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| 1 | Evaluation of latent links between irritable bowel syndrome and sleep quality显示文摘AIM:To examine the links between quality of sleep and the severity of intestinal symptoms in irritable bow-el syndrome(IBS).METHODS:One hundred and forty-two outpatients(110female,32 male)who met the Rome Ⅲ criteria for IBS with no psychiatric comorbidity were consecutively en-rolled in this study.Data on age,body mass index(BMI),and a set of life-habit variables were recorded,and IBS symptoms and sleep quality were evaluated using the questionnaires IBS Symptom Severity Score(IBS-SSS)and Pittsburgh Sleep Quality Index(PSQI).The associa-tion between severity of IBS and sleep disturbances was evaluated by comparing the global IBS-SSS and PSQI score(Pearson's correlation and Fisher's exact test)and then analyzing the individual items of the IBS-SSS and PSQI questionnaires by a unitary bowel-sleep model based on item response theory(IRT).RESULTS:IBS-SSS ranged from mild to severe(120-470).The global PSQI score ranged from 1 to 17(median 5),and 60 patients were found to be poor sleepers(PSQI>5).The correlation between the global IBS-SSS and PSQI score indicated a weak association(r=0.2 and 95% CI:-0.03 to 0.35,P<0.05),which becomes stronger using our unitary model.Indeed,the IBS and sleep disturbances severities,estimated as latent variables,resulted significantly high intra-subject cor-relation(posterior mean of r=0.45 and 95% CI:0.17 to 0.70,P<0.05).Moreover,the correlations between patient features(age,sex,BMI,daily coffee and alcohol intake)and IBS and sleep disturbances were also ana-lyzed through our unitary model.Age was a signif icant regressor,with patients≤50 years old showing more severe bowel disturbances(posterior mean=-0.38,P<0.05)and less severe sleep disturbances(posterior mean=0.49,P<0.05)than older patients.Higher daily coffee intake was correlated with a lower sever-ity of bowel disturbances(posterior mean=-0.31,P<0.05).Sex(female)and daily alcohol intake(modest)were correlated with less severe sleep disturbances.CONCLUSION:The unitary bowel-sleep model based on IRT revealed a strong positive correlation between the severity of IBS symptoms and sleep disturbances. | Massimo Bellini Angelo Gemignani Dario Gambaccini Simona Toti Danilo Menicucci Cristina Stasi Francesco Costa Maria Gloria Mumolo Angelo Ricchiuti Remo Bedini Nicola de Bortoli Santino Marchi | 2011 | World Journal of Gastroenterology2011，17，46： | 17 |
| 2 | Complications of diagnostic and therapeutic ERCP: a prospective multicenter study显示文摘 | E Masci G Toti A Mariani S Curioni A Lomazzi M Dinelli G Minoli C Crosta U Comin A Fertitta A Prada G Rubis Passoni P.A Testoni | 2001 | The American Journal of Gastroenterology2001，，2： | 4 |
| 3 | De novo malignancies after liver transplantation: The effect of immunosuppression-personal data and review of literature显示文摘BACKGROUND Immunosuppression has undoubtedly raised the overall positive outcomes in the post-operative management of solid organ transplantation. However, long-term exposure to immunosuppression is associated with critical systemic morbidities. De novo malignancies following orthotopic liver transplants (OLTs) are a serious threat in pediatric and adult transplant individuals. Data from different experiences were reported and compared to assess the connection between immunosuppression and de novo malignancies in liver transplant patients. AIM To study the role of immunosuppression on the incidence of de novo malignancies in liver transplant recipients. METHODS A systematic literature examination about de novo malignancies and immunosuppression weaning in adult and pediatric OLT recipients was described in the present review. Worldwide data were collected from highly qualified institutions performing OLTs. Patient follow-up, immunosuppression discontinuation