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| 1 | Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis显示文摘AIM: To investigate whether serum levels of two soluble forms of extracellular cytokeratin 18 (M30-antigen and M65-antigen) may differentiate nonalcoholic steatohepatitis (NASH) from simple steatosis in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 83 patients with suspected NAFLD and 49 healthy volunteers were investigated. Patients with suspected NAFLD were classified according to their liver histology into four groups: definitive NASH (n = 45), borderline NASH (n = 24), simple fatty liver (n = 9), and normal tissue (n = 5). Serum levels of caspase-3 generated cytokeratin-18 fragments (M30-antigen) and total cytokeratin-18 (M65-antigen) were determined by ELISA. RESULTS: Levels of M30-antigen and M65-antigen were significantly higher in patients with definitive NASH compared to the other groups. An abnormal value (> 121.60 IU/L) of M30-antigen yielded a 60.0% sensitivity and a 97.4% specificity for the diagnosis of NASH. Sensitivity and specificity of an abnormal M65-antigen level (> 243.82 IU/L) for the diagnosis of NASH were 68.9% and 81.6%, respectively. Among patients with NAFLD, M30-antigen and M65-antigen levels distinguished between advanced fibrosis and early-stage fibrosis with a sensitivity of 64.7% and 70.6%, and a specificity of 77.3% and 71.2%, respectively. CONCLUSION: Serum levels of M30-antigen and M65-antigen may be of clinical usefulness to identify patients with NASH. Further studies are mandatory to better assess the role of these apoptonecrotic biomarkers in NAFLD pathophysiology. | Yusuf Yilmaz Enver Dolar Engin Ulukaya Semra Akgoz Murat Keskin Murat Kiyici Sibel Aker Arzu Yilmaztepe Selim Gurel Macit Gulten Selim Giray Nak | 2007 | World Journal of Gastroenterology2007，13，6： | 19 |
| 2 | Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine显示文摘A tooth is a complex biological organ and consists of multiple tissues including the enamel, dentin, cementum and pulp. Tooth loss is the most common organ failure. Can a tooth be regenerated? Can adult stem cells be orchestrated to regenerate tooth structures such as the enamel, dentin, cementum and dental pulp, or even an entire tooth? If not, what are the therapeutically viable sources of stem cells for tooth regeneration? Do stem cells necessarily need to be taken out of the body, and manipulated ex vivo before they are transplanted for tooth regeneration? How can regenerated teeth be economically competitive with dental implants? Would it be possible to make regenerated teeth affordable by a large segment of the population worldwide? This review article explores existing and visionary approaches that address some of the above-mentioned questions. Tooth regeneration represents a revolution in stomatology as a shift in the paradigm from repair to regeneration: repair is by metal or artificial materials whereas regeneration is by biological restoration. Tooth regeneration is an extension of the concepts in the broad field of regenerative medicine to restore a tissue defect to its original form and function by biological substitutes. | Sibel Yildirim Susan Y. Fu Keith Kim Hong Zhou Chang Hun Lee Ang Li Sahng Gyoon Kim Shuang Wang Jeremy J. Mao | 2011 | International Journal of Oral Science2011，3，3： | 16 |
