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| 1 | 持续农业及其中国态势显示文摘农业是发生在生物-自然、社会-政治、经济-技术这三重环境内各种过程的综合体,因此农业的持续性也可归纳为生态、经济、社会三重定义。持续农业在不同的空间尺度上具有不同的意义,在地方和区域尺度上就是生态农业,在国家和全球尺度上,则更注意食物及其分配问题。据此。 | 蔡运龙 Smit,B | 1995 | 地理学报1995，50，2： | 43 |
| 2 | Can inhibin-B predict the outcome of microsurgical epididymal sperm aspiration in patients with suspected primary obstructive azoospermia?显示文摘瞄准:评估 inhibin-B 是否能预言 microsurgicalepidymal 精子渴望(方山) 的结果在有怀疑的主要妨碍的精子缺乏(OA ) 的病人的过程并且如果 inhibin-B 能在这些病人的诊断病情的检查代替阴囊的活体检视。方法:Inhibin-B 层次和阴囊的活体检视分数与有怀疑的主要 OA 的 MESAin 43 病人的结果有关。当 epididymalsperm 能在过程期间被识别时,方山被认为成功。结果:精子从 43 个病人(65%) 在在 28 的 epididymalaspirate 是在场的。Inhibin-B 价值不是有成功或失败的方山的显著地不同的住院病人。然而,修改 Johnsen 分数在有失败的方山的病人是显著地更低的(P = 0.003 ) 。失灵的睾丸网阻塞 orepididymal 与怀疑的主要 OA 在 15% 病人被发现,尽管有正常 inhibin-B 层次和正常阴囊的组织学,由失败的方山思考了。结论: Inhibin-B 不能用怀疑的主要 OA 在病人的病情的检查作为一个诊断工具代替阴囊的活体检视。阴囊的活体检视在识别可能有正常 inhibin-B 价值的有精子发生的拘捕的病人是有用的。 | Marij Smit Gert R. Dohle Mark F. Wildhagen Rob F. A. Weber | 2007 | Asian Journal of Andrology2007，9，3： | 12 |
| 3 | Near-infrared fluorescence imaging of a solitary fibrous tumor of the pancreas using methylene blue显示文摘A 67-year-old female presented with unexplained abdominal pain. A contrast-enhanced computed tomography scan of the abdomen incidentally revealed a mass in the uncinate process of the pancreas. This mass was resected and based on histopathological findings, diagnosed as a solitary fibrous tumor (SFT) of the pancreas. A SFT is an extremely rare benign mesenchymal tumor that in 65% of cases affects the visceral pleura but can also affect extra-pleural sites. The intraoperative demarcation of pancreatic tumors, such as SFTs, can bechallenging. In this report, the first clear intraoperative identification of a SFT of the pancreas in a human was shown using near-infrared fluorescence and methylene blue. | Joost R van der Vorst Alexander L Vahrmeijer Merlijn Hutteman Tjalling Bosse Vincent THBM Smit Cornelis JH van de Velde John V Frangioni Bert A Bonsing | 2012 | World Journal of Gastrointestinal Surgery2012，4，7： | 7 |
| 4 | 胡黄连的免疫调节和抗炎作用显示文摘 | Smit H F | 2001 | 国外医药(植物药分册)2001，16，6： | 6 |
| 5 | 金刚石中硫同位素组成揭示大陆形成过程的差异性显示文摘厚的岩石圈地幔的出现使得地球古老大陆变得稳定,然而关于这些古老大陆岩石圈地幔的形成却存在不同的成因解释。一些学者认为古老的大陆岩石圈地幔可通过俯冲洋壳平流增厚或堆叠等水平构造过程形成,而其他学者则认为地幔柱增生、海洋高原基底的熔融或地幔柱熔融残留物的底辟作用等垂向构造过程,在古老大陆岩石群地幔的形成过程中扮演了重要角色。目前,关于最早岩石圈的形成是通过水平还是垂向增生方式完成依然存在很大的争议,而不同的增生模式对于理解地球早期演化和板块作用的起始时限具有完全不同的意义。 | Smit K V Shirey S B Hauri E H Stern R A 袁超 | 2019 | 矿物岩石地球化学通报2019，38，5： | 5 |
