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| 1 | The effects of probiotics administration on the milk production,milk components and fecal bacteria microbiota of dairy cows显示文摘Probiotics administration can improve host health.This study aims to determine the effects of probiotics(Lactobacillus casei Zhang and Lactobacillus plantarum P-8) administration on milk production,milk functional components,milk composition,and fecal microbiota of dairy cows.Variations in the fecal bacteria microbiota between treatments were assessed based on 16 S rRNA profiles determined by Pac Bio single molecule real-time sequencing technology.The probiotics supplementation significantly increased the milk production and the contents of milk immunoglobulin G(IgG),lactoferrin(LTF),lysozyme(LYS)and lactoperoxidase(LP),while the somatic cell counts(SCC) significantly decreased(P < 0.01).However,no significant difference was found in the milk fat,protein and lactose contents(P > 0.05).Although the probiotics supplementation did not change the fecal bacteria richness and diversity,significantly more rumen fermentative bacteria(Bacteroides,Roseburia,Ruminococcus,Clostridium,Coprococcus and Dorea) and beneficial bacteria(Faecalibacterium prausnitzii) were found in the probiotics treatment group.Meanwhile,some opportunistic pathogens e.g.Bacillus cereus,Cronobacter sakazakii and Alkaliphilus oremlandii,were suppressed.Additionally,we found some correlations between the milk production,milk components and fecal bacteria.To sum up,our study demonstrated the beneficial effects of probiotics application in improving the quality and quantity of cow milk production. | Haiyan Xu Weiqiang Huang Qiangchuan Hou Lai-yu Kwok Zhihong Sun Huimin Ma Feiyan Zhao Yuan-Kun Lee Heping Zhang | 2017 | Science Bulletin2017，62，11： | 21 |
| 2 | Effect of dietary interventions on the intestinal microbiota of Mongolian hosts显示文摘The gut microbiota of Mongolian hosts has distinctive characteristics due to their meat- and dairyoriented daily diets and unique genotype.The aim of the present study was to investigate the effect of switching from the typical high protein and fat Mongolian diets to carbohydrate-rich meals composed principally of wheat,rice and naked oats on the host gut microbiota within 3 weeks.Our study took the advantage of the long sequence reads produced by the Pac Bio single molecule real-time sequencing technology to enable the profiling of subjects' gut microbiota communities along the diet intervention to the species precision.We found that the bacterial richness and diversity decreased apparently along the diet intervention.During the diet intervention,the gut microbiota composition displayed no significant difference at phylum level(with major phyla of Firmicutes,Bacteroidetes,Tenericutes and Proteobacteria).The relative abundances of some genera such as Bacteroidetes,Faecalibacterium,Roseburia,Alistipes,Streptococcus,and Oscillospira were significantly altered after the diet switching started.Notably,significant changes were also observed in the proportions of the species Bacteroides dorei,Bacteroides fragilis,Bacteroides thetaiotaomicron,Ruminococcus albus,Ruminococcus faecis,Roseburia faecis and Eubacterium ventriosum.These results have demonstrated that diet and host gut microbiota is closely linked. | Jing Li Haiyan Xu Zhihong Sun Qiangchuan Hou Lai-Yu Kwok Wuri Laga Yanjie Wang Huimin Ma Zhongjie Yu Bilige Menghe Heping Zhang | 2016 | Science Bulletin2016，61，20： | 14 |
| 3 | Large-field high-resolution two-photon digital scanned light-sheet microscopy显示文摘 | Weijian Zong Jia Zhao Xuanyang Chen Yuan Lin Huixia Ren Yunfeng Zhang Ming Fan Zhuan Zhou Heping Cheng Yujie Sun Liangyi Chen | 2015 | Cell Research2015，25，2： | 12 |
| 4 | Experimental detection of the inner core translational triplet显示文摘The translational oscillation of the solid inner core is one of the Earth’s fundamental normal modes, which is also called Slichter mode. The normal mode should be split to form a triplet due to the Earth’s rotation and ellipticity. In this study, according to the splitting pattern of Slichter mode, an attempt has been made to detect the possibility of Slichter triplet’s existence by using the product spectra of the long-term continuous gravity measurements from the superconducting gravimeters (SG) at 6 glob- ally-distributed permanent stations in the Global Geodynamics Projects network. The results indicate that the background noise level of the global SG observations is 0.0158 nm s–2 and the magnitude threshold of any global harmonic signals, which may be detected by the global