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| 1 | Gender gap in acute coronary heart disease:Myth or reality?显示文摘AIM: To investigate potential gender differences in the prevalence of cardiovascular risk factors, cardiovascular disease (CVD) management, and prognosis in acute coronary syndrome (ACS). METHODS: A systematic literature search was performed through Medline using pre-specified key words . An additional search was performed, focusing specifically on randomized controlled clinical trials in relation to therapeutic intervention and prognosis. In total, 92 relevant articles were found. RESULTS: Women with CVD tended to have more hypertension and diabetes at the time of presentation, whereas men were more likely to smoke. Coronary angiography and revascularization by percutaneous coronary intervention were performed more often in men. Women were at a greater risk of short-term mortality and complications after revascularization. Interestingly, women under 40 years presenting with ACS were athighest risk of cardiovascular death compared with men of the same age, irrespective of risk factors. This disadvantage disappeared in older age. The long-term mortality risk of ACS was similar in men and women, and even in favor of women. CONCLUSION: Mortality rates are higher among young women with ACS, but this difference tends to disappear with age, and long-term prognosis is even better among older women. | Mette Claassen Kirsten C Sybrandy Yolande E Appelman Folkert W Asselbergs | 2012 | World Journal of Cardiology2012，4，2： | 9 |
| 2 | Sofosbuvir and Daclatasvir Combination Therapy in a Liver Transplant Recipient With Severe Recurrent Cholestatic Hepatitis C显示文摘 | R. J. Fontana E. A. Hughes M. Bifano H. Appelman D. Dimitrova R. Hindes W. T. Symonds | 2013 | American Journal of Transplantation2013，，6： | 7 |
| 3 | Current status of assessment of fractional flow reserve显示文摘 | FANG Yi-min Grisana Grootenhuijs-Triyasut Pieter A. Doevendans Yolande Appelman | 2009 | Chinese Medical Journal2009，，6： | 5 |
| 4 | Outcomes of submucosal(T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection显示文摘AIM To investigate the outcomes and recurrences of p T1 b esophageal adenocarcinoma(EAC) following endoscopic mucosal resection(EMR) and associated treatments.METHODS Patients undergoing EMR with pathologically confirmed T1 b EAC at two academic referral centers were retrospectively identified.Patients were divided into 4 groups based on treatment following EMR:Endoscopic therapy alone(group A),endoscopic therapy with either chemotherapy,radiation or both(group B),surgicalresection(group C) or no further treatment/lost to follow-up(<12 mo)(group D).Pathology specimens were reviewed by a central pathologist.Follow-up data was obtained from the academic centers,primary care physicians and/or referring physicians.Univariate analysis was performed to identify factors predicting recurrence of EAC.RESULTS Fifty-three patients with T1 b EAC underwent EMR,of which 32(60%) had adequate follow-up ≥ 12 mo(median 34 mo,range 12-103).There were 16 patients in group A,9 in group B,7 in group C and 21 in group D.Median follow-up in groups A to C was 34 mo(range 12-103).Recurrent EAC developed overall in 9 patients(28%) including 6(38%) in group A(median:21 mo,range:6-73),1(11%) in group B(median:30 mo,range:30-30) and 2(29%) in group C(median 21 mo,range:7-35.Six of 9 recurrences were local;of the 6 recurrences,5 were treated with endoscopy alone.No predictors of recurrence of EAC were identified.CONCLUSION Endoscopic therapy of T1 b EAC may be a reasonable strategy for a subset of patients including those either refusing or medically unfit for esophagectomy. | Darren D Ballard Neel Choksi Jingmei Lin Eun-Young Choi B Joseph Elmunzer Henry Appelman Douglas K Rex Hala Fatima William Kessler John M DeWitt | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 5 | Association Between Helicobacter pylori and Barrett’s Esophagus, Erosive Esophagitis, and Gastroesophageal Reflux Symptoms显示文摘 | Joel H. Rubenstein John M. Inadomi James Scheiman Philip Schoenfeld Henry Appelman Min Zhang Val Metko John Y. Kao | 2014 | Clinical Gastroenterology and Hepatology2014，，2： | 2 |
| 6 | Subendometrial vasopressin to control intractable placental bleeding 显示文摘 | Lurie S Appelman Z Katz Z | 1997 | Lancet1997，349，9053： | 1 |
| 7 | Gender differences in coronaryheart disease显示文摘 | Maas AH Appelman YE | 2010 | Neth Heart2010，18，12： | 1 |
| 8 | Arteri- ovenous malformations of the gastrointestinal tract 显示文摘 | MOORE JD THOMPSON NW APPELMAN HD | 1976 | Arch Surg1976，111，4： | 1 |
| 9 | Preparing Instructional Designers for Game-Based Learning: Part 2显示文摘 | Atsusi Hirumi Bob Appelman Lloyd Rieber Richard Van Eck | 2010 | Tech Trends2010，54，4： | 1 |
| 10 | Thymosin treatment of chronic hepatitis B : A placebo - controlled pilot trial显示文摘 | Mutchnick MG Appelman DH Chung HT | 1991 | Hepatology1991，14，： | 1 |
| 11 | Initial experience with routine administration of etanereept in psoriasis 显示文摘 | De Groot M Appelman M Spuls P | 2006 | Br J Dermatol2006，155，4： | 1 |
| 12 | Sloughing esophagitis is associated with chronic debilitation and medications that injure the e- sophageal mucosa显示文摘 | Purdy JK Appelman HD McKenna BJ | 2012 | Mod Pathol2012，25，5： | 1 |
| 13 | Stromal Tumors of the Duodenum: a histologic and immunohistochemical study of 20 cases 显示文摘 | Goldblum JR Appelman HD | 1995 | Am J Surg Pathol1995，19，1： | 1 |
| 14 | Stormal tumors of the jejunum and ileum显示文摘 | Tworek JA Appelman HD Singleton TP | 1997 | Mod Pathol1997，10，3： | 1 |
| 15 | Preparing Instructional Designers for Game-Based Learning: Part 1 显示文摘 | Atsusi Hirtmai Bob Appelman Lloyd Rieber Richard Van Eck | 2010 | Tech Trends2010，54，3： | 1 |
| 16 | Clinical characteristics of type 1 diabeties patients with and without severe hypoglycemia显示文摘 | ter Braak EW Appelman AM ven de Lank M | 2000 | Diabetes Care2000，23，10： | 1 |
| 17 | Stromal tumors of theduodenum:Ahistologic and immunoh istochemical studyof 20cases显示文摘 | Goldblum TR Appelman HD | 1995 | Am J Surg Pathol1995，19，1： | 1 |
| 18 | Stromal tumor of the duodenum: a histological and immunohistochemical study of 20 cases显示文摘 | Coldbum JR Appelman HD | 1995 | Am J Surg Pathol1995，19，1： | 1 |
| 19 | Kinetics of the purified gluscose transporter direct measurement of the rates of interconversion of transporter isofonns 显示文摘 | APPelman JR Lienhard CE | 1989 | Biochemistry1989，28，： | 1 |
| 20 | The Y factor in the cardiac syndrome X 显示文摘 | Appelman Y | 2012 | Neth Heart J2012，20，9： | 1 |
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