| 3 | Lipoma within inverted Meckel’s diverticulum as a cause of recurrent partial intestinal obstruction and hemorrhage: A case report and review of literature显示文摘Lipoma within an inverted Meckel's diverticulum presen- ting with hemorrhage and partial intestinal obstruction is an exceptional clinical entity. We report a case of 47-year-old male with a history of recurrent episodes of partial intestinal obstruction and melena due to a subserosal lipoma located in the base of an inverted Meckel's diverticulum. According to our knowledge, this is the first case of a lipoma within a Meckel's diverticulum giving rise to this clinical scenario without the existence of heterotrophic gastric or pancreatic tissues. | Güldeniz Karadeniz Cakmak Ali Ugur Emre Oge Tascilar Sibel Bekta■ Bulent Hamdi Uan Oktay Irkorucu Kemal Karakaya Yucel Ustundag Mustafa Comert | 2007 | World Journal of Gastroenterology2007，13，7： | 11 |
| 4 | Outcomes of bowel program in spinal cord injury patients with neurogenic bowel dysfunction显示文摘In this study, we aimed to determine gastrointestinal problems associated with neurogenic bowel dysfunction in spinal cord injury patients and to assess the efficacy of bowel program on gastrointestinal problems and the severity of neurogenic bowel dysfunction. Fifty-five spinal cord injury patients were included in this study. A bowel program according to the characteristics of neurogenic bowel dysfunction was performed for each patient. Before and after bowel program, gastrointestinal problems(constipation, difficult intestinal evacuation, incontinence, abdominal pain, abdominal distension, loss of appetite, hemorrhoids, rectal bleeding and gastrointestinal induced autonomic dysreflexia) and bowel evacuation methods(digital stimulation, oral medication, suppositories, abdominal massage, Valsalva maneuver and manual evacuation) were determined. Neurogenic bowel dysfunction score was used to assess the severity of neurogenic bowel dysfunction. At least one gastrointestinal problem was identified in 44(80%) of the 55 patients before bowel program. Constipation(56%, 31/55) and incontinence(42%, 23/55) were the most common gastrointestinal problems. Digital rectal stimulation was the most common method for bowel evacuation, both before(76%, 42/55) and after(73%, 40/55) bowel program. Oral medication, enema and manual evacuation application rates were significantly decreased and constipation, difficult intestinal evacuation, abdominal distention, and abdominal pain rates were significantly reduced after bowel program. In addition, mean neurogenic bowel dysfunction score was decreased after bowel program. An effective bowel program decreases the severity of neurogenic bowel dysfunction and reduces associated gastrointestinal problems in patients with spinal cord injury. | Zuhal Ozisler Kurtulus Koklu Sumru Ozel Sibel Unsal-Delialioglu | 2015 | Neural Regeneration Research2015，10，7： | 9 |
| 5 | Effect of honey on bacterial translocation and intestinal morphology in obstructive jaundice显示文摘AIM:To evaluate the effects of honey on bacterial translocation and intestinal villus histopathology in experimental obstructive jaundice.METHODS:Thirty Wistar-Albino rats were randomly divided into three groups each including 10 animals:group Ⅰ,sham-operated;group Ⅱ,ligation and section of the common bile duct(BDL);group Ⅲ,bile duct ligation followed by oral supplementation of honey(BDL+honey) 10 g/kg per day.Liver,blood,spleen,mesenteric lymph nodes,and ileal samples were taken for microbiological,light and transmission electrone microscopic examination.RESULTS:Although the number of villi per centimeter and the height of the mucosa were higher in sham group,there was no statistically significant difference between sham and BDL + honey groups(P>0.05).On the other hand,there was a statistically significant