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| 1 | Municipal wastewater treatment in China:Development history and future perspectives显示文摘China has the world's largest and still growing wastewater sector and water market,thus its future development will have profound influence on the world.The high-speed development of China's wastewater sector over the past 40 years has forged its global leading treatment capacity and innovation ability.However,many problems were left behind,including underdeveloped sewers and sludge disposal facilities,low sustainability of the treatment processes,questionable wastewater treatment plant(WWTP)effluent discharge standards,and lacking global thinking on harmonious development between wastewater management,human society and the nature.Addressing these challenges calls for fundamental changes in target design,policy and technologies.In this mini-review,we revisit the development history of China's municipal wastewater management and identify the remaining challenges.Also,we highlight the future needs of sustainable development and exploring China's own wastewater management path,and outlook the future from several aspects including targets of wastewater management,policies and technologies,especially the new concept WWTP.Furthermore,we envisage the establishment of new-generation WWTPs with the vision of turning WWTP from a site of pollutant removal into a plant of energy,water and fertilizer recovery and an integrated part urban ecology in China. | Jiuhui Qu Hongchen Wang Kaijun Wang Gang Yu Bing Ke Han-Qing Yu Hongqiang Ren Xingcan Zheng Ji Li Wen-Wei Li Song Gao Hui Gong | 2019 | Frontiers of Environmental Science & Engineering2019，13，6： | 13 |
| 2 | Carbon pools and fluxes in the China Seas and adjacent oceans显示文摘The China Seas include the South China Sea, East China Sea, Yellow Sea, and Bohai Sea. Located off the Northwestern Pacific margin, covering 4700000 km^2 from tropical to northern temperate zones, and including a variety of continental margins/basins and depths, the China Seas provide typical cases for carbon budget studies. The South China Sea being a deep basin and part of the Western Pacific Warm Pool is characterized by oceanic features; the East China Sea with a wide continental shelf, enormous terrestrial discharges and open margins to the West Pacific, is featured by strong cross-shelf materials transport; the Yellow Sea is featured by the confluence of cold and warm waters; and the Bohai Sea is a shallow semiclosed gulf with strong impacts of human activities. Three large rivers, the Yangtze River, Yellow River, and Pearl River, flow into the East China Sea, the Bohai Sea, and the South China Sea, respectively. The Kuroshio Current at the outer margin of the Chinese continental shelf is one of the two major western boundary currents of the world oceans and its strength and position directly affect the regional climate of China. These characteristics make the China Seas a typical case of marginal seas to study carbon storage and fluxes. This paper systematically analyzes the literature data on the carbon pools and fluxes of the Bohai Sea,Yellow Sea, East China Sea, and South China Sea, including different interfaces(land-sea, sea-air, sediment-water, and marginal sea-open ocean) and different ecosystems(mangroves, wetland, seagrass beds, macroalgae mariculture, coral reefs, euphotic zones, and water column). Among the four seas, the Bohai Sea and South China Sea are acting as CO_2 sources, releasing about0.22 and 13.86–33.60 Tg C yr^(-1) into the atmosphere, respectively, whereas the Yellow Sea and East China Sea are acting as carbon sinks, absorbing about 1.15 and 6.92–23.30 Tg C yr^(-1) of atmospheric CO_2, respectively. Overall, if only the CO_2 exchange at the sea-air interface is considered, the Chinese marginal seas appear to be a source of atmospheric CO_2, with a net release of 6.01–9.33 Tg C yr^(-1), mainly from the inputs of rivers and adjacent oceans. The riverine dissolved inorganic carbon (DIC) input into the Bohai Sea and Yellow Sea, East China Sea, and South China Sea are 5.04, 14.60, and 40.14 Tg C