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| 1 | Treatment with NADPH oxidase inhibitor apocynin alleviates diabetic neuropathic pain in rats显示文摘Increased reactive oxygen species by the activation of NADPH oxidase(NOX) contributes to the development of diabetic complications.Apocynin,a NOX inhibitor,increases sciatic nerve conductance and blood flow in diabetic rats.We investigated potential protective effect of apocynin in rat diabetic neuropathy and its precise mechanism of action at molecular level.Rat models of streptozotocin-induced diabetes were treated with apocynin(30 and 100 mg/kg per day,intragastrically) for 4 weeks.Mechanical hyperalgesia and allodynia were determined weekly using analgesimeter and dynamic plantar aesthesiometer.Western blot analysis and histochemistry/immunohistochemistry were performed in the lumbar spinal cord and sciatic nerve respectively.Streptozotocin injection reduced pain threshold in analgesimeter,but not in aesthesiometer.Apocynin treatment increased pain threshold dose-dependently.Western blot analysis showed an increase in catalase and NOX-p47 phox protein expression in the spinal cord.However,protein expressions of neuronal and inducible nitric oxide synthase(n NOS,i NOS),superoxide dismutase,glutathion peroxidase,nitrotyrosine,tumor necrosis factor-α,interleukin-6,interleukin-1β,aldose reductase,cyclooxygenase-2 or MAC-1(marker for increased microgliosis) in the spinal cord remained unchanged.Western blot analysis results also demonstrated that apocynin decreased NOX-p47 phox expression at both doses and catalase expression at 100 mg/kg per day.Histochemistry of diabetic sciatic nerve revealed marked degeneration.n NOS and i NOS immunoreactivities were increased,while S-100 immunoreactivity(Schwann cell marker) was decreased in sciatic nerve.Apocynin treatment reversed these changes dose-dependently.In conclusion,decreased pain threshold of diabetic rats was accompanied by increased NOX and catalase expression in the spinal cord and increased degeneration in the sciatic nerve characterized by increased NOS expression and Schwann cell loss.Apocynin treatment attenuates neuropathic pain by decelerating the increased oxidative stress-mediated pathogenesis in diabetic rats. | Murat Olukman Aytül onal Fatma Gül celenk Yigit Uyankgil Türker cavusoglu Neslihan Düzenli Sibel ülker | 2018 | Neural Regeneration Research2018，13，9： | 4 |
| 2 | Equilibrium and kinetics of the biosorption of lead ( Ⅱ ) from aqueous solutions by Cephalosporium aphidicola 显示文摘 | Sibel T Tamer A Sara O A | 2006 | Separation and Purification Technology2006，47，： | 1 |
| 3 | Simultaneous determination of various pesticides in fruit juices by HPLC - DAD 显示文摘 | SIBEL T GUL O BUKET A | 2005 | Food Control2005，16，： | 1 |
| 4 | Biosor-ption of a textile dye (Acid Blue 40)by cone bio-mass of thuja orientalis: estimation of equilibrium, thermodynamic and kinetic parameters显示文摘 | TAMER A SAFA O SIBEL T | 2008 | Bioreso-urce Technology2008，99，： | 1 |
| 5 | Equilibrium and kinetics of biosorption of lead (Ⅱ) from aqueous solutions by Cephalosporium aphidicola显示文摘 | Tunali Sibel Akar T Sara OA | 2006 | Separation and Purificat ion Technology2006，47，3： | 1 |
| 6 | Fcmtal subcortical neuronal circuits and clinical neuropsychiatry显示文摘 | Sibel T Cummings JL | 2002 | J Psychosom Res2002，53，2： | 1 |
| 7 | Spectroscopic investigations of the inter- actions of tramadol hydroehloride and 5-azacytidine drugs with human serum albumin and human hemoglobin proteins显示文摘 | Sibel T Ahmet C Osman D | 2013 | J Photoeben Pbo- tobiol B2013，120，1： | 1 |
| 8 | The effect of fatty acid content on water vapour and carbon dioxide transmissions of cellulose-based edible films显示文摘 | AYRANCI E SIBEL T | 2001 | Food Chemistry2001，72，： | 1 |
| 9 | Internal loading of phosphorus from sediments of Lake Pontchartrain(Louisiana,USA)with implications for eutrophication显示文摘 | ERIC D R NHAN T N SIBEL B | 2012 | Hydrobiologia2012，684，： | 1 |
| 10 | Fontal subcortical neuronal circuits and clinical neuropsychiatry显示文摘 | Sibel T Cummings JL | 2002 | J Psychosom Res2002，53，2： | 1 |
| 11 | Equilibrium and ki- netics of biosorption of lead (II) from aqueous solutions by Cephalosporium aphid cola 显示文摘 | Tunali Sibel Akar T Safa O A | 2006 | Separation and Purification Technology2006，47，3： | 1 |
| 12 | Management of Differentiated Thyroid Cancer in the Presence of Resistance to Thyroid Hormone and TSH-Secreting Adenomas: A Report of Four Cases and Review of the Literature显示文摘 | U?ur ünlütürk Chutintorn Sriphrapradang Murat Faik Erdo?an Rfat Emral Sibel Güldiken Samuel Refetoff Sevim Güllü | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，6： | 1 |
| 13 | Equilibrium and kinetics of biosorption of lead(Ⅱ) from aqueous solutions by Cephalosporium aphidicola显示文摘 | Tunali Sibel Akar T Sara O A | 2006 | Separation and Purification Technology2006，47，3： | 1 |
| 14 | Equilibirum and kinetics of biosorption of lead (II) from aqueous solutions by Cephalosporium aphid cola 显示文摘 | TUNALI SIBEL AKAR T SAFA O A | 2006 | Separation and Puriifcation Technology2006，47，3： | 1 |
| 15 | Frontal-subcortical neuronal circuits and clinical neuropsychiatry an update显示文摘 | Sibel T Jeffrey LC | 2002 | J Psychosomatic Res2002，53，2： | 1 |
| 16 | HSP-10 in ovarian cancer:Expression and suppression of T-cell signaling显示文摘 | Cicek G T | 2006 | Gynecologic Oncology2006，101，3： | 1 |
| 17 | Simultaneous determination of various pesticides in fruit juices by HPLC - DAD 显示文摘 | ] Sibel T Giil0 | 2005 | Food Control2005，16，： | 1 |
| 18 | The roles of oxidized low-densitylipoprotein and interleukin-6 levels in acute atheroma thrombotic and la-cunar ischemic stroke显示文摘 | Baburhan G Sibel G Burhan T | 2008 | Angiology2008，59，1： | 1 |
| 19 | Preparation of active antimicrobial methyl cellulose/carvacrol/montmorillonite nancomposite fihns and investigation of carvacrol release 显示文摘 | Sibel T Osman D | 2011 | Food Science and Technology2011，44，2： | 1 |
| 20 | Biosorption potential of the waste biomaterial obtained from Cucumis melo for the removal of Pb24 ions from aqueous media:equilibrium,kinetic,thermodynamic and mechanism analysis显示文摘 | Sibel T A Sercan A Tugba A | 2012 | Chemical Engineering Journal2012，18，： | 1 |
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