difference between BDL group and other groups(P<0.05).The electron microscopic changes werealso different between these groups.Sham and honey groups had similar incidence of bacterial translocation(P>0.05).BDL group had significantly higher rates of bacterial translocation as compared with sham and honey groups.Bacterial translocation was predominantly detected in mesenteric lymph nodes.CONCLUSION:Supplementation of honey in presence of obstructive jaundice ameliorates bacterial translocation and improves ileal morphology. | Cem Gencay Kemal Kismet Bulent Kilicoglu Serap Erel Mehmet Ali Akkus Sibel Serin Kilicoglu Sabahattin Muratoglu Asli Elif Sunay Esra Erdemli | 2008 | World Journal of Gastroenterology2008，14，21： | 8 |
| 6 | Comparison of intravitreal bevacizumab and triamcinolone acetonide theraphies for diffuse diabetic macular edema显示文摘AIM: To compare therapeutic effects of intravitreal triamcinolone acetonide(IVTA) versus intravitreal bevacizumab(IVB) injections for bilateral diffuse diabetic macular edema(DDME). METHODS: Forty eyes of 20 patients with bilateral DDME participated in this study. For each patient, 4 mg/0.1 m L IVTA was injected to one eye and 2.5 mg/0.1 m L IVB was injected to the other eye. The effects of injection for diabetic macular edema(DME) were evaluated using best-corrected visual acuity(BCVA), central macular thickness(CMT) by optical coherence tomography(OCT)and intraocular pressure(IOP) by applanation tonometer.Patients underwent eye examinations, including BCVA,CMT, and IOP at pre-injection, 1, 4, 8, 12 and 24 wk after injection. During the follow-up, second injections were performed to eyes which have CMT greater than 400 μm at 12 wk for salvage therapy.RESULTS: BCVA(logarithm of the minimum angle of resolution) at pre-injection, 1, 4, 8, 12 and 24 wk after injection was 0.71 ±0.19, 0.62 ±0.23, 0.63 ±0.12, 0.63 ±0.13,0.63±0.14 and 0.61±0.24 in the IVTA group and 0.68±0.25,0.61 ±0.22, 0.60 ±0.24, 0.62 ±0.25, 0.65 ±0.26 and 0.59 ±0.25 in the IVB group, respectively. CMT(μm) at pre-injection,1, 4, 8, 12 and 24 wk after injection was 544 ±125, 383±96,335 ±87, 323 ±87, 333 ±92, 335 ±61 in the IVTA group and514 ±100, 431 ±86, 428 ±107, 442 ±106, 478 ±112, 430 ±88 in the IVB group respectively. Reduction ratios of mean CMT were 29% at 1wk, 38% at 4wk, 40% at 8wk, 38% at12 wk, and 38% at 24 wk in the IVTA group. Second IVTA injections were performed to the 6 eyes(30%) at 12 wk.Reduction ratios of mean CMT were 16% at 1wk, 17% at4wk, 14% at 8wk, 7% at 12 wk, and 16% at 24 wk in the IVB group. Second IVB injections were performed to the15 eyes(75%) at 12 wk.CONCLUSION: This study showed earlier and more frequent macular edema recurrences in the eyes treated with bevacizumab compared with the ones treated with triamcinolone acetonide. Triamcinolone acetonide was found to provide more efficient and long-standing effect in terms of reducing CMT compared with the bevacizumab. | Sibel Aksoy Gursel Yilmaz Imren Akkoyun Ayse Canan Yazici | 2015 | International Journal of Ophthalmology(English edition)2015，8，3： | 6 |