yr^(-1),respectively. The DIC input from adjacent oceans is as high as 144.81 Tg C yr^(-1), significantly exceeding the carbon released from the seas to the atmosphere. In terms of output, the depositional fluxes of organic carbon in the Bohai Sea, Yellow Sea, East China Sea, and South China Sea are 2.00, 3.60, 7.40, and 5.92 Tg C yr^(-1), respectively. The fluxes of organic carbon from the East China Sea and South China Sea to the adjacent oceans are 15.25–36.70 and 43.93 Tg C yr^(-1), respectively. The annual carbon storage of mangroves, wetlands, and seagrass in Chinese coastal waters is 0.36–1.75 Tg C yr^(-1), with a dissolved organic carbon(DOC) output from seagrass beds of up to 0.59 Tg C yr^(-1). Removable organic carbon flux by Chinese macroalgae mariculture account for 0.68 Tg C yr^(-1) and the associated POC depositional and DOC releasing fluxes are 0.14 and 0.82 Tg C yr^(-1), respectively. Thus, in total, the annual output of organic carbon, which is mainly DOC, in the China Seas is 81.72–104.56 Tg C yr^(-1). The DOC efflux from the East China Sea to the adjacent oceans is 15.00–35.00 Tg C yr^(-1). The DOC efflux from the South China Sea is 31.39 Tg C yr^(-1). Although the marginal China Seas seem to be a source of atmospheric CO_2 based on the CO_2 flux at the sea-air interface, the combined effects of the riverine input in the area, oceanic input, depositional export,and microbial carbon pump(DOC conversion and output) indicate that the China Seas represent an important carbon storage area. | Nianzhi JIAO Yantao LIANG Yongyu ZHANG Jihua LIU Yao ZHANG Rui ZHANG Meixun ZHAO Minhan DAI Weidong ZHAI Kunshan GAO Jinming SONG Dongliang YUAN Chao LI Guanghui LIN Xiaoping HUANG Hongqiang YAN Limin HU Zenghu ZHANG Long WANG Chunjie CAO Yawei LUO Tingwei LUO Nannan WANG Hongyue DANG Dongxiao WANG Si ZHANG | 2018 | Science China Earth Sciences2018，61，11： | 12 |
| 3 | Testing coral paleothermometers(B/Ca, Mg/Ca, Sr/Ca, U/Ca and δ^(18)O) under impacts of large riverine runoff显示文摘Sea surface temperature(SST) proxies including B/Ca, Mg/Ca, Sr/Ca, U/Ca and δ18O were analyzed in the skeleton of a Porites coral collected from the Zhujiang River(Pearl River) Estuary(ZRE). These geochemical proxies are influenced by river runoff and this area of the northern South China Sea is strongly affected by seasonal freshwater floods. We assessed the robustness of each SST proxy through comparison with the local instrumental SST. Coral Sr/Ca shows the highest correlation with SST variations(r2=0.59), suggesting Sr/Ca is the most robust SST proxy. In contrast, coral δ18O(r2=0.46), B/Ca(r2=0.43) and U/Ca(r2=0.41) ratios were only moderately correlated with SST variations, suggesting that they are disturbed by some other factors in addition to SST. The poor correlation(r2=0.27) between SST and Mg/Ca indicates that Mg/Ca in coral skeletons is not a simple function of SST variations. This may ultimately limit the use of Mg/Ca as a coral paleothermometer. | CHEN Tianran YU Kefu ZHAO Jianxin YAN Hongqiang SONG Yinxian FENG Yuexing CHEN Tegu | 2015 | Acta Oceanologica Sinica2015，34，8： | 4 |
| 4 | Uniform single atomic Cu_(1)-C_(4)sites anchored in graphdiyne for hydroxylation of benzene to phenol显示文摘For single-atom catalysts(SACs),the catalyst supports are not only anchors for single atoms,but also modulators for geometric and electronic structures,which determine their catalytic performance.Selecting an appropriate support to prepare SACs with uniform coordination environments is critical for achieving optimal performance and clarifying the relationship between the structure and the property of SACs.Approaching such a goal is still a significant challenge.Taking advantage of the strong d-πinteraction between Cu atoms and diacetylenic in a graphdiyne(GDY)support,we present an efficient and simple strategy for fabricating Cu single atoms anchored on GDY(Cu_(1)/GDY)with uniform Cu_(1)-C_(4)single sites under mild conditions.The Cu atomic structure was confirmed by combining synchrotron radiation X-ray absorption spectroscopy,X-ray photoele ctron spectroscopy and density functional theory(DFT)calculations.The