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| 1 | Laser Welding of TC-1 Titanium Alloy显示文摘The technology of CO2 laser welding and joint properties of titanium alloy were investigated. The problem of moltenpool protection was resolved by designing a shielding trailer and a special clamp. Joints with silvery appearance wereobtained, which have no pore and crack. In addition, the welding speed could reach 3 m/min for the plate of 1.5 mmthickness being penetrated. The reason of the porosity formation in partial penetration joints is that the keyholescan be easily cut apart in the radial direction, which makes the gas enclosed in the molten pool. The surface oxideof specimens can not affect the porosity formation in welds directly. | Hanbin DU, Lunji HU, Xiyuan HU and Jianhua LIUSchool of Mater. Sci. & Eng., Huazhong University of Science and Technology, Wuhan 430074, China | 2003 | Journal of Materials Science & Technology2003，19，5： | 2 |
| 2 | Cigarette smoke‑induced malignant transformation via STAT3 signalling in pulmonary epithelial cells in a lung‑on‑a‑chip model显示文摘Background Chronic obstructive pulmonary disease(COPD)is a severe public health problem.Cigarette smoke(CS)is a risk factor for COPD and lung cancer.The underlying molecular mechanisms of CS-induced malignant transformation of bronchial epithelial cells remain unclear.In this study,we describe a lung-on-a-chip to explore the possible mechanistic link between cigarette smoke extract(CSE)-associated COPD and lung cancer.Methods An in vitro lung-on-a-chip model was used to simulate pulmonary epithelial cells and vascular endothelial cells with CSE.The levels of IL-6 and TNF-αwere tested as indicators of inflammation using an enzyme-linked immune sorbent assay.Apical junction complex mRNA expression was detected with qRT-PCR as the index of epithelial-to-mesenchymal transition(EMT).The effects of CSE on the phosphorylation of signal transduction and transcriptional activator 3(STAT3)were detected by Western blotting.Flow cytometry was performed to investigate the effects of this proto-oncogene on cell cycle distribution.Results Inflammation caused by CSE was achieved in a lung-on-a-chip model with a mimetic movement.CSE exposure induced the degradation of intercellular connections and triggered the EMT process.CSE exposure also activated the phosphorylation of proto-oncogene STAT3,while these effects were inhibited with HJC0152.Conclusions CSE exposure in the lung-on-a-chip model caused activation of STAT3 in epithelial cells and endothelial cells.HJC0152,an inhibitor of activated STAT3,could be a potential treatment for CS-associated COPD and lung cancer. | Wei Hou Siyi Hu Ken‑tye Yong Jie Zhang Hanbin Ma | 2020 | Bio-Design and Manufacturing2020，3，4： | 1 |
| 3 | Covalently tethering disulfonic acid moieties onto polyoxometalate boosts acid strength and catalytic performance for hydroxyalkylation/alkylation reaction显示文摘Solid acid catalysts are widely used in the production of various high-value added and industrially important chemicals.Although the use of organosilicon compounds to modify the vacancy site has been extensively studied,the covalent tethering-SO_(3)H functionalized organosilicon modified polyoxometalates(POMs)has been rarely reported.In this work,two catalysts(TBA_(4)[SiW_(11)O_(39)(O(SiC_(3)H_(6)SO_(3)H)_(2))](compound 2)and TBA_(4)[SiW_(11)O_(39)(O(SiC_(8)H_(8)SO_(3)H)_(2))](compound 3))were synthesized successfully through covalently grafting different sulfonic acid(-SO_(3)H)groups onto[SiW_(11)O_(39)]^(8−)cluster,respectively.Compound 2 was achieved by surface grafting and in situ oxidation(3-mercaptopropyl)-trimethoxysilane,while compound 3 was achieved by surface grafting of 2-(4-chlorosulfonylphenyl)ethyltrimethoxysilane.Strong Brønsted acid strength of compounds 2 and 3 can be demonstrated by different methods including potentiometric titration,pyridine adsorption studies,and the ^(31)P trimethylphosphine oxides(TMPO)nuclear magnetic resonance(NMR).The systematic