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| 1 | E2 enzymes: more than just middle men显示文摘 | Mikaela D Stewart Tobias Rltterhoff Rachel E Klevit Peter S Brzovic | 2016 | Cell Research2016，26，4： | 17 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 4 | Microdosimetric properties of ionizing electrons in water显示文摘 | STEWART R D WILSON W E MCDONALD J C | 2002 | Phys Med Biol2002，47，1： | 1 |
| 5 | A systematic review of resilience in the physieallyill显示文摘 | Stewart D E Yuen T | 2011 | Psychosomatics2011，52，3： | 1 |
| 6 | A gene map of the human genome显示文摘 | Schuler G D Boguski M S Stewart E A | 1996 | Science1996，274，： | 1 |
| 7 | Abrasive wear behaviour of conventional and nanocomposite HVOF-sprayed WC-Co coatings显示文摘 | STEWART D A SHIPWAY P H MCCARTN E Y D G | 1999 | Wear1999，225，2： | 1 |
| 8 | Reactive processin-gof poly(ethylene 2,6-naphthalate dicarboxylate)/poly(ethylene terephthalate)blends显示文摘 | Stewart M E Cox A J Naylor D M | | 0，，19： | 1 |
| 9 | ICEPAK- modeling the ice-filling and ice-melting processes of thermal energy storage tanks 显示文摘 | Stewart W E Jr Gute G D Saunders C K | 1995 | ASHRAE Transactions1995，101，1： | 1 |
| 10 | Effect of reinforcement corrosion on reliability of highway bridges显示文摘 | Val D V Stewart M G Melchers R E | 1998 | Engineering Structures1998，20，11： | 1 |
| 11 | Electrochemical noise measurements of stress corrosion cracking of sensitised austenitic stainless steel in high-purity oxygenated water at 288 °C显示文摘 | STEWART J WELLS D B SCOTT P M WILLIAMS D E | 1992 | Corros Sci1992，33，1： | 1 |
| 12 | Effect of number of receptors for gonadotropin-releasing hormone on the release of luteinizing hormone显示文摘 | Wise M E Nieman D Stewart J | 1984 | Biology of Reproduc- tion1984，31，5： | 1 |
| 13 | The MOS short-form general health survey: reliability and validity in a patient population显示文摘 | Stewart A L Hays R D Ware J E Jr | 1988 | Med Care1988，26，7： | 1 |
| 14 | Effect of reinforcement corrosion on reliability of highway bridges 显示文摘 | Val D V Stewart M G Melchers R E | 1998 | Engineering Structures1998，20，11： | 1 |
| 15 | Vascular endothelial growth factor expression and tumor angiogenesis are regulated by androgen in hormone responsive human prostate carcinoma: evidence for androgen dependent destabilization of vascular endothelial growth factor transcripts 显示文摘 | Stewart RJ Panigrapy D Flgnn E | 2001 | J Urol2001，165，2： | 1 |
| 16 | An automated system for micro-batch protein crystallization and screening 显示文摘 | CHAYEN N E STEWART S MAEDER D L | 1990 | J Appl Crystallogr1990，23，： | 1 |
| 17 | An euler-bernoulli beam with dynamic frictionless contact : penalty approximation and existence显示文摘 | AHN J STEWART D E | 2007 | Numerical Functional Analysis and Optimization2007，28，910： | 1 |
| 18 | Effect of number of receptors for gonadotropinreleasing hormone on the release of luteinizing hormone显示文摘 | WISE M E NIEMAN D STEWART J | 1984 | Biol Reprod1984，31，10： | 1 |
| 19 | IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy 显示文摘 | Suppiah V Moldovan M Ahlenstiel G Berg T Weltman M Abate ML Bassendine M Spengler U Dote GJ Powell E Riordan S Sheridan D Smedile A Fragomeli V Muller T Bahlo M Stewart GJ Booth DR George J | 2009 | Nat Genet2009，41，10： | 1 |
| 20 | Kinetics and mechanisms of chorine dioxide oxidation of tryptophan 显示文摘 | Stewart D J Napolitano M J Bakhmutova- Albert E V | 2008 | Inorganic Chemistry2008，47，5： | 1 |
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