as-prepared Cu1/GDY exhibits much higher activity than state-of-the-art SACs in direct benzene oxidation to phenol with H_(2)O_(2)reaction,with turnover frequency values of 251 h^(-1)at room temperature and 1889 h^(-1)at 60℃,respectively.Furthermore,even with a high benzene conversion of86%,high phenol sele ctivity(96%)is maintaine d,which can be ascribed to the hydrophobic and oleophyllic surface nature of Cu1/GDY for benzene adsorption and phenol desorption.Both experiments and DFT calculations indicate that Cu_(1)-C_(4)single sites are more effective at activating H_(2)O_(2)to form Cu=O bonds,which are important active intermediates for benzene oxidation to phenol. | Jia Yu Changyan Cao Hongqiang Jin Weiming Chen Qikai Shen Peipei Li Lirong Zheng Feng He Weiguo Song Yuliang Li | 2022 | National Science Review2022，9，9： | 3 |
| 5 | A method of forced extrapolation of the global magnetic field in the solar corona显示文摘We present a method of forced-field(i.e., non-force-free field: NFFF) extrapolation of the global magnetic field in the corona, on the basis of single-layer vector magnetogram, by extending an extrapolation technique of local magnetic field first developed by Hu et al.(2008). The forced coronal magnetic field is described by a system with the minimum dissipation rate(MDR) which is appropriate for the corona as a forced and open system. The obtained solution of the magnetic field can be decomposed into three components including one potential field and two linear force-free fields(LFFF). Starting from the given single-layer vector magnetogram, the bottom boundary condition for each component is determined with an iterative method to achieve a minimum difference of the transverse component between the extrapolated field and the original magnetogram. The final extrapolated forced field is given by the sum of the three component fields with the obtained bottom boundaries. The method is tested with an analytic magnetohydrostatic(MHS) solution. It is shown that the extrapolated forced field is highly consistent with the MHS solution at least from the solar disk to the heliocentric distance of 1.5 solar radii(R⊙). For instance, the complements of normalized and mean vector errors(E’n, E’m) are as high as ~97% and 95%, respectively. Further comparisons between magnetic strength, force and field line distributions indicate that the MHS solution has been successfully reconstructed. | WANG Bing CHEN Yao HU Qiang JIANG ChaoWei SONG HongQiang WU Zhao NING Hao | 2020 | Science China(Technological Sciences)2020，63，2： | 3 |
| 6 | Control of phase,polarization,and amplitude based on geometric phase in a racemic helix array显示文摘The Pancharatnam–Berry geometric phase has attracted great interest due to the elegant phase control strategy via geometric transformation of optical elements.The commonly used geometric phase is associated with circular polarization states.Here,we show that by exploiting the geometric phase associated with the two elliptical eigenpolarization states in a racemic metallic helix array,exotic features including full range phase modulation for linear polarization states,diverse polarization conversion,and full complex amplitude modulation can be obtained with rotation of the helices.As a proof of concept,several devices for implementing polarization conversion,vortex beam generating,and lateral dual focusing are built with a racemic helix array in the microwave regime.The calculated and experimental results validate our proposals,which can stimulate various advanced metadevices. | CHAO WU QUAN LI ZHIHUI ZHANG SONG ZHAO HONGQIANG LI | 2021 | Photonics Research2021，9，11： | 2 |
| 7 | The Association Between Epoxide Hydrolase Genetic Variant and Effectiveness of Nicotine Replacement Therapy in a Han Chinese Population显示文摘Dear Editor,Nicotine is a psychoactive alkaloid that is thought to play a key role in addiction to commercial tobacco products[1]and cotinine is its primary metabolite[2].Pharmacological treatment,such as nicotine replacement therapy(NRT),is a valid solution to this problem.Tobacco smoke contains many carcinogens such as nitrosamines[i.e.,nicotinederived nitrosamine ketone(NNK)and N-nitrosonornicotine(NNN)],and | Fan Wang Yanlong Liu Song Guo Dafang Chen Hongqiang Sun | 2016 | Neuroscience Bulletin2016，32，6： | 2 |
