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| 1 | Anti-diabetic activity of quercetin extracted from Phyllanthus emblica L.fruit: In silico and in vivo approaches显示文摘In this study, molecular interactions of the ligands, quercetin, gallic acid, and metformin with various diabetes mellitus-related protein targets, such as glycogen phosphorylase and peroxisome proliferatoractivated receptor gamma, were assessed. It was revealed that quercetin possesses good binding affinity to both targets. Quercetin is a major constituent of methanolic extracts of Phyllanthus emblica fruit. The antihyperglycemic effect of quercetin in streptozotocin(STZ)-induced diabetic rats was examined. The isolated quercetin administered at a dose of 75 mg/kg body weight produced a maximum decrease of14.78% in blood glucose levels in the diabetic rats after 7 days of treatment. Furthermore, quercetin doses of 50 and 75 mg/kg were shown to significantly improve the profiles of triglycerides, high-density lipoprotein, very-low-density lipoprotein, low-density lipoprotein, and total cholesterol at the end of the study in STZ-induced diabetic rats. The administration of quercetin(25, 50, and 75 mg/kg body weight)daily for 28 days in STZ-induced diabetic rats resulted in a significant decrease in blood glucose and urine sugar levels, with a considerable rise in plasma insulin and hemoglobin levels. Therefore, quercetin is a potential drug with antidiabetic and antihyperglycemic action mediated by changes in the levels of glucose, cholesterol, and triglycerides as indicated by in silico and in vivo studies. | Prabhu Srinivasan S.Vijayakumar Swaminathan Kothandaraman Manogar Palani | 2018 | Journal of Pharmaceutical Analysis2018，8，2： | 18 |
| 2 | Biodegradation of mixture of VOC's in a biofilter显示文摘Volatile organic compounds(VOC’s) in air have become major concern in recent years. Biodegradation of a mixture of ethanol and methanol vapor was evaluated in a laboratory biofilter with a bed of compost and polystyrene particles using an acclimated mixed culture. The continuous performance of the biofilter was studied with different proportion of ethanol and methanol at different initial concentration and flow rates. The result showed significant removal for both ethanol and methanol, which were composition dependent. The presence of either compound in the mixture inhibited the biodegradation of the other. | D.Arulneyam T. Swaminathan | 2004 | Journal of Environmental Sciences2004，16，1： | 9 |
| 3 | 亚洲大豆锈病研究进展(英文)显示文摘亚洲大豆锈病(SBR)是由豆薯层锈菌(Phakopsora pachyrhizi Syd.&P.Syd.)侵染引起的危害大豆植株的真菌病害,从20世纪开始锈病已经在世界范围内流行,造成大豆产量的下降,给种植者带来巨大的经济损失。一直以来,喷施农药是防治亚洲大豆锈病的唯一有效措施,然而,这种传统的防治方法不仅增加了大豆的生产成本,而且造成了环境的污染。因此,培育抗锈品种是锈病防治最经济有效的措施,在此宗旨的基础上,本文详细地阐述了亚洲大豆锈病的分类、流行、病菌分子生物学和病害的防治方法等。 | 刘敏 LIEPOLD C SWAMINATHAN S CIANZIO S R | 2014 | 中国油料作物学报2014，36，5： | 7 |
| 4 | TiO_2–PANI/Cork composite: A new floating photocatalyst for the treatment of organic pollutants under sunlight irradiation显示文摘A novel photocatalyst based on TiO_2–PANI composite supported on small pieces of cork has been reported. It was prepared by simple impregnation method of the polyaniline(PANI)–modified TiO_2 on cork. The TiO_2–PANI/Cork catalyst shows the unique feature of floating on the water surface. The as-synthesized catalyst was characterized by X-ray diffraction(XRD),scanning electron micrograph(SEM), transmission electron microscopy(TEM), thermogravimetric analysis(TGA), Fourier transform infrared spectroscopy(FT-IR), UV–vis diffuse reflectance spectra(UV–vis DRS) and the Brunauer–Emmett–Teller(BET) surface area analysis. Characterization suggested the formation of anatase highly dispersed on the cork surface. The prepared floating photocatalyst showed high efficiency for the degradation of methyl orange dye and other organic pollutants under solar irradiation and constrained conditions, i.e., no-stirring and no-oxygenation. The TiO_2–PANI/Cork floating photocatalyst can be reused for at least four consecutive times without significant decrease of the degradation efficiency. | Mouheb Sboui Mohamed Faouzi Nsib Ali Rayes Meenakshisundaram Swaminathan Ammar Houas | 2017 | Journal of Environmental Sciences2017，29，10： | 5 |
