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| 1 | Continuous wound infusion of local anaesthetic agents following colorectal surgery:Systematic review and meta-analysis显示文摘AIM:To provide a specifi c review and meta-analysis of the available evidence for continuous wound infusion of local anaesthetic agents following midline laparoto-my for major colorectal surgery. METHODS: Medline, Embase, trial registries, conference proceedings and article reference lists were searched to identify randomised, controlled trials of continuous wound infusion of local anaesthetic agents following colorectal surgery. The primary outcomes were opioid consumption, pain visual analogue scores (VASs), return to bowel function and length of hospital stay. Weighted mean difference were calculated for continuous outcomes. RESULTS: Five trials containing 542 laparotomy wounds were eligible for inclusion. There was a sig- nificant decrease in post-operative pain VAS at rest on day 3 (weighted mean difference: -0.43; 95% CI: -0.81 to -0.04; P = 0.03) but not on post-operative day 1 and 2. Local anaesthetic infusion was associated with a signifi cant reduction in pain VAS on movement on all three post-operative days (day 1 weighted mean difference: -1.14; 95% CI: -2.24 to -0.041; P = 0.04, day 2 weighted mean difference: -0.97, 95% CI: -1.91to -0.029; P = 0.04, day 3 weighted mean difference: -0.61; 95% CI: 1.01 to -0.20; P = 0.0038). Local an- aesthetic wound infusion was associated with a signifi - cant decrease in total opioid consumption (weighted mean difference: -40.13; 95% CI: -76.74 to -3.53; P = 0.03). There was no signifi cant decrease in length of stay (weighted mean difference: -20.87; 95% CI: -46.96 to 5.21; P = 0.12) or return of bowel function (weighted mean difference: -9.40; 95% CI: -33.98 to 15.17; P = 0.45). CONCLUSION: The results of this systematic re- view and meta-analysis suggest that local anaesthetic wound infusion following laparotomy for major color- ectal surgery is a promising technique but do not pro- vide conclusive evidence of benefi t. Further research is required including cost-effectiveness analysis. | Alan Karthikesalingam Stewart R Walsh Sheraz R Markar Umar Sadat Tjun Y Tang Charles M Malata | 2008 | World Journal of Gastroenterology2008，14，34： | 4 |
| 2 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 3 | Migraine prevalence, disease burden, and the need for preventive therapy显示文摘 | R B. Lipton M E. Bigal M Diamond F Freitag M L. Reed W F. Stewart | 2007 | Neurology2007，，5： | 2 |
| 4 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 5 | Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders显示文摘 | Kim J M Stewart R Kim S W | 2007 | Biol Psychiatry2007，62，5： | 1 |
| 6 | Expression and activity of the CDK inhibitor p57 Kip2 in chondrocytes undergoing hypertrophic differentiation 显示文摘 | Stewart M C Kadlcek R M Robbins P D | 2004 | J Bone Miner Res2004，19，1： | 1 |
| 7 | Radiation stress in water waves; a physical discussion,with applications显示文摘 | LONGUET-HIGGINS M S STEWART R W | 1964 | Deep-Sea Res1964，11，4： | 1 |
| 8 | Mural thrombosis of the heart induced by radiation显示文摘 | BROWN J M FARJARDO L F STEWART J R | 1973 | Arth Pathol1973，96，1： | 1 |
| 9 | Disability and chronic pain after open mesh and laparoscopic inguinal hernia repair显示文摘 | BOZUK M SCHUSTER R STEWART D | 2003 | Am Surg2003，，： | 1 |
| 10 | Psychological em- powerment and stractural empowerement among nurse practitioners显示文摘 | Stewart J G Menulty R Griffin M T | 2010 | J Am Acad Nurse Praet2010，22，1： | 1 |
| 11 | Vasopressors for the treat- ment of maternal hypotension following spinal anaesthesia for e- lective caesarean section: past, present and future显示文摘 | Heesen M Stewart A Fernando R | 2015 | Anaesthe- sia2015，70，3： | 1 |
| 12 | The use of reflectance spectrophotometery for the assay of raw meat pigments 显示文摘 | Stewart M R Zipser M W Watts B M | 1965 | Journal of Food Science1965，30，： | 1 |
| 13 | Differentiation of Hunmn Embryonic Stem Cells into Corneal Epithelia|-like Cells by In Vitro Replication of theComeal Epithelial Stem Cell Niche 显示文摘 | Ahtnad S Stewart R Yung S Kolli S Armstrong L Stojkovie M Figueiredo F IAko M | 2007 | StemCells2007，255，： | 1 |
| 14 | Region growing with pulse-coupled neural networks: an alternative to seeded re-gion growing 显示文摘 | Stewart R D Fermin I Opper M | 2002 | IEEE Transactions on Neural Networks2002，13，6： | 1 |
| 15 | Reduction of chromium (VI) at sub-μg 1-1 levels by fulvic acid 显示文摘 | ECKERT J M STEWART J J WAITE T D SZYMCZAK R WILLIAMS K L | 1990 | Analytica Chimica Acta1990，236，： | 1 |
| 16 | 30-month post- breast cancer treatment lymphoedema显示文摘 | Armer J M Stewart B R Shook R P | 2009 | J Lymphoede ma2009，4，1： | 1 |
| 17 | C natural abundance in plant communities along a rainfall gradient: a biological integrator of water availability显示文摘 | Stewart (3 R Turnbull M H Schmidt et ai | 1995 | Australian Journal of Plant Physiology1995，，： | 1 |
| 18 | Region growing with pulse-coupled neural networks: an alternative to seeded region grow- ing 显示文摘 | STEWART R D FERMIN I OPPER M | 2002 | IEEE Transactions on Neural Network2002，13，6： | 1 |
| 19 | Growth of alligator weed (A lternanthera philoxeroides)and population development of Agasicles hygrophila in northern New Zealand显示文摘 | Stewart C A Chapman R B Frampton C M A | 2000 | Plant Protection Quarterly2000，15，1： | 1 |
| 20 | HARMONY4:52-week efficacy of albiglutide vsinsulin glargine in patients w ith type 2diabetes mellitus显示文摘 | Pratley R Stewart M Cirkel D | 2013 | Diabetologia2013，，： | 1 |
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