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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Gynecologic oncologists involvement on ovarian cancer standard of care receipt and survival显示文摘AIM:To examine the influence of gynecologic oncolo-gists(GO) in the United States on surgical/chemotherapeutic standard of care(SOC), and how this translates into improved survival among women with ovarian cancer(OC).METHODS: Surveillance, Epidemiology, and End Result(SEER)-Medicare data were used to identify 11688 OC patients(1992-2006). Only Medicare recipients with an initial surgical procedure code(n = 6714) were included. Physician specialty was identified by linking SEER-Medicare to the American Medical Association Masterfile. SOC was defined by a panel of GOs. Multivariate logistic regression was used to determine predictors of receiving surgical/chemotherapeutic SOCand proportional hazards modeling to estimate the effect of SOC treatment and physician specialty on survival. RESULTS: About 34% received surgery from a GO and 25% received the overall SOC. One-third of women had a GO involved sometime during their care. Women receiving surgery from a GO vs non-GO had 2.35 times the odds of receiving the surgical SOC and 1.25 times the odds of receiving chemotherapeutic SOC(P < 0.01). Risk of mortality was greater among women not receiving surgical SOC compared to those who did [hazard ratio = 1.22(95%CI: 1.12-1.33), P < 0.01], and also was higher among women seen by non-GOs vs GOs(for surgical treatment) after adjusting for covariates. Median survival time was 14 mo longer for women receiving combined SOC. CONCLUSION: A survival advantage associated with receiving surgical SOC and overall treatment by a GO is supported. Persistent survival differences, particularly among those not receiving the SOC, require further investigation. | Sun Hee Rim Shawn Hirsch Cheryll C Thomas Wendy R Brewster Darryl Cooney Trevor D Thompson Sherri L Stewart | 2016 | World Journal of Obstetrics and Gynecology2016，5，2： | 3 |
| 3 | 子宫炎性肌纤维母细胞肿瘤通常存在ALK与IGFBP5和THBS1基因的融合显示文摘炎性肌纤维母细胞肿瘤能够发生在包括子宫在内的多个解剖部位。子宫炎性肌纤维母细胞肿瘤与发生在软组织的炎性肌纤维母细胞肿瘤相似,也通常表达ALK,并存在ALK基因重排。该文着重分析子宫炎性肌纤维母细胞肿瘤的基因融合特征。 | Haimes J D Stewart C J R Kudlow B A 赵芳 魏建国 | 2018 | 临床与实验病理学杂志2018，34，1： | 2 |
| 4 | Lipid peroxidation associated with accelerated aging of soybean axes 显示文摘 | Stewart R R C Bewley J D | 1980 | Plant Physiology1980，65，2： | 1 |
| 5 | Determination of total and speciated arsenic in rice by ion chromatography and inductively coupled plasma mass spectrometry 显示文摘 | HEITKEMPER D T VELA N P STEWART K R | 2001 | J Anal Atom Spectrom2001，16，： | 1 |
| 6 | Expression and activity of the CDK inhibitor p57 Kip2 in chondrocytes undergoing hypertrophic differentiation 显示文摘 | Stewart M C Kadlcek R M Robbins P D | 2004 | J Bone Miner Res2004，19，1： | 1 |
| 7 | Microdosimetric properties of ionizing electrons in water显示文摘 | STEWART R D WILSON W E MCDONALD J C | 2002 | Phys Med Biol2002，47，1： | 1 |
| 8 | A contingency perspective on organizational learning: integrating environment context, organizational learning processes and types of learning 显示文摘 | GNYAWALI D R STEWART A C | 2003 | Management learning2003，34，1： | 1 |
| 9 | Disability and chronic pain after open mesh and laparoscopic inguinal hernia repair显示文摘 | BOZUK M SCHUSTER R STEWART D | 2003 | Am Surg2003，，： | 1 |
| 10 | Interleukin-18 enhances athero-sclerosis in apolipoprotein E-/-Mice through release of interferon-γ显示文摘 | Stewart CW Punnaivanam R Alan D | 2002 | Circ Res2002，90，2： | 1 |
| 11 | Evaluation of pulmonary lesions with FDG-PET显示文摘 | KNIGHT S B DELBEKE D STEWART J R | 1996 | Chest1996，109，： | 1 |
| 12 | Experience with the use of methylcellulose as a viscous pore fluid in centrifuge models显示文摘 | STEWART D P CHEN Y R KUTTER B L | 1998 | Geoteehnical Testing Journal1998，21，4： | 1 |
| 13 | Region growing with pulse-coupled neural networks: an alternative to seeded re-gion growing 显示文摘 | Stewart R D Fermin I Opper M | 2002 | IEEE Transactions on Neural Networks2002，13，6： | 1 |
| 14 | Reduction of chromium (VI) at sub-μg 1-1 levels by fulvic acid 显示文摘 | ECKERT J M STEWART J J WAITE T D SZYMCZAK R WILLIAMS K L | 1990 | Analytica Chimica Acta1990，236，： | 1 |
| 15 | Lipid peroxidation associated with accelerated aging of soybean axes 显示文摘 | Stewart R C Bewley J D | 1980 | Plant Physi- ology1980，65，2： | 1 |
| 16 | The missing memristor found 显示文摘 | Strukov D B Snider G S Stewart G R | 2008 | Nature (S0028-0836)2008，453，： | 1 |
| 17 | An improved in vivo method for atrioventricu lar node ablation via thoracotomy显示文摘 | Maciver R H Stewart R D Backer C L Tsao S Harrington D A Mavroudis C | 2010 | Braz J Med Biol Res2010，43，： | 1 |
| 18 | Region growing with pulse-coupled neural networks: an alternative to seeded region grow- ing 显示文摘 | STEWART R D FERMIN I OPPER M | 2002 | IEEE Transactions on Neural Network2002，13，6： | 1 |
| 19 | Tetralogy of fallot : results of a pulmonary valve-sparing strategy 显示文摘 | Stewart R D Backer C L Young L | 2005 | Ann Thorac Surg2005，80，4： | 1 |
| 20 | HARMONY4:52-week efficacy of albiglutide vsinsulin glargine in patients w ith type 2diabetes mellitus显示文摘 | Pratley R Stewart M Cirkel D | 2013 | Diabetologia2013，，： | 1 |
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