SG, is 0.0152 nm s–2 in the subtidal frequency band from 0.162 to 0.285 cph in which Slichter triplet may occur. it implies that the signatures, related to the triplet, may be identified in the global SG observations, if they exist. It is found that there is a group of global harmonic signatures with the periods of 5.310, 4.995 and 4.344 h emerging significantly from the background noise in the global SG observations. They are in good agreement with the splitting pattern of Slichter mode. It implies that this group of signatures may be related to the inner core translational oscillations. The associated density contrast across the inner core boundary may be deduced as between the values provided in the Earth models of the PREM and 1066 A. | XU JianQiao SUN HePing ZHOU JiangCun | 2010 | Chinese Science Bulletin2010，55，3： | 9 |
| 5 | Constraining the focal mechanism of the Lushan earthquake with observations of the Earth's free oscillations显示文摘The amplitudes of the Earth's free oscillations have a close relationship to earthquake focal mechanisms. Focal mechanisms of large earthquakes can be well analyzed and constrained with observations of long period free oscillations. Although the 2013 Lushan earthquake was only moderately sized, observable spherical normal modes were excited and clearly observed by a superconductive gravimeter and a broadband seismometer. We compare observed free oscillations with synthetic normal modes corresponding to four different focal mechanisms for the Lushan earthquake. The results show that source parameters can be analyzed and constrained by spherical normal modes in a 2.3–5 mHz frequency band. The scalar seismic moment M0 has a major influence on the amplitudes of free oscillations; additionally, the strike, dip, rake and depth of the hypocenter have minor influences. We found that the synthetic modes corresponding to the focal mechanism determined by the Global Centroid Moment Tensor show agreement to the observed modes, suggesting that earthquake magnitudes predicted in this way can readily reflect the total energy released by the earthquake. The scalar seismic moment obtained by far-field body wave inversion is significantly underestimated. Focal mechanism solutions can be improved by joint inversion of far- and near-field data. | JIANG Ying HU XiaoGang LIU ChengLi SUN HePing | 2014 | Science China Earth Sciences2014，57，9： | 8 |
| 6 | Changes in the thermodynamic properties of alkaline granite after cyclic quenching following high temperature action显示文摘During the development of hot dry rock,the research on thermal fatigue damage caused by thermal shock of cold and heat cycles is the basis that ensures the long-term utilization of geothermal resources,but there are not enough relevant studies at present.Based on this,the thermal damage tests of granite at different temperatures(250,350,450°C)and quenching cycles(1,5,10,15 cycles)were carried out.Preliminary reveals the damage mechanism and heat transfer law of the quenching cycle effect on hot dry rock.The results show that with the increase of temperature and cycles,the uneven thermal expansion of minerals and the thermal shock caused by quenching promote the crack development of granite,resulting in the decrease of P-wave velocity,thermal conductivity and uniaxial compressive strength of granite.Meanwhile,the COMSOL was used to simulate the heat transfer of hot dry rock under different heat treatment conditions.It concluded that the increase in the number of quenching cycles reduced the heat transfer capacity of the granite,especially more than 10 quenching cycles,which also reflects that the thermal fatigue damage leads to a longer time for the temperature recovery of the hot dry rock mass.In addition,the three-dimensional nonlinear fitting relationship among thermal conductivity,temperature and cycle number was established for the first time,which can better reveal the change rule of thermal conductivity after quenching thermal fatigue effect of hot dry rock.The research results provide theoretical support for hot dry rock reservoir reconstruction and production efficiency evaluation. | Jianjun Hu Heping Xie Qiang Sun Cunbao Li Guikang Liu | 2021 | International Journal of Mining Science and Technology2021，31，5： | 8 |
