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| 1 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 2 | Past and recent changes in air and permafrost temperatures in eastern Siberia显示文摘 | Romanovsky V E Sazonova T S Balobaev V T | 2007 | Global and Planetary Change2007，56，34： | 1 |
| 3 | Intelligent system for fish stock prediction and allowable catch evaluation显示文摘 | Sazonova L Osipov G Godovnikov M | 1999 | Environment Modeling &Software1999，，14： | 1 |
| 4 | Factors affecting obstetric outcome of singletons born after IVF 显示文摘 | Sazonova A Koillen K Thurin-Kjellberg A | 2011 | Hum Reprod2011，26，10： | 1 |
| 5 | Cerebral oxi- metry in neurosurgical patients with cerebraovascular dis- eases--Ⅰ: analysis of causes of intraoperative changes in rSO2 values and its prognostic significance 显示文摘 | Shmigel'skiǐ AV Lubnin Alu Sazonova OB | 2000 | Anesteziol Reanimatol2000，，4： | 1 |
| 6 | Minocycline and tissue-type plasminogen activator for stroke : assessment of interaction potential 显示文摘 | MACHADO L S SAZONOVA I Y KOZAK A | 2009 | Stroke2009，40，9： | 1 |
| 7 | Obstetric outcome after in vitro fertilization with single or double embryo transfer显示文摘 | Sazonova A Kallen K Thurin-Kjellberg A | 2011 | Hum Reprod2011，26，： | 1 |
| 8 | Determina- tion of electron orbital magnetic moments in carbon nanotubes显示文摘 | Minot E Yaish Y Sazonova V McEuen P | 2004 | Nature2004，428，： | 1 |
| 9 | Obstetric outcome af- ter in vitro fertilization with single or double embryo transfer显示文摘 | Sazonova A Kallen K Thurin-Kjellberg A | 2011 | Hu- man Reproduction2011，26，： | 1 |
| 10 | Extracellular matrix presentation modulates vascular smooth muscle cell mechanotransduction显示文摘 | Sazonova OV Isenberg BC Herrmann J | 2015 | Matrix Biology2015，41，： | 1 |
| 11 | Electrochemical impedance spectroscopy of poly ( 3 - methylthiophene ) and poly ( 3 - octyl- thiophene) film electrodes 显示文摘 | TOLSTOPYATOVA E G SAZONOVA S N MALEV V V | 2005 | Electrochimica Acta2005，50，78： | 1 |
| 12 | A tunable carbon nanotube electromechanical oscillator显示文摘 | Sazonova V Yaish Y Ustunel H Roundy D Arias T A McEuen P L | 2004 | Nature2004，431，： | 1 |
| 13 | Sheared peridotite xenolith from the V.Grib kimberlite pipe,Arkhangelsk Diamond Province,Russia:Texture,composition,and origin显示文摘The petrography and mineral composition of a mantle-derived garnet peridotite xenolith from the V.Grib kimberlite pipe(Arkhangelsk Diamond Province,Russia) was studied.Based on petrographic characteristics,the peridotite xenolith reflects a sheared peridotite.The sheared peridotite experienced a complex evolution with formation of three main mineral assemblages:(1) a relict harzburgite assemblage consist of olivine and orthopyroxene porphyroclasts and cores of garnet grains(Gar1) with sinusoidal rare earth elements(REE) chondrite C1 normalized patterns;(2) a neoblastic olivine and orthopyroxene assemblage;(3) the last assemblage associated with the formation of clinopyroxene and garnet marginal zones(Gar2).Major and trace element compositions of olivine,orthopyroxene,clinopyroxene and garnet indicate that both the neoblast and clinopyroxene-Gar2 mineral assemblages were in equilibrium with a high Fe-Ti carbonate-silicate metasomatic agent.The nature of the metasomatic agent was estimated based on high field strength elements(HFSE) composition of olivine neoblasts,the garnet-clinopyroxene equilibrium condition and calculated by REE-composition of Gar2 and clinopyroxene.All these evidences indicate that the agent was a high temperature carbonate-silicate melt that is geochemically linked to the formation of the protokimberlite melt. | Alexey Vladimirovich Kargin Lyudmila Vyacheslavovna Sazonova Anna Andreevna Nosova Vladimir Anatolievich Pervov Elena Vladimirovna Minevrina Vladimir Anatolievich Khvostikov Zhanna Petrovna Burmii | 2017 | Geoscience Frontiers2017，8，4： | 1 |
| 14 | Past and recent changes in air and permafrost temperatures in eastern Siberia显示文摘 | V.E. Romanovsky T.S. Sazonova V.T. Balobaev N.I. Shender D.O. Sergueev | 2006 | Global and Planetary Change2006，，3： | 1 |
| 15 | Obstetric outcome after in vitro fertilization with single or double embryo transfer显示文摘 | Sazonova A Kllen K Thurin-Kjellberg A | 2011 | Hum Reprod2011，26，： | 1 |
| 16 | Minocycline and tissue - type plasminogen activator for stroke : assessment of interaction potential 显示文摘 | Machado LS Sazonova IY Kozak A | 2009 | Stroke2009，40，9： | 1 |
| 17 | A model for regional-scale estimation of temporal and spatial variability of active layer thickness and mean annual ground temperature显示文摘 | Sazonova T S Romanovsky V E | 2003 | Permafrost and Periglacial Processes2003，14，： | 1 |
| 18 | Isolation,purification,and identificationof virule nce protein VirE2 from Agrobacterium tumefaciens显示文摘 | Volokhina IV Sazonova IA Velikov VA | 2005 | Mikrobiologiia2005，74，1： | 1 |
| 19 | Obstetric outcome after in vitro fertilization with single or double embryo transfer显示文摘 | Sazonova A Kallen K Thurin-Kjellberg A | 2011 | Hum Reprod2011，26，： | 1 |
| 20 | Factors affecting obstetric outcome of singletons born after IVF 显示文摘 | Sazonova A Kallen K Thurin-Kjellberg A | 2011 | Hum Reprod2011，26，10： | 1 |
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