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| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | Current endoscopic approach to indeterminate biliary strictures显示文摘Biliary strictures are considered indeterminate when basic work-up, including transabdominal imaging and endoscopic retrograde cholangiopancreatography with routine cytologic brushing, are non-diagnostic. Indeterminate biliary strictures can easily be mischaracterized which may dramatically affect patient's outcome. Early and accurate diagnosis of malignancy impacts not only a patient's candidacy for surgery, but also potential timely targeted chemotherapies. A significant portion of patients with indeterminate biliary strictures have benign disease and accurate diagnosis is, thus, paramount to avoid unnecessary surgery. Current sampling strategies have suboptimal accuracy for the diagnosis of malignancy. Emerging data on other diagnostic modalities, such as ancillary cytology techniques, single operator cholangioscopy, and endoscopic ultrasonography-guided fine needle aspiration, revealed promising results with much improved sensitivity. | David W Victor Stuart Sherman Tarkan Karakan Mouen A Khashab | 2012 | World Journal of Gastroenterology2012，18，43： | 3 |
| 3 | The treatment of traumatic optic neuropathy显示文摘 | Leonard A Levin Roy W Beck Michael P Joseph Stuart Seiff Raymond Kraker | 1999 | Ophthalmology1999，，7： | 2 |
| 4 | NEMO Satellite Sensor Imaging Payload 显示文摘 | Myers W A Smith R D Stuart J L | 1998 | Proceeding of SPIE1998，3437，： | 1 |
| 5 | Emerging ap- plications of stimuli-response polymer materials 显示文摘 | Stuart M A C Huck W T S Genzer J | 2010 | Nat Mater2010，9，： | 1 |
| 6 | Impact of Entrepreneurial Management Experience on Early Performance 显示文摘 | STUART R W ABETTI P A | 1990 | Journal of Business Venturing1990，5，3： | 1 |
| 7 | Cooperation and competition in pathogenic bacteria显示文摘 | ASHLEIGH S G STUART A W ANGUS B | 2004 | Letters to Nature2004，430，10： | 1 |
| 8 | Emerging applications of stimuli-responsive polymer materials显示文摘 | Stuart M A C Huck W T S Genzer J | 2010 | Nature Materials2010，9，： | 1 |
| 9 | T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation:a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART)显示文摘 | Hazenberg M D Stuart J W Otto S A | 2000 | {H}Blood2000，，01： | 1 |
| 10 | Bioeompatibility of methyleellulose-based constructs designed for intracerebral gelation following experimental traumatic brain injury 显示文摘 | Matthew C T Deborah A S Stuart W H | 2001 | Biomaterials2001，22，： | 1 |
| 11 | The oribatid mite Scheloribates moestus (Acari: Oribatida ) alters litter chemistry and nutrient cycling during decomposition 显示文摘 | Kyle W Stuart G A | 2011 | Soil Biology & Biochemistry2011，43，2： | 1 |
| 12 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 13 | Subfascial endoscopic perforator surgery is associated with significantly less morbidity and shorter hospital stay than open operation (Linton's procedure)显示文摘 | Adam D T Bradburg A W | 1997 | Br J Surg1997，84，10： | 1 |
| 14 | Distinguishing base-surge deposits and volcaniclastic fluviatile sediments, an ancient example from the Lower Devonian Snowy River Volcanics, South-eastern Australia 显示文摘 | Stuart W B Cas R A F | 2000 | Sedimentology2000，47，： | 1 |
| 15 | Value-based business strategy显示文摘 | BRANDENBURGER A STUART H W | 1996 | J of Economics and Management Strategy1996，5，1： | 1 |
| 16 | The social distribution of neighborhood-scaleair pollution and monitoring protection显示文摘 | Stuart A L Mudhasakul S Sriwatanapongse W | 2009 | Journal of the Air&Waste Management Association2009，59，5： | 1 |
| 17 | Biform games显示文摘 | BRANDENBURGER A STUART H W | 2007 | Management Science2007，53，4： | 1 |
| 18 | Value-based business strategy 显示文摘 | Brandenburger A Stuart Jr H W | 1996 | Journal of Economic Management Strategy1996，，5： | 1 |
| 19 | Modularized battery management for large lithium ion cells显示文摘 | STUART T A ZHU W | 2011 | Journal of Power Sources2011，11，： | 1 |
| 20 | Enhancment of ovulation rate in gilts by increasing diatary engry and administering insulin during follicular growth 显示文摘 | Cox N M Stuart T G Althen W A | 1987 | Anim Sci1987，64，： | 1 |
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