| 7 | Study on characteristics of long-term gravity changes at Wuhan station显示文摘We consider the characteristics of long-term changes in non-tidal gravity and their implication to the local perturbations in barometric pressure and water storage and to the local vertical crustal movement using the long-term continuous gravity observations from a superconducting gravimeter (SG) at Wu-han station,together with the co-site measurements from a Global Positioning System (GPS) receiver and an absolute gravimeter FG5. The observation results indicate that there are obvious seasonal variations in the long-term gravity changes measured with the SG. About 70 percent of the whole sea-sonal changes come from the contribution of the local disturbances in air pressure and water storage,while over 95 percent of the annual changes are attributed to the loading effects of these environmental perturbations. Due to the absence of direct measurements of the local water storage,especially those of the underground water,the global assimilating models of land water LaD (Land Dynamics) and GLDAS (Global Land Data Assimilation System) cannot virtually describe the real hydrologic distur-bances around the station. The resulting gravity changes,which are simulated theoretically by means of convolution integration of the loading Green’s functions and water models LaD and GLDAS,show significantly time delay of about 55 days from those measured with the SG. Compared with the meas-urements of the absolute gravity with the FG5,the long-term drift rate of the SG is determined as about 17.13 nms-2/a. From the co-site GPS measurements,it is found that the local crust is slowly subsiding at a rate of 3.71±0.16 mm/a,and the related gravity variation is estimated as 13.88±0.22 nms-2/a. In other words,the ratio of the changes in gravity and altitude related to the local vertical crustal movement is about -37.41 nms-2/cm. It implies that a considerable mass adjustment may be associated with the local vertical crustal movement,and its dynamic mechanism should be investigated further. | XU JianQiao ZHOU JiangCun LUO ShaoCong SUN HePing | 2008 | Chinese Science Bulletin2008，53，13： | 8 |
| 8 | Geodesy Discipline: Progress and Perspective显示文摘The geodesy discipline has been evolving and constantly intersecting and merging with other disciplines in the last 50 years,due to the continuous progress of geodetic observation techniques and expansion of application fields.This paper first introduces the development and roles of geodesy and its formation.Secondly,the development status of geodesy discipline is analyzed from the progress of observation techniques and cross-discipline formation is analyzed from the expansion of application fields.Furthermore,the development trend of geodesy is stated from the perspective of national requirements and scientific developments.Finally,the sub-disciplines for geodesy are suggested at the present stage,based on the requirements of the National Natural Science Foundation of China and development status of geodesy itself,which can provide references for topic selection and fund application of geodetic scientific research. | Yibin YAO Yuanxi YANG Heping SUN Jiancheng LI | 2021 | Journal of Geodesy and Geoinformation Science2021，4，4： | 8 |
| 9 | Antigenic analysis of grass carp reovirus using single-chain variable fragment antibody against IgM from Ctenopharyngodon idella显示文摘Grass carp (Ctenopharyngodon idella) is an important species of freshwater aquaculture fish in China. However, grass carp reovirus (GCRV) can cause fatal hemorrhagic disease in yearling populations. Until now, a strategy to define the antigenic capacity of the virus's structural proteins for preparing an effective vaccine has not been available. In this study, some single-chain variable fragment antibodies (scFv), which could specifically recognize grass carp IgM, were selected from a constructed mouse na ve antibody phage display cDNA library. The identified scFv C1B3 clone was shown to possess relatively higher specific binding activity to grass carp IgM. Furthermore, ELISA analysis indicated that the IgM level in serum from virus-infected grass carp was more than two times higher than that of the control group at 5-7 days post infection. Moreover, Western blot analysis demonstrated that the outer capsid protein VP7 has a specific immuno-binding-reaction with the serum IgM from virus-infected grass carp. Our results suggest that VP7 can induce a stronger immune response in grass carp than the other GCRV structural proteins, which implies that VP7 protein could be used as a preferred immunogen for vaccine design. | CHEN CongLin SUN XiaoYun LIAO LanJie LUO ShaoXiang LI ZhouQuan ZHANG XiaoHua WANG YaPing GUO QionLin FANG Qin DAI HePing | 2013 | Science China(Life Sciences)2013，56，1： | 6 |