| 7 | Assessment of the long-term visual and anatomical outcomes of ranibizumab to treat neovascular age-related macular degeneration显示文摘AIM: To investigate the long-term visual and anatomical outcomes of patients who underwent intravitreal ranibizumab monotherapy to treat neovascular age-related macular degeneration(AMD) and followed-up for at least 2 y.METHODS: A total of 74 eyes of 74 patients who underwent ranibizumab monotherapy for neovascular AMD were included in this retrospective study.RESULTS: The average patient age was 72.1±6.5(range, 57-85)y, the average follow-up time 46.2±13.1(range, 24-75)mo, and the average number of visits 24.1±9.5(range, 8-48). The mean number of injections in year 1 was 4.5, 1.6 in year 2, 0.9 in year 3, 0.4 on year 4, and 0.1 in the following years. Within the entire follow-up period, the mean number of injections was 7.6±4.4(range, 2-21). The mean visual acuity was 48.1±15(range, 15-76) letters at baseline and 45.7±19(range, 7-75) at year 5. The mean central macular thickness was 303±78(range, 178-552) μm at baseline and 251±51(range, 138-359) μm at year 5. Scars developed in 47(63.5%) eyes at the end of the follow-up period, and atrophy was evident in 6(8.1%) eyes.CONCLUSION: Ranibizumab monotherapy can stabilize visual acuity for a mean period of 4 y in patients with neovascular AMD. | Bekir Kücük Sibel Kadayifcilar Bora Eldem | 2018 | International Journal of Ophthalmology(English edition)2018，11，4： | 6 |
| 8 | Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal cancer显示文摘AIM: To assess the incidence of MLH1 (the human MutL homologue) and MSH2 (the human MutS homologue) protein expression in Turkish patients with sporadic colorectal cancers and to compare their survival and clinicopathological features. METHODS: We validated the tissue microarray technology in 77 colorectal carcinomas by analyzing the immunohistochemical expression of proteins involved in two main pathways of colorectal carcinogenesis: p53 protein for loss of heterozygosity tumors; MLH1 and MSH2 proteins for microsatellite instability (MSI). RESULTS: Our analysis showed that 29 (39.2%) had loss of MLH1 expression, 5 (6.8%) had loss of MSH2 expression and 2 cases had loss of expression of both proteins. We found that 60% of MSH2-negative tumors were located in the right side of the colon; all MSH2-negative cases were women. In addition, the loss of MSH2 expression was correlated with low p53 expression. Neither MLH1 nor MSH2 expressions were associated with prognosis, although there seemed a tendency of longer survival (71.7 ± 8.65 mo vs 47.08 ± 5.26 mo) for the patients with MLH1-negative versus MLH1-positive carcinomas. There were not significant differences in overall and recurrence-free survival among MLH1/MSH2-positive and -negative cases.CONCLUSION: Our data supports that Turkish patients with MLH1- and MSH2-defective tumors have some distinct features from each other. Although prognostic importance remains controversial, immunohistochemical analysis of mismatch repair genes may be used as a routine histopathological examination of sporadic colorectal carcinomas. | Sibel Erdamar Esra Ucaryilmaz Gokhan Demir Tayfun Karahasanoglu Gulen Dogusoy Ahmet Dirican Suha Goksel | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 9 | 不同含水率条件下EPS颗粒轻量土蠕变特性试验研究显示文摘为了得到轻量土路基中央部位在长期荷载作用下的蠕变规律,通过单向固结蠕变试验,分析了不同含水率EPS颗粒轻量土、素土在不同轴向压力下的蠕变特性。研究表明:固定其他因素,轴向压力越大,含水率越高,土样蠕变变形越大。轻量土加载1d基本上可以达到总变形的93%~98%,蠕变变形具有明显的衰减特征。轻量土是一种结构性土体,与素土蠕变机理完全不同。当轴向压力小于压缩屈服应力时,轻量土蠕变变形主要是孔隙闭合、水分的排出、固体颗粒移动的结果;当压力大于压缩屈服应力时,轻量土土样原有结构被破坏,EPS颗粒自身会被压缩。基于土体衰减蠕变特征,本文依据双曲线模型建立了轻量土经验蠕变模型,基本上可以反映路基中央部位轻量土的蠕变规律,经验模型适用于轻量土条件为轴向压力小于土体压缩屈服应力。试验与理论计算分析表明,轻量土固结特性优于素土,路基沉降在施工过程中就可以达到稳定,运营期间的工后沉降基本可以忽略。 | 刘德方 侯天顺 Sibel Pamukcu | 2017 | 工程地质学报2017，25，1： | 5 |