| 8 | Phosphorus fractions and matrix-bound phosphine in coastal surface sediments of the Southwest Yellow Sea显示文摘 | Yuning Hong Jinju Geng Song Qiao Yongzhan Zhang Lili Ding Xiaorong Wang Hongqiang Ren | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 9 | Covalently tethering disulfonic acid moieties onto polyoxometalate boosts acid strength and catalytic performance for hydroxyalkylation/alkylation reaction显示文摘Solid acid catalysts are widely used in the production of various high-value added and industrially important chemicals.Although the use of organosilicon compounds to modify the vacancy site has been extensively studied,the covalent tethering-SO_(3)H functionalized organosilicon modified polyoxometalates(POMs)has been rarely reported.In this work,two catalysts(TBA_(4)[SiW_(11)O_(39)(O(SiC_(3)H_(6)SO_(3)H)_(2))](compound 2)and TBA_(4)[SiW_(11)O_(39)(O(SiC_(8)H_(8)SO_(3)H)_(2))](compound 3))were synthesized successfully through covalently grafting different sulfonic acid(-SO_(3)H)groups onto[SiW_(11)O_(39)]^(8−)cluster,respectively.Compound 2 was achieved by surface grafting and in situ oxidation(3-mercaptopropyl)-trimethoxysilane,while compound 3 was achieved by surface grafting of 2-(4-chlorosulfonylphenyl)ethyltrimethoxysilane.Strong Brønsted acid strength of compounds 2 and 3 can be demonstrated by different methods including potentiometric titration,pyridine adsorption studies,and the ^(31)P trimethylphosphine oxides(TMPO)nuclear magnetic resonance(NMR).The systematic investigation of the relationship among POM structures,acid strength,and electron density was carried out based on density functional theory(DFT)calculation and experimental results,which revealed that covalent modification of compounds 2 and 3 decreased the electron density of the O-H bond,and promoted the release of H^(+).When applied in hydroxyalkylation/alkylation(HAA)reaction of 2-methylfuran(2-MF)with cyclohexanone,compound 2 exhibited better catalytic performance with conversion of ~93%,monocyclic fuel precursors(1a)yield of 79.9% and selectivity of 85.7% than compound 3,which can be attributed to strong Brønsted acid and the intramolecular hydrogen-bonding interactions between the neighboring -SO_(3)H moieties in compound 2.Finally,compound 2 also showed excellent catalytic activity in the HAA reaction of 2-MF with several different aldehydes and ketones(e.g.,furfuraldehyde,5-methylfurfuraldehyde,acetone,butyraldehyde and 4-methoxybenzaldehyde).This result opens a new pathway for design and fabrication of novel solid acid catalysts. | Lifei Lian Yubing Liu Xianfeng Yi Hanbin Hu Xiang Chen Hongqiang Li Wei Chen Anming Zheng Yu-Fei Song | 2022 | Science China Chemistry2022，65，4： | 1 |
| 10 | Dynamic evolution of nitrogen and oxygen dual-coordinated single atomic copper catalyst during partial oxidation of benzene to phenol显示文摘Single atom catalysts(SACs)with metal_(1)-N_(x)sites have shown promising activity and selectivity in direct catalytic oxidation of benzene to phenol.The reaction pathway is considered to be involving two steps,including a H_(2)O_(2)molecule dissociated on the metal single site to form the(metal_(1)-N_(x))=O active site,and followed by the dissociation of another H_(2)O_(2)on the other side of metal atom to form O=(metal_(1)-N_(x))=O intermediate center,which is active for the adsorption of benzene molecule via the formation of a C-O bond to form phenol.In this manuscript,we report a Cu SAC with nitrogen and oxygen dual-coordination(Cu1-N3O1 moiety)that doesn’t need the first H_(2)O_(2)activation process,as verified by both experimental and density function theory(DFT)calculations results.Compared with the counterpart nitrogen-coordinated Cu SAC(denoted as Cu1/NC),Cu SAC with nitrogen and oxygen dual-coordination(denoted as Cu1/NOC)exhibits 2.5 times higher turnover frequency(TOF)and 1.6 times higher utilization efficiency of H_(2)O_(2).Particularly,the coordination number(CN)of Cu atom in Cu1/NOC maintains four even after H_(2)O_(2)treatment and reaction.Combining DFT calculations,the dynamic evolution of single atomic Cu with nitrogen and oxygen dualcoordination in hydroxylation of benzene is proposed.These findings provide an efficient route to improve the catalytic performance through regulating the coordination environments of SACs and demonstrate a new reaction mechanism in hydroxylation of benzene to phenol reaction. | Weiming Chen Hongqiang Jin Feng He Peixin Cui Changyan Cao Weiguo Song | 2022 | Nano Research2022，15，4： | 1 |