| 6 | Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation显示文摘AIM To investigate the relation of two different mutations to the outcome of partial external biliary diversion(PEBD)in severe bile salt export pump(BSEP) deficiency.METHODS Mutations in the gene encoding BSEP leading to severe BSEP deficiency in two unrelated patients were identified by genomic sequencing. Native liver biopsies and transiently transfected human embryonic kidney(HEK) 293 cells expressing either wild-type or mutated BSEP were subjected to immunofluorescence analysis to assess BSEP transporter localization. Bile acid profiles of patient and control bile samples were generated by ultra-performance liquid chromatographytandem mass spectrometry. Wild-type and mutant BSEP transport of [~3H]-labeled taurocholate(TC) and taurochenodeoxycholate(TCDC) was assessed by vesicular transport assays.RESULTS A girl(at 2 mo) presented with pruritus, jaundice and elevated serum bile salts(BS). PEBD stabilized liver function and prevented liver transplantation. She was heterozygous for the BSEP deletion p.T919 del and the nonsense mutation p.R1235 X. At the age of 17 years relative amounts of conjugated BS in her bile were normal, while total BS were less than 3% as compared to controls. An unrelated boy(age 1.5 years) presenting with severe pruritus and elevated serum BS was heterozygous for the same nonsense and another missense mutation, p.G1032 R. PEBD failed to alleviate pruritus, eventually necessitating liver transplantation. BS concentration in bile was about 5% of controls. BS were mainly unconjugated with an unusual low amount of chenodeoxycholate derivatives(< 5%). The patients' native liver biopsies showed canalicular BSEP expression. Both BSEP p.T919 del and p.G1032 R were localized in the plasma membrane in HEK293 cells. In vitro transport assays showed drastic reduction of transport by both mutations. Using purified recombinant BSEP as quantifiable reference, per-molecule transport rates for TC and TCDC were determined to be 3 and 2 BS molecules per wild-type BSEP transporter per minute, respectively.CONCLUSION In summary, our findings suggest that residual function of BSEP as well as substrate specificity influence the therapeutic effectiveness of PEBD in progressive familial intrahepatic cholestasis type 2(PFIC-2). | Philipp Ellinger Jan Stindt Carola Droge Katharina Sattler Claudia Stross Stefanie Kluge Diran Herebian Sander HJ Smits Martin Burdelski Sebastian Schulz-Jürgensen Antje Ballauff Jan Schulte am Esch Ertan Mayatepek Dieter Haussinger Ralf Kubitz Lutz Schmitt | 2017 | World Journal of Gastroenterology2017，23，29： | 4 |
| 7 | 低温机械灌注与冷藏保存在尸肾移植中的应用显示文摘 | 何超 何强 Moers C Smits JM Maathuis MJ | 2009 | 中华移植杂志(电子版)2009，3，1： | 4 |
| 8 | 淡水水体底泥中厌氧氨氧化菌的原位鉴别显示文摘采用16S rRNA方法对江苏省新沂河的底泥样品进行了厌氧氨氧化菌的原位检测,建立了样品的16S rRNA克隆文库,共包括6个16S rRNA克隆序列.对文库中克隆序列利用ARB软件包进行了排队分析及系统发育树的绘制.分析结果表明,新沂河底泥样品中含有与已知厌氧氨氧化菌Candidatus“Brocadia anammoxidans”相似性为91%的16S rRNA基因,经鉴定为厌氧氨氧化菌Brocadia分支的新种类.样品中还含有组成Planctomycetes新分支的16S rRNA基因,它们与已知厌氧氨氧化菌序列的遗传距离较远,其微生物特性还有待进一步研究.厌氧氨氧化菌在淡水环境中的发现将有助于进一步研究厌氧氨氧化过程在受损淡水生态系统修复重建中的作用,重新认识其中的氮循环过程. | 阮晓红 张瑛 Markus C.Schmid Toine Smits 赵振华 | 2006 | 环境科学2006，27，7： | 4 |
