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| 1 | 酒精摄入、心脏生物标志物和心房颤动风险与不良结局显示文摘酒精摄入和新发心房颤动相关性证据不一,尤其是在低剂量下。该研究评估欧洲队列在整个饮酒范围内酒精摄入、生物标志物和新发心房颤动的关系。方法和结果:在一个以社区为基础的汇集队列中,研究者随访107845人,以评估酒精摄入(酒精种类和饮酒方式)与新发心房颤动的关系。研究者收集经典心血管病危险因素和新发心力衰竭的信息,并检测生物标记物氨基末端脑钠肽前体和高敏肌钙蛋白I。 | 陈嘉睿(译) 练桂丽((审校) Csengeri D Sprünker NA Di Castelnuovo A Niiranen T Vishram-Nielsen JK Costanzo S S derberg S Jensen SM Vartiainen E Donati MB Magnussen C Camen S Gianfagna F L chen ML Kee F Kontto J Mathiesen EB Koenig W Stefan B de Gaetano G J rgensen T Kuulasmaa K Zeller T Salomaa V Iacoviello L Schnabel RB | 2021 | 中华高血压杂志2021，29，2： | 9 |
| 2 | Comparison of non-schistosomal rectosigmoid cancer and schistosomal rectosigmoid cancer显示文摘AIM: To compare the clinicopathological features of patients with non-schistosomal rectosigmoid cancer and schistosomal rectosigmoid cancer.METHODS: All the patients with rectosigmoid carcinoma who underwent laparoscopic radical surgical resection in the Shanghai Minimally Invasive Surgical Center at Ruijin Hospital affiliated to Shanghai JiaoTong University between October 2009 and October2013 were included in this study. Twenty-six cases of colonic schistosomiasis diagnosed through colonoscopy and pathological examinations were collected. Symptoms,endoscopic findings and clinicopathological characteristics were evaluated retrospectively.RESULTS: There were no significant differences between patients with and without schistosomiasis in gender, age, CEA, CA19-9, preoperative biopsy findings or postoperative pathology. Patients with rectosigmoid schistosomiasis had a significantly higher CA-125 level and a larger proportion of these patients were at an early tumor stage(P = 0.003). Various morphological characteristics of schistosomiasis combined with rectosigmoid cancer could be found by colonoscopic examination: 46% were fungating mass polyps, 23%were congestive and ulcerative polyps, 23% were cauliflower-like masses, 8% were annular masses.Only 27% of the patients were diagnosed with rectal carcinoma preoperatively after the biopsy. Computed tomography(CT) scans showed thickened intestinal walls combined with linear and tram-track calcifications in 26 patients.CONCLUSION: Rectosigmoid carcinoma combined with schistosomiasis is associated with higher CA-125 values and early tumor stages. CA-125 and CT scans have a reasonable sensitivity for the accurate diagnosis. | Hao Feng Ai-Guo Lu Xue-Wei Zhao Ding-Pei Han Jing-Kun Zhao Lei Shi Tobias S Schiergens Serene ML Lee Wen-Peng Zhang Wolfgang E Thasler | 2015 | World Journal of Gastroenterology2015，21，23： | 6 |
| 3 | Artificial intelligence in gastroenterology: A state-of-the-art review显示文摘The development of artificial intelligence(AI)has increased dramatically in the last 20 years,with clinical applications progressively being explored for most of the medical specialties.The field of gastroenterology and hepatology,substantially reliant on vast amounts of imaging studies,is not an exception.The clinical applications of AI systems in this field include the identification of premalignant or malignant lesions(e.g.,identification of dysplasia or esophageal adenocarcinoma in Barrett’s esophagus,pancreatic malignancies),detection of lesions(e.g.,polyp identification and classification,small-bowel bleeding lesion on capsule endoscopy,pancreatic cystic lesions),development of objective scoring systems for risk stratification,predicting disease prognosis or treatment response[e.g.,determining survival in patients post-resection of hepatocellular carcinoma),determining which patients with inflammatory bowel disease(IBD)will benefit from biologic therapy],or evaluation of metrics such as bowel preparation score or quality of endoscopic examination.The objective of this comprehensive review is to analyze the available AI-related studies pertaining to the entirety of the gastrointestinal tract,including the upper,middle and lower tracts;IBD;the hepatobiliary system;and the pancreas,discussing the findings and clinical applications,as well as outlining the current limitations and future directions in this field. | Paul T Kröner Megan ML Engels Benjamin S Glicksberg Kipp W Johnson Obaie Mzaik Jeanin E van Hooft Michael B Wallace Hashem B El-Serag Chayakrit Krittanawong | 2021 | World Journal of Gastroenterology2021，27，40： | 6 |
