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| 1 | Hypertriglyceridemia-induced pancreatitis: A case-based review显示文摘Hypertriglyceridemia is an established cause of pancreatitis. In a case-based approach, we present a review of hypertriglyceridemia and how it can cause pancreatitis. We outline how to investigate and manage such patients. A 35 year old man presented to the emergency department with abdominal pain and biochemical evidence of acute pancreatitis. There was no history of alcohol consumption and biliary imaging was normal. The only relevant past medical history was that of mild hyperlipidemia, treated with diet alone. Physical exam revealed epigastric tenderness, right lateral rectus palsy, lipemia retinalis, bitemporal hemianopsia and a delay in the relaxation phase of his ankle reflexes. Subsequent laboratory investigation revealed marked hypertriglyceridemia and panhypopituarism. An enhanced CT scan of the head revealed a large suprasellar mass impinging on the optic chiasm and hypothalamus. The patient was treated supportively; thyroid replacement and lipid lowering agents were started. He underwent a successful resection of a craniopharyngioma. Post- operatively, the patient did well on hormone replacement therapy. He has had no further attacks of pancreatitis. This case highlights many of the factors involved in the regulation of triglyceride metabolism. We review the common causes of hypertriglyceridemia and the proposed mechanisms resulting in pancreatitis. The incidence and management of hypertriglyceridemia- induced pancreatitis are also discussed. | S Ian Gan Alun L Edwards Christopher J Symonds Paul L Beck | 2006 | World Journal of Gastroenterology2006，12，44： | 35 |
| 2 | Sofosbuvir and Daclatasvir Combination Therapy in a Liver Transplant Recipient With Severe Recurrent Cholestatic Hepatitis C显示文摘 | R. J. Fontana E. A. Hughes M. Bifano H. Appelman D. Dimitrova R. Hindes W. T. Symonds | 2013 | American Journal of Transplantation2013，，6： | 7 |
| 3 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 4 | O68 SOFOSBUVIR AND RIBAVIRIN FOR THE TREATMENT OF CHRONIC HCV WITH CIRRHOSIS AND PORTAL HYPERTENSION WITH AND WITHOUT DECOMPENSATION: EARLY VIROLOGIC RESPONSE AND SAFETY显示文摘 | N. Afdhal G. Everson J.L. Calleja G. McCaughan W.T. Symonds J. Denning L. McNair J.G. McHutchison S. Arterburn M. Charlton R. Reddy T. Asselah E. Gane X. Forns | 2014 | Journal of Hepatology2014，，1： | 3 |
| 5 | Senescence and p130/Rb12: a new beginning to the end显示文摘 | Francesco P Fiorentinot Catherine E Symonds Marcella Macaluso Antonio Giordano | 2009 | Cell Research2009，19，9： | 3 |
| 6 | Sofosbuvir and Ribavirin for Treatment of Compensated Recurrent Hepatitis C Virus Infection After Liver Transplantation显示文摘 | Michael Charlton Edward Gane Michael P. Manns Robert S. Brown Michael P. Curry Paul Y. Kwo Robert J. Fontana Richard Gilroy Lewis Teperman Andrew J. Muir John G. McHutchison William T. Symonds Diana Brainard Brian Kirby Hadas Dvory-Sobol Jill Denning Sara | 2014 | Gastroenterology2014，，： | 2 |
| 7 | The Serotonin Transporter Polymorphism rs25531 Is Associated with Irritable Bowel Syndrome显示文摘 | Ruth Kohen Monica E. Jarrett Kevin C. Cain Sang-Eun Jun Grace P. Navaja Sarah Symonds Margaret M. Heitkemper | 2009 | Digestive Diseases and Sciences2009，，12： | 2 |
| 8 | O6 SOFOSBUVIR/LEDIPASVIR FIXED DOSE COMBINATION IS SAFE AND EFFECTIVE IN DIFFICULT-TO-TREAT POPULATIONS INCLUDING GENOTYPE-3 PATIENTS, DECOMPENSATED GENOTYPE-1 PATIENTS, AND GENOTYPE-1 PATIENTS WITH PRIOR SOFOSBUVIR TREATMENT EXPERIENCE显示文摘 | E.J. Gane R.H. Hyland D. An P.S. Pang W.T. Symonds J.G. Mchutchison C.A. Stedman | 2014 | Journal of Hepatology2014，，1： | 2 |
| 9 | Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis显示文摘 | John A Green John M Kirwan Jayne F Tierney Paul Symonds Lydia Fresco Mandy Collingwood Christopher J Williams | 2001 | The Lancet . 2001 (9284)2001，，： | 2 |
| 10 | P1232 SOFOSBUVIR AND RIBAVIRIN FOR THE TREATMENT OF RECURRENT HEPATITIS C INFECTION AFTER LIVER TRANSPLANTATION: RESULTS OF A PROSPECTIVE, MULTICENTER STUDY显示文摘 | D. Samuel M. Charlton E. Gane R. Brown M. Curry P. Kwo R. Fontana R. Gilroy L. Teperman A.J. Muir J.G. McHutchison W.T. Symonds J. Denning L. McNair S. Arterburn N. Terrault X. Forns M. Manns | 2014 | Journal of Hepatology2014，，1： | 2 |
| 11 | Methoxyehlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouse 显示文摘 | Borgeest C Symonds D Mayer LP | 2002 | Toxicol Sci2002，68，2： | 1 |
| 12 | Chemoradiation:the new gold standard for non-surgical treatment of cervical cancer显示文摘 | Symonds P | 2002 | Clin Oncol2002，14，： | 1 |
| 13 | Elastic, finite deflection and strain rate effects in a mode approximation technique for plastic deformation of pulse loaded structures显示文摘 | Symonds P S | 1980 | Journal of Mechanical Engineering Science1980，22，4： | 1 |
| 14 | The establishment and degeneration of a temporary creek system in response to managed coastal realignment: The Wash, UK显示文摘 | SYMONDS A M COLLINS M B | 2007 | Earth Surface Processes and Landforms2007，32，12： | 1 |
| 15 | Epidemiology of Leptospira weilii serovar Topaz infections in Australia 显示文摘 | Slack AT Symonds ML Dohnt MF | 2007 | Commun Dis Intell2007，31，： | 1 |
| 16 | A laboratory study of caustic flooding for two Alberta crude oils显示文摘 | Symonds R W P Farouq Ali S M Thomas S | 1991 | J Canada Petrol Technol1991，30，1： | 1 |
| 17 | Relationship between survival and yield related traits in Solanum pimpinellifolium under salt stress显示文摘 | Rao E S Kadirvel P Symonds R C | 2013 | Euphytica2013，190，2： | 1 |
| 18 | Cost horizons and certainty equivalents:an approach to stochastic progrmming of heating oil显示文摘 | Charnes A Cooper W Symonds G | | 0，，3： | 1 |
| 19 | The late radiotherapy normal tissue injury phenotypes of telangiec- tasia,fibrosis and atrophy in breast cancer patients have distinct genotype-dependent causes显示文摘 | Giotopoulos G Symonds RP Foweraker K | 2007 | Br J Cancer2007，96，6： | 1 |
| 20 | Progesterone re ceptor isoform expression in the guinea pig myometrium ftom normal and growth restricted pregnancies显示文摘 | Palliser H K Zakar T Symonds I M | 2010 | Reproductive Sciences2010，17，： | 1 |
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