| 10 | Attitude control for QTR using exponential nonsingular terminal sliding mode control显示文摘For the problem of attitude control of a quad tilt rotor aircraft with unknown external disturbances, a class of control methods based on a new exponential fast nonsingular terminal sliding surface, a new fast reaching law, and a super twisting sliding mode disturbance observer is investigated. First, the new exponential nonsingular terminal sliding surface is designed by using the advantages of nonsingular terminal sliding mode finite time convergence and strong robustness. Second, to solve the problem of a long convergence time and the serious shaking of the traditional reaching law, a new fast reaching law model with characteristics of the second-order sliding mode is put forward. Third,considering the existence of complex disturbances, the super twisting sliding mode disturbance observer is used to estimate and compensate the composite disturbances online. Finally, compared with the traditional nonsingular fast sliding mode control, simulation results show that the proposed control scheme achieves a good control performance. | LIU Haibo WANG Heping SUN Junlei | 2019 | Journal of Systems Engineering and Electronics2019，30，1： | 5 |
| 11 | Characteristics of tidal gravity changes in Lhasa,Tibet,China显示文摘Tidal gravity changes arise from the response of the solid Earth to the tidal forces of the Sun,Moon and planets close to the Earth,and are a comprehensive reflection of the structure and distribution of physical properties of the Earth's interior.As a result,observations of tidal gravity changes are the basis of studies on other global and/or regional dynamic processes.The characteristics of tidal gravity changes in the region of the Tibetan Plateau were investigated through continuous gravity measurements recorded with a superconducting gravimeter (SG) installed in Lhasa over a year.Through contrast measurements with a spring gravimeter LaCoste-Romberg ET20 at the same site,the gravity observations in Lhasa were scaled to the international tidal gravity reference in Wuhan.Meanwhile,the scale factor of the SG was determined accurately as-777.358 ± 0.136 nm s-2V-1,which is about 2.2% less than the value provided by the manufacturer.The results indicate that the precision of the tidal gravity observations made with the SG in Lhasa was very high.The standard deviation was 0.459 nm s-2,and the uncertainties of for the four main tidal waves (i.e.O 1,K 1,M 2 and S 2) were better than 0.006%.In addition,the observations of the diurnal gravity tides had an obvious pattern of nearly diurnal resonance.As a result,it is affirmed that the Lhasa station can provide a local tidal gravity reference for gravity measurements on the Tibetan Plateau and its surrounding regions.The loading effects of oceanic tides on tidal gravity observations in Lhasa are so weak that the resulting perturbations in the gravimetric factors are less than 0.6%.However,the loading effects of the local atmosphere on either the tidal or nontidal gravity observations are significant,although no seasonal variations were found.After removal of the atmospheric effects,the standard deviation of the SG observations in Lhasa decreased obviously from 2.009 to 0.459 nm s-2.Having removed the loading effects of oceanic tides and local atmosphere,it was found that the tidal gravity observations made with the SG in Lhasa significantly differed by about 1% from those expected theoretically,which may be related to active tectonic movement and the extremely thick crust in the region of the Tibetan Plateau.A more-certain conclusion requires longer accumulation of SG data and further associated theoretical studies. | XU JianQiao CHEN XiaoDong ZHOU JiangCun SUN HePing | 2012 | Chinese Science Bulletin2012，57，20： | 5 |
| 12 | Check of free oscillation signal with SG data显示文摘The observation of the Earth’s free oscillation is an important way to study the Earth’s inner structure and geophysical parameters. Many geophysicists have investigated the Earth’s normal modes with strainmeters and spring gravimeters. Since the superconducting gravimeters appeared, people have gained a new kind of more stable instruments to detect the normal modes. The measurement for the Earth’s free oscillation with the superconducting gravimeters is one of the main goals of the Global Geodynamics Project. In this note, we have investigated the Earth’s normal modes excited by Peru Ms 7.9 Earthquake on June 23, 2001 with the superconducting gravimeter C032 at the Wuhan station. After having completed the subtraction of gravity tides with the 20th order polynomial fitting, and the correction for pressure and the analysis of the noise spectrum of the superconducting gravimeter, we accurately observed all base normal modes from 0S0 to 0S32 and the splittings of 0S2 and 0S3. Those results show a good | Xiang’e Lei Houze Xu Heping Sun | 2002 | Chinese Science Bulletin2002，47，18： | 4 |