| 9 | Clinical use of dendritic cells for cancer therapy显示文摘 | Sébastien Anguille Evelien L Smits Eva Lion Viggo F van Tendeloo Zwi N Berneman | 2014 | Lancet Oncology2014，，7： | 3 |
| 10 | Molecular Simulation of CO2/H2 Mixture Separation in Metal-organic Frameworks: Effect of Catenation and Electrostatic Interactions显示文摘In this work grand canonical Monte Carlo simulations were performed to study gas separation in three pairs of isoreticular metal-organic frameworks (IRMOFs) with and without catenation at room temperature.Mixture composed of CO2 and H2 was selected as the model system to separate.The results show that CO2 selectivity in catenated MOFs with multi-porous frameworks is much higher than their non-catenated counterparts.The simulations also show that the electrostatic interactions are very important for the selectivity,and the contributions of different electrostatic interactions are different,depending on pore size,pressure and mixture composition.In fact,changing the electrostatic interactions can even qualitatively change the adsorption behavior.A general conclusion is that the electrostatic interactions between adsorbate molecules and the framework atoms play a dominant role at low pressures,and these interactions in catenated MOFs have much more pronounced effects than those in their non-catenated counterparts,while the electrostatic interactions between adsorbate molecules become evident with increasing pressure,and eventually dominant. | 阳庆元 许青 刘蓓 仲崇立 Smit Berend | 2009 | Chinese Journal of Chemical Engineering2009，17，5： | 3 |
| 11 | The constituent equation of piezoelectric bi- morphs显示文摘 | SMITS Jan G DALKE Susan I COONEY Thomas K | 1991 | Sensors and Actuator A1991，28，1： | 2 |
| 12 | Fiber-Reinforced Polymer Bridge Design in the Netherlands: Architectural Challenges toward Innovative, Sustainable, and Durable Bridges显示文摘本文综述了纤维增强复合材料(FRP)在荷兰桥梁的建筑性与结构性设计方面的应用,讨论了这种相对较新的材料给建筑师和工程师带来的挑战和机遇。本文涵盖了纤维增强复合材料的最新结构处理方案,以及对于纤维增强复合材料在建筑方面应用的讨论,这些应用来源于笔者与其他科研人员在建筑上的实践。 | Joris Smits | 2016 | Engineering2016，2，4： | 2 |
| 13 | Effects of hypoxia and elevated carbon dioxide concentration on water flax through populus roots显示文摘 | Smit B | 1988 | Tree Physiol1988，4，： | 2 |
| 14 | Altered Myocardial Substrate Metabolism and Decreased Diastolic Function in Nonischemic Human Diabetic Cardiomyopathy显示文摘 | Luuk J. Rijzewijk Rutger W. van der Meer Hildo J. Lamb Hugo W.A.M. de Jong Mark Lubberink Johannes A. Romijn Jeroen J. Bax Albert de Roos Jos W. Twisk Robert J. Heine Adriaan A. Lammertsma Johannes W.A. Smit Michaela Diamant | 2009 | Journal of the American College of Cardiology2009，，16： | 2 |