| 10 | Effects of resveratrol on hydrogen peroxide-induced oxidative stress in embryonic neural stem cells显示文摘Resveratrol,a natural phenolic compound,has been shown to prevent cardiovascular diseases and cancer and exhibit neuroprotective effects.In this study,we examined the neuroprotective and antioxidant effects of resveratrol against hydrogen peroxide in embryonic neural stem cells.Hydrogen peroxide treatment alone increased catalase and glutathione peroxidase activities but did not change superoxide dismutase levels compared with hydrogen peroxide + resveratrol treatment.Nitric oxide synthase activity and concomitant nitric oxide levels increased in response to hydrogen peroxide treatment.Conversely,resveratrol treatment decreased nitric oxide synthase activity and nitric oxide levels.Resveratrol also attenuated hydrogen peroxide-induced nuclear or mitochondrial DNA damage.We propose that resveratrol may be a promising agent for protecting embryonic neural stem cells because of its potential to decrease oxidative stress by inducing higher activity of antioxidant enzymes,decreasing nitric oxide production and nitric oxide synthase activity,and alleviating both nuclear and mitochondrial DNA damage. | Sibel Konyalioglu Guliz Armagan Ayfer Yalcin Cigdem Atalayin Taner Dagci | 2013 | Neural Regeneration Research2013，8，6： | 5 |
| 11 | A predictive score for retinopathy of prematurity by using clinical risk factors and serum insulin-like growth factor-1 levels显示文摘AIM: To detect the impact of insulin-like growth factor-1(IGF-1) and other risk factors for the early prediction of retinopathy of prematurity(ROP) and to establish a scoring system for ROP prediction by using clinical criteria and serum IGF-1 levels.METHODS: The study was conducted with 127 preterm infants. IGF-1 levels in the 1 st day of life, 1 st, 2 nd, 3 rd and 4 th week of life was analyzed. The score was established after logistic regression analysis, considering the impact of each variable on the occurrences of any stage ROP. A validation cohort containing 107 preterm infants was included in the study and the predictive ability of ROP score was calculated.RESULTS: Birth weights(BW), gestational weeks(GW) and the prevalence of breast milk consumption were lower, respiratory distress syndrome(RDS), bronchopulmonarydysplasia(BPD) and necrotizing enterocolitis(NEC) were more frequent, the duration of mechanical ventilation and oxygen supplementation was longer in patients with ROP(P<0.05). Initial serum IGF-1 levels tended to be lower in newborns who developed ROP. Logistic regression analysis revealed that low BW(<1250 g), presence of intraventricular hemorrhage(IVH) and formula feeding increased the risk of ROP. Afterwards, the scoring system was validated on 107 infants. The negative predictive values of a score less than 4 were 84.3%, 74.7% and 79.8% while positive predictive values were 76.3%, 65.5% and 71.6% respectively.CONCLUSION: In addition to BW <1250 g and IVH, formula consumption was detected as a risk factor for the development of ROP. Breastfeeding is important for prevention of ROP in preterm infants. | Yesim Coskun Ceyhun Dalkan Ozge Yabas Ozlem Onay Demirel Elif Samiye Bayar Sibel Sakarya Tuba Muftuoglu Dilaver Ersanli Nerin Bahceciler ipek Akman | 2017 | International Journal of Ophthalmology(English edition)2017，10，11： | 4 |
| 12 | 年龄相关性黄斑变性的脉络膜厚度评价(英文)显示文摘目的:通过光学相干断层扫描(optical coherence tomography,OCT;RTVue 100-2;V 5.1,Optovue,Fremont,CA,USA)测量比较非新生血管性与新生血管性年龄相关性黄斑变性(age-related macular degeneration,AMD)黄斑中心凹下脉络膜厚度(subfoveal choroidal thickness,SFCT),并分析脉络膜厚度(choroidal thickness,CT)对AMD新血管形成的影响。方法:本研究为回顾性、横断面研究。以单侧眼患有新生血管性AMD且对侧眼患有非新生血管性AMD的24例患者(48眼)作为研究组,选取年龄与眼轴长度相匹配的40例健康眼作为对照组。非新生血管性AMD亚组研究对象是黄斑区有玻璃疣和/或色素变化眼,而新生血管性AMD亚组研究对象是由于脉络膜新生血管而致视网膜下或视网膜内有渗出液和/或脂性渗出眼。运用OCT垂直测量外侧高反射线(视网膜色素上皮层)到脉络膜巩膜交界面间的距离。选取7个不同点进行脉络膜厚度测量,测量区域为距黄斑中心凹颞侧和鼻侧1500μm范围,测量间距为500μm。测量结果在亚组间进行统计学对比研究。结果:研究组患者平均年龄为72.4±8.97(60~82)岁,对照组受试者平均年龄为71.2±8.8(58~81)岁。新生血管性AMD组中平均SFCT明显大于非新生血管性AMD组的厚度(P<0.05)。非新生血管性AMD组中,平均SFCT与平均鼻、颞侧脉络膜厚度比较,差异无统计学意义(P>0.05);而新生血管性AMD组中,平均SFCT与平均鼻、颞侧脉络膜厚度比较,差异有统计学意义(P<0.05)。结论:运用OCT对脉络膜厚度进行测量,有助于理解AMD的病理生理机制。然而,仍需要大型前瞻性研究来探求新生血管性AMD中SFCT增厚的原因。 | Erkan Unsal Kadir Eltutar Ozen Ayranci Osmanbasoglu Sibel Zιrtιloglu Osman Kιzιlay Hulya Gungel | 2014 | 国际眼科杂志2014，14，9： | 4 |