| 13 | Detection of spheriodal free oscillation excited by Peru 8.2 M_(s) earthquake with five international superconducting gravimeter data显示文摘In this paper, authors obtain the spectral peaks of the earth free oscillation and check all normal modes from 0S0 to 0S48 accurately, with the Fourier analysis and the maximum entropy spectrum method dealing jointly with six groups of the observational residual data from five international superconducting gravimeter stations. By comparing the observational results in this paper with three former groups of observations or models, authors notice an extra discrepancy between two observational 0S2 modes excited separately by Peru earthquake and Alaska earthquake, which probably mirrors the anisotropy of the Earth's inner core. The analysis on the splitting 1S2 mode shows that the asymmetric factor of rotationwise spectral splitting is possible to be different from that of anti-rotationwise spectral splitting. | LEI Xiang'e XU Houze SUN Heping | 2005 | Science China Earth Sciences2005，48，1： | 4 |
| 14 | Diversity of lactic acid bacteria and yeasts in traditional sourdoughs collected from western region in Inner Mongolia of China显示文摘 | Jiachao Zhang Wenjun Liu Zhihong Sun Qiuhua Bao Fang Wang Jie Yu Wei Chen Heping Zhang | 2010 | Food Control2010，，5： | 4 |
| 15 | A survey on chemical and microbiological composition of kurut, naturally fermented yak milk from Qinghai in China显示文摘 | Heping Zhang Jie Xu Junguo Wang Menghebilige Tiansong Sun Haiping Li Mingruo Guo | 2007 | Food Control2007，，6： | 3 |
| 16 | Observation and research of deep underground multi-physical fields—Huainan–848 m deep experiment显示文摘Compared with the surface,the deep environment has the advantages of allowing“super-quiet and ultra-clean”-geophysical field observation with low vibration noise and little electromagnetic interference,which are conducive to the realization of long-term and high-precision observation of multi-physical fields,thus enabling the solution of a series of geoscience problems.In the Panyidong Coal Mine,where there are extensive underground tunnels at the depth of 848 m below sea level,we carried out the first deep-underground geophysical observations,including radioactivity,gravity,magnetic,magnetotelluric,background vibration and six-component seismic observations.We concluded from these measurements that(1)the background of deep subsurface gravity noise in the long-period frequency band less than 2 Hz is nearly two orders of magnitude weaker than that in the surface observation environment;(2)the underground electric field is obviously weaker than the surface electric field,and the relatively high frequency of the underground field,greater than 1 Hz,is more than two orders of magnitude weaker than that of the surface electric field;the east-west magnetic field underground is approximately the same as that at the surface;the relatively high-frequency north-south magnetic field underground,below 10 Hz,is at least one order of magnitude lower than that at the surface,showing that the underground has a clean electromagnetic environment;(3)in addition to the highfrequency and single-frequency noises introduced by underground human activities,the deep underground space has a significantly lower background vibration noise than the surface,which is very beneficial to the detection of weak earthquake and gravity signals;and(4)the underground roadway support system built with ferromagnetic material interferes the geomagnetic field.We also found that for deep observation in the“ultra-quiet and ultra-clean”environment,the existing geophysical equipment and observation technology have problems of poor adaptability and insufficient precision as well as data cleaning problems,such as the effective separation of the signal and noise of deep observation data.It is also urgent to interpret and comprehensively utilize these high-precision multi-physics observation data. | Yun WANG Yaxin YANG Heping SUN Chengliang XIE Qisheng ZHANG Xiaoming CUI Chang CHEN Yongsheng HE Qiangqiang MIAO Chaomin MU Lianghui GUO Jiwen TENG | 2023 | Science China Earth Sciences2023，66，1： | 3 |