| 11 | 4-13 Rydberg-to-M-shell X-ray Emission of Hollow Xe Atoms/ions above Metallic Surfaces显示文摘According to the classical over-barrier model[1;2], as a slow highly charged Xeq+ ion approaches a critical distance R =p 2q from the surface with the work function W, it begins to resonantly capture conduction electrons into high Rydberg states (principal quantum number around n q). | Song Zhangyong Yang Zhihu Zhang Hongqiang Shao Jianxiong Cui Ying Zhang Yanping Zhang Xiaoan Zhao Yongtao Chen Ximeng Xiao Guoqing | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 12 | Breaking the activity limitation of iridium single-atom catalyst in hydrogenation of quinoline with synergistic nanoparticles catalysis显示文摘Single-atom catalysts(SACs)with the advantages of homogeneous and heterogeneous catalysts have become a hot-spot in catalysis field.However,for lack of metal–metal bond in SACs,H_(2)has to go through heterolytic dissociation pathway,which has higher barrier than homolytic dissociation pathway,and thus limits the hydrogenation activity of SACs.Herein,we propose and demonstrate through constructing synergistic iridium single atoms and nanoparticles co-existed catalyst(denoted as Ir_(1+NPs)/CMK)to boost the catalytic activity of quinoline hydrogenation.Both experimental and density functional theory calculation results confirm that Ir_(1)single sites activate quinoline,while Ir nanoparticles boost hydrogen dissociation.H atoms generated at Ir nanoparticles migrate to the quinoline bounded Ir_(1)single sites to complete hydrogenation.The Ir_(1+NPs)/CMK catalyst exhibits much higher reactivity with turnover frequency of 7,800 h^(−1)than those counterpart Ir_(1)/CMK and IrNPs/CMK catalysts,and is 20,000 times higher activity of commercial Ir/C benchmark catalyst for hydrogenation of quinoline under the same reaction conditions.This synergistic catalysis strategy between single atoms and nanoparticles provides a solution to further improve the performance of SACs for hydrogenation. | Qikai Shen Hongqiang Jin Peipei Li Xiaohu Yu Lirong Zheng Weiguo Song Changyan Cao | 2022 | Nano Research2022，15，6： | 0 |
| 13 | Super-High Initial Velocity Mechanism of Bullet Propulsion with Adaptive Pressure-Maintaining Chamber显示文摘To deal with the problem that the initial velocity of the bullet is difficult to increase,the research on the super-high initial velocity propulsion in the barrel weapon with an adaptive pressure-maintaining chamber are conducted.Considering the law of gun-powder burning and the flow characteristics of gun-powder gas in multi-chamber,the scheme of super-high initial velocity propulsion with an adaptive pressure-maintaining chamber is designed,the ballistic model of the barrel weapon with super-high velocity bullet propulsion is established.The research results show that the technical scheme can greatly increase the initial velocity of the bullet with the peak pressure keeping nearly the same as the tradition barrel weapon.The research results can provide a theoretical foundation to significantly increase the initial velocity in barrel weapons using solid propellants,and have an important reference value to comprehensively increase the power of the barrel weapons. | Junbo Xiao Hongqiang Li Zhenqiang Liao Ming Qiu Jie Song | 2020 | Journal of Beijing Institute of Technology2020，29，1： | 0 |
