventricular in comparison with biventricular circulatory support in acute heart failure显示文摘 | Santos LA Benicio A Ed MJ | 2012 | Rev Bras Cir Cardiovasc2012，27，4： | 1 |
| 6 | the AutonomousLearnet ,English Teaching Forum显示文摘 | Computer and the EFL Class: Their Advantages and a Possible Outcome | 1998 | (Oct-Dec)1998，，： | 1 |
| 7 | Cavo- pulmonary anastomosis associated with left ventricular in comparison with biventricular circulatory support in acute heart failure显示文摘 | Santos LA Benicio A Mattos Jflnior Ed | 2012 | Rev Bras Cir Cardiovasc2012，27，4： | 1 |
| 8 | Forum computers and the EFL class :their advantages and a possible outcome 显示文摘 | Benicio G | 1998 | The Autonomous Learner1998，36，： | 1 |
| 9 | The evolution of CANMAT Bipolar Disorder Guidelines: past, present, and future显示文摘 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Schaffer Serge Beaulieu Martin Alda Claire O’Donovan Glenda MacQueen Roger S McIntyre Verinder Sharma Arun Ravindran L Trevor Young Roumen Milev David J Bond Benicio N Frey Benjamin I Goldstein | 2013 | Bipolar Disorders2013，，： | 1 |
| 10 | Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes 显示文摘 | Cunha BM Benicio N | 2006 | Neuroscience Letters2006，398，： | 1 |
| 11 | A comparative study of pulse current formation for positive plates of automotive lead acid batteries 显示文摘 | Flamarion B Diniz Lucila Ester P Borges Benicio de B Nero | 2002 | J Power Sources2002，109，： | 1 |
| 12 | Determinants of long-term mortality of current palliative surgical treatment for dilated cardiomyopathy 显示文摘 | Moreira LF Benicio A Bacal F | 2003 | Eur J Cardiothorac Surg2003，23，5： | 1 |
| 13 | Paraplegia following intraaortic balloon circulatory assistance显示文摘 | Moreira L F Auler Junior J O Jr | 1999 | Arq Bras Cardiol1999，72，4： | 1 |
| 14 | Aqueous two-phase systems extraction of α-toxin from costridium perfringens type A 显示文摘 | Maria Taciana Holanda Cavalcanti Tatiana Souza Porto Benicio de Barros Neto | 2006 | J Chromatogr B2006，833，2： | 1 |
| 15 | Microstructure of undercooled Pb-Sn alloys显示文摘 | Walman Benicio de Castro Manuel de Lucena Maia Claudio Shyinti Kiminami | 2001 | Materials Science and Engineering:A2001，304，： | 1 |
| 16 | Investigation of serum high-sensitive C-reactive protein levels across all mood states in bipolar disorder显示文摘 | ?ngelo B. Cunha Ana C. Andreazza Fabiano A. Gomes Benicio N. Frey Leonardo E. Silveira Carlos A. Gon?alves Flávio Kapczinski | 2008 | European Archives of Psychiatry and Clinical Neuroscience2008，，5： | 1 |
| 17 | Aqueous two-phase systems extraction of α-toxin from clostridium perfringens type A 显示文摘 | Maria Taciana Holanda Cavaleanti Tatiana Souza Porto Benicio de Barros Neto | 2006 | Journal of Chromatography B2006，833，2： | 1 |
| 18 | Ges-tational weight gain and prepregnancy weight influence post-partum weight retention in a cohort of Brazilian women 显示文摘 | Kac G Benicio MH Velasquez - Melendez G | 2004 | JNutr2004，134，3： | 1 |
| 19 | Phenanthrene and pyrene oxidation in contaminated soils using Fenton' s reagent显示文摘 | Paula Tereza de Souza e Silva Valdinete Lins da Silva Benicio de Barros Neto | 2009 | Journal of Hazardous Materials2009，，161： | 1 |
| 20 | Application of Doehlert Designs for Optimisation of an On-Line Preconcentration System for Copper Determination by Flame Atomic Absorption Spectrometry显示文摘 | SERGIO L C FERREIRA MARCOS A BEZERRA WALTER N L DOS SANTOS BENICIO B NETO | 2003 | Talanta2003，61，： | 1 |
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