and incidence of de novo malignancies were reported. Likewise, the review assesses the differences in adult and pediatric recipients by describing the adopted immunosuppression regimens and the different type of diagnosed solid and blood malignancy.RESULTS Emerging evidence suggests that the liver is an immunologically privileged organ able to support immunosuppression discontinuation in carefully selected recipients. Malignancies are often detected in liver transplant patients undergoing daily immunosuppression regimens. Post-transplant lymphoproliferative diseases and skin tumors are the most detected de novo malignancies in the pediatric and adult OLT population, respectively. To date, immunosuppression withdrawal has been achieved in up to 40% and 60% of well-selected adult and pediatric recipients, respectively. In both populations, a clear benefit of immunosuppression weaning protocols on de novo malignancies is difficult to ascertain because data have not been specified in most of the clinical experiences. CONCLUSION The selected populations of tolerant pediatric and adult liver transplant recipients greatly benefit from immunosuppression weaning. There is still no strong clinical evidence on the usefulness of immunosuppression withdrawal in OLT recipients on malignancies. An interesting focus is represented by the complete reconstitution of the immunological pathways that could help in decreasing the incidence of de novo malignancies and may also help in treating liver transplant patients suffering from cancer. | Tommaso Maria Manzia Roberta Angelico Carlo Gazia Ilaria Lenci Martina Milana Oludamilola T Ademoyero Domiziana Pedini Luca Toti Marco Spada Giuseppe Tisone Leonardo Baiocchi | 2019 | World Journal of Gastroenterology2019，25，35： | 3 |
| 4 | Impact of immunosuppression minimization and withdrawal in long-term hepatitis C virus liver transplant recipients显示文摘AIM:To investigate the effects of different immunosuppressive regimens and avoidance on fibrosis progression in hepatitis C virus(HCV)liver transplant(LT)recipients.METHODS:We retrospectively compared the liver biopsies of well-matched HCV LT recipients under calcineurin inhibitors(CNI group,n=21)and mycophenolate(MMF group,n=15)monotherapy,with those patients who successfully withdrawn immunosuppression(IS)therapy from at least 3 years(TOL group,n=10).To perform the well-matched analysis,all HCV transplanted patients from December 1993 were screened.Only those HCV patients who reached the following criteria were considered for the analysis:(1)at least3 years of post-operative follow-up;(2)patients with normal liver graft function under low dose CNI monotherapy(CNI group);(3)patients with normal liver graft function under antimetabolite(Micophenolate Mofetil or coated mycophenolate sodium)monotherapy(MMF group);and(4)recipients with normal liver function without any IS.We excluded from the analysis recipients who were IS free or under monotherapy for<36 mo,recipients with cirrhosis or with unstable liver function tests.RESULTS:Thirty six recipients were enrolled in the study.Demographics,clinical data,time after LT and baseline liver biopsies were comparable in the three groups.After six years of follow-up,there was no worsening of hepatic fibrosis in the MMF group(2.5±1.5Ishak Units vs 2.9±1.7 Ishak Units,P=0.5)and TOL group(2.7±10.7 vs 2.5±1.2,P=0.2).In contrast,a significant increase in the fibrosis score was observed in the CNI group(2.2±1.7 vs 3.9±1.6,P=0.008).The yearly fibrosis progression rate was significantly worse in the CNI group(0.32±0.35)vs MMF group(0.03±0.31,P=0.03),and TOL group(-0.02±0.27,P=0.02).No differences have been reported in grading scores for CNI group(2.79±1.9,P=0.7),MMF group(3.2±1.5,P=0.9)and TOL group(3.1±1.4,P=0.2).Twenty four patients were treated with low dose ribavirin(8TOL,7 MMF,9 CNI).The hepatitis C titers were comparable in the three groups.No episodes of rejection have been reported despite differences of liver function test in the three groups during the observational period.CONCLUSION:IS withdrawal and MMF monotherapy is safe and seems to be associated with the slowest fibrosis progression in HCV LT recipients. | Tommaso Maria Manzia Roberta Angelico Paolo Ciano Jon Mugweru Kofi Owusu Daniele Sforza Luca Toti Giuseppe Tisone | 2014 | World Journal of Gastroenterology2014，20，34： | 3 |