| 15 | 经肝动脉^90Y放射性栓塞治疗的新进展显示文摘放射性栓塞治疗(RE)是经过10余年探索而建立起来的一种治疗模式,发展迅速。该文对RE领域新进展进行综述,就RE患者选择、疗效判断以及将来的临床应用进行探讨。 | 李莉(译) 冯对平(译) 李思进(审校) Arthur J.A.T. Braat Maarten L.J. Smits Manon N.G.J.A. Braat Andor F. van den Hoven Jip F. Prince Hugo W.A.M. de Jong Maurice A.A.J. van den Bosch Marnix G.E.H. Lam | 2018 | 中华核医学与分子影像杂志2018，38，8： | 2 |
| 16 | 广泛经皮针刀筋膜切断术联合脂肪移植术:一种治疗掌腱膜挛缩的新疗法显示文摘背景手术切除治疗掌腱膜挛缩症复发率高且康复时间延长。本文将介绍一种新型微创手术替代治疗掌腱膜挛缩症的方法及其成果。方法过程包括采用广泛经皮针刀筋膜切断术将束带完全松解,并与真皮分离。随后,由此产生的松弛组织用以自体脂肪填充。术后伸直位制动1周,然后,建议术后3~6个月患者白天可以正常用手,夜间伸直位固定。本组患者共91例(99只手),手术在迈阿密和鹿特丹进行;对50例患者的手部伸展角度进行测量(平均随访44周)。结果近端指间关节挛缩的治疗效果显著,伸展角度由61°改善至27°,掌指关节挛缩的伸展角度由37°改善至-5°。94%患者在2~4周内手部恢复正常功能,95%患者对结果非常满意。无新的瘢痕生成,大部分恢复了柔软的手掌脂肪垫。发生了1例神经损伤的并发症,1例术后切口感染,4例复杂区域疼痛综合征。结论这一新的微创技术缩短了康复时间,增加了缺损的皮下脂肪组织,产生了柔软无痕的皮肤。并且有能力处理多个掌指纹,可解决整只手的异常情况。治疗过程安全有效,尤其对首次治疗者。目前,前瞻性随机对照研究过程充分确定了其治疗掌腱膜挛缩症的作用。(循证医学证据等级:Ⅳ级,疗法) | Steven E. R. Hovius Hester J. Kan Xander Smit Ruud Wf Selles Eufimiano Cardoso Roger K. Khouri 李可竹(译) 郭澍(译) 孙强(译) 魏峰(译) 高景恒(译) | 2013 | 中国美容整形外科杂志2013，24，1： | 2 |
| 17 | 选择奶牛乳头药浴液的核心原则显示文摘奶牛乳头药浴液是牧场的必备产品,因此牧场应对乳头药浴液的选择引起重视。乳头药浴液应满足以下要求:足够的杀菌效力,对乳头皮肤无刺激,保持乳头皮肤的光滑滋润,并能有助于乳头皮肤损伤的愈合和恢复。在寒冷的冬季,选择的乳头药浴液不能结冰,也不能具有挥发的特性,否则会带走乳头的热量,加剧乳头的冻伤。乳头药浴液要易于擦干,不会在牛奶中残留等。 | William Smits 赵玲玲 | 2017 | 中国乳业2017，，3： | 2 |
| 18 | Therapeutic Potential of Fecal Microbiota Transplantation显示文摘 | Loek P. Smits Kristien E.C. Bouter Willem M. de Vos Thomas J. Borody Max Nieuwdorp | 2013 | Gastroenterology2013，，5： | 2 |
| 19 | WONCA研究论文摘要汇编——硝苯地平和安慰剂治疗慢性冻疮的随机对照试验显示文摘目的一些观察性研究及较早期的单一小型临床试验表明,硝苯地平是经常用来治疗冻疮的药物。本研究旨在探讨在治疗冻疮方面,社区医疗患者每日口服硝苯地平60 mg的效果是否优于安慰剂。方法本研究采用随机、安慰剂对照、双盲、交叉研究,研究设计同较早期的研究。32例慢性冻疮患者被随机分为硝苯地平组(每日服用硝苯地平2次,每次30 mg)和安慰剂组。依照100 mm视觉模拟量表,患者每日对疼痛和功能障碍情况进行评分,并在日记里记录下来。以患者的疼痛和功能障碍评分作为指标来评价硝苯地平与安慰剂的效果。本研究把试验时的环境温度考虑在内,检查患者以前的研究治疗是否存在后续效应,并且对试验的不良影响进行了监测。结果治疗6周后,在视觉模拟疼痛平均评分方面,硝苯地平组优于安慰剂组1.84 mm[95%CI(-6.67,2.99)],但两组差异无统计学意义(P=0.44)。视觉模拟功能障碍平均评分方面,安慰剂组优于硝苯地平组0.56 mm[95%CI(-2.97,4.09)],但两组差异亦无统计学意义(P=0.75)。研究中未发现两组患者存在以前研究治疗方案的后续效应。硝苯地平组患者收缩压显著降低,并且有较高的水肿发病率。结论与较早期的研究结果不同,本研究未发现硝苯地平治疗慢性冻疮的效果优于安慰剂,不建议应用硝苯地平来治疗慢性冻疮。 | SOUWER I H BOR J H SMITS P 本刊编辑部 | 2016 | 中国全科医学2016，19，34： | 2 |
| 20 | Clinical assessment of patients with advanced non-small-cell lung cancer eligible for second-line chemotherapy: A prognostic score from individual data of nine randomised trials显示文摘 | Massimo Di Maio Nicola Lama Alessandro Morabito Egbert F. Smit Vassilis Georgoulias Koji Takeda Elisabeth Quoix Dora Hatzidaki Floris M. Wachters Vittorio Gebbia Chun-Ming Tsai Carlos Camps Wolfgang Schuette Paolo Chiodini Maria Carmela Piccirillo Frances | 2009 | European Journal of Cancer2009，，4： | 2 |
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