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| 1 | Enhancement of acellular cartilage matrix scaffold by Wharton’s jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration显示文摘Articular cartilage defect repair is a problem that has long plagued clinicians.Although mesenchymal stem cells(MSCs)have the potential to regenerate articular cartilage,they also have many limitations.Recent studies have found that MSC-derived exosomes(MSC-Exos)play an important role in tissue regeneration.The purpose of this study was to verify whether MSC-Exos can enhance the reparative effect of the acellular cartilage extracellular matrix(ACECM)scaffold and to explore the underlying mechanism.The results of in vitro experiments show that human umbilical cord Wharton’s jelly MSC-Exos(hWJMSC-Exos)can promote the migration and proliferation of bone marrow-derived MSCs(BMSCs)and the proliferation of chondrocytes.We also found that hWJMSC-Exos can promote the polarization of macrophages toward the M2 phenotype.The results of a rabbit knee osteochondral defect repair model confirmed that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration.We demonstrated that hWJMSC-Exos can regulate the microenvironment of the articular cavity using a rat knee joint osteochondral defect model.This effect was mainly manifested in promoting the polarization of macrophages toward the M2 phenotype and inhibiting the inflammatory response,which may be a promoting factor for osteochondral regeneration.In addition,microRNA(miRNA)sequencing confirmed that hWJMSC-Exos contain many miRNAs that can promote the regeneration of hyaline cartilage.We further clarified the role of hWJMSC-Exos in osteochondral regeneration through target gene prediction and pathway enrichment analysis.In summary,this study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. | Shuangpeng Jiang Guangzhao Tian Zhen Yang Xiang Gao Fuxin Wang Juntan Li Zhuang Tian Bo Huang Fu Wei Xinyu Sang Liuqi Shao Jian Zhou Zhenyong Wang Shuyun Liu Xiang Sui Quanyi Guo Weimin Guo Xu Li | 2021 | Bioactive Materials2021，6，9： | 11 |
| 2 | Progress of regional oceanography study associated with western boundary current in the South China Sea显示文摘Recent progress of physical oceanography in the South China Sea (SCS) associated with the western boundary current (WBC) and eddies is reviewed in this paper. It includes Argo observations of the WBC, eddy detection in the WBC based on satellite images, cross-continental shelf exchange in the WBC, eddy-current interaction, interannual variability of the WBC, air-sea interaction, the SCS throughflow (SCSTF), among others. The WBC in the SCS is strong, and its structure, variability and dynamic processes on seasonal and interannual time scales are yet to be fully understood. In this paper, we summarize progresses on the variability of the WBC, eddy-current interaction, air-sea interaction, and the SCSTF achieved in the past few years. Firstly, using the drifting buoy observations, we point out that the WBC becomes stronger and narrower after it reaches the central Vietnam coast. The possible mechanisms influencing the ocean circulation in the northern SCS are discussed, and the dynamic mechanisms that induce the countercurrent in the region of northern branch of WBC in winter are also studied quantitatively using momentum balance. The geostropic component of the WBC was diagnosed using the ship observation along 18°N, and we found that the WBC changed significantly on interannual time scale. Secondly, using the ship observations, two anti-cyclonic eddies in the winter of 2003/2004 in the northern SCS, and three anti-cyclonic eddies in the summer of 2007 along 18°N were studied. The results show that the two anti-cyclonic eddies can propagate southwestward along the continental shelf at the speed of first Rossby wave (~0.1 ms-1 ) in winter, and the interaction between the three anti-cyclonic eddies in summer and the WBC in the SCS is preliminarily revealed. Eddies on the continental shelf of northern SCS propagated southeastward with a maximum speed of 0.09 ms-1 , and those to the east of Vietnam coast had the largest kinetic energy, both of which imply strong interaction between eddy activity and WBC in the SCS. Thirdly, strong intraseasonal variability (ISV) of sea surface temperature (SST) near the WBC regions was found, and the ISV signal of SST in winter weakens the ISV signal of latent heat flux by 20%. Fourthly, the long-term change of SCSTF volume transport and its connection with the ocean circulation in the Pacific were discussed. | WANG DongXiao LIU QinYan XIE Qiang HE ZhiGang ZHUANG Wei SHU YeQiang XIAO XianJun HONG Bo WU XiangYu SUI DanDan | 2013 | Chinese Science Bulletin2013，58，11： | 10 |