| 5 | CD133-Targeted Paclitaxel Delivery Inhibits Local Tumor Recurrence in a Mouse Model of Breast Cancer显示文摘 | Suresh Kumar Swaminathan Emilie Roger Udaya Toti Lin Niu John R. Ohlfest Jayanth Panyam | 2013 | Journal of Controlled Release2013，，： | 2 |
| 6 | Volume changes of autogenous bone grafts after alveolar ridge augmentation of atrophic maxillae and mandibles显示文摘 | SBORDONE L TOTI P MENCHINI-FABRIS G B | 2009 | Int J Oral Maxillofac Surg2009，38，10： | 1 |
| 7 | Liver Transplantation in the Presence of Portal Vein Thrombosis : Report From a Single Center 显示文摘 | Orlando G Luca LD Toti L | 2004 | Transplantation Proceedings2004，36，： | 1 |
| 8 | Orbital solitary fibrous tumor with aggressive behavior:Three cases and review of the literature显示文摘 | Polito E Tosi M Toti P | 2002 | Graefes Arch Clin Exp Ophthalmol2002，240，7： | 1 |
| 9 | The subretinal fluid in retinal detachment显示文摘 | Toti P Morocutti A Sforzi C | | 0，，： | 1 |
| 10 | Thromhin regulates soluble fms-like tyrosine kinase-1 (sFIt-l) expression in first trimester decidua: implications for preeclampsia显示文摘 | Lockwood CJ Toti P Arcuri F | 2007 | AmJ Pathol2007，170，4： | 1 |
| 11 | Human placenta and fetal membranes express nerve growth factor mRNA and protein 显示文摘 | Toti P Ciarmela P Florio P | 2006 | Endocrinol Invest2006，，29： | 1 |
| 12 | Ecology, metabolite production and substrate utilization in endophytic fungi 显示文摘 | Petrini O Sieber T N Toti L | 1992 | Nat Toxins1992，，1： | 1 |
| 13 | Electrospun nanofibers scMfolds: engineering soft tissues 显示文摘 | James R Toti US Laurencin CT | 2011 | Methods Mol Biol2011，726，： | 1 |
| 14 | Different viscosity grade sodium alginate and modified sodium alginatemembranes in pervaporation separation of water + acetic acid and water+ isopropanol mixtures显示文摘 | Toti U S Aminabhavi T M | 2004 | J Membr Sei2004，228，2： | 1 |
| 15 | Procoagulant microparticles:(c)riminal partners'in atherothrombosis and deleterious cellular exchanges显示文摘 | Morel O Toti F Bakouboula B | 2006 | Pathophysiol Haemost Thromb2006，35，12： | 1 |
| 16 | Complications of diagnostic and therapeutic ERCP: a prospective multicenter study显示文摘 | E Masci G Toti A Mariani S Curioni A Lomazzi M Dinelli G Minoli C Crosta U Comin A Fertitta A Prada G Rubis Passoni P.A Testoni | 2001 | The American Journal of Gastroenterology2001，，2： | 1 |
| 17 | A quantitative risk assessment approach for mosquito-borne diseases: malaria re- emergence in southern France显示文摘 | Poncon N Tran A Toty C | 2008 | Malar J2008，7，： | 1 |
| 18 | Efficacy and side effects of praziquantel against Schistosoma mansoni in a community of western C?te d’Ivoire显示文摘 | Giovanna Raso Eliézer K N'Goran Abale Toty Anne Luginbühl Cynthia A Adjoua Norbert T Tian-Bi Isaac I Bogoch Penelope Vounatsou Marcel Tanner Jürg Utzinger | 2003 | Transactions of the Royal Society of Tropical Medicine and Hygiene2003，，1： | 1 |
| 19 | Differential regulation of colony stimulating factor 1 and macrophage migration inhibitory fac- tor expression by inflammatory cytokines in term human decidua: implications for macrophage trafficking at the fetal-maternal inter- face 显示文摘 | Arcuri F Buchwalder L Toti P | 2007 | Biol Reprod2007，76，3： | 1 |
| 20 | Procoagulant microparticles : disrup- ting the vascular homeostasis equation? 显示文摘 | Morel O Toti F Hugel B | 2006 | Arterioscler Thromb Vase Biol2006，26，12： | 1 |
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