| 5 | Solar active fire clay based hetero-Fenton catalyst over a wide pH range for degradation of Acid Violet 7显示文摘Fe(III) immobilized fire clay (Fe-FC) was prepared using ferric nitrate by solid state dispersion method and this hetero-Fenton catalyst was applied for the degradation of Acid Violet 7 (AV 7) under natural sunlight. The 26% ferric nitrate loaded fire clay was found to be most efficient. The experimental conditions such as solution pH, H2O2 concentration for efficient degradation of AV 7 have been determined. Unlike Fenton catalyst, Fe-FC is photoactive over a wide pH range of 3-7. This catalyst was found to be stable and reusable. The GC-MS analysis of experimental solutions during irradiation revealed the formation of 2,8-diaminonaphthalene-1,3,6- triol, 8-aminonaphthalene-1,2,3,6-tetrol, 2-aminonaphthalene-1,3,6,8-tetrol and 2-aminobenzene-1,3-diol/5-aminonbenzene-1,3-diol/ 2-aminobenzene-1,4-diol as intermediates. The 26% ferric nitrate loaded fire clay was characterized by XRD, ICP-AES, BET surface area, FT-IR, SEM-EDS and UV-DRS studies. | Inbasekaran Muthuvel Balu Krishnakumar Meenakshisundaram Swaminathan | 2012 | Journal of Environmental Sciences2012，24，3： | 3 |
| 6 | Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study显示文摘 | Timothy J Price Marc Peeters Tae Won Kim Jin Li Stefano Cascinu Paul Ruff Atilli Satya Suresh Anne Thomas Sergei Tjulandin Kathy Zhang Swaminathan Murugappan Roger Sidhu | 2014 | Lancet Oncology2014，，6： | 2 |
| 7 | Isolation and in silico evaluation of antidiabetic molecules of Cynodon dactylon (L.)显示文摘 | Hasthi V. Annapurna Babu Apoorva Natesan Ravichandran Kallur Purushothaman Arun Pemaiah Brindha Sethuraman Swaminathan Mahadevan Vijayalakshmi Arumugam Nagarajan | 2013 | Journal of Molecular Graphics and Modelling2013，，： | 2 |
| 8 | Introduction of a second channel: Implications for pricing and profits显示文摘 | Wei Huang Jayashankar M. Swaminathan | 2007 | European Journal of Operational Research2007，，1： | 2 |
| 9 | Crystal structure of staphylococcal enterotoxin B, a superantigen显示文摘 | Swaminathan S Furey W Pletcher J | 1992 | Nature1992，359，6398： | 2 |
| 10 | Rapid Detection of Food-Borne Pathogenic Bacteria显示文摘 | B Swaminathan P Feng | 1994 | Annual Review of Microbiology1994，，： | 2 |
| 11 | Changes in content of organic acids and tea polyphenols during kombucha tea fermentation显示文摘 | R. Jayabalan S. Marimuthu K. Swaminathan | 2006 | Food Chemistry2006，，1： | 2 |
| 12 | CD133-Targeted Paclitaxel Delivery Inhibits Local Tumor Recurrence in a Mouse Model of Breast Cancer显示文摘 | Suresh Kumar Swaminathan Emilie Roger Udaya Toti Lin Niu John R. Ohlfest Jayanth Panyam | 2013 | Journal of Controlled Release2013，，： | 2 |
| 13 | Dynamo显示文摘 | Giuseppe DeCandia Deniz Hastorun Madan Jampani Gunavardhan Kakulapati Avinash Lakshman Alex Pilchin Swaminathan Sivasubramanian Peter Vosshall Werner Vogels | 2007 | ACM SIGOPS Operating Systems Review2007，，6： | 2 |
| 14 | Robust and secure image hashing 显示文摘 | SWAMINATHAN A MAO Y WU M | 2006 | IEEE Transactions on Information Forensics and Security2006，1，2： | 1 |
| 15 | CD209 gene polymorphisms in South Indian HIV and HIV - TB patients 显示文摘 | Selvaraj P Alagarasu K Swaminathan S | 2009 | Infect Genet Evol2009，9，2： | 1 |
| 16 | Robust and secure image hashing显示文摘 | SWAMINATHAN A MAO Yi-nian WU Min | 2006 | IEEE Trans on Information Forensics and Security2006，1，2： | 1 |
| 17 | Application of response surface methodology to evaluate the optimum environmental conditions for the enhanced production of surfactin显示文摘 | SEN R SWAMINATHAN TS | 1997 | Appi Microbiol Biotech1997，47，4： | 1 |
| 18 | In- creased thrombosis after arterial injury in human C-reac- tive protein-transgenic mice 显示文摘 | Danenberg HD Szalai AJ Swaminathan RV | 2003 | Circulation2003，108，5： | 1 |
| 19 | Modeling of simultaneous switching noise in high speed systems显示文摘 | Chun S Swaminathan M | 2001 | IEEE Transactions on Advanced Packaging2001，24，2： | 1 |
| 20 | Study of lactic acid extraction with higher molecular weight aliphatic amines显示文摘 | Choudhury B Basha A Swaminathan T | 1998 | J Chem Tech Biotechnol1998，72，： | 1 |
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