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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Cooperation and competition in pathogenic bacteria显示文摘 | ASHLEIGH S G STUART A W ANGUS B | 2004 | Letters to Nature2004，430，10： | 1 |
| 3 | Steroid hormone influence on brain calbindin-D28k in male prepubertal and ovariectomized rats显示文摘 | Stuart E B Thompson J M Rhees R W | 2001 | Developmental Brain Research2001，129，2： | 1 |
| 4 | Boards, CEOs, and Surviving a Financial Crisis: Evidence from the Internet Shakeout 显示文摘 | DOWELL G W S SHACKELL M B STUART N V | 2011 | Strategic Management Journal2011，32，10： | 1 |
| 5 | Technical efficiency evaluation of logging contractors using a nonparametric model 显示文摘 | Lebel L G Stuart W B | 1998 | International Journal of Forest Engineering1998，9，2： | 1 |
| 6 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 7 | Femtosecond pulsed laser ablation of metal alloy and semiconductor largets显示文摘 | TRELENBERG T W DINH L N STUART B C | 2004 | Applied Surjace Science2004，229，： | 1 |
| 8 | Distinguishing base-surge deposits and volcaniclastic fluviatile sediments, an ancient example from the Lower Devonian Snowy River Volcanics, South-eastern Australia 显示文摘 | Stuart W B Cas R A F | 2000 | Sedimentology2000，47，： | 1 |
| 9 | Technical efficiency evaluation of logging contractors using a nonparametric mode 1 显示文摘 | LEBEL L G STUART W B | 1998 | Inter Journal of Forest Engineering1998，9，2： | 1 |
| 10 | Technical efficiency evaluation of logging contractors using a nonparametric model 显示文摘 | LeBel L G and Stuart W B | 1998 | Inter J of Forest Engineering1998，9，2： | 1 |
| 11 | Cooperation and competition in pathogenic bacteria 显示文摘 | Ashleigh S G Stuart A W Angus B | 2004 | Letters to Nature2004，430，： | 1 |
| 12 | Technical efficiency evaluation of logging contractors using a nonparametric model 显示文摘 | LEBEL L G STUART W B | 1998 | Inter J of Forest Engineering1998，9，2： | 1 |
| 13 | Effects of participation in a martial arts-based antibullying program in elementary schools 显示文摘 | Stuart W T Bridget K B Timothy D N Eric M V Peter F Stephen W T | 2008 | Psychology in the School2008，45，10： | 1 |
| 14 | Returns to scale in the Eastern United States logging industry 显示文摘 | STUART W B GRACE L A GRALA R K | 2010 | Forest Poli- cy and Economics2010，12，6： | 1 |
| 15 | A second-generation reactive empirical bond order (RE- BO) potential energy expression for hydrocarbons显示文摘 | Brenner D W Shenderova O A Harrison J A Stuart S J Ni B Sinnott S B | 2002 | Journal of Physics: Condensed Matter2002，14，： | 1 |
| 16 | Carbonaceous Sedimentary Source - Rock Model for Carlin - Type and Orogenic Gold Depos- its显示文摘 | Ross R L Stuart W B Valeriy V M | 2011 | Economic Geology2011，，106： | 1 |
| 17 | A second-generation reactive empirical bond order (REBO) potential energy expression for hydrocarbons显示文摘 | Brenner D W SHenderova O A Harrison J A Stuart S J Ni B Sinnott S B | 2002 | Journal of Physics:Condensed Matter2002，14，： | 1 |
| 18 | Natural history of cervical human papillomavirus infection in young women: A longitudinal cohort study 显示文摘 | Ciaran B J Stuart C Heather W | 2001 | Lancet2001，357，： | 1 |
| 19 | Activation of chimeric and full-length growth hormone receptors by growth hormone receptor monoclonal antibodies显示文摘 | Scott W R Stuart N B Jennifer E R | 1998 | The Journal of Biological Chemistry1998，273，9： | 1 |
| 20 | Laser-induced damage in dielectrics with nanosecond to sub-picosecond pulses 显示文摘 | STUART B C FEIT M D RUBENCHIK A M SHORE B W PERRY M D | 1995 | Phys Rev Lett1995，74，： | 1 |
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