| 13 | Effect of dyspnea and clinical variables on the quality of life and functional capacity in patients with chronic obstructive pulmonary disease and congestive heart failure显示文摘背景:长期的妨碍的肺的疾病(COPD ) 和充血心力衰竭(CHF ) 是否定地影响病人的生命的功能的条件和质量的二慢性病。我们在在 COPD 和 CHF 病人的生命的功能的能力和质量上估计了症状和临床的变量的效果。方法:学习包括了 42 COPD 和 39 个 CHF 病人。在两个耐心的组,呼吸困难用 Borg 规模被估计;由梭散步和心肺的锻练测试和由短 form-36 (SF36 ) 的生命的质量的功能的能力。结果:不,统计上,有效差量关于呼吸困难分数,梭散步测试和 SF36 的亚群分数的多数在两二个疾病组被发现(P >
0.05 ) 。一统计上,有效差量在山峰 VO (2 ) 被观察赞成 COPD 组(P <
0.05 ) 。没有重要关系在呼吸困难 20 之间被建立并且在 CHF 病人在 COPD 病人,和左室的喷射部分(LVEF ) 在一秒(FEV (1 )) 强迫了吐气的体积(P >
0.05 ) 。重要否定关联在在两个疾病组的呼吸困难分数和功能的能力测试之间被观察(P <
0.05 ) 。在另一方面,没有关系在 LVEF 和 FEV 和生命和功能的能力的质量(1 ) 之间被发现(P >
0.05 ) 。结论:然而,症状影响在两个疾病组的生命的功能的能力和质量,这被揭示疾病严厉的客观指示物不显示出一种类似的关系。除了与疾病有关的客观数据,因此,我们建议症状应该也被考虑估计心肺的康复节目并且在后面起来期间。 | Hale Karapolat Sibel Eyigor Alev Atasever Mehdi Zoghi Sanem Nalbantgil Berrin Durmaz | 2008 | Chinese Medical Journal2008，，7： | 4 |
| 14 | Treatment with NADPH oxidase inhibitor apocynin alleviates diabetic neuropathic pain in rats显示文摘Increased reactive oxygen species by the activation of NADPH oxidase(NOX) contributes to the development of diabetic complications.Apocynin,a NOX inhibitor,increases sciatic nerve conductance and blood flow in diabetic rats.We investigated potential protective effect of apocynin in rat diabetic neuropathy and its precise mechanism of action at molecular level.Rat models of streptozotocin-induced diabetes were treated with apocynin(30 and 100 mg/kg per day,intragastrically) for 4 weeks.Mechanical hyperalgesia and allodynia were determined weekly using analgesimeter and dynamic plantar aesthesiometer.Western blot analysis and histochemistry/immunohistochemistry were performed in the lumbar spinal cord and sciatic nerve respectively.Streptozotocin injection reduced pain threshold in analgesimeter,but not in aesthesiometer.Apocynin treatment increased pain threshold dose-dependently.Western blot analysis showed an increase in catalase and NOX-p47 phox protein expression in the spinal cord.However,protein expressions of neuronal and inducible nitric oxide synthase(n NOS,i NOS),superoxide dismutase,glutathion peroxidase,nitrotyrosine,tumor necrosis factor-α,interleukin-6,interleukin-1β,aldose reductase,cyclooxygenase-2 or MAC-1(marker for increased microgliosis) in the spinal cord remained unchanged.Western blot analysis results also demonstrated that apocynin decreased NOX-p47 phox expression at both doses and catalase expression at 100 mg/kg per day.Histochemistry of diabetic sciatic nerve revealed marked degeneration.n NOS and i NOS immunoreactivities were increased,while S-100 immunoreactivity(Schwann cell marker) was decreased in sciatic nerve.Apocynin treatment reversed these changes dose-dependently.In conclusion,decreased pain threshold of diabetic rats was accompanied by increased NOX and catalase expression in the spinal cord and increased degeneration in the sciatic nerve characterized by increased NOS expression and Schwann cell loss.Apocynin treatment attenuates neuropathic pain by decelerating the increased oxidative stress-mediated pathogenesis in diabetic rats. | Murat Olukman Aytül onal Fatma Gül celenk Yigit Uyankgil Türker cavusoglu Neslihan Düzenli Sibel ülker | 2018 | Neural Regeneration Research2018，13，9： | 4 |