| 3 | Involvement of the ipsilateral and contralateral cerebellum in the acquisition of unilateral classical eyeblink conditioning in guinea pigs显示文摘 | Bo HU Xi LIN Lü-shuai HUANG Li YANG Hua FENG Jian-feng SUI | 2009 | Acta Pharmacologica Sinica2009，30，2： | 4 |
| 4 | Balancing the anionic framework polarity for enhanced thermoelectric performance in YbMg_(2)Sb_(2) Zintl compounds显示文摘1-2-2-type Zintl phase compound has aroused great interest for potential thermoelectric applications.However,YbMg_(2)Sb_(2) is seldom studied due to the very low electrical conductivity resulting from the large difference in the electronegativity between Mg and Sb.In this paper,we adjust the covalently bonded network of MgeSb by replacing part of the Mg with Zn which has the electronegativity closer to that of Sb.The decreased polarity in the anionic framework offers more free distance for electrons for the enhanced Hall mobility and electrical conductivity.Together with the increased point defect and the decreased lattice thermal conductivity by introduction of Zn,the maximum ZT value of ~0.8 at 773 K is achieved in YbMg_(0.9)Zn_(1.1)Sb_(2) which is~100% enhancement compared with that of YbMg_(2)Sb_(2). | Zongwei Zhang Xinyu Wang Yijie Liu Chen Chen Honghao Yao Li Yin Xiaofang Li Shan Li Fan Zhang Fengxian Bai Jiehe Sui Bo Yu Feng Cao Xingjun Liu Jun Mao Guoqiang Xie Qian Zhang | 2019 | Journal of Materiomics2019，5，4： | 3 |
| 5 | Hardware Design and Test of a Gear-Shifting Control System of a Multi-gear Transmission for Electric Vehicles显示文摘The performance of electric vehicles is affected by the shift quality of multi-gear transmission.The realization of dual-target tracking control requires the transmission control unit(TCU)to accurately measure and process the input signals of the gear-shifting control system and precisely control the drive motor torque and the position of shift motors.An electric-vehicle-dedicated TCU was designed to meet the above design requirements.Its function modules included a single-chip control circuit,shift position signal sampling circuit,signal conditioning circuit of the rotational speed and angle,controller area network communication circuit,and shift motor drive circuit.A hardware-in-the-loop simulation test system showed that the TCU design scheme met measurement accuracy requirements and coordinated the actions of the shift actuator and motor control unit to achieve fast and smooth shifting before the road test.The power interruption time of the shifting process was within 350 ms.The reliability of the TCU design was further verified in a 150,000-km vehicle road test. | Feng Tian Liqi Sui Yuanfan Zeng Bo Li Xingyue Zhou Lijun Wang Hongxu Chen | 2019 | Automotive Innovation2019，2，3： | 3 |
| 6 | Long-term clinical outcomes of patients with unprotected left main bifurcation lesions treated with 2-stent techniques显示文摘 | PEI Han-jun SUI Yong-gang WU Yong-jian YANG Yue-jin XU Bo CHEN Ji-lin QIAO Shu-bin LI Jian-jun Q1N Xue-wen YAO 1Vlin YUAN Jin-qing CHEN Jue LIU Hai-bo YOU Shi-jie GAO Run-lin | 2013 | Chinese Medical Journal2013，，13： | 2 |
| 7 | A comparison of the spontaneous firing patterns between principal cells and fast spiking interneurons from dentate gyrus in waking guinea pigs显示文摘Objective To explore the possible mechanisms that cause the dentate gyrus (DG) neurons to play different roles in information coding. Methods In vivo extracellular single unit recording was performed on 22 waking female guinea pigs, which were positioned in a sound-attenuated recording chamber without any muscular relaxants. The spontaneous firing patterns of the DG neurons were detected and compared. Results There were two different electrophysiological populations in the DG of guinea pigs, principal cells (PCs) and fast spiking interneurons (INs). Of the PCs, 1.3% discharged regularly, 48.1% irregularly and 50.6% in bursts; in contrast, of the INs units, 64.1% discharged regularly, 2.6% irregularly and 33.3% in bursts. The