| 14 | NO_(2) sensing with CdS nanowires at room temperature under green light illumination显示文摘Detection of ppb-level NO_(2) gas under atmosphere is urgent to meet the requirements of the rapidly developing internet of things.Compared with traditional sensing methods,light illumination has been considered as a key approach for excellent gas sensor performance under moderate conditions.Herein,we developed a green-light-assisted gas sensor based on cadmium sulfide nanowires(CdS NWs)that has good NO_(2) sensing capability at ambient temperature.The response values of NO_(2) are 236%and 11%to 10 ppm and 12.5 ppb,respectively.Furthermore,the CdS NWs sensor has a high selectivity for NO_(2) over a variety of interference gases,as well as good stability.The cleaning light activation and the sulfur vacancy-trapped charge behavior of CdS NWs are observed,which suggest a light-assisted sensing mechanism.These results suggest that light-induced charge separation behavior might significantly improve gas-sensing characteristics. | Peipei Li Hongqiang Jin Jia Yu Weiming Chen Runqing Zhao Changyan Cao Weiguo Song | 2022 | Materials Futures2022，1，2： | 0 |
| 15 | Study of Characteristic LX-ray Spectra of Thick and Thin Au Target by Carbon Ions显示文摘 | Song Zhangyong Yang Zhihu Ruan Fangfang Cai Xiaohong Zhang Hongqiang Shao Jianxiong Cui Ying Xie Jiangshan Gao Zhimin Du Juan Liu Liewen | 2006 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2006，，1： | 0 |
| 16 | Characteristics and applications of interplanetary coronal mass ejection composition显示文摘In situ measurements of interplanetary coronal mass ejection(ICME)composition,including elemental abundances and charge states of heavy ions,open a new avenue to study coronal mass ejections(CMEs)besides remote-sensing observations.The ratios between different elemental abundances can diagnose the plasma origin of CMEs(e.g.,from the corona or chromosphere/photosphere)due to the first ionization potential(FIP)effect,which means elements with different FIPs get fractionated between the photosphere and corona.The ratios between different charge states of a specific element can provide the electron temperature of CMEs in the corona due to the freeze-in effect,which can be used to investigate their eruption process.In this review,we first give an overview of the ICME composition and then demonstrate their applications in investigating some important subjects related to CMEs,such as the origin of filament plasma and the eruption process of magnetic flux ropes.Finally,we point out several important questions that should be addressed further for better utilizing the ICME composition to study CMEs. | SONG HongQiang YAO Shuo | 2020 | Science China(Technological Sciences)2020，63，11： | 0 |
| 17 | 4-21 M X-ray Emission of Hollow Xeq+ Atoms above Metallic Surfaces显示文摘A highly charged ion (HCI) has a large potential energy, which is equal to the binding energies of all the elec-trons removed to create the ion. When such a slow HCI approaches and then enters into a solid surface, an \abovethe surface' and a \below the surface' hollow atom will be formed, respectively, by capturing electrons from thesurface into its empty levels. Not only new aspects of atom physics has been introduced by hollow atoms, but alsoHCI applications in material science has promising prospects, such as surface analysis, the synthesis of materialswith new properties, and the formation of nanostructure that have been an active area of research in recent years[1??6]. | Song Zhangyong Yang Zhihu Zhang Hongqiang Shao Jianxiong Cui Ying Zhang Yanping Zhang Xiaoan Zhao Yongtao Chen Ximeng Xiao Guoqing | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 18 | Preparation and Performance of Chitosan/Citric Acid Modified Magnesium Oxychloride Cement显示文摘Citric acid(CA)and chitosan(CS)were employed to modify magnesium oxychloride cement(MOC).Multiscale measurements were implemented to study the properties of the modified MOC pastes.Results show that the addition of CA/CS significantly changes the content of each phase and the microstructure of phase 5.The single addition of CA can effectively increase the compressive strength of MOC after 7 d curing,while CS exerts no obvious effect on the compressive strength.As to the simultaneous addition of CA and CS,the compressive strength of MOC gradually decreases with the increasing content of CS.Interestingly,mixing CA and CS significantly enhances the water resistance of MOC and decreases the degradation rate of MOC in phosphate buffered solution,which can be ascribed to the low specific surface area of the plate-like crystals in the modified MOC and the reduction of pores in the structure. | SONG Zijian LIU Lang YU Peipei ZHANG Yunsheng LI Xincheng CHU Hongqiang JIANG Linhua | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，6： | 0 |