| 15 | Exercise in patients coping with breast cancer: An overview显示文摘Breast cancer is the most common type of cancer in women, but fortunately has high survival rates. Many studies have been performed to investigate the effects of exercise in patients diagnosed with breast cancer. There is evidence that exercise after the diagnosis of breast cancer improves mortality, morbidity, health related quality of life, fatigue, physical functioning, muscle strength, and emotional wellbeing. Based on scientific data, breast cancer patients should be recommended to participate in rehabilitation programs including aerobic and strength training. The aim of this article is to review the recently published data on the effect of exercise in patients with breast cancer in order to present the current perspective on the topic. | Sibel Eyigor Selcen Kany?lmaz | 2014 | World Journal of Clinical Oncology2014，5，3： | 3 |
| 16 | Increased syndecan-1 and glypican-3 predict poor perinatal outcome and treatment resistance in intrahepatic cholestasis显示文摘Background:Intrahepatic cholestasis of pregnancy(ICP)increases the risk of adverse pregnancy outcomes.This study aimed to explore the association between serum syndecan-1 and glypican-3 levels and the adverse perinatal outcome as well as the responses to the treatment of ursodeoxycholic acid(UDCA).Methods:This prospective,case control study included 88 pregnant women(44 women with ICP and 44 healthy controls).The primary end points were the perinatal outcome and the response to UDCA therapy.A logistic regression model was used to identify the independent risk factors of adverse pregnancy outcomes and reduced response to UDCA therapy.Results:Women with ICP had significantly higher serum syndecan-1(1.27±0.36 ng/m L vs.0.98±0.50 ng/m L;P=0.003),glypican-3(1.78±0.13 ng/m L vs.1.69±0.16 ng/m L;P=0.004),AST(128.59±1.44 vs.13.29±1.32 U/L;P<0.001),and ALT(129.84±1.53 vs.8.00±3.67 U/L;P<0.001)levels compared with the controls.The increased levels of syndecan-1(OR=4.715,95%CI:1.554–14.310;P=0.006),glypican-3(OR=8.465,95%CI:3.372–21.248;P=0.007),ALT(OR=1.382,95%CI:1.131–1.690;P=0.002),and postprandial bile acid(PBA)(OR=3.392,95%CI:1.003–12.869;P=0.026)were correlated to ICP.The adverse neonatal outcome was related to increased glypican-3(OR=4.275,95%CI:2.726–5.635;P=0.039),and PBA(OR=3.026,95%CI:1.069–13.569;P=0.037).Increases of syndecan-1(OR=7.464,95%CI:2.130–26.153,P=0.017)and glypican-3(OR=6.194,95%CI:2.951–13.002;P=0.025)were the risk factors of decreased response to UDCA treatment.Conclusion:Syndecan-1 and glypican-3 might be powerful determinants in predicting adverse perinatal outcome in patients with ICP,and they can be used to predict the response to the UDCA treatment. | Basak Gümüs Güler Sibel Ozler | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，3： | 3 |
| 17 | 干湿循环作用下废弃泡沫轻量土水稳定性试验研究显示文摘为了研究干湿循环条件下轻量土的水稳定性,通过密度试验、无侧限抗压强度试验和质量损失率试验,研究了轻量土的物理特性和力学性能。研究发现,轻量土的密度、强度和质量在长期干湿循环作用下具有很高的稳定性,其中强度还出现了一定程度的增长。这是由于轻量土中的水泥发生水解水化反应及轻量土各组分之间的相互作用,使土体的结构性逐渐增强,最终形成一个致密而稳定的网络状胶结结构,来抵抗干湿循环环境产生的侵蚀作用。在经受30次干湿循环作用后,密度的绝对变化量为0.02~0.06g/cm3,相对变化量为0.93%~4.47%。轻量土的密度在干湿循环作用下能够保持稳定,泡沫掺量对轻量土密度的影响较为显著。强度的绝对增长量为276.79~891.64kPa,相对增长量为71.46%~114.15%。其中,水泥掺量和含水量变化时,强度随干湿循环次数增加而变化比较敏感。质量损失率的变化范围大致在-1.00%~1.00%之间;随着干湿循环时间的推移,质量能够趋于稳定。即:轻量土在干湿循环作用下具有良好的水稳定性。 | 任俊卿 侯天顺 Sibel Pamukcu | 2017 | 公路2017，62，2： | 3 |