spontaneous firing patterns of PCs were significantly different from those of INs (P<0.01). In addition, the differences of several interspike interval (ISI) parameters also have been observed: (1) the ISI coefficients of variation of PCs (3.39±3.56) were significantly higher than those of INs (1.08±0.46) (P<0.01); (2) the ISI asymmetric indexes of PCs (0.047±0.059) were significantly lower than those of INs (0.569±0.238) (P<0.01). Conclusion In the DG, the spontaneous firing patterns of PCs were significantly different from those of INs. The former were prone to fire in bursts, the latter were prone to fire regularly. The different roles in information coding between PCs and INs might be caused by their different firing patterns. | Bo HU Li YANG Wei HUANG Jian-Feng SUI | 2006 | Neuroscience Bulletin2006，22，1： | 2 |
| 8 | Immunogenicity and Efficacy of Liposome-encapsulated Influenza Split Vaccine in BALB/c Mice显示文摘The cellular immunity of current influenza split vaccine is relatively low. It is necessary to develop a novel vaccine to improve the cellular immunity. Thes of this study prepared liposome-encapsulated influenza split vaccine and tested it in BALB/c mice. The mice were immunized once with 4 μg of haemagglutinin of monovalent A/New Caledonia/20/99(H1N1) encapsulated with liposomes or the split virus vaccine only through intrastomach injection. In a comparative study, it was observed that the liposome-encapsulated vaccine elicited a higher neutralizing antibody response, more effectively stimulated spleen cell proliferation, increased cell subsets like CD4+ and CD4+/CD8+, and triggered IL-4 and IFN-γ production. | QI Feng-chun WANG Chun-yi WANG Ya-jun HANG Xue-mei ZHANG Yan SUI Bo LI Xiao-bo SHENG Jun | 2007 | Chemical Research in Chinese Universities2007，23，3： | 1 |
| 9 | The Mechanism and Characterization of Dye-Free Coloration on Tussah Silk Based on Tryptophan显示文摘 | Sui Yan Ling Wei Chun Yan Liu Wen Jing Wang Bo Li Shao Quan Cui Yong Zhu | 2011 | Advanced Materials Research2011，，175： | 1 |
| 10 | Interferences and contami- nants encountered in modern mass spectrometry显示文摘 | Keller BO Sui J Young AB | 2008 | Anal Chim Aeta2008，627，1： | 1 |
| 11 | Hierarchical macro-microporous WPU-ECM scaffolds combined with Microfracture Promote in Situ Articular Cartilage Regeneration in Rabbits显示文摘Tissue engineering provides a promising avenue for treating cartilage defects.However,great challenges remain in the development of structurally and functionally optimized scaffolds for cartilage repair and regeneration.In this study,decellularized cartilage extracellular matrix(ECM)and waterborne polyurethane(WPU)were employed to construct WPU and WPU-ECM scaffolds by water-based 3D printing using low-temperature deposition manufacturing(LDM)system,which combines rapid deposition manufacturing with phase separation techniques.The scaffolds successfully achieved hierarchical macro-microporous structures.After adding ECM,WPU scaffolds were markedly optimized in terms of porosity,hydrophilia and bioactive components.Moreover,the optimized WPU-ECM scaffolds were found to be more suitable for cell distribution,adhesion,and proliferation than the WPU scaffolds.Most importantly,the WPU-ECM scaffold could facilitate the production of glycosaminoglycan(GAG)and collagen and the upregulation of cartilage-specific genes.These results indicated that the WPU-ECM scaffold with hierarchical macro-microporous structures could recreate a favorable microenvironment for cell adhesion,proliferation,differentiation,and ECM production.In vivo studies further revealed that the hierarchical macro-microporous WPU-ECM scaffold combined with the microfracture procedure successfully regenerated hyaline cartilage in a rabbit model.Six months after implantation,the repaired cartilage showed a similar histological structure and mechanical performance to that of normal cartilage.In conclusion,the hierarchical macro-microporous WPU-ECM scaffold may be a promising candidate for cartilage tissue engineering applications in the future. | Mingxue Chen YangYang Li Shuyun Liu Zhaoxuan Feng Hao Wang Dejin Yang Weimin Guo Zhiguo Yuan Shuang Gao Yu Zhang Kangkang Zha Bo Huang Fu Wei Xinyu Sang Qinyu Tian Xuan Yang Xiang sui Yixin Zhou Yufeng Zheng Quanyi Guo | 2021 | Bioactive Materials2021，6，7： | 1 |
