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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Studies on flaovr volatiles of some sweet corn products显示文摘 | Buttery R G Stern D J Ling L C | 1982 | Journal of Agricultural and Food Chemistry1982，30，： | 1 |
| 3 | XPD codon 751 polymorphism,metabolism genes,smoking,and bladder cancer risk显示文摘 | STERN M C JOHNSON L R BELL D A | 2002 | Cancer Epidemiol Biomarkers Prev2002，11，101： | 1 |
| 4 | Value orientations,gender andenvironmental concern显示文摘 | Stern P C Dietz T Kalof L | 1993 | Environment and Behavior1993，，25： | 1 |
| 5 | Post-synthesis alkoxide formation within metal-organic framework materials: A strategy for incorporating highly coordinatively unsaturated metal ions 显示文摘 | Mullort K L Farha O K Stern C L | 2009 | J Am Chem Soc2009，131，11： | 1 |
| 6 | Nanostructured hydrotreating catalysts for electrochemical hydrogen evolution显示文摘 | Morales-Guio C G Stern L-A Hu X L | 2014 | Chemical Society Reviews2014，43，18： | 1 |
| 7 | Value orientations,gender,and environmental concern显示文摘 | Stern P C Dietz T Kalof L | 1993 | Environment and Behavior1993，25，： | 1 |
| 8 | Novel technique for management of distal ureter and en block resection of bladder cuff during hand-assisted laparoscopic nephroureterectomy显示文摘 | Vardi l Y Stern J A Gonzalez C M | 2006 | Urology2006，67，： | 1 |
| 9 | Antibodies to beta2 glycoprotein I are associated with in vitro fertilization implantation failure as well as recurrent miscarriage: results of a prevalence study 显示文摘 | Stern C Chamley L Hale L | 1998 | Fertil Steril1998，70，5： | 1 |
| 10 | Isolation and identification of 'diazepam-like' compounds from bovine urine显示文摘 | Luk K C Stern L Welgele M | 1983 | Journal of Natural Products1983，46，6： | 1 |
| 11 | The Chlamydomonas reinhardtii plastid chromosome:islands of genes in a sea of repeats显示文摘 | MAUL J E LILLY J W CUI L DE PAMPHILIS C W MILLER W HARRIS E H STERN D B | 2002 | Plant Cell2002，14，11： | 1 |
| 12 | Muscle histochemical and biochemical properties in relation to meat quality during selection for increased lean tissue growth rate in pigs 显示文摘 | Karlsson A Enfalt A C Essen-Gustavsson B Lundstrom K Rydhmer L Stern S | 1993 | J Anim Sci1993，71，： | 1 |
| 13 | The structure-directing properties of ^2-显示文摘 | WELK M E NORQUIST A J STERN C L | 2000 | Inorg Chem2000，39，18： | 1 |
| 14 | A molecular pathway determining left-right asymmetry in chick embryogenesis显示文摘 | JOHNSON R L STERN C D | 1995 | Cell1995，82，： | 1 |
| 15 | Oxygen isotopeevidence of climate change from pedogenic clay minerals in the Hima-layan molasse显示文摘 | Stern L A Chamberlain C P Reynolds R C | 1997 | Geochimica et Cosmochimica Acta1997，61，4： | 1 |
| 16 | Cu(C10H9N3)2 MOF5·2H2O(M= Nb,Ta):Aligned ^2- oxide fluoride anions 显示文摘 | NORQUIST A J STERN C L POEPPELMEIER K R | 1999 | Inorg Chem1999，38，15： | 1 |
| 17 | Con- ducting Interorganizational Research Using Key In- formants显示文摘 | KUMAR N STERN L W ANDERSON J C | 1993 | Academy of Management Journal1993，36，6： | 1 |
| 18 | A value-belief-norm theory of support for social movements:The case of environmentalism显示文摘 | Stern P C Dietz T Abel T D Guagnano G A Kalof L (1999) | 1999 | Human Ecology Review1999，6，2： | 1 |
| 19 | Synthesis of the neutral ( CuF(NC5H5)4 ) 2 NbOFs cluter 显示文摘 | NORQUIST A J WELK M E STERN C L | 2000 | Chem Mater2000，12，7： | 1 |
| 20 | Antiphospholipid antibodies and coagulation defects in women with implantation failure after IVF and recurrent miscarriage 显示文摘 | Stern C Chamley L | 2006 | Reprod Biomed Online2006，13，1： | 1 |
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