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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Estimation of the incidence of stroke using a capture-recapture model including covariates 显示文摘 | Tilling K Sterne J A Wolfe C D | 2002 | International Journal of Epidemiology2002，30，6： | 1 |
| 3 | Developmental alter- ations of frontal-striatal-thalamic connectivity in obsessive-com- pulsive disorder显示文摘 | Fitzgerald K D Welsh R C Stern E R | 2011 | J Am Aca Child Adolesc Psychiatry2011，50，9： | 1 |
| 4 | Studies on flaovr volatiles of some sweet corn products显示文摘 | Buttery R G Stern D J Ling L C | 1982 | Journal of Agricultural and Food Chemistry1982，30，： | 1 |
| 5 | XPD codon 751 polymorphism,metabolism genes,smoking,and bladder cancer risk显示文摘 | STERN M C JOHNSON L R BELL D A | 2002 | Cancer Epidemiol Biomarkers Prev2002，11，101： | 1 |
| 6 | China's changing energy intensity trend: a decomposition analysis 显示文摘 | Ma C Stern D | 2008 | Energy Economics2008，30，： | 1 |
| 7 | Protection to + 12Gz显示文摘 | Burns J W Ivan D J Stern C H | 2001 | Aviat Space Environ Med2001，72，5： | 1 |
| 8 | Effect of cooling rate and dehydration regimen on the histological appearance of human ovarian cortex following cryopreservation in 1,2-propanediol 显示文摘 | GOOK A EDGAR D H STERN C | 1999 | Hum Reprod1999，14，8： | 1 |
| 9 | Evaluation of a mathematical model of rnmen digestion and an in vitro simulation of rumen proteolysis to estimate the rumen- undegraded nitrogen content of feedstuffs显示文摘 | Krishnamoorthy U Sniffen C J Stern M D | 1983 | Brit J Nutr1983，50，3： | 1 |
| 10 | Role of the JAK/STAT signaling pathway in diabetic nephropathy显示文摘 | Marrero M B Banes-Berceli A K Stern D M Eaton D C | 2006 | Am J Physiol2006，290，4： | 1 |
| 11 | Verification and validation of RANS maneuvering simulation of Esso Osaka: effects of drift and rudder angle forces and moments显示文摘 | Simonsen C D Stern F | 2003 | Computers and Fluids2003，32，： | 1 |
| 12 | China's Changing Energy Intensity Trend:A Decomposition Analysis显示文摘 | Ma C Stern D | | 0，，： | 1 |
| 13 | Public and stakeholder participation for managing and reducing the risks of shale gas development显示文摘 | North D W Stern P C Webler T | 2014 | Environmental science&technology2014，48，83： | 1 |
| 14 | Peer Nomination: A Tool for Identifying Medical Student Exemplars in Clinical Competence and Caring, Evaluated at Three Medical Schools 显示文摘 | McCormack W T Lazarus C Stern D etal | 2007 | Academic Medicine2007，82，11： | 1 |
| 15 | The chick,a great model system becomes even greater显示文摘 | Stern C D | 2005 | Dev Cell2005，，8： | 1 |
| 16 | Evaluation of mathraatical of digestion and in vitro simulation of rumen proteolysis to estimate the rumen undegxaded nitrogen content of feedstuffs显示文摘 | Krishnamoorthy U C Siffen C J Stern M D | 1983 | British Journal of Nutrition1983，50，55： | 1 |
| 17 | Evaluation of mathematical model of digesta and in vitro simulation of rumen proteolysis to estimate the rumen undegraded nitrogen content of feedstuffs 显示文摘 | Krishnamoorthy U C Sniffen C J Stern M D | 1983 | British Journal of Nutrition1983，50，： | 1 |
| 18 | Prefrontal temporal Circuitry for Episodic Encoding and Subsequent Memory 显示文摘 | Kircbbof B A Wagner A D Maril A Stern C E | 2000 | The Journal of Neuroscience2000，20，16： | 1 |
| 19 | Procedural and strain-related variables significantly affect outcome in a murine model of focal cerebral ischemia显示文摘 | CONNOLLY E S J R WINFREE C J STERN D M | 1996 | Neurosurgery1996，38，3： | 1 |
| 20 | The Chlamydomonas reinhardtii plastid chromosome:islands of genes in a sea of repeats显示文摘 | MAUL J E LILLY J W CUI L DE PAMPHILIS C W MILLER W HARRIS E H STERN D B | 2002 | Plant Cell2002，14，11： | 1 |
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