| 12 | Model test of the tunnel subjected to high water pressure in Jinping Second Cascade Hydropower Station,China显示文摘In the area with high groundwater pressure,grout curtain is often adopted to reduce the water pressure on tunnel lining.A series of model tests for the diversion tunnel of the Jinping Second Cascade Hydropower Station,China,is designed to study the effect of grout curtain.The impact of the thickness of grout curtain,permeability of grout curtain,internal water pressure and drainage inflow on the distribution of water pressure are discussed.The results indicates that under un-drained condition,water pressure is equal to hydrostatic one no matter grout curtain is selected or not,water pressure under drained condition is far less than that of un-drained condition,drainage in tunnel can reduce tunnel water pressure effectively.For same inflow,both increasing of thickness and decrease of hydraulic conductivity of grout curtain can reduce water pressure effectively.For the same water pressure,the smaller inflow of grout curtain,the less volume of water to be discharged.The impact of hydraulic conductivity of grout curtain is more obvious than that of thickness.With increasing of internal water pressure,the water pressure of grout curtain increases too,and the water pressure increases nearly linearly.The proposed thickness of grout curtain for the diversion tunnels is 16 m. | WANG JianXiu 1,2,FENG Bo 2,HU LiSheng 2,TIAN PuZhuo 2,SUI DongChang 2,TANG YiQun 1,2 &YANG Ping 1,2 1 Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education,Tongji University,Shanghai 200092,China 2 Department of Geotechnical Engineering,Tongji University,Shanghai 200092,China | 2011 | Science China(Technological Sciences)2011，54，S1： | 1 |
| 13 | Effect of a lipidic extract from Lepidium meyenii on sexual behavior in mice and rats显示文摘 | Bo Lin Zheng Kan He Calvin Hyungchan Kim Lingling Rogers Yu Shao Zhen Yen Huang Yang Lu Sui Jun Yan Lu Cheng Qien Qun Yi Zheng | 2000 | Urology2000，，4： | 1 |
| 14 | Patterned glass ceramic design for high-brightness high-color-quality laser-driven lightings显示文摘Up-to-date laser-driven lightings confront a challenge of simultaneously achieving good photometric and chromatic performances.Herein,the coupling of“patterned package design”and“phosphor wheel”was proposed and demonstrated effectively to deal with this tough issue,based on a new architecture of CaAlSiN3:Eu2+(CASN:Eu)glass ceramic film(GCF)on Y_(3)Al_(5)O_(12):Ce^(3+)(YAG:Ce)GC plate.The fabricated composite has no interface between the two functional layers and retains the admirable luminescent features from CASN:Eu and YAG:Ce for the microstructural integrity during co-sintering.The studies on laser-microcrystalline interactions reveal that the luminescence saturation is almost determined by thermal quenching for YAG:Ce,but is ascribed to thermal/intensity quenching which are equally crucial for CASN:Eu.Benefiting from the elaborate architecture design,good color chromaticity tunability was obtained,and severe photon reabsorption was reduced.Moreover,accompanied with the rotation induced increase of thermal convection to air and pulse-like excitation,the constructed lighting engine under blue laser driven shows bright white light with luminous flux(LF)higher than 1000 lm,adjustable chromaticity from cool to warm,and improved color rendering index(CRI)approaching to 70. | Qiugui HUANG Hang LIN Bo WANG Shisheng LIN Pengfei WANG Ping SUI Ju XU Yao CHENG Yuansheng WANG | 2022 | Journal of Advanced Ceramics2022，11，6： | 1 |
| 15 | Color image encryption based on gyrator transform and Arnold transform显示文摘 | Liansheng Sui Bo Gao | 2013 | Optics and Laser Technology2013，，： | 1 |
| 16 | Guanidinoamidized Linear Polyethyleneimine for Gene Delivery显示文摘Guanidine was introduced to low molecular weight linear polyethyleneimine(LPEI) via amide groups, to explore the effect of both guanidine degree and pendant chain length on its transfection behavior. The resulting guanidinoamidized LPEIs(GLPEIs) could dramatically reduce LPEI's toxicity, enhance its DNA-packaging capability, cellular uptake and therefore transfection efficiency. These polyplexes were taken up very efficiently via caveolae-mediated endocytosis and their transfection efficiencies in ovarian cancer cells were significantly improved compared to native LPEI10 k polyplexes. Among these