| 19 | Shift Phenomenon of Peak-channel of ^(241)Am Source by Si(Au) Semiconductor Detector Made in IMP显示文摘First we calibrated the spectrometer in atmosphere using the peak-channel of 241Am, Thc-c' standard radioactive source while the window diameter isφ3. 0 mm and gained following formula with respect to the energy (E/MeV) ofαand the channel (Ch): E=1. 507 55 + 0. 016 31×Ch+6. 235 24×10-6×Ch2 So, when E=5. 486 MeV, the Ch is equal to 221. 493. When changing the diameter of incident window toφ1.5 mm, we find the peak-channel of | Song Zhangyong Yang Zhihu Ruan Fangfang Zhang Hongqiang Shao Jianxiong Cui Ying Xie Jiangshan Gao Zhimin | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 20 | Clinical efficacy of low-dose emetine for patients with COVID-19:a real-world study显示文摘Objective:Emetine,an isoquinoline alkaloid that is enriched at high concentrations in the lung,has shown potent in vitro activity against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The aim of this study was to better understand the effectiveness of low-dose emetine for patients with coronavirus disease 2019(COVID-19).Methods:In this real-world study,63 patients with mild or common COVID-19 were recruited from Wuhan Fangcang Shelter Hospital and five COVID-19-designated hospitals in Anhui Province,China from February to March 2020.Thirty-nine patients from Wuhan Fangcang Shelter Hospital were assigned to a pragmatic randomized controlled clinical trial,and 24 patients from the 5 COVID-19-designated hospitals in Anhui Province underwent a real-world study.The medication course of emetine was less than 10 days.The main symptoms and adverse reactions of all patients were observed and recorded.The primary outcome measure was the time required for a negative SARS-CoV-2 RNA result or the negative result rate on day 10.Secondary outcomes included axillary temperature,transcutaneous oxygen saturation,and respiratory frequency recovery.The study was approved by the Ethics Committee of The First Affiliated Hospital of Anhui Medical University on February 20,2019(approval No.PJ2020-03-19)and was registered with the Chinese Clinical Trial Registry on February 20,2019(registration number:ChiCTR2000030022).Results:The oxygen saturation values were higher in the treatment group than in the control group on the first day after enrollment for patients treated at Fangcang Shelter Hospital.The axillary body temperature,respiratory rate,and oxygen saturation among patients in Fangcang Shelter Hospital were related to the time effect but not to the intervention measures.The respiratory rate and oxygen saturation of patients in the Anhui designated hospitals were related to the intervention measures but not to the time effect.The axillary body temperature of patients in Anhui designated hospitals was related to the time effect but not to the intervention measures.Conclusion:Our preliminary study shows that low-dose emetine combined with basic conventional antiviral drugs improves clinical symptoms in patients with mild and common COVID-19 without apparent adverse effects,suggesting that moderately increased doses of emetine may have good potential for treatment and prevention of COVID-19. | Song Fan Qi Zhen Cheng Chen Wenjun Wang Qibing Wu Huihui Ma Chengyuan Zhang Li Zhang Baojing Lu Huiyao Ge Liang Yong Bao Li Yafen Yu Weiwei Chen Yiwen Mao Guangbo Qu Li Su Aoli Wang Zhen Ding Haiwen Li Jin Zhang Yonglian Wang Yufeng Gao Xihai Xu Zhongming Zhu Jun Chen Long Zhang Hongqiang Liang Song Wu Meng Huang Quan Xia Ping Li Yehuan Sun Chaozhao Liang Wei Wei Qingsong Liu Liangdan Sun | 2021 | Journal of Bio-X Research2021，4，2： | 0 |
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