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| 1 | Treatment with NADPH oxidase inhibitor apocynin alleviates diabetic neuropathic pain in rats显示文摘Increased reactive oxygen species by the activation of NADPH oxidase(NOX) contributes to the development of diabetic complications.Apocynin,a NOX inhibitor,increases sciatic nerve conductance and blood flow in diabetic rats.We investigated potential protective effect of apocynin in rat diabetic neuropathy and its precise mechanism of action at molecular level.Rat models of streptozotocin-induced diabetes were treated with apocynin(30 and 100 mg/kg per day,intragastrically) for 4 weeks.Mechanical hyperalgesia and allodynia were determined weekly using analgesimeter and dynamic plantar aesthesiometer.Western blot analysis and histochemistry/immunohistochemistry were performed in the lumbar spinal cord and sciatic nerve respectively.Streptozotocin injection reduced pain threshold in analgesimeter,but not in aesthesiometer.Apocynin treatment increased pain threshold dose-dependently.Western blot analysis showed an increase in catalase and NOX-p47 phox protein expression in the spinal cord.However,protein expressions of neuronal and inducible nitric oxide synthase(n NOS,i NOS),superoxide dismutase,glutathion peroxidase,nitrotyrosine,tumor necrosis factor-α,interleukin-6,interleukin-1β,aldose reductase,cyclooxygenase-2 or MAC-1(marker for increased microgliosis) in the spinal cord remained unchanged.Western blot analysis results also demonstrated that apocynin decreased NOX-p47 phox expression at both doses and catalase expression at 100 mg/kg per day.Histochemistry of diabetic sciatic nerve revealed marked degeneration.n NOS and i NOS immunoreactivities were increased,while S-100 immunoreactivity(Schwann cell marker) was decreased in sciatic nerve.Apocynin treatment reversed these changes dose-dependently.In conclusion,decreased pain threshold of diabetic rats was accompanied by increased NOX and catalase expression in the spinal cord and increased degeneration in the sciatic nerve characterized by increased NOS expression and Schwann cell loss.Apocynin treatment attenuates neuropathic pain by decelerating the increased oxidative stress-mediated pathogenesis in diabetic rats. | Murat Olukman Aytül onal Fatma Gül celenk Yigit Uyankgil Türker cavusoglu Neslihan Düzenli Sibel ülker | 2018 | Neural Regeneration Research2018，13，9： | 4 |
| 2 | Mechanical and chemi- cal behavior of spruce wood modified by heat 显示文摘 | SIBEL Y ENGIN D G UMIT C Y | 2006 | Building and Environment2006，41，： | 1 |
| 3 | Mechanical properties and decay resistance of wood-polymer composites prepared from fast growing species in Turkey显示文摘 | ümit C Yildiz Sibel Yildiz Enqin D Gezer | 2005 | Bioresouce Technology2005，96，： | 1 |
| 4 | Spectroscopic investigations of the inter- actions of tramadol hydroehloride and 5-azacytidine drugs with human serum albumin and human hemoglobin proteins显示文摘 | Sibel T Ahmet C Osman D | 2013 | J Photoeben Pbo- tobiol B2013，120，1： | 1 |
| 5 | Sensitivity of Verticillium dahliae to prochloraz and prochloraz manganese complex and control of verticillium wilt of cotton in the field 显示文摘 | Sener K Sibel D Suat S | 2005 | Crop Protection2005，22，： | 1 |
| 6 | Synthesis and characteriza tion of acrylamide-acrylic acid hydrogels and adsorption of some textile dyes显示文摘 | SIBEL D DILEK S OLGUN G | 1999 | Nuclear Instruments and Methods in Physics Research1999，151，4： | 1 |
| 7 | Internal loading of phosphorus from sediments of Lake Pontchartrain(Louisiana,USA)with implications for eutrophication显示文摘 | ERIC D R NHAN T N SIBEL B | 2012 | Hydrobiologia2012，684，： | 1 |
| 8 | Determination of trace element contents of baby foods from Turkey显示文摘 | Sibel S Kadriye O S Ozgur D U | 2007 | Food Chemistry2007，105，1： | 1 |
| 9 | Sensitivity of Verticillium dahliae to prochloraz and prochloraz-manganese complex and control of Verticillium wilt of cotton in the field显示文摘 | SENER K Sibel D Suat S | 2003 | Crop Protection2003，，22： | 1 |
| 10 | Preparation of active antimicrobial methyl cellulose/carvacrol/montmorillonite nancomposite fihns and investigation of carvacrol release 显示文摘 | Sibel T Osman D | 2011 | Food Science and Technology2011，44，2： | 1 |
| 11 | Multifunctional nanoagent for thrombus-targeted fibrinolytic therapy显示文摘 | Jason R McCarthy Irina Y Sazonova S Sibel Erdem Tetsuya Hara Brian D Thompson Purvish Patel Ion Botnaru Charles P Lin Guy L Reed Ralph Weissleder Farouc A Jaffer | 2012 | Nanomedicine2012，，7： | 1 |
| 12 | Economic Liberalization and the Antecedents of Top Management Teams: Evidence from Turkish 'Big' Business 显示文摘 | SIBEL Y BEHL D | 2006 | British Journal of Management2006，17，3： | 1 |
| 13 | Evaluating the potential risk of microcystins to blue crab (Callinectes sapidus) fisheries and human health in a eutrophic estuary显示文摘 | Ana C G Sibel B Padmanava D | 2010 | Harmful Algae2010，9，2： | 1 |
| 14 | Electrochemical studies of ganciclovir at glassy carbon electrodes and its direct determination in serum and pharmaceutics by square wave and differential pulse voltammetry 显示文摘 | BENGI U BURCU D SIBEL A O | 2005 | Anal Chim Acta2005，537，： | 1 |
| 15 | Effects of electrolytes on the electrokinetic properties of pumice suspensions显示文摘 | SIBEL T OSMAN D | 2009 | Journal of Dispersion Science & Technology2009，30，4： | 1 |
| 16 | Mechanical properties and decay resistance of wood-polymer composites prepared from fast growing species in Turkey显示文摘 | Umit C Y Sibel Y Enqin D G | 2005 | Biovesouce Technotogy2005，96，： | 1 |
| 17 | Electrochemical studies of ganciclovir at glassy carbon electrodes and its direct determination in serum and pharmaceutics by square wave and differential pulse vohammetry显示文摘 | BENGI u BURCU d SIBEL a o | | 0，，： | 1 |
| 18 | Fatigue, anxiety and depression in canc- er patients 显示文摘 | Havva T Hatice T Sibel D | 2011 | Neurology Psychiatry and Brain Research2011，17，： | 1 |
| 19 | Spectroscopic investigations of the inter- actions of tramadol hydrochloride and 5-azacytidine drugs with human serum albumin and human hemoglobin proteins 显示文摘 | Sibel T Ahmet C Osman D | 2013 | J Photochen Pho- tobiol B2013，120，1： | 1 |
| 20 | Synthesis and characterization of acrylamide-acrylic acid hydrogels and adsorption of some textile dyes显示文摘 | Sibel D Dilek S Olgun G | 1999 | Nuel Instrum Methods in Physics Research B1999，151，： | 1 |
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