GLPEIs, LPEI-C3-G100 showed higher DNA affinity even than LPEI25 k and the highest transfection efficiency, probably due to the optimization of polymer chain flexibility. Of notice, LPEI-C3-G100 polyplexes could more effectively accumulate into cytoplasm than LPEI25 k, although the transfection efficiency of LPEI-C3-G100 polyplexes was not superior to that of LPEI25 k polyplexes, which would be probably attributed to the more efficient release of LPEI25 k polyplexes than LPEI-C3-G100 polyplexes in the cytoplasm. | Bo Zhang Xin-peng Ma Mei-hua Sui Edward Van Kirk Willia m J.Murdoch Maciej Radosz 林能明 申有青 | 2015 | Chinese Journal of Polymer Science2015，33，6： | 1 |
| 17 | Interferences and contaminants encountered in modern mass spectrometry 显示文摘 | Keller BO Sui J Young AB | 2008 | Anal Clim Acta2008，627，1： | 1 |
| 18 | The cable branch box, ring network cabinet gel erosion显示文摘 | SUI Dongyang WU Chao GUAN Bo | 2014 | Rural Electri- cian2014，，5： | 1 |
| 19 | Interaction of {11■2} twin variants in hexagonal close-packed titanium显示文摘As multiple{11■2}twin variants are often formed during deformation in hexagonal close-packed (hcp)titanium, the twin-twin interaction structure has a profound influence on mechanical properties. In this paper, the twin-twin interaction structures of the{11■2}contraction twin in cold-rolled commercial purity titanium were studied by using electron backscatter diffraction (EBSD) and transmission electron microscopy (TEM). Formation of the{11■2}twin variants was found to deviate the rank of Schmid factor,and the non-Schmid behavior was explained by the high-angle grain boundary nucleation mechanism.All the observed twin-twin pairs manifested a quilted-looking structure, which consists of the incoming twins being arrested by the obstacle twins. Furthermore, the quilted-looking{11■2}twin-twin boundary was revealed by TEM and high resolution TEM observations. De-twinning, lattice rotation and curved twin boundary were observed in the obstacle twin due to the twin-twin reaction with the impinging twin. A twin-twin interaction mechanism for the{11■2}twin variants was proposed in terms of the dislocation dissociation, which will enrich the understanding for the propagation of twins and twinning-induced hardening in hcp metals and alloys. | Xiaocui Li Jingwei Li Bo Zhou Mingchao Yu Manling Sui | 2019 | Journal of Materials Science & Technology2019，35，4： | 1 |
| 20 | Synoptic mode of Antarctic summer sea ice superimposed on interannual and decadal variability显示文摘In contrast to decreased Arctic sea ice extent,Antarctic sea ice extent shows a somewhat increased trend.There is a large interannual variability of Antarctic sea ice,especially in the Pacific sector of the Southern Ocean.The change and variability of Antarctic sea ice in synoptic timescales in the recent decades remain unclear.We identify synoptic modes of variability of Antarctic summer sea ice by applying the Self Organizing Map(SOM)technique to daily sea ice concentration data for the period 1979–2018.Nearly 40%of the variability is characterized by opposite changes between sea ice cover in the Bellingshausen,Amundsen and western Ross Seas and in the rest of the Antarctic seas,and another 30%by meridional asymmetry in the Weddell,Amundsen,and Ross Seas.Most of these spatial patterns may be explained by the dynamics and thermodynamic processes associated with anomalous atmospheric circulations related to the Southern Annular Mode(SAM)with a structure of strong zonal asymmetry.The interannual variability of the sea ice modes appears to have little connection to SAM,and only a weak relation to ENSO.The annual frequencies of SOM node occurrences also show a great decadal variability.Node 9 appears mainly prior to 1990;while node 1 occurs mainly after 1990.The decadal variability of nodes 1 and 9 is associated with the asymmetrical SAM,which results from two wavetrains excited over northern Australia and the southeastern Indian Ocean.These results further highlight the importance of understanding the role of southern mid-to-high latitude atmospheric intrinsic variability in predicting Antarctic summer sea ice variations from synoptic to decadal timescales. | YU Le-Jiang ZHONG Shi-Yuan SUI Cui-Juan ZHANG Zhao-Ru SUN Bo | 2021 | Advances in Climate Change Research2021，12，2： | 1 |
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