| 4 | Ursodeoxycholic acid improves gastrointestinal motility defects in gallstone patients显示文摘AIM: To simultaneously evaluate the presence of defects in gallbladder and gastric emptying, as well as in intestinal transit in gallstone patients (GS) and the effect of chronic ursodeoxycholic acid (UDCA) administration on these parameters and on serum bile acids and clinical outcome in GS and controls (CTR). METHODS: After a standard liquid test meal, gallbla-dder and gastric emptying (by ultrasound), oroileal transit time (OITT) (by an immunoenzymatic technique) and serum bile acids (by HPLC) were evaluated before and after 3 mo of UDCA (12 mg/kg bw/d) or placebo administration in 10 symptomatic GS and 10 matched healthy CTR. RESULTS: OITT was longer in GS than in CTR (P < 0.0001); UDCA significantly reduced OITT in GS (P < 0.0001), but not in CTR. GS had longer gastric half-emptying time (t1/2) than CTR (P < 0.0044) at baseline; after UDCA, t1/2 significantly decreased (P < 0.006) in GS but not in CTR. Placebo administration had no effect on gastric emptying and intestinal transit in both GS and CTR. CONCLUSION: The gallstone patient has simultaneous multiple impairments of gallbladder and gastric emptying, as well as of intestinal transit. UDCA administration restores these defects in GS, without any effect in CTR. These results confirm the pathogenetic role of gastrointestinal motility in gallstone disease and suggest an additional mechanism of action for UDCA in reducing bile cholesterol supersaturation. | A Colecchia G Mazzella L Sandri F Azzaroli M Magliuolo P Simoni ML Bacchi-Reggiani E Roda D Festi | 2006 | World Journal of Gastroenterology2006，12，33： | 4 |
| 5 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 6 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 7 | Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleomorphic adenomas with t(3,8)(p21;q12)translocations 显示文摘 | Kas K Voz ML Roijer E | 1997 | Nat Genet1997，15，2： | 1 |
| 8 | Gemcitabine and docetaxel in patients with unresectable leiomyosarcoma: results of a phase Ⅱ trial显示文摘 | Hensley ML Maki R Venkatraman E | 2002 | J Clin Oncol2002，20，12： | 1 |
| 9 | Relative efficacy of intravenous immunoglobulin G in ameliorating thrombocytopenia induced by antiplatelet GP Ⅱ IbⅢa versus GPlbalpha antibodies 显示文摘 | Webster ML Sayeh E Crow M | 2006 | Blood2006，108，3： | 1 |
| 10 | Altered expres-sion of c-IAP1,survivin,and Smac contributes tochemotherapy resistance in thyroid cancer cells显示文摘 | TirròE Consoli ML Massimino M | 2006 | CancerRes2006，66，8： | 1 |
| 11 | Essential role of adenosine triphosphate in activation of 17beta-hydroxysteroid dehydrogenase in the rat Leydig cell显示文摘 | Khanum A Buczko E Dufau ML | 1997 | Endocrinology1997，138，4： | 1 |
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| 13 | Photodynamic therapy induces rapid cell death by apoptosis in LS178Y mouse lymphoma cells显示文摘 | Agarwal ML Clay ME Harvey E J | 1991 | Cancer Res1991，51，21： | 1 |
| 14 | Endothelium-derived nitric oxide regulates systemic and pulmonary vascular resistance during acute hypoxia in humans显示文摘 | Blitzer ML Loh E Roddy MA | 1996 | JACC1996，28，3： | 1 |
| 15 | Bean abscission cellulase:Characterization of a cDNA clone and regulation of gene expression by ethylene and auxin显示文摘 | TUCKER ML SEXTON R DEL CAMPLLLO E | 1955 | Plant Physiol1955，88，： | 1 |
| 16 | Major depressive disorder: new clinical, neurobiological, and treatment perspectives显示文摘 | Kupfer DJ Frank E Phillips ML | 2012 | Lancet2012，379，9820： | 1 |
| 17 | Pharmacodynamic effect and clinical effcacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomized trials显示文摘 | O'DONOGHUE ML BRAUNWALK E ANTMAN EM et ol | 2009 | Lancet2009，374，9694： | 1 |
| 18 | Generation and charac- terization of p53 null transformed hepatic pmgenitor cell:oval cells give rise to hepatocellular carcinoma 显示文摘 | Dumble ML Croager E J Yeoh GC | 2002 | Carcinogenesis2002，23，3： | 1 |
| 19 | Role of MicroRNA 1207-5P and Its Host Gene, the Long Non-Coding RNA Pvtl, as Mediators of Extracellular Matrix Accumulation in the Kidney : Im- plications for Diabetic Nephropathy显示文摘 | Alvarez ML Khosroheidari M Eddy E | 2013 | PLoS One2013，8，77： | 1 |
| 20 | Procalcitonin strip test in the early detection of severe acute pancreatitis显示文摘 | Kyl(a)np(a)(a)-B(ac)k ML Takala A Kemppainen E | | 0，，02： | 1 |
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