investigation of the relationship among POM structures,acid strength,and electron density was carried out based on density functional theory(DFT)calculation and experimental results,which revealed that covalent modification of compounds 2 and 3 decreased the electron density of the O-H bond,and promoted the release of H^(+).When applied in hydroxyalkylation/alkylation(HAA)reaction of 2-methylfuran(2-MF)with cyclohexanone,compound 2 exhibited better catalytic performance with conversion of ~93%,monocyclic fuel precursors(1a)yield of 79.9% and selectivity of 85.7% than compound 3,which can be attributed to strong Brønsted acid and the intramolecular hydrogen-bonding interactions between the neighboring -SO_(3)H moieties in compound 2.Finally,compound 2 also showed excellent catalytic activity in the HAA reaction of 2-MF with several different aldehydes and ketones(e.g.,furfuraldehyde,5-methylfurfuraldehyde,acetone,butyraldehyde and 4-methoxybenzaldehyde).This result opens a new pathway for design and fabrication of novel solid acid catalysts. | Lifei Lian Yubing Liu Xianfeng Yi Hanbin Hu Xiang Chen Hongqiang Li Wei Chen Anming Zheng Yu-Fei Song | 2022 | Science China Chemistry2022，65，4： | 1 |
| 4 | A study on the melt flow in full penetration laser beam welding for titanium alloy显示文摘 | Du Hanbin Hu Lunji Liu Jianhua | 2004 | Computational Material Science2004，29，： | 1 |
| 5 | A study on the metal flow in full penetration laser beam welding for titanium alloy显示文摘 | Hanbin Du Lunji Hu | 2004 | Computational Materials Science2004，29，： | 1 |
| 6 | Laser Welding of TC--1 Titanium Alloy显示文摘 | Du Hanbin Hu Lunji Hu Xiyuan | 2003 | Journal of Materials Sci- ences ~ Technology2003，19，5： | 1 |
| 7 | Maternal Preconception Serum Alanine Aminotransferase Levels and Risk of Preterm Birth among Reproductive-Aged Women—China,2013-2017显示文摘Summary What is already known about this topic?The significance of maternal liver health concerning preterm birth(PTB)is well recognized;however,there is a gap in understanding the precise influence of preconception serum alanine aminotransferase(ALT)levels on the risk of PTB.What is added by this report? | Chuanyu Zhao Jiajing Jia Hanbin Wu Qin Xu Xinyi Lyu Meiya Liu Xuan Hu Jueming Lei Yuzhi Deng Yuan He Yuanyuan Wang Zuoqi Peng Ya Zhang Hongguang Zhang Qiaomei Wang Haiping Shen Yiping Zhang Donghai Yan Ying Yang Xu Ma | 2024 | China CDC weekly2024，6，10： | 0 |
| 8 | Flexural and longitudinal shear performance of precast lightweight steel-ultra-high performance concrete composite beam显示文摘In this study,the flexural and longitudinal shear performances of two types of precast lightweight steel–ultra-high performance concrete(UHPC)composite beams are investigated,where a cluster UHPC slab(CUS)and a normal UHPC slab(NUS)are connected to a steel beam using headed studs through discontinuous shear pockets and full-length shear pockets,respectively.Results show that the longitudinal shear force of the CUS is greater than that of the NUS,whereas the interfacial slip of the former is smaller.Owing to its better integrity,the CUS exhibits greater flexural stiffness and a higher ultimate bearing capacity than the NUS.To further optimize the design parameters of the CUS,a parametric study is conducted to investigate their effects on the flexural and longitudinal shear performances.The square shear pocket is shown to be more applicable for the CUS,as the optimal spacing between two shear pockets is 650 mm.Moreover,a design method for transverse reinforcement is proposed;the transverse reinforcement is used to withstand the splitting force caused by studs in the shear pocket and prevent the UHPC slab from cracking.According to calculation results,the transverse reinforcement can be canceled when the compressive strength of UHPC is 150 MPa and the volume fraction of steel fiber exceeds 2.0%. | Ze MO Jiangrui QIU Hanbin XU Lanlan XU Yuqing HU | 2023 | Frontiers of Structural and Civil Engineering2023，17，5： | 0 |
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