| 18 | 动荷载下EPS颗粒混合轻量土的动强度特性试验研究显示文摘为研究EPS颗粒混合轻量土的动强度特性,以黄土作为原料土制备试样,对EPS颗粒掺入比为0.14%、0.31%、0.54%、0.86%、1.31%,水泥掺入比为10%、15%、20%的EPS颗粒混合轻量土进行室内动三轴试验。试验结果表明:EPS颗粒混合轻量土在动荷载作用过程中,动应变增长比较平稳,没有出现变形急速陡转的情况,而且压应变明显大于拉应变。选择5%压应变作为破坏标准进行分析。随着围压和水泥掺入比的增大,EPS颗粒混合轻量土动强度增大;随着EPS颗粒掺入比的增大,EPS颗粒混合轻量土动强度减小。相比较于本试验配制的重塑黄土动强度,不同配比的EPS颗粒混合轻量土的动强度增大幅度为20.8%~232.9%。该结论可为EPS颗粒混合轻量土在地基改良方面的应用提供参考和理论支持。 | 董理 侯天顺 骆亚生 Sibel Pamukcu | 2018 | 中国农村水利水电2018，，6： | 3 |
| 19 | Dynamics of circulating microparticles in chronic kidney disease and transplantation:Is it really reliable marker?显示文摘The deterioration of endothelial structure plays a very important role in the development of vascular diseases. It is believed that endothelial dysfunction starts in the early stage of kidney disease and is a risk factor of an unfavorable cardiovascular prognosis. Because a direct assessment of biological states in endothelial cells is not applicable, the measurement of endothelial microparticles(EMPs) detached from endothelium during activation or apoptosis is thought to be a marker of early vascular disease and endothelial dysfunction in children with chronic kidney disease(CKD). Few studies have shown increased circulating EMPs and its relationship with cardiovascular risk factors in patients with CKD.MPs contain membrane proteins and cytosolic material derived from the cell from which they originate. EMPs having CD144, CD 146, CD31+/CD41-, CD51 and CD105 may be used to evaluate the vascular endothelial cell damage and determine asymptomatic patients who might be at higher risk of developing cardiovascular disease in CKD and renal transplant. | Ismail Dursun Sibel Yel Emel Unsur | 2015 | World Journal of Transplantation2015，5，4： | 3 |
| 20 | Analysis of serum antibody profile against H pylori VacA and CagA antigens in Turkish patients with duodenal ulcer显示文摘AIM: To investigate the frequency of seropositivity aga- inst CagA, VacA proteins and to determine their indepen- dent effects on the development of duodenal ulcer (DU) in Turkish patients. METHODS: The study was designed as a prospective one from a tertiary referral hospital. Dyspeptic patients who were referred to our endoscopy unit for upper gas- trointestinal endoscopy between June 2003 and March 2004 and diagnosed to have DU or nonulcer dyspepsia (NUD) were included. Biopsies from the antrum and body of the stomach were taken in order to assess the current H pylori status by histology, rapid urease test and culture. Fasting sera were obtained from all patients and H pylori status of all sera was determined by IgG antibo- dies using an enzyme-linked immunosorbent assay (ELI- SA) kit. All seropositive patients were further analysed using Western blot assays detecting IgG antibodies aga- inst CagA and VacA proteins. The χ2 test was used for statistical comparison of the values and age-sex adjusted multiple regression analysis was used to determine the independent effects of CagA and VacA seropositivities on the development of DU. RESULTS: Sixty-three patients with DU and 62 patients with NUD were eligible for the final analysis. Seropositi- vity for anti-CagA was detected in 51 of 62 (82%), andin 55 of 63 (87%) patients with NUD and DU, respec- tively (p = no significance), and seropositivity for anti- VacA was found in 25 of 62 (40% ) and in 16 of 63 (25%) patients, with NUD and DU, respectively. CONCLUSION: These findings suggest that none of the- se virulence factors is associated with the development of DU in the studied Turkish patients with dyspepsia. | Yusuf Erzin Sibel Altun Ahmet Dobrucali Mustafa Aslan Sibel Erdamar Ahmet Dirican Murat Tuncer Bekir Kocazeybek | 2006 | World Journal of Gastroenterology2006，12，42： | 3 |
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