| 17 | Temporal variations in free core nutation period显示文摘Based on the nearly diurnal resonance in the tidal gravity observations,the temporal variations in period of the Earth's free core nutation (FCN) are investigated by using the tidal gravity observations of 18-year duration recorded continu-ously with a superconducting gravimeter (SG) at Brussels. The effects of the global oceanic tide loading and local barometric pressure on the SG observations have been removed by using eleven high-precision global digital models of oceanic tides and barometric pressure measurements recorded simultaneously at the same site. The results indicate that there exist decade-scale variations in the FCN period. The results should be further confirmed by the measurements using other space-based geodetic techniques (such as the very long baseline interferometry) and the SG observations from globally distributed stations. | Jianqiao Xu Heping Sun | 2009 | Earthquake Science2009，22，4： | 3 |
| 18 | Mid-infrared photon counting and resolving via efficient frequency upconversion显示文摘Optical detectors with single-photon sensitivity and large dynamic range would facilitate a variety of applications.Specifically,the capability of extending operation wavelengths into the mid-infrared region is highly attractive.Here we implement a mid-infrared frequency upconversion detector for counting and resolving photons at 3μm.Thanks to the spectrotemporal engineering of the involved optical fields,the mid-infrared photons could be spectrally translated into the visible band with a conversion efficiency of 80%.In combination with a silicon avalanche photodiode,we obtained unprecedented performance with a high overall detection efficiency of 37%and a low noise equivalent power of 1.8×10^(-17) W∕Hz1∕2.Furthermore,photon-number-resolving detection at mid-infrared wavelengths was demonstrated,for the first time to our knowledge,with a multipixel photon counter.The implemented upconversion detector exhibited a maximal resolving photon number up to 9 with a noise probability per pulse of 0.14%at the peak detection efficiency.The achieved photon counting and resolving performance might open up new possibilities in trace molecule spectroscopy,sensitive biochemical sensing,and free-space communications,among others. | KUN HUANG YINQI WANG JIANAN FANG WEIYAN KANG YING SUN YAN LIANG QIANG HAO MING YAN HEPING ZENG | 2021 | Photonics Research2021，9，2： | 2 |
| 19 | Application of superconductive gravity technique on the constraints of core-mantle coupling parameters显示文摘The parameters, i.e. the Period and the Quality factor, of the Earth's free core nutation (FCN) are closely related to the dissipative coupling between the core and the mantle. Based on the FCN parameters obtained from the actual observations and theoretical simulation, significantly constrained in this study were several key parameters near the core-mantle boundary (CMB), related to the core and mantle coupling, including viscosity at the top of liquid core, conductivity at the bottom of the mantle, and dynamic ellipticity of the CMB. In order to choose high quality observations from global stations of the superconducting gravimeters (SG) on the Global Geodynamics Project (GGP) network, we adopted two criteria, the standard deviations of harmonic analysis on tidal observations and the quality of the FCN parameters calculated with the observations from single station. After the mean ocean tidal effects of the recent ocean tidal models were removed, the FCN parameters were retrieved by stacking the tidal gravity observations from the GGP network. The results were in a good agreement with those in the recent research by using the SG and/or the VLBI observations. Combined with an FCN theoretical model deduced by angular momentum method, the viscous and electromagnetic coupling parameters near the CMB were evaluated. Numerical results indicated that the viscosity at the top of the liquid core was in the range from 6.6×102 to 2.6×103 Pa·s, which was in good agreement with those obtained from the Earth's nutation, the FCN and variations in the length of day (LOD). The conductivity at the bottom of the mantle should be as large as 2.6×106-1.0×107 S m-1 to match the FCN quality factors from the actual observations. The dissipative coupling had a little influence of 1-2 sidereal days for the FCN period. | CUI XiaoMing SUN HePing XU JianQiao ZHOU JiangCun | 2012 | Science China Earth Sciences2012，55，3： | 2 |
| 20 | Isolation and identification of lactic acid bacteria from Tarag in Eastern Inner Mongolia of China by 16S rRNA sequences and DGGE analysis显示文摘 | Wenjun Liu Qiuhua Bao Jirimutu Manjun Qing Siriguleng Xia Chen Ting Sun Meihua Li Jiachao Zhang Jie Yu Menghe Bilige Tiansong Sun Heping Zhang | 2011 | Microbiological Research2011，，2： | 2 |
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