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| 1 | Identification of pathologic features associated with “ulcerative colitis-like” Crohn's disease显示文摘AIM: To identify pathologic features associated with this 'ulcerative colitis(UC)-like' subgroup of Crohn's disease(CD).METHODS: Seventeen subjects diagnosed as having UC who underwent proctocolectomy(RPC) from 2003-2007 and subsequently developed CD of the ileal pouch were identified. UC was diagnosed based on preoperative clinical, endoscopic, and pathologic studies. Eighteen patients who underwent RPC for UC within the same time period without subsequently developing CD were randomly selected and used as controls. Pathology reports and histological slides were reviewed for a wide range of gross and microscopic pathological features, as well as extent of disease. The demographics, gross description and histopathology of the resection specimens were reviewed and compared between the two groups. RESULTS: Patients with 'UC-like' CD were on average 13 years younger than those with 'true' UC(P < 0.01). More severe disease in the proximal involved region and active ileitis with/without architectural distortion were observed in 6 of 17(35%) and 7 of 17(41%) 'UC-like' CD cases, respectively, but in none of the 'true' UC cases(P < 0.05). Active appendicitis occurred in 8 of 16(50%) 'UC-like' CD cases but in only two(11%) 'true' UC cases(P < 0.05). Conspicuous lamina propria neutrophils were more specific for 'UClike' CD(76% vs 22%, P < 0.05). In addition, prominent lymphoid aggregates tended to be more common in 'UC-like' CD(P = 0.07). The 'true' UC group contained a greater number of cases with severe activity(78% vs 47%). Therefore, the features more commonly seen in 'UC-like' CD were not due to a more severe disease process. Crohn's granulomas and transmural inflammation in non-ulcerated areas were absent in both groups.CONCLUSION: More severe disease in the proximal involved region, terminal ileum involvement, active appendicitis, and prominent lamina propria neutrophils may be morphological factors associated with 'UC-like' CD. | Samuel D James Paul E Wise Tania Zuluaga-Toro David A Schwartz M Kay Washington Chanjuan Shi | 2014 | World Journal of Gastroenterology2014，20，36： | 4 |
| 2 | Determination of organic acids in Vaccinium berry standard reference materials显示文摘 | Phillips M M Case R J Rimmer C A Sander L C Sharpless K E Wise S A Yen J H | 2010 | Analytical and Bioanalytical Chemistry2010，398，1： | 1 |
| 3 | Placental p-gly coprotein deficiency enhance ssusceptibiliy to chemically induced birth defects in mice 显示文摘 | Lankas G R Wise L D Cartwright M E | 1998 | Reprod Toxicol1998，12，4： | 1 |
| 4 | Constitutive modeling of nanotube-reinforced polymer composites显示文摘 | Odegard G M Gates T S Wise K E | 2003 | Composites Science and Technology2003，63，： | 1 |
| 5 | Effect of number of receptors for gonadotropin-releasing hormone on the release of luteinizing hormone显示文摘 | Wise M E Nieman D Stewart J | 1984 | Biology of Reproduc- tion1984，31，5： | 1 |
| 6 | Constitutive modeling of nanotube-reinforced polymer composites显示文摘 | Odegard G M Gates T S Wise K E Park C Siochi E J | 2003 | Composites Science and Technology2003，63，： | 1 |
| 7 | Tei- choic acid hydrolase activity in soil bacteria 显示文摘 | WISE E M WISE J R GLICKMAN R S | 1972 | Pro- ceedings of the National Academy of Sciences of the United States of America1972，69，1： | 1 |
| 8 | A wetlandaquifer interaction test显示文摘 | Wise W R Annable M D Walser J A E | 2000 | Journal of Hydrology2000，227，： | 1 |
| 9 | Effect of number of receptors for gonadotropinreleasing hormone on the release of luteinizing hormone显示文摘 | WISE M E NIEMAN D STEWART J | 1984 | Biol Reprod1984，31，10： | 1 |
| 10 | IL-12 enhances CTL synapse formation and induces self-reactivity 显示文摘 | Markiewicz M A Wise E L Buchwald Z S | 2009 | J Immunol2009，182，3： | 1 |
| 11 | Effect of dietary vitamin C on weight gain tissue ascorbate concentration, stress response and disease resistance of channel catfish Ictaiurus punctatus 显示文摘 | Li M H Wise D J Robinson E H | 1998 | J World Aquac Soc1998，29，1： | 1 |
| 12 | Estradiol is a Neuroprotective Factor in in Vivo and in Vitro Models of Brain Injury显示文摘 | WISE P M DUBAL D B WILSON M E | 2000 | Journal of Neurocytology2000，29，： | 1 |
| 13 | Stability of passively modelocked lasers with fast saturable absorbers显示文摘 | SERGEEV A M VANIN E V WISE F W | 1997 | Opt Commun1997，140，： | 1 |
| 14 | Penicillin: its basic site of action as an inhibitor of a peptide cross-linking reaction in cell wall mucopeptide synthesis显示文摘 | Wise E M Park J T | 1965 | Proc NatlAcadSci1965，54，： | 1 |
| 15 | Factors Associated with Use of Interactive Cancer Communication System: An Application of the Comprehensive Model of Information Seeking显示文摘 | Han J Y Wise M Kim E | 2010 | Journal of Computer-Mediated Communication2010，15，3： | 1 |
| 16 | Placental Pglycoprotein Deficiency Enhances Susceptibility to Chemically Induced Birty Defects in Mice显示文摘 | LANKAS G R WISE L D CARTWRIGHT M E | 1998 | Reprod Toxicol1998，12，： | 1 |
| 17 | The phosphorus requirement of calves显示文摘 | WISE M B SMITH S E BARNES L L | 1958 | Journal of Animal Science1958，，17： | 1 |
| 18 | Placental p-glycoprotein deficiency enhances susceptibility to chemically induced birth defects inmice显示文摘 | Lankas G R Wise L D Cartwright M E | 1998 | Reprod Toxicol1998，12，4： | 1 |
| 19 | Identification and comparison of low-molecular-weight neutral constituents in two different coal extracts显示文摘 | CHANG H-C K NISHIOKA M BARTLE K D WISE S A BAYONAJ M MARKlDES K E LEE M L | 1988 | Fuel1988，67，1： | 1 |
| 20 | The role of specific gravity for removal of hot melt adhesives in reeyelable grades 显示文摘 | Wise E M Arnold J M | 1992 | Tappi J1992，75，9： | 1 |
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